ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 126/670 423/7206 1.27483417188e-35 ko05033 Nicotine addiction 37/670 56/7206 2.07158535978e-25 ko04724 Glutamatergic synapse 56/670 152/7206 7.42516122409e-21 ko04721 Synaptic vesicle cycle 36/670 80/7206 4.18881317601e-17 ko05032 Morphine addiction 42/670 110/7206 1.45173148843e-16 ko04713 Circadian entrainment 47/670 136/7206 2.17680109176e-16 ko04728 Dopaminergic synapse 55/670 185/7206 1.10804472242e-15 ko04723 Retrograde endocannabinoid signaling 52/670 175/7206 7.12075090825e-15 ko04727 GABAergic synapse 39/670 110/7206 3.2276902389e-14 ko04725 Cholinergic synapse 46/670 160/7206 1.02821486945e-12 ko04020 Calcium signaling pathway 62/670 265/7206 2.88236424929e-12 ko04024 cAMP signaling pathway 63/670 279/7206 1.08809762687e-11 ko04921 Oxytocin signaling pathway 51/670 209/7206 5.35190048984e-11 ko04911 Insulin secretion 35/670 117/7206 1.70377475917e-10 ko05031 Amphetamine addiction 29/670 91/7206 1.24377836564e-09 ko04726 Serotonergic synapse 37/670 137/7206 1.27668213324e-09 ko04970 Salivary secretion 28/670 95/7206 1.69344872997e-08 ko04261 Adrenergic signaling in cardiomyocytes 44/670 205/7206 1.10458566632e-07 ko04720 Long-term potentiation 27/670 99/7206 1.81696682571e-07 ko05030 Cocaine addiction 22/670 73/7206 3.81169671328e-07 ko04966 Collecting duct acid secretion 12/670 26/7206 1.07574732859e-06 ko04022 cGMP-PKG signaling pathway 42/670 216/7206 3.59772958527e-06 ko04730 Long-term depression 21/670 78/7206 5.28819662193e-06 ko05203 Viral carcinogenesis 7/670 277/7206 1.09860521834e-05 ko03040 Spliceosome 1/670 145/7206 1.71392193825e-05 ko04972 Pancreatic secretion 25/670 111/7206 2.16060581094e-05 ko04971 Gastric acid secretion 23/670 98/7206 2.2734227288e-05 ko04540 Gap junction 27/670 128/7206 3.9141647859e-05 ko05168 Herpes simplex infection 3/670 182/7206 4.26337060233e-05 ko04070 Phosphatidylinositol signaling system 24/670 112/7206 9.03353836679e-05 ko05322 Systemic lupus erythematosus 2/670 151/7206 9.25396980791e-05 ko04742 Taste transduction 16/670 61/7206 9.79252643989e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 18/670 74/7206 0.000106528037551 ko05110 Vibrio cholerae infection 16/670 63/7206 0.000148277227594 ko04514 Cell adhesion molecules (CAMs) 26/670 130/7206 0.000167104976863 ko04964 Proximal tubule bicarbonate reclamation 10/670 29/7206 0.000175859046309 ko04925 Aldosterone synthesis and secretion 22/670 105/7206 0.000239154554916 ko04010 MAPK signaling pathway 50/670 321/7206 0.000239311396988 ko04120 Ubiquitin mediated proteolysis 2/670 138/7206 0.000286775720173 ko04745 Phototransduction - fly 11/670 38/7206 0.000478569573506 ko04360 Axon guidance 38/670 233/7206 0.000512358518551 ko03013 RNA transport 4/670 166/7206 0.000625412414389 ko05164 Influenza A 4/670 167/7206 0.000629547218376 ko04924 Renin secretion 18/670 86/7206 0.000987755394711 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/670 14/7206 0.00098785457548 ko05169 Epstein-Barr virus infection 7/670 206/7206 0.00142888098141 ko04630 Jak-STAT signaling pathway 3/670 132/7206 0.00218433530437 ko04961 Endocrine and other factor-regulated calcium reabsorption 13/670 59/7206 0.00249818026409 ko04740 Olfactory transduction 16/670 80/7206 0.00283604498282 ko04260 Cardiac muscle contraction 18/670 98/7206 0.00435273576577 ko04626 Plant-pathogen interaction 6/670 18/7206 0.00441879568481 ko05010 Alzheimer's disease 31/670 202/7206 0.0045200094333 ko04060 Cytokine-cytokine receptor interaction 7/670 191/7206 0.00497650694589 ko05120 Epithelial cell signaling in Helicobacter pylori infection 17/670 92/7206 0.00559029763227 ko05162 Measles 3/670 120/7206 0.00624801996894 ko04750 Inflammatory mediator regulation of TRP channels 21/670 122/7206 0.00654263842852 ko04015 Rap1 signaling pathway 39/670 278/7206 0.00820147713521 ko04510 Focal adhesion 11/670 240/7206 0.00884250403667 ko01524 Platinum drug resistance 1/670 76/7206 0.00889574928102 ko04612 Antigen processing and presentation 1/670 77/7206 0.00899082890664 ko05166 HTLV-I infection 15/670 292/7206 0.00989752971146 ko05161 Hepatitis B 7/670 173/7206 0.0115991296916 ko04621 NOD-like receptor signaling pathway 6/670 157/7206 0.0121321714184 ko05215 Prostate cancer 3/670 111/7206 0.0122714014154 ko04214 Apoptosis - fly 1/670 72/7206 0.0130463188674 ko00310 Lysine degradation 1/670 73/7206 0.0132287792242 ko05205 Proteoglycans in cancer 14/670 271/7206 0.0139791791215 ko04141 Protein processing in endoplasmic reticulum 8/670 184/7206 0.0144660787475 ko04014 Ras signaling pathway 38/670 279/7206 0.0151967580018 ko04710 Circadian rhythm 9/670 43/7206 0.0155589698641 ko04146 Peroxisome 2/670 89/7206 0.0156839277448 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 14/670 79/7206 0.0171453530179 ko05220 Chronic myeloid leukemia 2/670 85/7206 0.0223780427335 ko04330 Notch signaling pathway 1/670 62/7206 0.0276586598957 ko00680 Methane metabolism 7/670 34/7206 0.0339947278662 ko04071 Sphingolipid signaling pathway 23/670 162/7206 0.0388236834446 ko00330 Arginine and proline metabolism 1/670 61/7206 0.0419035341754 ko05323 Rheumatoid arthritis 14/670 89/7206 0.0427309328371 ko05140 Leishmaniasis 2/670 75/7206 0.0442945479786 ko00240 Pyrimidine metabolism 4/670 110/7206 0.0446270417856 ko04072 Phospholipase D signaling pathway 27/670 197/7206 0.0451319303873 ko00471 D-Glutamine and D-glutamate metabolism 2/670 4/7206 0.0456174833601 ko05414 Dilated cardiomyopathy 17/670 112/7206 0.0463943142278 ko04915 Estrogen signaling pathway 19/670 131/7206 0.0471085386608