ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	204/1252	423/7206	6.4648514395e-52
ko04724	Glutamatergic synapse	96/1252	152/7206	4.6930490565e-37
ko05033	Nicotine addiction	50/1252	56/7206	4.80141990254e-32
ko05032	Morphine addiction	74/1252	110/7206	1.92752842782e-31
ko04713	Circadian entrainment	83/1252	136/7206	1.45329233004e-30
ko04727	GABAergic synapse	69/1252	110/7206	1.33863203391e-26
ko04725	Cholinergic synapse	82/1252	160/7206	4.11018941181e-23
ko04728	Dopaminergic synapse	88/1252	185/7206	7.48924912293e-22
ko04721	Synaptic vesicle cycle	52/1252	80/7206	2.31420353965e-21
ko04723	Retrograde endocannabinoid signaling	82/1252	175/7206	6.57102047719e-20
ko04024	cAMP signaling pathway	110/1252	279/7206	5.53641352938e-19
ko04911	Insulin secretion	61/1252	117/7206	5.94710886635e-18
ko04020	Calcium signaling pathway	102/1252	265/7206	8.9282193804e-17
ko04921	Oxytocin signaling pathway	86/1252	209/7206	3.09741179158e-16
ko04726	Serotonergic synapse	62/1252	137/7206	1.90052124462e-14
ko04742	Taste transduction	37/1252	61/7206	3.78594069958e-14
ko04744	Phototransduction	26/1252	36/7206	5.87923790199e-13
ko04720	Long-term potentiation	48/1252	99/7206	7.59421543628e-13
ko05031	Amphetamine addiction	45/1252	91/7206	1.65367075965e-12
ko04261	Adrenergic signaling in cardiomyocytes	77/1252	205/7206	3.25546961681e-12
ko03040	Spliceosome	1/1252	145/7206	4.33914198157e-11
ko04970	Salivary secretion	43/1252	95/7206	2.02966973253e-10
ko04360	Axon guidance	77/1252	233/7206	3.43119709179e-09
ko04925	Aldosterone synthesis and secretion	43/1252	105/7206	1.06642289711e-08
ko04971	Gastric acid secretion	41/1252	98/7206	1.60316335637e-08
ko05030	Cocaine addiction	32/1252	73/7206	1.08639923472e-07
ko04740	Olfactory transduction	34/1252	80/7206	1.10086988176e-07
ko03013	RNA transport	7/1252	166/7206	3.81284947545e-07
ko05322	Systemic lupus erythematosus	6/1252	151/7206	6.4579249853e-07
ko05168	Herpes simplex infection	9/1252	182/7206	7.60456122275e-07
ko05203	Viral carcinogenesis	20/1252	277/7206	9.33266283186e-07
ko04022	cGMP-PKG signaling pathway	66/1252	216/7206	1.51564788534e-06
ko04972	Pancreatic secretion	40/1252	111/7206	1.81142794655e-06
ko04060	Cytokine-cytokine receptor interaction	11/1252	191/7206	2.44567845087e-06
ko04730	Long-term depression	31/1252	78/7206	2.61016274969e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1252	74/7206	2.72478284763e-06
ko04010	MAPK signaling pathway	88/1252	321/7206	5.11007997723e-06
ko04540	Gap junction	42/1252	128/7206	1.69311285191e-05
ko05164	Influenza A	10/1252	167/7206	1.78794474044e-05
ko04745	Phototransduction - fly	18/1252	38/7206	1.84576478416e-05
ko04141	Protein processing in endoplasmic reticulum	12/1252	184/7206	1.85589657893e-05
ko04070	Phosphatidylinositol signaling system	38/1252	112/7206	2.1968172994e-05
ko04621	NOD-like receptor signaling pathway	9/1252	157/7206	2.47416084595e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	24/1252	59/7206	3.22014257462e-05
ko04110	Cell cycle	8/1252	145/7206	3.22197018941e-05
ko04072	Phospholipase D signaling pathway	57/1252	197/7206	5.14355251147e-05
ko04610	Complement and coagulation cascades	2/1252	79/7206	7.01423611312e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1252	79/7206	7.01423611312e-05
ko05110	Vibrio cholerae infection	24/1252	63/7206	7.67935049026e-05
ko04924	Renin secretion	30/1252	86/7206	7.81113499457e-05
ko05169	Epstein-Barr virus infection	16/1252	206/7206	7.88467345376e-05
ko04514	Cell adhesion molecules (CAMs)	41/1252	130/7206	8.89168383398e-05
ko04612	Antigen processing and presentation	2/1252	77/7206	0.000106045086118
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1252	79/7206	0.000123621688858
ko05414	Dilated cardiomyopathy	36/1252	112/7206	0.000125245566082
ko04966	Collecting duct acid secretion	13/1252	26/7206	0.00013660100139
ko04014	Ras signaling pathway	73/1252	279/7206	0.000190234250075
ko04976	Bile secretion	27/1252	80/7206	0.000483622752224
ko00520	Amino sugar and nucleotide sugar metabolism	1/1252	55/7206	0.000526875088725
ko04371	Apelin signaling pathway	49/1252	177/7206	0.00057176124613
ko04064	NF-kappa B signaling pathway	5/1252	96/7206	0.000595960398015
ko04260	Cardiac muscle contraction	31/1252	98/7206	0.000638848419357
ko04120	Ubiquitin mediated proteolysis	10/1252	138/7206	0.000884571879097
ko05162	Measles	8/1252	120/7206	0.000917076443751
ko04915	Estrogen signaling pathway	38/1252	131/7206	0.00097926475736
ko04923	Regulation of lipolysis in adipocytes	25/1252	77/7206	0.00121737966908
ko04912	GnRH signaling pathway	35/1252	122/7206	0.00162346081029
ko04146	Peroxisome	5/1252	89/7206	0.0017103967071
ko03420	Nucleotide excision repair	1/1252	46/7206	0.00278682463442
ko05161	Hepatitis B	16/1252	173/7206	0.00308155446751
ko05140	Leishmaniasis	4/1252	75/7206	0.00324210637955
ko00240	Pyrimidine metabolism	8/1252	110/7206	0.00325532689265
ko04750	Inflammatory mediator regulation of TRP channels	34/1252	122/7206	0.00355979611489
ko05321	Inflammatory bowel disease (IBD)	2/1252	56/7206	0.00381206332709
ko05205	Proteoglycans in cancer	30/1252	271/7206	0.00415058148189
ko03022	Basal transcription factors	1/1252	44/7206	0.00425359782751
ko05144	Malaria	1/1252	45/7206	0.00450585826106
ko04115	p53 signaling pathway	4/1252	74/7206	0.00480025747072
ko04916	Melanogenesis	38/1252	142/7206	0.00485310787644
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1252	14/7206	0.00518470418275
ko00590	Arachidonic acid metabolism	2/1252	52/7206	0.00540943744945
ko00330	Arginine and proline metabolism	3/1252	61/7206	0.00614710742341
ko04622	RIG-I-like receptor signaling pathway	3/1252	62/7206	0.00624168812137
ko04918	Thyroid hormone synthesis	25/1252	86/7206	0.00624675069694
ko00140	Steroid hormone biosynthesis	1/1252	41/7206	0.00632217909331
ko04657	IL-17 signaling pathway	6/1252	87/7206	0.0065161745918
ko04626	Plant-pathogen interaction	8/1252	18/7206	0.00685783961474
ko03018	RNA degradation	6/1252	84/7206	0.00898808878323
ko03320	PPAR signaling pathway	4/1252	69/7206	0.0095513703181
ko04015	Rap1 signaling pathway	65/1252	278/7206	0.00956905776852
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1252	182/7206	0.00995935012338
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1252	40/7206	0.0100315104296
ko04630	Jak-STAT signaling pathway	12/1252	132/7206	0.0102527468538
ko04930	Type II diabetes mellitus	17/1252	54/7206	0.0104701752872
ko04964	Proximal tubule bicarbonate reclamation	11/1252	29/7206	0.0107250853604
ko00310	Lysine degradation	5/1252	73/7206	0.0127791651152
ko00982	Drug metabolism - cytochrome P450	1/1252	37/7206	0.0145861168561
ko04658	Th1 and Th2 cell differentiation	8/1252	96/7206	0.0146411670242
ko05222	Small cell lung cancer	7/1252	89/7206	0.0158689242759
ko04217	Necroptosis	19/1252	178/7206	0.0158754623045
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1252	100/7206	0.015904080215
ko00071	Fatty acid degradation	2/1252	45/7206	0.0169144947194
ko05145	Toxoplasmosis	12/1252	126/7206	0.0172499420731
ko04062	Chemokine signaling pathway	48/1252	201/7206	0.0178570451349
ko04214	Apoptosis - fly	5/1252	72/7206	0.0178604210031
ko00480	Glutathione metabolism	3/1252	55/7206	0.0184740694764
ko05231	Choline metabolism in cancer	34/1252	134/7206	0.0205690560536
ko00230	Purine metabolism	46/1252	194/7206	0.0211019483013
ko05133	Pertussis	7/1252	87/7206	0.0215822242881
ko04960	Aldosterone-regulated sodium reabsorption	13/1252	41/7206	0.0218282171183
ko04210	Apoptosis	20/1252	180/7206	0.0220077486895
ko00562	Inositol phosphate metabolism	24/1252	89/7206	0.0232363630609
ko04270	Vascular smooth muscle contraction	38/1252	154/7206	0.0232605243647
ko05418	Fluid shear stress and atherosclerosis	19/1252	173/7206	0.0249737442387
ko04922	Glucagon signaling pathway	32/1252	128/7206	0.0252880245148
ko04510	Focal adhesion	29/1252	240/7206	0.0298571699867
ko04114	Oocyte meiosis	34/1252	139/7206	0.0313119817076
ko05166	HTLV-I infection	37/1252	292/7206	0.0328882820937
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1252	15/7206	0.032906729446
ko05214	Glioma	21/1252	79/7206	0.0361058768575
ko05034	Alcoholism	54/1252	238/7206	0.0362830150375
ko04973	Carbohydrate digestion and absorption	13/1252	42/7206	0.0377083284627
ko05131	Shigellosis	7/1252	82/7206	0.0385970902173
ko05202	Transcriptional misregulation in cancer	22/1252	188/7206	0.040012648026
ko04710	Circadian rhythm	13/1252	43/7206	0.0402357737075
ko05320	Autoimmune thyroid disease	1/1252	29/7206	0.0478786873272
ko05340	Primary immunodeficiency	1/1252	30/7206	0.0491926062828