ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 166/1026 423/7206 1.2468221823e-39 ko04724 Glutamatergic synapse 71/1026 152/7206 2.46308802215e-22 ko05033 Nicotine addiction 39/1026 56/7206 4.34649011933e-21 ko04020 Calcium signaling pathway 92/1026 265/7206 1.08612018016e-17 ko04713 Circadian entrainment 57/1026 136/7206 1.72555649912e-15 ko05032 Morphine addiction 50/1026 110/7206 1.85638005168e-15 ko04725 Cholinergic synapse 59/1026 160/7206 4.83560680237e-13 ko04727 GABAergic synapse 45/1026 110/7206 4.76203945807e-12 ko04723 Retrograde endocannabinoid signaling 60/1026 175/7206 1.27335964165e-11 ko04728 Dopaminergic synapse 61/1026 185/7206 5.89849704862e-11 ko04024 cAMP signaling pathway 80/1026 279/7206 2.14059397808e-10 ko04911 Insulin secretion 44/1026 117/7206 2.2658852176e-10 ko04921 Oxytocin signaling pathway 63/1026 209/7206 2.0500043939e-09 ko04726 Serotonergic synapse 46/1026 137/7206 7.00662627724e-09 ko03040 Spliceosome 1/1026 145/7206 9.36617219404e-09 ko04721 Synaptic vesicle cycle 32/1026 80/7206 1.15769374715e-08 ko04360 Axon guidance 65/1026 233/7206 3.12284832596e-08 ko04022 cGMP-PKG signaling pathway 61/1026 216/7206 5.18457037483e-08 ko04742 Taste transduction 26/1026 61/7206 5.91170821859e-08 ko03010 Ribosome 1/1026 129/7206 7.25008317942e-08 ko04970 Salivary secretion 33/1026 95/7206 3.68057630116e-07 ko05322 Systemic lupus erythematosus 3/1026 151/7206 3.85411359666e-07 ko03013 RNA transport 5/1026 166/7206 1.61215260292e-06 ko04261 Adrenergic signaling in cardiomyocytes 55/1026 205/7206 2.04936423702e-06 ko05031 Amphetamine addiction 30/1026 91/7206 5.0652213469e-06 ko04730 Long-term depression 26/1026 78/7206 2.06869598158e-05 ko05203 Viral carcinogenesis 17/1026 277/7206 2.20915652667e-05 ko04971 Gastric acid secretion 30/1026 98/7206 2.70173229855e-05 ko04720 Long-term potentiation 30/1026 99/7206 3.18645025735e-05 ko04710 Circadian rhythm 17/1026 43/7206 3.85940360247e-05 ko04120 Ubiquitin mediated proteolysis 5/1026 138/7206 6.31049325995e-05 ko04072 Phospholipase D signaling pathway 49/1026 197/7206 6.87459482676e-05 ko04010 MAPK signaling pathway 71/1026 321/7206 0.000109268806933 ko04925 Aldosterone synthesis and secretion 30/1026 105/7206 0.000109807047277 ko05164 Influenza A 8/1026 167/7206 0.000116180811741 ko04514 Cell adhesion molecules (CAMs) 35/1026 130/7206 0.000117561747854 ko05030 Cocaine addiction 23/1026 73/7206 0.000135278305436 ko04014 Ras signaling pathway 62/1026 279/7206 0.000224900628848 ko04070 Phosphatidylinositol signaling system 30/1026 112/7206 0.000516938815273 ko05014 Amyotrophic lateral sclerosis (ALS) 22/1026 74/7206 0.00057640343562 ko04270 Vascular smooth muscle contraction 38/1026 154/7206 0.000616749346482 ko05168 Herpes simplex infection 11/1026 182/7206 0.000767568394656 ko04972 Pancreatic secretion 29/1026 111/7206 0.000856443535387 ko04371 Apelin signaling pathway 41/1026 177/7206 0.00142604641524 ko05133 Pertussis 3/1026 87/7206 0.00170800816433 ko04540 Gap junction 31/1026 128/7206 0.00208545092876 ko04217 Necroptosis 12/1026 178/7206 0.0022517133152 ko04750 Inflammatory mediator regulation of TRP channels 30/1026 122/7206 0.00232803367932 ko04930 Type II diabetes mellitus 16/1026 54/7206 0.00286877716122 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 21/1026 79/7206 0.0032578100867 ko04141 Protein processing in endoplasmic reticulum 13/1026 184/7206 0.00365785892498 ko04612 Antigen processing and presentation 3/1026 77/7206 0.00497599703101 ko04964 Proximal tubule bicarbonate reclamation 10/1026 29/7206 0.00501245290598 ko04146 Peroxisome 4/1026 89/7206 0.00540161216438 ko04711 Circadian rhythm - fly 6/1026 13/7206 0.0057524558813 ko04015 Rap1 signaling pathway 56/1026 278/7206 0.00641691386914 ko04961 Endocrine and other factor-regulated calcium reabsorption 16/1026 59/7206 0.00806332898264 ko05410 Hypertrophic cardiomyopathy (HCM) 24/1026 100/7206 0.00871550847462 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/1026 14/7206 0.00886997823893 ko05414 Dilated cardiomyopathy 26/1026 112/7206 0.00924253278804 ko00260 Glycine, serine and threonine metabolism 1/1026 48/7206 0.0110855786714 ko05169 Epstein-Barr virus infection 17/1026 206/7206 0.0111169417127 ko04960 Aldosterone-regulated sodium reabsorption 12/1026 41/7206 0.0114473362919 ko04142 Lysosome 11/1026 151/7206 0.0128100465955 ko04620 Toll-like receptor signaling pathway 6/1026 100/7206 0.0138593998905 ko04621 NOD-like receptor signaling pathway 12/1026 157/7206 0.0148714467963 ko03022 Basal transcription factors 1/1026 44/7206 0.0160878289746 ko00071 Fatty acid degradation 1/1026 45/7206 0.0163918088238 ko04745 Phototransduction - fly 11/1026 38/7206 0.0169856211715 ko03420 Nucleotide excision repair 1/1026 46/7206 0.0170996508145 ko05130 Pathogenic Escherichia coli infection 4/1026 77/7206 0.0204146192949 ko04922 Glucagon signaling pathway 28/1026 128/7206 0.0205749855452 ko04110 Cell cycle 11/1026 145/7206 0.0216630556856 ko04260 Cardiac muscle contraction 22/1026 98/7206 0.0276603325721 ko04622 RIG-I-like receptor signaling pathway 3/1026 62/7206 0.0282530474186 ko04626 Plant-pathogen interaction 6/1026 18/7206 0.0332042808878 ko05162 Measles 9/1026 120/7206 0.0340832553875 ko04512 ECM-receptor interaction 18/1026 79/7206 0.0349709509539 ko00630 Glyoxylate and dicarboxylate metabolism 1/1026 38/7206 0.0352107298711 ko03410 Base excision repair 1/1026 38/7206 0.0352107298711 ko05012 Parkinson's disease 13/1026 155/7206 0.0358112265257 ko05016 Huntington's disease 20/1026 215/7206 0.0369287354916 ko05131 Shigellosis 5/1026 82/7206 0.0369980633385 ko00240 Pyrimidine metabolism 8/1026 110/7206 0.0378916138024 ko04916 Melanogenesis 29/1026 142/7206 0.038822940262 ko04214 Apoptosis - fly 4/1026 72/7206 0.0396093949647 ko04924 Renin secretion 19/1026 86/7206 0.0429572100593 ko04918 Thyroid hormone synthesis 19/1026 86/7206 0.0429572100593