ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	190/1163	423/7206	1.51202605797e-47
ko04724	Glutamatergic synapse	88/1163	152/7206	1.95844071511e-32
ko05033	Nicotine addiction	48/1163	56/7206	1.57256360881e-30
ko04713	Circadian entrainment	76/1163	136/7206	9.71764719338e-27
ko05032	Morphine addiction	64/1163	110/7206	5.33226005572e-24
ko04727	GABAergic synapse	63/1163	110/7206	3.98129178594e-23
ko04728	Dopaminergic synapse	85/1163	185/7206	4.30438029748e-22
ko04725	Cholinergic synapse	74/1163	160/7206	1.44001624141e-19
ko04721	Synaptic vesicle cycle	48/1163	80/7206	4.53976751082e-19
ko04723	Retrograde endocannabinoid signaling	76/1163	175/7206	4.35500892686e-18
ko04911	Insulin secretion	59/1163	117/7206	4.40465119621e-18
ko04024	cAMP signaling pathway	100/1163	279/7206	2.89725832412e-16
ko04020	Calcium signaling pathway	95/1163	265/7206	2.0292148683e-15
ko04742	Taste transduction	37/1163	61/7206	3.34738438941e-15
ko04744	Phototransduction	27/1163	36/7206	6.74433831884e-15
ko04726	Serotonergic synapse	59/1163	137/7206	4.20205090788e-14
ko04740	Olfactory transduction	42/1163	80/7206	5.09939272992e-14
ko04921	Oxytocin signaling pathway	76/1163	209/7206	4.99916153124e-13
ko05031	Amphetamine addiction	42/1163	91/7206	1.33400904766e-11
ko04261	Adrenergic signaling in cardiomyocytes	71/1163	205/7206	5.31519049489e-11
ko04970	Salivary secretion	42/1163	95/7206	7.46648453755e-11
ko04720	Long-term potentiation	43/1163	99/7206	8.97544177174e-11
ko03040	Spliceosome	1/1163	145/7206	3.14614465151e-10
ko05203	Viral carcinogenesis	12/1163	277/7206	9.78203582278e-10
ko05030	Cocaine addiction	32/1163	73/7206	1.78087097746e-08
ko04925	Aldosterone synthesis and secretion	41/1163	105/7206	1.95046288555e-08
ko05168	Herpes simplex infection	6/1163	182/7206	5.56978973714e-08
ko04360	Axon guidance	70/1163	233/7206	6.0475137369e-08
ko04971	Gastric acid secretion	38/1163	98/7206	7.72459012911e-08
ko03013	RNA transport	5/1163	166/7206	8.70210555515e-08
ko04060	Cytokine-cytokine receptor interaction	9/1163	191/7206	1.20807738542e-06
ko04621	NOD-like receptor signaling pathway	6/1163	157/7206	1.60160916149e-06
ko04022	cGMP-PKG signaling pathway	62/1163	216/7206	2.08150176362e-06
ko05322	Systemic lupus erythematosus	6/1163	151/7206	5.06019949204e-06
ko04972	Pancreatic secretion	37/1163	111/7206	6.21049205725e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1163	74/7206	7.02462819402e-06
ko05164	Influenza A	8/1163	167/7206	9.19190518054e-06
ko04514	Cell adhesion molecules (CAMs)	41/1163	130/7206	1.0144650207e-05
ko04610	Complement and coagulation cascades	1/1163	79/7206	2.0626171083e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1163	79/7206	2.0626171083e-05
ko04745	Phototransduction - fly	17/1163	38/7206	2.95132960579e-05
ko04120	Ubiquitin mediated proteolysis	6/1163	138/7206	3.10990829745e-05
ko04010	MAPK signaling pathway	80/1163	321/7206	3.4648073751e-05
ko04141	Protein processing in endoplasmic reticulum	11/1163	184/7206	3.99218137062e-05
ko04260	Cardiac muscle contraction	32/1163	98/7206	4.30209840763e-05
ko04540	Gap junction	39/1163	128/7206	4.59050613639e-05
ko04730	Long-term depression	27/1163	78/7206	6.37746605245e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1163	79/7206	7.50350797971e-05
ko04976	Bile secretion	27/1163	80/7206	9.01540668531e-05
ko04924	Renin secretion	28/1163	86/7206	0.00015694901598
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1163	59/7206	0.000236712461052
ko04964	Proximal tubule bicarbonate reclamation	13/1163	29/7206	0.000251606309872
ko05140	Leishmaniasis	2/1163	75/7206	0.000386298366449
ko04064	NF-kappa B signaling pathway	4/1163	96/7206	0.000406044306993
ko04750	Inflammatory mediator regulation of TRP channels	35/1163	122/7206	0.000426582654518
ko05205	Proteoglycans in cancer	24/1163	271/7206	0.000524109942537
ko04110	Cell cycle	9/1163	145/7206	0.000534363230798
ko04014	Ras signaling pathway	67/1163	279/7206	0.000618221277401
ko04072	Phospholipase D signaling pathway	50/1163	197/7206	0.000766457326363
ko05162	Measles	7/1163	120/7206	0.000996815346298
ko04070	Phosphatidylinositol signaling system	32/1163	112/7206	0.00102127591558
ko05169	Epstein-Barr virus infection	17/1163	206/7206	0.00103228148803
ko05161	Hepatitis B	13/1163	173/7206	0.00108095396488
ko04146	Peroxisome	4/1163	89/7206	0.0012074156909
ko04966	Collecting duct acid secretion	11/1163	26/7206	0.00135788615575
ko04612	Antigen processing and presentation	3/1163	77/7206	0.0015332012526
ko05414	Dilated cardiomyopathy	31/1163	112/7206	0.00170898089882
ko00590	Arachidonic acid metabolism	1/1163	52/7206	0.00198225574628
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1163	182/7206	0.00211462969892
ko04371	Apelin signaling pathway	44/1163	177/7206	0.00252850224542
ko04214	Apoptosis - fly	3/1163	72/7206	0.00321478201908
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1163	14/7206	0.00337074733881
ko00240	Pyrimidine metabolism	7/1163	110/7206	0.0036587090223
ko05166	HTLV-I infection	30/1163	292/7206	0.00437827297697
ko03420	Nucleotide excision repair	1/1163	46/7206	0.00447020503764
ko05219	Bladder cancer	1/1163	48/7206	0.00467734913048
ko04658	Th1 and Th2 cell differentiation	6/1163	96/7206	0.00501261670155
ko04657	IL-17 signaling pathway	5/1163	87/7206	0.00502551518459
ko05110	Vibrio cholerae infection	19/1163	63/7206	0.00508791350519
ko05321	Inflammatory bowel disease (IBD)	2/1163	56/7206	0.00573850213646
ko03022	Basal transcription factors	1/1163	44/7206	0.00669336347949
ko05144	Malaria	1/1163	45/7206	0.00685842942424
ko00071	Fatty acid degradation	1/1163	45/7206	0.00685842942424
ko04915	Estrogen signaling pathway	33/1163	131/7206	0.0078398236034
ko00280	Valine, leucine and isoleucine degradation	2/1163	54/7206	0.00841139617075
ko00480	Glutathione metabolism	2/1163	55/7206	0.00865826630829
ko05215	Prostate cancer	8/1163	111/7206	0.00868211150648
ko05131	Shigellosis	5/1163	82/7206	0.00971120288092
ko00310	Lysine degradation	4/1163	73/7206	0.00974133759772
ko04630	Jak-STAT signaling pathway	11/1163	132/7206	0.0117676023933
ko04923	Regulation of lipolysis in adipocytes	21/1163	77/7206	0.0119151249805
ko04217	Necroptosis	17/1163	178/7206	0.0131565633642
ko00330	Arginine and proline metabolism	3/1163	61/7206	0.0133390340997
ko04622	RIG-I-like receptor signaling pathway	3/1163	62/7206	0.0137043919085
ko04916	Melanogenesis	34/1163	142/7206	0.0150144050039
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1163	40/7206	0.0154271527464
ko04626	Plant-pathogen interaction	7/1163	18/7206	0.0173210890842
ko05133	Pertussis	6/1163	87/7206	0.0178610480289
ko00380	Tryptophan metabolism	2/1163	50/7206	0.0184279546851
ko01524	Platinum drug resistance	5/1163	76/7206	0.0184368245219
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1163	100/7206	0.019650269292
ko05145	Toxoplasmosis	11/1163	126/7206	0.019998792119
ko00982	Drug metabolism - cytochrome P450	1/1163	37/7206	0.022657309518
ko03410	Base excision repair	1/1163	38/7206	0.0236767158974
ko03018	RNA degradation	6/1163	84/7206	0.024041568065
ko04115	p53 signaling pathway	5/1163	74/7206	0.0252971846135
ko04930	Type II diabetes mellitus	15/1163	54/7206	0.0255564101329
ko00620	Pyruvate metabolism	2/1163	46/7206	0.0256558497183
ko00270	Cysteine and methionine metabolism	2/1163	47/7206	0.0262354232421
ko04640	Hematopoietic cell lineage	4/1163	64/7206	0.0263166651302
ko04620	Toll-like receptor signaling pathway	8/1163	100/7206	0.0273599253694
ko04137	Mitophagy - animal	6/1163	82/7206	0.0328947116373
ko04668	TNF signaling pathway	11/1163	120/7206	0.0334756459985
ko04270	Vascular smooth muscle contraction	35/1163	154/7206	0.0345106982748
ko04973	Carbohydrate digestion and absorption	12/1163	42/7206	0.0352301170832
ko05418	Fluid shear stress and atherosclerosis	18/1163	173/7206	0.0363972225939
ko00600	Sphingolipid metabolism	4/1163	63/7206	0.0370142826636
ko04216	Ferroptosis	2/1163	44/7206	0.0373846907616
ko04210	Apoptosis	19/1163	180/7206	0.0398045342258
ko00562	Inositol phosphate metabolism	22/1163	89/7206	0.0406773463196
ko04140	Autophagy - animal	17/1163	164/7206	0.0412476192885
ko04015	Rap1 signaling pathway	57/1163	278/7206	0.0461569414179
ko04912	GnRH signaling pathway	28/1163	122/7206	0.0463910565557
ko03320	PPAR signaling pathway	5/1163	69/7206	0.0469983131398
ko04218	Cellular senescence	19/1163	177/7206	0.0490709895654
ko05206	MicroRNAs in cancer	19/1163	177/7206	0.0490709895654