ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	187/1076	423/7206	6.31871723274e-51
ko04724	Glutamatergic synapse	85/1076	152/7206	2.08139702412e-32
ko05033	Nicotine addiction	48/1076	56/7206	3.88319661821e-32
ko05032	Morphine addiction	63/1076	110/7206	4.99084470445e-25
ko04727	GABAergic synapse	62/1076	110/7206	3.95069803941e-24
ko04721	Synaptic vesicle cycle	51/1076	80/7206	1.74879751649e-23
ko04713	Circadian entrainment	69/1076	136/7206	3.83012937052e-23
ko04728	Dopaminergic synapse	83/1076	185/7206	4.76462572416e-23
ko04725	Cholinergic synapse	73/1076	160/7206	6.51441503294e-21
ko04723	Retrograde endocannabinoid signaling	76/1076	175/7206	3.89081753933e-20
ko04024	cAMP signaling pathway	98/1076	279/7206	9.85318424397e-18
ko04742	Taste transduction	36/1076	61/7206	2.19556256693e-15
ko04921	Oxytocin signaling pathway	77/1076	209/7206	3.06619622729e-15
ko04726	Serotonergic synapse	57/1076	137/7206	2.19635009925e-14
ko04911	Insulin secretion	51/1076	117/7206	5.70755912998e-14
ko04020	Calcium signaling pathway	85/1076	265/7206	8.38214236731e-13
ko04720	Long-term potentiation	44/1076	99/7206	1.3837241919e-12
ko04261	Adrenergic signaling in cardiomyocytes	69/1076	205/7206	1.00230765792e-11
ko05031	Amphetamine addiction	40/1076	91/7206	2.249665974e-11
ko04744	Phototransduction	23/1076	36/7206	2.67358704386e-11
ko04970	Salivary secretion	38/1076	95/7206	1.96601805216e-09
ko03040	Spliceosome	1/1076	145/7206	2.18713792352e-09
ko04360	Axon guidance	70/1076	233/7206	2.99737451278e-09
ko05203	Viral carcinogenesis	12/1076	277/7206	1.39483672761e-08
ko04971	Gastric acid secretion	36/1076	98/7206	7.24535875952e-08
ko04060	Cytokine-cytokine receptor interaction	6/1076	191/7206	1.43066927482e-07
ko05030	Cocaine addiction	29/1076	73/7206	1.94276904373e-07
ko05168	Herpes simplex infection	6/1076	182/7206	4.29074048026e-07
ko05164	Influenza A	5/1076	167/7206	4.77179420103e-07
ko04740	Olfactory transduction	30/1076	80/7206	5.30668479046e-07
ko04010	MAPK signaling pathway	80/1076	321/7206	1.77685191896e-06
ko04925	Aldosterone synthesis and secretion	35/1076	105/7206	2.3415406435e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1076	74/7206	3.61815534879e-06
ko04966	Collecting duct acid secretion	14/1076	26/7206	4.1801397943e-06
ko05322	Systemic lupus erythematosus	5/1076	151/7206	4.5532469496e-06
ko04120	Ubiquitin mediated proteolysis	4/1076	138/7206	5.18074944114e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1076	79/7206	7.24574878037e-06
ko04022	cGMP-PKG signaling pathway	57/1076	216/7206	9.75612956985e-06
ko04621	NOD-like receptor signaling pathway	6/1076	157/7206	1.17237171694e-05
ko03013	RNA transport	7/1076	166/7206	1.30421053832e-05
ko04540	Gap junction	38/1076	128/7206	1.52083985602e-05
ko04141	Protein processing in endoplasmic reticulum	9/1076	184/7206	2.17378011419e-05
ko04730	Long-term depression	26/1076	78/7206	3.7934057665e-05
ko04745	Phototransduction - fly	16/1076	38/7206	4.70345594036e-05
ko05169	Epstein-Barr virus infection	12/1076	206/7206	6.07542640579e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1076	59/7206	6.6119448485e-05
ko04972	Pancreatic secretion	33/1076	111/7206	6.75070457368e-05
ko05414	Dilated cardiomyopathy	33/1076	112/7206	7.52050438208e-05
ko04260	Cardiac muscle contraction	30/1076	98/7206	7.62800274524e-05
ko04612	Antigen processing and presentation	1/1076	77/7206	8.04165834916e-05
ko05110	Vibrio cholerae infection	22/1076	63/7206	9.80950424811e-05
ko04014	Ras signaling pathway	65/1076	279/7206	0.000150512218525
ko04514	Cell adhesion molecules (CAMs)	36/1076	130/7206	0.000152590578918
ko04072	Phospholipase D signaling pathway	49/1076	197/7206	0.000225968820008
ko04070	Phosphatidylinositol signaling system	32/1076	112/7206	0.00023257151697
ko05162	Measles	5/1076	120/7206	0.000246513187556
ko04064	NF-kappa B signaling pathway	3/1076	96/7206	0.000254512118886
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1076	14/7206	0.000311983937273
ko04924	Renin secretion	26/1076	86/7206	0.000327531682859
ko05205	Proteoglycans in cancer	21/1076	271/7206	0.000348441486374
ko04110	Cell cycle	8/1076	145/7206	0.000564130310984
ko03008	Ribosome biogenesis in eukaryotes	2/1076	79/7206	0.000641258849661
ko05161	Hepatitis B	11/1076	173/7206	0.000727078801109
ko05140	Leishmaniasis	2/1076	75/7206	0.000907366083773
ko04750	Inflammatory mediator regulation of TRP channels	32/1076	122/7206	0.0011596752566
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1076	100/7206	0.00161251715186
ko04915	Estrogen signaling pathway	33/1076	131/7206	0.00180789909132
ko04146	Peroxisome	4/1076	89/7206	0.00260503511984
ko04668	TNF signaling pathway	7/1076	120/7206	0.002772100521
ko00240	Pyrimidine metabolism	6/1076	110/7206	0.00279112955537
ko01524	Platinum drug resistance	3/1076	76/7206	0.00336990272412
ko00480	Glutathione metabolism	1/1076	55/7206	0.003409663786
ko04371	Apelin signaling pathway	41/1076	177/7206	0.00366316979417
ko04976	Bile secretion	22/1076	80/7206	0.00383253722956
ko04640	Hematopoietic cell lineage	2/1076	64/7206	0.00418887487517
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1076	182/7206	0.00421501075864
ko00590	Arachidonic acid metabolism	1/1076	52/7206	0.0050120536401
ko03018	RNA degradation	4/1076	84/7206	0.00517831449622
ko00330	Arginine and proline metabolism	2/1076	61/7206	0.00608595799413
ko04214	Apoptosis - fly	3/1076	72/7206	0.00697732946179
ko04964	Proximal tubule bicarbonate reclamation	10/1076	29/7206	0.00706938819185
ko00260	Glycine, serine and threonine metabolism	1/1076	48/7206	0.00711779380429
ko04912	GnRH signaling pathway	29/1076	122/7206	0.00972724134318
ko04015	Rap1 signaling pathway	57/1076	278/7206	0.0099255856736
ko05144	Malaria	1/1076	45/7206	0.0105668146405
ko00071	Fatty acid degradation	1/1076	45/7206	0.0105668146405
ko03022	Basal transcription factors	1/1076	44/7206	0.0105695612947
ko00620	Pyruvate metabolism	1/1076	46/7206	0.0108677860407
ko03420	Nucleotide excision repair	1/1076	46/7206	0.0108677860407
ko05145	Toxoplasmosis	9/1076	126/7206	0.011163658981
ko04626	Plant-pathogen interaction	7/1076	18/7206	0.0114324302113
ko05321	Inflammatory bowel disease (IBD)	2/1076	56/7206	0.0129627624671
ko04630	Jak-STAT signaling pathway	10/1076	132/7206	0.0134866627714
ko04217	Necroptosis	15/1076	178/7206	0.0137646514442
ko04657	IL-17 signaling pathway	5/1076	87/7206	0.0143293917388
ko05166	HTLV-I infection	29/1076	292/7206	0.0147304835532
ko00983	Drug metabolism - other enzymes	1/1076	42/7206	0.0156875260881
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1076	15/7206	0.0163487570429
ko04916	Melanogenesis	32/1076	142/7206	0.016596680285
ko04350	TGF-beta signaling pathway	7/1076	103/7206	0.01723954119
ko05418	Fluid shear stress and atherosclerosis	15/1076	173/7206	0.0172423253592
ko04622	RIG-I-like receptor signaling pathway	3/1076	62/7206	0.0196398989677
ko00310	Lysine degradation	4/1076	73/7206	0.019821697486
ko04620	Toll-like receptor signaling pathway	7/1076	100/7206	0.023040896872
ko04923	Regulation of lipolysis in adipocytes	19/1076	77/7206	0.0231013277646
ko01200	Carbon metabolism	10/1076	128/7206	0.0233670733948
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1076	40/7206	0.0236202748952
ko00140	Steroid hormone biosynthesis	1/1076	41/7206	0.0245808015427
ko05222	Small cell lung cancer	6/1076	89/7206	0.0247361425868
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1076	92/7206	0.0256956774418
ko04114	Oocyte meiosis	30/1076	139/7206	0.0304796336565
ko04658	Th1 and Th2 cell differentiation	7/1076	96/7206	0.0306214675242
ko04930	Type II diabetes mellitus	14/1076	54/7206	0.0328298268434
ko05133	Pertussis	6/1076	87/7206	0.0332668673333
ko00982	Drug metabolism - cytochrome P450	1/1076	37/7206	0.0348157346748
ko04140	Autophagy - animal	15/1076	164/7206	0.034865526485
ko03410	Base excision repair	1/1076	38/7206	0.0359867438319
ko00270	Cysteine and methionine metabolism	2/1076	47/7206	0.0383451281185
ko05215	Prostate cancer	9/1076	111/7206	0.0433104344447
ko05212	Pancreatic cancer	6/1076	83/7206	0.0444457046761
ko04115	p53 signaling pathway	5/1076	74/7206	0.0482610294798
ko04973	Carbohydrate digestion and absorption	11/1076	42/7206	0.0494121388531
ko04670	Leukocyte transendothelial migration	14/1076	151/7206	0.0494574048446