ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	143/867	423/7206	3.39415426362e-34
ko05033	Nicotine addiction	44/867	56/7206	1.71769457947e-30
ko04724	Glutamatergic synapse	73/867	152/7206	1.49285320594e-28
ko05032	Morphine addiction	57/867	110/7206	1.24524091845e-24
ko04727	GABAergic synapse	54/867	110/7206	6.1922491241e-22
ko04723	Retrograde endocannabinoid signaling	69/867	175/7206	6.7086923248e-21
ko04728	Dopaminergic synapse	71/867	185/7206	1.10830843185e-20
ko04721	Synaptic vesicle cycle	43/867	80/7206	1.16058316032e-19
ko04713	Circadian entrainment	54/867	136/7206	9.64501624996e-17
ko04725	Cholinergic synapse	59/867	160/7206	2.12143171489e-16
ko04726	Serotonergic synapse	50/867	137/7206	7.18082160869e-14
ko04024	cAMP signaling pathway	75/867	279/7206	5.64276861817e-12
ko04911	Insulin secretion	41/867	117/7206	5.96750772277e-11
ko04742	Taste transduction	26/867	61/7206	1.62984581875e-09
ko04744	Phototransduction	18/867	36/7206	2.57120528495e-08
ko05031	Amphetamine addiction	31/867	91/7206	2.87390026388e-08
ko04020	Calcium signaling pathway	62/867	265/7206	1.28366693454e-07
ko05030	Cocaine addiction	26/867	73/7206	1.3706415787e-07
ko03040	Spliceosome	1/867	145/7206	2.24638293091e-07
ko04720	Long-term potentiation	31/867	99/7206	2.55796686041e-07
ko04514	Cell adhesion molecules (CAMs)	37/867	130/7206	3.28425796584e-07
ko04921	Oxytocin signaling pathway	51/867	209/7206	4.30604935648e-07
ko04261	Adrenergic signaling in cardiomyocytes	49/867	205/7206	1.72685628752e-06
ko04120	Ubiquitin mediated proteolysis	2/867	138/7206	7.45039345803e-06
ko04970	Salivary secretion	27/867	95/7206	1.64121345834e-05
ko04966	Collecting duct acid secretion	12/867	26/7206	1.64509318505e-05
ko05203	Viral carcinogenesis	13/867	277/7206	2.95047297359e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	22/867	74/7206	3.48757915562e-05
ko04972	Pancreatic secretion	29/867	111/7206	4.2375374686e-05
ko04070	Phosphatidylinositol signaling system	29/867	112/7206	4.77423318271e-05
ko05164	Influenza A	5/867	167/7206	5.34933165117e-05
ko05322	Systemic lupus erythematosus	4/867	151/7206	6.45482093636e-05
ko04730	Long-term depression	22/867	78/7206	0.000127371087565
ko04141	Protein processing in endoplasmic reticulum	7/867	184/7206	0.000129440175492
ko04621	NOD-like receptor signaling pathway	5/867	157/7206	0.000154754859617
ko05168	Herpes simplex infection	7/867	182/7206	0.000182553002368
ko04010	MAPK signaling pathway	61/867	321/7206	0.000209290385039
ko04971	Gastric acid secretion	25/867	98/7206	0.000216943949116
ko03013	RNA transport	6/867	166/7206	0.000239415126755
ko04964	Proximal tubule bicarbonate reclamation	11/867	29/7206	0.000317796337263
ko04072	Phospholipase D signaling pathway	41/867	197/7206	0.000339245265342
ko04360	Axon guidance	46/867	233/7206	0.000647978777256
ko04925	Aldosterone synthesis and secretion	25/867	105/7206	0.000688862635356
ko05205	Proteoglycans in cancer	16/867	271/7206	0.000817602230303
ko04014	Ras signaling pathway	52/867	279/7206	0.000984697065428
ko04612	Antigen processing and presentation	1/867	77/7206	0.00114823997887
ko04060	Cytokine-cytokine receptor interaction	10/867	191/7206	0.00214584662305
ko04217	Necroptosis	9/867	178/7206	0.00223321153557
ko05110	Vibrio cholerae infection	16/867	63/7206	0.00286501614741
ko04976	Bile secretion	19/867	80/7206	0.00286839595005
ko05161	Hepatitis B	9/867	173/7206	0.00298668360279
ko04064	NF-kappa B signaling pathway	3/867	96/7206	0.00391691760105
ko04260	Cardiac muscle contraction	22/867	98/7206	0.00416297919565
ko04610	Complement and coagulation cascades	2/867	79/7206	0.00478817373432
ko03008	Ribosome biogenesis in eukaryotes	2/867	79/7206	0.00478817373432
ko04022	cGMP-PKG signaling pathway	40/867	216/7206	0.00541661092229
ko04640	Hematopoietic cell lineage	1/867	64/7206	0.00563771541386
ko05140	Leishmaniasis	2/867	75/7206	0.00688795893017
ko05166	HTLV-I infection	21/867	292/7206	0.00759378305785
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	18/867	79/7206	0.00775971927418
ko04915	Estrogen signaling pathway	26/867	131/7206	0.00934195382897
ko05034	Alcoholism	42/867	238/7206	0.010848997944
ko04930	Type II diabetes mellitus	13/867	54/7206	0.0110324035577
ko04540	Gap junction	25/867	128/7206	0.0129272037822
ko04110	Cell cycle	8/867	145/7206	0.0134947538508
ko04710	Circadian rhythm	11/867	43/7206	0.0148753504534
ko05120	Epithelial cell signaling in Helicobacter pylori infection	19/867	92/7206	0.015110780894
ko05162	Measles	6/867	120/7206	0.0151775912837
ko04371	Apelin signaling pathway	32/867	177/7206	0.0185074025028
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/867	14/7206	0.0196557027464
ko04745	Phototransduction - fly	10/867	38/7206	0.0197395989287
ko04961	Endocrine and other factor-regulated calcium reabsorption	13/867	59/7206	0.0255323580536
ko05219	Bladder cancer	1/867	48/7206	0.0255395309315
ko04960	Aldosterone-regulated sodium reabsorption	10/867	41/7206	0.0258717297721
ko04218	Cellular senescence	12/867	177/7206	0.0261943619956
ko04510	Focal adhesion	18/867	240/7206	0.0262009374091
ko04071	Sphingolipid signaling pathway	29/867	162/7206	0.0270533700976
ko04330	Notch signaling pathway	2/867	62/7206	0.0292527613812
ko05133	Pertussis	4/867	87/7206	0.0299059715206
ko04115	p53 signaling pathway	3/867	74/7206	0.0301732945129
ko00310	Lysine degradation	3/867	73/7206	0.0301887098862
ko04630	Jak-STAT signaling pathway	8/867	132/7206	0.0303825213538
ko04146	Peroxisome	4/867	89/7206	0.0309339832272
ko05016	Huntington's disease	16/867	215/7206	0.0332451077487
ko04062	Chemokine signaling pathway	34/867	201/7206	0.0362903765074
ko00240	Pyrimidine metabolism	6/867	110/7206	0.0368964844682
ko00071	Fatty acid degradation	1/867	45/7206	0.037465328516
ko03420	Nucleotide excision repair	1/867	46/7206	0.0378768248086
ko05169	Epstein-Barr virus infection	15/867	206/7206	0.0380333588157
ko04137	Mitophagy - animal	4/867	82/7206	0.0407270010697
ko05231	Choline metabolism in cancer	24/867	134/7206	0.0432896021167
ko04210	Apoptosis	13/867	180/7206	0.0477026314241
ko00562	Inositol phosphate metabolism	17/867	89/7206	0.0478892117776
ko04750	Inflammatory mediator regulation of TRP channels	22/867	122/7206	0.0483578322085