ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 69/681 152/7206 9.7258085569e-32 ko05033 Nicotine addiction 41/681 56/7206 1.33568310072e-30 ko04080 Neuroactive ligand-receptor interaction 114/681 423/7206 4.08315885204e-27 ko04727 GABAergic synapse 49/681 110/7206 2.54657801383e-22 ko05032 Morphine addiction 48/681 110/7206 2.0659872783e-21 ko04723 Retrograde endocannabinoid signaling 61/681 175/7206 7.99451328811e-21 ko04713 Circadian entrainment 49/681 136/7206 1.32040698752e-17 ko04721 Synaptic vesicle cycle 36/681 80/7206 7.11723634481e-17 ko04728 Dopaminergic synapse 56/681 185/7206 5.12168309681e-16 ko04744 Phototransduction 21/681 36/7206 3.236639626e-13 ko04725 Cholinergic synapse 46/681 160/7206 1.85001634432e-12 ko04726 Serotonergic synapse 41/681 137/7206 7.43337503156e-12 ko04024 cAMP signaling pathway 63/681 279/7206 2.10420937185e-11 ko04911 Insulin secretion 36/681 117/7206 6.03859326551e-11 ko04261 Adrenergic signaling in cardiomyocytes 45/681 205/7206 6.77878004547e-08 ko04742 Taste transduction 21/681 61/7206 7.18053251648e-08 ko04020 Calcium signaling pathway 53/681 265/7206 8.4552647448e-08 ko04921 Oxytocin signaling pathway 45/681 209/7206 9.61416425916e-08 ko04970 Salivary secretion 26/681 95/7206 3.92248004498e-07 ko05030 Cocaine addiction 22/681 73/7206 5.05767477456e-07 ko05031 Amphetamine addiction 25/681 91/7206 6.06838228311e-07 ko04720 Long-term potentiation 25/681 99/7206 3.31316613339e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 20/681 74/7206 1.06061362231e-05 ko04060 Cytokine-cytokine receptor interaction 3/681 191/7206 1.35858963317e-05 ko03040 Spliceosome 1/681 145/7206 1.79190515291e-05 ko05164 Influenza A 2/681 167/7206 2.06426946635e-05 ko04010 MAPK signaling pathway 54/681 321/7206 2.15277922756e-05 ko05203 Viral carcinogenesis 8/681 277/7206 2.25714501036e-05 ko04120 Ubiquitin mediated proteolysis 1/681 138/7206 2.51523557957e-05 ko04514 Cell adhesion molecules (CAMs) 28/681 130/7206 2.53634588272e-05 ko04925 Aldosterone synthesis and secretion 24/681 105/7206 3.17641623446e-05 ko05322 Systemic lupus erythematosus 2/681 151/7206 6.17216368095e-05 ko04730 Long-term depression 19/681 78/7206 8.42394501793e-05 ko04972 Pancreatic secretion 24/681 111/7206 9.73661747994e-05 ko05168 Herpes simplex infection 4/681 182/7206 0.000155120791845 ko05162 Measles 1/681 120/7206 0.000194626686708 ko04260 Cardiac muscle contraction 21/681 98/7206 0.000313526793557 ko04022 cGMP-PKG signaling pathway 37/681 216/7206 0.000328909851933 ko04740 Olfactory transduction 18/681 80/7206 0.000373763722635 ko05205 Proteoglycans in cancer 10/681 271/7206 0.000416477098475 ko03013 RNA transport 4/681 166/7206 0.000643052254833 ko05166 HTLV-I infection 12/681 292/7206 0.000686840671088 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 17/681 79/7206 0.00130188451945 ko04932 Non-alcoholic fatty liver disease (NAFLD) 6/681 182/7206 0.00191796686962 ko04540 Gap junction 23/681 128/7206 0.00210038514432 ko04745 Phototransduction - fly 10/681 38/7206 0.0021736726758 ko04630 Jak-STAT signaling pathway 3/681 132/7206 0.00224148261922 ko04971 Gastric acid secretion 19/681 98/7206 0.00242107536696 ko04961 Endocrine and other factor-regulated calcium reabsorption 13/681 59/7206 0.00288551953783 ko05169 Epstein-Barr virus infection 8/681 206/7206 0.00346739148658 ko04621 NOD-like receptor signaling pathway 5/681 157/7206 0.00353605856487 ko05161 Hepatitis B 6/681 173/7206 0.00358631478845 ko04964 Proximal tubule bicarbonate reclamation 8/681 29/7206 0.00434528605653 ko00564 Glycerophospholipid metabolism 2/681 99/7206 0.005331546743 ko04140 Autophagy - animal 6/681 164/7206 0.00662458028238 ko04966 Collecting duct acid secretion 7/681 26/7206 0.00867513107734 ko05140 Leishmaniasis 1/681 75/7206 0.00885909182772 ko04072 Phospholipase D signaling pathway 30/681 197/7206 0.00886645620697 ko04014 Ras signaling pathway 39/681 279/7206 0.0118665835975 ko05016 Huntington's disease 10/681 215/7206 0.0123941263319 ko04214 Apoptosis - fly 1/681 72/7206 0.0132061107958 ko04930 Type II diabetes mellitus 11/681 54/7206 0.0154865192255 ko04360 Axon guidance 33/681 233/7206 0.0164569322172 ko04350 TGF-beta signaling pathway 3/681 103/7206 0.0167702629794 ko04976 Bile secretion 14/681 80/7206 0.0199453292579 ko04110 Cell cycle 6/681 145/7206 0.0216972927017 ko05414 Dilated cardiomyopathy 18/681 112/7206 0.0218527851639 ko05418 Fluid shear stress and atherosclerosis 8/681 173/7206 0.0248272734075 ko04750 Inflammatory mediator regulation of TRP channels 19/681 122/7206 0.0275157687904 ko00330 Arginine and proline metabolism 1/681 61/7206 0.0275418079688 ko04330 Notch signaling pathway 1/681 62/7206 0.0275953549887 ko00561 Glycerolipid metabolism 1/681 63/7206 0.027908508302 ko04640 Hematopoietic cell lineage 1/681 64/7206 0.0284816162854 ko04612 Antigen processing and presentation 2/681 77/7206 0.0312594659187 ko04510 Focal adhesion 13/681 240/7206 0.0320422061573 ko05215 Prostate cancer 4/681 111/7206 0.0321022825751 ko04064 NF-kappa B signaling pathway 3/681 96/7206 0.0328909641529 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/681 14/7206 0.0367029061441 ko05010 Alzheimer's disease 28/681 202/7206 0.0372056234897 ko04210 Apoptosis 9/681 180/7206 0.038196196549 ko04931 Insulin resistance 6/681 137/7206 0.0383116521396 ko04146 Peroxisome 3/681 89/7206 0.0446169788178 ko01524 Platinum drug resistance 2/681 76/7206 0.0453181203977 ko04218 Cellular senescence 9/681 177/7206 0.0495802681364