ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	165/997	423/7206	1.07741786935e-40
ko05033	Nicotine addiction	49/997	56/7206	2.52249713439e-35
ko04724	Glutamatergic synapse	85/997	152/7206	5.64281604402e-35
ko05032	Morphine addiction	68/997	110/7206	7.23595113931e-32
ko04727	GABAergic synapse	63/997	110/7206	6.36378010662e-27
ko04713	Circadian entrainment	66/997	136/7206	1.08193792723e-22
ko04723	Retrograde endocannabinoid signaling	75/997	175/7206	1.6847562207e-21
ko04728	Dopaminergic synapse	77/997	185/7206	4.20962550174e-21
ko04721	Synaptic vesicle cycle	46/997	80/7206	4.74342281869e-20
ko04725	Cholinergic synapse	68/997	160/7206	2.41299290445e-19
ko04024	cAMP signaling pathway	93/997	279/7206	2.0034242928e-17
ko04911	Insulin secretion	48/997	117/7206	2.69018878807e-13
ko04742	Taste transduction	32/997	61/7206	7.9894275661e-13
ko04726	Serotonergic synapse	51/997	137/7206	4.20837209799e-12
ko04921	Oxytocin signaling pathway	65/997	209/7206	6.66917471995e-11
ko04261	Adrenergic signaling in cardiomyocytes	64/997	205/7206	8.56450148683e-11
ko04020	Calcium signaling pathway	76/997	265/7206	1.37471851855e-10
ko04744	Phototransduction	21/997	36/7206	5.29528076377e-10
ko05031	Amphetamine addiction	36/997	91/7206	9.00956516185e-10
ko05030	Cocaine addiction	31/997	73/7206	1.71685653851e-09
ko04720	Long-term potentiation	37/997	99/7206	3.41701924391e-09
ko03040	Spliceosome	1/997	145/7206	1.4412450728e-08
ko04360	Axon guidance	64/997	233/7206	3.38718686458e-08
ko04970	Salivary secretion	33/997	95/7206	1.85863354018e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/997	74/7206	2.06339541476e-07
ko05168	Herpes simplex infection	5/997	182/7206	5.63329844644e-07
ko05203	Viral carcinogenesis	14/997	277/7206	2.03241398865e-06
ko04925	Aldosterone synthesis and secretion	33/997	105/7206	2.6257446789e-06
ko04010	MAPK signaling pathway	74/997	321/7206	4.54736345074e-06
ko04072	Phospholipase D signaling pathway	50/997	197/7206	1.31137264899e-05
ko03013	RNA transport	6/997	166/7206	1.8509399378e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/997	79/7206	1.8657636949e-05
ko04022	cGMP-PKG signaling pathway	53/997	216/7206	2.04556331235e-05
ko05322	Systemic lupus erythematosus	5/997	151/7206	2.21706808671e-05
ko04972	Pancreatic secretion	32/997	111/7206	3.63182566128e-05
ko04971	Gastric acid secretion	29/997	98/7206	4.29201989581e-05
ko04060	Cytokine-cytokine receptor interaction	9/997	191/7206	4.64403407786e-05
ko04740	Olfactory transduction	25/997	80/7206	5.14027229426e-05
ko05164	Influenza A	7/997	167/7206	5.7700125698e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/997	59/7206	7.22207874642e-05
ko04514	Cell adhesion molecules (CAMs)	35/997	130/7206	8.61644524024e-05
ko04141	Protein processing in endoplasmic reticulum	9/997	184/7206	0.000125910490946
ko05414	Dilated cardiomyopathy	31/997	112/7206	0.000139348827223
ko05205	Proteoglycans in cancer	18/997	271/7206	0.000213563912312
ko04260	Cardiac muscle contraction	27/997	98/7206	0.000308032062156
ko04966	Collecting duct acid secretion	11/997	26/7206	0.000354882896401
ko04120	Ubiquitin mediated proteolysis	6/997	138/7206	0.00041261384526
ko04915	Estrogen signaling pathway	33/997	131/7206	0.000466574753364
ko04540	Gap junction	32/997	128/7206	0.000658854662527
ko00240	Pyrimidine metabolism	4/997	110/7206	0.000689418252307
ko04730	Long-term depression	22/997	78/7206	0.000756374509675
ko04371	Apelin signaling pathway	40/997	177/7206	0.00128468567862
ko04070	Phosphatidylinositol signaling system	28/997	112/7206	0.00133898178995
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/997	14/7206	0.00134139921103
ko03008	Ribosome biogenesis in eukaryotes	2/997	79/7206	0.00146592149553
ko04621	NOD-like receptor signaling pathway	9/997	157/7206	0.00150761005721
ko04640	Hematopoietic cell lineage	1/997	64/7206	0.00153190232305
ko04014	Ras signaling pathway	57/997	279/7206	0.00188704992796
ko05140	Leishmaniasis	2/997	75/7206	0.00208226781616
ko05110	Vibrio cholerae infection	18/997	63/7206	0.00255548725615
ko04064	NF-kappa B signaling pathway	4/997	96/7206	0.0027567526779
ko04976	Bile secretion	21/997	80/7206	0.00288572170293
ko04932	Non-alcoholic fatty liver disease (NAFLD)	12/997	182/7206	0.00308288114449
ko03018	RNA degradation	3/997	84/7206	0.00363102980554
ko05169	Epstein-Barr virus infection	15/997	206/7206	0.00400661637325
ko00480	Glutathione metabolism	1/997	55/7206	0.00505589934026
ko05410	Hypertrophic cardiomyopathy (HCM)	24/997	100/7206	0.00526103226643
ko04924	Renin secretion	21/997	86/7206	0.00713473442734
ko04612	Antigen processing and presentation	3/997	77/7206	0.00723822665264
ko05162	Measles	7/997	120/7206	0.00734810176633
ko00590	Arachidonic acid metabolism	1/997	52/7206	0.00751018317175
ko05133	Pertussis	4/997	87/7206	0.00762645261834
ko04146	Peroxisome	4/997	89/7206	0.00778317681104
ko04217	Necroptosis	13/997	178/7206	0.00814011927822
ko04062	Chemokine signaling pathway	41/997	201/7206	0.00924487554271
ko00310	Lysine degradation	3/997	73/7206	0.0102345942636
ko00260	Glycine, serine and threonine metabolism	1/997	48/7206	0.0110023558977
ko04923	Regulation of lipolysis in adipocytes	19/997	77/7206	0.0114040132441
ko04964	Proximal tubule bicarbonate reclamation	9/997	29/7206	0.0134293688551
ko05161	Hepatitis B	13/997	173/7206	0.0136790757662
ko00330	Arginine and proline metabolism	2/997	61/7206	0.0137424855366
ko04110	Cell cycle	10/997	145/7206	0.0143359170829
ko04214	Apoptosis - fly	3/997	72/7206	0.0148291005469
ko04137	Mitophagy - animal	4/997	82/7206	0.0148697661277
ko00071	Fatty acid degradation	1/997	45/7206	0.0163082620527
ko00620	Pyruvate metabolism	1/997	46/7206	0.0165003252004
ko03420	Nucleotide excision repair	1/997	46/7206	0.0165003252004
ko04918	Thyroid hormone synthesis	20/997	86/7206	0.0172042808033
ko05321	Inflammatory bowel disease (IBD)	2/997	56/7206	0.0191941606455
ko03320	PPAR signaling pathway	3/997	69/7206	0.0209129117019
ko04750	Inflammatory mediator regulation of TRP channels	26/997	122/7206	0.0234629271052
ko03022	Basal transcription factors	1/997	44/7206	0.0252039126954
ko04658	Th1 and Th2 cell differentiation	6/997	96/7206	0.025591860986
ko05145	Toxoplasmosis	9/997	126/7206	0.0263292339447
ko01200	Carbon metabolism	9/997	128/7206	0.0269409037551
ko05034	Alcoholism	45/997	238/7206	0.0275509355017
ko00280	Valine, leucine and isoleucine degradation	2/997	54/7206	0.0277378173382
ko04210	Apoptosis	15/997	180/7206	0.0285307943327
ko00562	Inositol phosphate metabolism	20/997	89/7206	0.0287509998256
ko04140	Autophagy - animal	13/997	164/7206	0.0288449866261
ko04670	Leukocyte transendothelial migration	12/997	151/7206	0.0318516775158
ko04270	Vascular smooth muscle contraction	31/997	154/7206	0.0326582426194
ko04015	Rap1 signaling pathway	51/997	278/7206	0.0329913629636
ko04962	Vasopressin-regulated water reabsorption	14/997	58/7206	0.033224033831
ko04745	Phototransduction - fly	10/997	38/7206	0.0335335887676
ko04510	Focal adhesion	22/997	240/7206	0.0358465840418
ko00980	Metabolism of xenobiotics by cytochrome P450	1/997	40/7206	0.0360024607359
ko04622	RIG-I-like receptor signaling pathway	3/997	62/7206	0.0402736890226
ko04350	TGF-beta signaling pathway	7/997	103/7206	0.0425358938978
ko04930	Type II diabetes mellitus	13/997	54/7206	0.0443681817429
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/997	15/7206	0.0455998918937