ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	198/1191	423/7206	2.00290386361e-51
ko04724	Glutamatergic synapse	89/1191	152/7206	1.70448228786e-32
ko05033	Nicotine addiction	48/1191	56/7206	4.86383896864e-30
ko05032	Morphine addiction	66/1191	110/7206	3.51090782556e-25
ko04713	Circadian entrainment	74/1191	136/7206	2.07147091484e-24
ko04727	GABAergic synapse	64/1191	110/7206	2.06697683717e-23
ko04721	Synaptic vesicle cycle	52/1191	80/7206	2.15418724409e-22
ko04728	Dopaminergic synapse	84/1191	185/7206	1.00200994933e-20
ko04725	Cholinergic synapse	74/1191	160/7206	5.97678631622e-19
ko04024	cAMP signaling pathway	104/1191	279/7206	1.35722401241e-17
ko04723	Retrograde endocannabinoid signaling	76/1191	175/7206	1.79092957103e-17
ko04020	Calcium signaling pathway	98/1191	265/7206	2.2569791998e-16
ko04742	Taste transduction	36/1191	61/7206	5.695614695e-14
ko04744	Phototransduction	26/1191	36/7206	1.74452988233e-13
ko04921	Oxytocin signaling pathway	78/1191	209/7206	1.8253699948e-13
ko04726	Serotonergic synapse	58/1191	137/7206	4.91179199362e-13
ko04911	Insulin secretion	52/1191	117/7206	8.09034992472e-13
ko04261	Adrenergic signaling in cardiomyocytes	72/1191	205/7206	4.76818041399e-11
ko05031	Amphetamine addiction	41/1191	91/7206	1.30542540267e-10
ko03040	Spliceosome	1/1191	145/7206	1.96545432153e-10
ko04720	Long-term potentiation	43/1191	99/7206	1.9766305916e-10
ko04970	Salivary secretion	40/1191	95/7206	2.6026803032e-09
ko05203	Viral carcinogenesis	14/1191	277/7206	4.56570929384e-09
ko04060	Cytokine-cytokine receptor interaction	8/1191	191/7206	1.66895918508e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1191	74/7206	6.88036289993e-07
ko04925	Aldosterone synthesis and secretion	38/1191	105/7206	8.55120350129e-07
ko04360	Axon guidance	68/1191	233/7206	9.25424421442e-07
ko04022	cGMP-PKG signaling pathway	64/1191	216/7206	9.87657537762e-07
ko03013	RNA transport	7/1191	166/7206	1.27095427815e-06
ko05030	Cocaine addiction	29/1191	73/7206	1.73346087668e-06
ko04740	Olfactory transduction	31/1191	80/7206	1.93210018058e-06
ko04070	Phosphatidylinositol signaling system	39/1191	112/7206	2.0253288981e-06
ko05322	Systemic lupus erythematosus	6/1191	151/7206	2.21481383844e-06
ko05168	Herpes simplex infection	9/1191	182/7206	2.33977118461e-06
ko05164	Influenza A	8/1191	167/7206	4.2693480875e-06
ko04971	Gastric acid secretion	34/1191	98/7206	1.2129028893e-05
ko04966	Collecting duct acid secretion	14/1191	26/7206	1.4192631817e-05
ko04621	NOD-like receptor signaling pathway	8/1191	157/7206	1.73984249537e-05
ko05169	Epstein-Barr virus infection	14/1191	206/7206	3.70759797753e-05
ko04010	MAPK signaling pathway	81/1191	321/7206	4.26321679741e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1191	79/7206	4.27156100526e-05
ko04514	Cell adhesion molecules (CAMs)	40/1191	130/7206	6.22550885936e-05
ko04141	Protein processing in endoplasmic reticulum	12/1191	184/7206	7.32044489998e-05
ko04924	Renin secretion	29/1191	86/7206	9.54365983841e-05
ko04745	Phototransduction - fly	16/1191	38/7206	0.000164792996583
ko04610	Complement and coagulation cascades	2/1191	79/7206	0.00017522279534
ko03008	Ribosome biogenesis in eukaryotes	2/1191	79/7206	0.00017522279534
ko04120	Ubiquitin mediated proteolysis	8/1191	138/7206	0.000188816614843
ko04072	Phospholipase D signaling pathway	53/1191	197/7206	0.000191785857937
ko04972	Pancreatic secretion	34/1191	111/7206	0.000240082765343
ko05140	Leishmaniasis	2/1191	75/7206	0.000249700016108
ko05161	Hepatitis B	12/1191	173/7206	0.000251604214866
ko05414	Dilated cardiomyopathy	34/1191	112/7206	0.000260428002534
ko04110	Cell cycle	9/1191	145/7206	0.000265239208739
ko04064	NF-kappa B signaling pathway	4/1191	96/7206	0.000274311250824
ko04730	Long-term depression	26/1191	78/7206	0.00029503889732
ko05110	Vibrio cholerae infection	22/1191	63/7206	0.000434780896929
ko04260	Cardiac muscle contraction	30/1191	98/7206	0.000497465565663
ko05205	Proteoglycans in cancer	25/1191	271/7206	0.000592942885411
ko04612	Antigen processing and presentation	3/1191	77/7206	0.00102014396091
ko04540	Gap junction	36/1191	128/7206	0.00102673580418
ko04626	Plant-pathogen interaction	9/1191	18/7206	0.00104547814143
ko04976	Bile secretion	25/1191	80/7206	0.00117701798074
ko05162	Measles	8/1191	120/7206	0.00181794653703
ko04915	Estrogen signaling pathway	35/1191	131/7206	0.00278363997893
ko04014	Ras signaling pathway	65/1191	279/7206	0.00296778515849
ko04923	Regulation of lipolysis in adipocytes	23/1191	77/7206	0.00304989898329
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1191	14/7206	0.00387620572481
ko04371	Apelin signaling pathway	44/1191	177/7206	0.00394489992205
ko05144	Malaria	1/1191	45/7206	0.00438110001141
ko00071	Fatty acid degradation	1/1191	45/7206	0.00438110001141
ko03420	Nucleotide excision repair	1/1191	46/7206	0.00441309540192
ko04964	Proximal tubule bicarbonate reclamation	11/1191	29/7206	0.00461462834253
ko00480	Glutathione metabolism	2/1191	55/7206	0.00563786874931
ko05321	Inflammatory bowel disease (IBD)	2/1191	56/7206	0.00576491134678
ko00562	Inositol phosphate metabolism	25/1191	89/7206	0.00578476538085
ko00240	Pyrimidine metabolism	8/1191	110/7206	0.00623406091209
ko03022	Basal transcription factors	1/1191	44/7206	0.00674872781112
ko00310	Lysine degradation	4/1191	73/7206	0.00677823365895
ko05131	Shigellosis	5/1191	82/7206	0.00688018364639
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1191	59/7206	0.00725762992732
ko05166	HTLV-I infection	32/1191	292/7206	0.00781056709365
ko00590	Arachidonic acid metabolism	2/1191	52/7206	0.00824039914455
ko04630	Jak-STAT signaling pathway	11/1191	132/7206	0.00885265184985
ko00330	Arginine and proline metabolism	3/1191	61/7206	0.00917788701093
ko04622	RIG-I-like receptor signaling pathway	3/1191	62/7206	0.00918798790966
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1191	100/7206	0.00922776746515
ko04146	Peroxisome	6/1191	89/7206	0.00930171579887
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1191	40/7206	0.00987080584927
ko04657	IL-17 signaling pathway	6/1191	87/7206	0.0127931252382
ko05133	Pertussis	6/1191	87/7206	0.0127931252382
ko04750	Inflammatory mediator regulation of TRP channels	31/1191	122/7206	0.0131965827775
ko00630	Glyoxylate and dicarboxylate metabolism	1/1191	38/7206	0.0147721183617
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1191	182/7206	0.0147836524512
ko05145	Toxoplasmosis	11/1191	126/7206	0.0151545857405
ko00290	Valine, leucine and isoleucine biosynthesis	3/1191	4/7206	0.0157925476944
ko03018	RNA degradation	6/1191	84/7206	0.0173510325483
ko05219	Bladder cancer	2/1191	48/7206	0.0176441110873
ko04115	p53 signaling pathway	5/1191	74/7206	0.0182052401231
ko00500	Starch and sucrose metabolism	1/1191	35/7206	0.0220742340202
ko04710	Circadian rhythm	13/1191	43/7206	0.0221926291218
ko04922	Glucagon signaling pathway	31/1191	128/7206	0.0222691170962
ko00982	Drug metabolism - cytochrome P450	1/1191	37/7206	0.0232120448798
ko04214	Apoptosis - fly	5/1191	72/7206	0.0249397492527
ko04933	AGE-RAGE signaling pathway in diabetic complications	13/1191	135/7206	0.0263043247199
ko04640	Hematopoietic cell lineage	4/1191	64/7206	0.0263570315015
ko04658	Th1 and Th2 cell differentiation	8/1191	96/7206	0.0266430727142
ko04510	Focal adhesion	27/1191	240/7206	0.0266830699712
ko05215	Prostate cancer	10/1191	111/7206	0.0285601474894
ko04350	TGF-beta signaling pathway	9/1191	103/7206	0.0318087439993
ko04210	Apoptosis	19/1191	180/7206	0.0321418710935
ko04140	Autophagy - animal	17/1191	164/7206	0.0328429919375
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1191	92/7206	0.0336162209197
ko03320	PPAR signaling pathway	5/1191	69/7206	0.0340328027745
ko05206	MicroRNAs in cancer	19/1191	177/7206	0.039715953193
ko04620	Toll-like receptor signaling pathway	9/1191	100/7206	0.0414507312283
ko01524	Platinum drug resistance	6/1191	76/7206	0.0426293810722
ko00512	Mucin type O-glycan biosynthesis	9/1191	29/7206	0.0443267335619
ko05202	Transcriptional misregulation in cancer	21/1191	188/7206	0.0462977203064
ko04670	Leukocyte transendothelial migration	16/1191	151/7206	0.0463248944152
ko05418	Fluid shear stress and atherosclerosis	19/1191	173/7206	0.0486323956339
ko05340	Primary immunodeficiency	1/1191	30/7206	0.0489249450167
ko04711	Circadian rhythm - fly	5/1191	13/7206	0.0494097252681