ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 24/252 80/7206 1.07189901813e-16 ko04724 Glutamatergic synapse 31/252 152/7206 5.49243342922e-16 ko05033 Nicotine addiction 19/252 56/7206 1.4569495894e-14 ko04728 Dopaminergic synapse 32/252 185/7206 2.54768817263e-14 ko04080 Neuroactive ligand-receptor interaction 46/252 423/7206 2.24754454363e-12 ko04727 GABAergic synapse 23/252 110/7206 2.28721009502e-12 ko04723 Retrograde endocannabinoid signaling 27/252 175/7206 4.9488708925e-11 ko04713 Circadian entrainment 22/252 136/7206 1.33948149601e-09 ko05032 Morphine addiction 19/252 110/7206 6.08899416377e-09 ko04725 Cholinergic synapse 20/252 160/7206 6.34090527158e-07 ko05030 Cocaine addiction 13/252 73/7206 1.13917844103e-06 ko05031 Amphetamine addiction 14/252 91/7206 2.74353157085e-06 ko04961 Endocrine and other factor-regulated calcium reabsorption 11/252 59/7206 4.85884311872e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 12/252 74/7206 8.20506241525e-06 ko04726 Serotonergic synapse 16/252 137/7206 2.07703622226e-05 ko05010 Alzheimer's disease 18/252 202/7206 0.00023372531814 ko04720 Long-term potentiation 11/252 99/7206 0.000635853609948 ko04911 Insulin secretion 12/252 117/7206 0.000755285335115 ko04024 cAMP signaling pathway 21/252 279/7206 0.00118158496943 ko04972 Pancreatic secretion 11/252 111/7206 0.00165082734701 ko04540 Gap junction 12/252 128/7206 0.00166493264671 ko05034 Alcoholism 18/252 238/7206 0.00181517506725 ko04514 Cell adhesion molecules (CAMs) 12/252 130/7206 0.00190143599223 ko04260 Cardiac muscle contraction 10/252 98/7206 0.00213903995035 ko04145 Phagosome 13/252 162/7206 0.00430919185645 ko04730 Long-term depression 8/252 78/7206 0.0056613994795 ko04261 Adrenergic signaling in cardiomyocytes 15/252 205/7206 0.00595021513484 ko05110 Vibrio cholerae infection 7/252 63/7206 0.00612390426998 ko05205 Proteoglycans in cancer 2/252 271/7206 0.00628921639884 ko04921 Oxytocin signaling pathway 15/252 209/7206 0.00689541648274 ko04010 MAPK signaling pathway 20/252 321/7206 0.0117065772152 ko04966 Collecting duct acid secretion 4/252 26/7206 0.0119046732556 ko02024 Quorum sensing 3/252 15/7206 0.0140773776536 ko04060 Cytokine-cytokine receptor interaction 1/252 191/7206 0.0151611143873 ko04020 Calcium signaling pathway 17/252 265/7206 0.0153280344679 ko00230 Purine metabolism 1/252 194/7206 0.0153939623613 ko04970 Salivary secretion 8/252 95/7206 0.0177078843439 ko04510 Focal adhesion 2/252 240/7206 0.0182208626343 ko05203 Viral carcinogenesis 3/252 277/7206 0.0189353170343 ko04217 Necroptosis 1/252 178/7206 0.0218197220685 ko05164 Influenza A 1/252 167/7206 0.0314603945043 ko05323 Rheumatoid arthritis 7/252 89/7206 0.035666484903 ko05120 Epithelial cell signaling in Helicobacter pylori infection 7/252 92/7206 0.0415749670924 ko05167 Kaposi's sarcoma-associated herpesvirus infection 12/252 191/7206 0.043532569095 ko04360 Axon guidance 14/252 233/7206 0.0439093988572 ko04014 Ras signaling pathway 16/252 279/7206 0.0451984497714 ko04611 Platelet activation 1/252 163/7206 0.0472800876384 ko04915 Estrogen signaling pathway 9/252 131/7206 0.0487131944216 ko04978 Mineral absorption 4/252 40/7206 0.0498782812052