ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	182/991	423/7206	4.53370279915e-53
ko05033	Nicotine addiction	49/991	56/7206	1.87516615982e-35
ko04724	Glutamatergic synapse	85/991	152/7206	3.51975575826e-35
ko05032	Morphine addiction	63/991	110/7206	4.49338876705e-27
ko04713	Circadian entrainment	70/991	136/7206	3.81997166665e-26
ko04727	GABAergic synapse	61/991	110/7206	3.31756570116e-25
ko04728	Dopaminergic synapse	81/991	185/7206	4.51039922307e-24
ko04024	cAMP signaling pathway	101/991	279/7206	4.36937739622e-22
ko04723	Retrograde endocannabinoid signaling	74/991	175/7206	5.76877330952e-21
ko04725	Cholinergic synapse	70/991	160/7206	6.68692588288e-21
ko04721	Synaptic vesicle cycle	46/991	80/7206	3.68634932281e-20
ko04911	Insulin secretion	53/991	117/7206	6.71729529453e-17
ko04020	Calcium signaling pathway	87/991	265/7206	6.43503172298e-16
ko04921	Oxytocin signaling pathway	72/991	209/7206	1.09220530702e-14
ko04742	Taste transduction	34/991	61/7206	1.14935095702e-14
ko04726	Serotonergic synapse	54/991	137/7206	4.78927134913e-14
ko05031	Amphetamine addiction	41/991	91/7206	2.94508260081e-13
ko04720	Long-term potentiation	42/991	99/7206	1.82521869134e-12
ko04261	Adrenergic signaling in cardiomyocytes	65/991	205/7206	1.77069937719e-11
ko04740	Olfactory transduction	33/991	80/7206	1.08355398575e-09
ko04744	Phototransduction	20/991	36/7206	4.01350157088e-09
ko05030	Cocaine addiction	30/991	73/7206	6.93530359463e-09
ko04970	Salivary secretion	35/991	95/7206	1.19677844751e-08
ko03040	Spliceosome	1/991	145/7206	1.44871468677e-08
ko04925	Aldosterone synthesis and secretion	37/991	105/7206	1.84411227591e-08
ko04971	Gastric acid secretion	35/991	98/7206	3.02376862949e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	28/991	74/7206	1.81361154931e-07
ko05203	Viral carcinogenesis	13/991	277/7206	7.51540965707e-07
ko04360	Axon guidance	60/991	233/7206	8.68751423496e-07
ko04010	MAPK signaling pathway	75/991	321/7206	1.83085320043e-06
ko05168	Herpes simplex infection	6/991	182/7206	3.08649791017e-06
ko04745	Phototransduction - fly	17/991	38/7206	3.28131349395e-06
ko04060	Cytokine-cytokine receptor interaction	7/991	191/7206	5.29605861734e-06
ko05322	Systemic lupus erythematosus	4/991	151/7206	6.16059814035e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/991	79/7206	1.02066588759e-05
ko04621	NOD-like receptor signaling pathway	5/991	157/7206	1.07397586229e-05
ko05164	Influenza A	6/991	167/7206	1.8657472321e-05
ko04022	cGMP-PKG signaling pathway	53/991	216/7206	1.92796418159e-05
ko04072	Phospholipase D signaling pathway	49/991	197/7206	2.15320219195e-05
ko04120	Ubiquitin mediated proteolysis	4/991	138/7206	2.64733714401e-05
ko04972	Pancreatic secretion	32/991	111/7206	3.43680513624e-05
ko04260	Cardiac muscle contraction	29/991	98/7206	3.96914071607e-05
ko04514	Cell adhesion molecules (CAMs)	35/991	130/7206	5.39822206566e-05
ko03013	RNA transport	7/991	166/7206	8.32224735697e-05
ko04141	Protein processing in endoplasmic reticulum	9/991	184/7206	0.000124340257931
ko04610	Complement and coagulation cascades	1/991	79/7206	0.000203454693682
ko04540	Gap junction	33/991	128/7206	0.000236723525462
ko05414	Dilated cardiomyopathy	30/991	112/7206	0.000242719695616
ko04966	Collecting duct acid secretion	11/991	26/7206	0.000336277327873
ko04976	Bile secretion	23/991	80/7206	0.000423154391666
ko04924	Renin secretion	24/991	86/7206	0.000442508849303
ko04915	Estrogen signaling pathway	33/991	131/7206	0.00044278703274
ko04750	Inflammatory mediator regulation of TRP channels	31/991	122/7206	0.000483291976081
ko05110	Vibrio cholerae infection	19/991	63/7206	0.000639431518258
ko04070	Phosphatidylinositol signaling system	29/991	112/7206	0.000725913094912
ko04064	NF-kappa B signaling pathway	3/991	96/7206	0.000846126905013
ko04110	Cell cycle	7/991	145/7206	0.000859699428016
ko05169	Epstein-Barr virus infection	13/991	206/7206	0.000932180282758
ko04014	Ras signaling pathway	58/991	279/7206	0.000971538159817
ko05205	Proteoglycans in cancer	20/991	271/7206	0.00115180237776
ko04350	TGF-beta signaling pathway	4/991	103/7206	0.00138159068676
ko03008	Ribosome biogenesis in eukaryotes	2/991	79/7206	0.0014497375065
ko04146	Peroxisome	3/991	89/7206	0.00173865880316
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/991	59/7206	0.00201837787131
ko05140	Leishmaniasis	2/991	75/7206	0.00208128676877
ko04612	Antigen processing and presentation	2/991	77/7206	0.00220075960001
ko04730	Long-term depression	21/991	78/7206	0.00233378904159
ko05161	Hepatitis B	11/991	173/7206	0.00246956178733
ko05162	Measles	6/991	120/7206	0.00297617572867
ko04214	Apoptosis - fly	2/991	72/7206	0.00303424994272
ko04964	Proximal tubule bicarbonate reclamation	10/991	29/7206	0.00388338433127
ko00480	Glutathione metabolism	1/991	55/7206	0.00503725588675
ko04912	GnRH signaling pathway	28/991	122/7206	0.00503751080268
ko04630	Jak-STAT signaling pathway	8/991	132/7206	0.00702721581789
ko04626	Plant-pathogen interaction	7/991	18/7206	0.00727855138552
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/991	14/7206	0.00746972966899
ko00240	Pyrimidine metabolism	6/991	110/7206	0.00763820770477
ko04371	Apelin signaling pathway	37/991	177/7206	0.00770100763895
ko04217	Necroptosis	13/991	178/7206	0.0107384116665
ko05219	Bladder cancer	1/991	48/7206	0.011047420211
ko05410	Hypertrophic cardiomyopathy (HCM)	23/991	100/7206	0.0119296817054
ko04015	Rap1 signaling pathway	53/991	278/7206	0.012539725385
ko04330	Notch signaling pathway	2/991	62/7206	0.0141239866649
ko00310	Lysine degradation	3/991	73/7206	0.0151402172165
ko04930	Type II diabetes mellitus	14/991	54/7206	0.0155509560657
ko05144	Malaria	1/991	45/7206	0.0163693289834
ko00071	Fatty acid degradation	1/991	45/7206	0.0163693289834
ko03420	Nucleotide excision repair	1/991	46/7206	0.0164589160849
ko05321	Inflammatory bowel disease (IBD)	2/991	56/7206	0.0192831809965
ko05034	Alcoholism	45/991	238/7206	0.0216483706557
ko04510	Focal adhesion	21/991	240/7206	0.0217358449624
ko05166	HTLV-I infection	27/991	292/7206	0.0236715298764
ko00983	Drug metabolism - other enzymes	1/991	42/7206	0.024206641732
ko03022	Basal transcription factors	1/991	44/7206	0.0250055243322
ko04657	IL-17 signaling pathway	5/991	87/7206	0.0272983608151
ko00562	Inositol phosphate metabolism	20/991	89/7206	0.0283439200722
ko01524	Platinum drug resistance	4/991	76/7206	0.0284105675292
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/991	182/7206	0.0286757888944
ko04640	Hematopoietic cell lineage	3/991	64/7206	0.0286928275114
ko04114	Oocyte meiosis	28/991	139/7206	0.0337959092186
ko05016	Huntington's disease	19/991	215/7206	0.0342636045212
ko00980	Metabolism of xenobiotics by cytochrome P450	1/991	40/7206	0.0359270281275
ko04210	Apoptosis	15/991	180/7206	0.0364104365176
ko03018	RNA degradation	5/991	84/7206	0.0370222496397
ko04922	Glucagon signaling pathway	26/991	128/7206	0.0373650143513
ko05010	Alzheimer's disease	38/991	202/7206	0.0381691468973
ko04973	Carbohydrate digestion and absorption	11/991	42/7206	0.038564273257
ko00330	Arginine and proline metabolism	3/991	61/7206	0.0400629762458
ko04622	RIG-I-like receptor signaling pathway	3/991	62/7206	0.0401857502955
ko05231	Choline metabolism in cancer	27/991	134/7206	0.0414678755658
ko04923	Regulation of lipolysis in adipocytes	17/991	77/7206	0.0439776680162
ko04668	TNF signaling pathway	9/991	120/7206	0.0445365443891
ko04916	Melanogenesis	28/991	142/7206	0.0477558917328