ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 48/369 145/7206 4.49563494776e-27 ko04110 Cell cycle 40/369 145/7206 2.1196540627e-19 ko03440 Homologous recombination 22/369 41/7206 2.18790363813e-18 ko03030 DNA replication 21/369 38/7206 5.83871771869e-18 ko03013 RNA transport 41/369 166/7206 6.11018801768e-18 ko04111 Cell cycle - yeast 30/369 90/7206 2.43077878006e-17 ko03008 Ribosome biogenesis in eukaryotes 27/369 79/7206 4.94151658038e-16 ko00240 Pyrimidine metabolism 30/369 110/7206 1.17876370006e-14 ko03460 Fanconi anemia pathway 21/369 51/7206 1.25438169989e-14 ko03420 Nucleotide excision repair 17/369 46/7206 3.55806990981e-11 ko03430 Mismatch repair 12/369 22/7206 1.10827073901e-10 ko04113 Meiosis - yeast 20/369 70/7206 1.41554262885e-10 ko03410 Base excision repair 13/369 38/7206 2.27388545e-08 ko04144 Endocytosis 1/369 342/7206 4.23620661912e-07 ko03020 RNA polymerase 10/369 29/7206 9.16874329671e-07 ko03022 Basal transcription factors 12/369 44/7206 1.29341687543e-06 ko05205 Proteoglycans in cancer 1/369 271/7206 1.50401453164e-05 ko04151 PI3K-Akt signaling pathway 4/369 390/7206 1.52667890996e-05 ko03018 RNA degradation 15/369 84/7206 1.90538467158e-05 ko04810 Regulation of actin cytoskeleton 1/369 264/7206 2.24706006234e-05 ko00230 Purine metabolism 23/369 194/7206 0.000165892370105 ko03015 mRNA surveillance pathway 14/369 93/7206 0.000244728785765 ko04015 Rap1 signaling pathway 3/369 278/7206 0.000441482846277 ko04024 cAMP signaling pathway 3/369 279/7206 0.000442370712511 ko04510 Focal adhesion 2/369 240/7206 0.000496504359476 ko04261 Adrenergic signaling in cardiomyocytes 1/369 205/7206 0.000525418741877 ko05166 HTLV-I infection 29/369 292/7206 0.000565785104204 ko04114 Oocyte meiosis 17/369 139/7206 0.000694879601916 ko04360 Axon guidance 2/369 233/7206 0.000719018275473 ko04010 MAPK signaling pathway 5/369 321/7206 0.00111192391212 ko04022 cGMP-PKG signaling pathway 2/369 216/7206 0.00147795218308 ko04014 Ras signaling pathway 4/369 279/7206 0.00201931257597 ko04921 Oxytocin signaling pathway 2/369 209/7206 0.00212581116789 ko05010 Alzheimer's disease 2/369 202/7206 0.00305751538968 ko04152 AMPK signaling pathway 1/369 161/7206 0.0033064583329 ko04072 Phospholipase D signaling pathway 2/369 197/7206 0.00450292429214 ko05012 Parkinson's disease 1/369 155/7206 0.00486283483872 ko04141 Protein processing in endoplasmic reticulum 2/369 184/7206 0.00614890678637 ko04728 Dopaminergic synapse 2/369 185/7206 0.00616832360386 ko05152 Tuberculosis 2/369 187/7206 0.00625265422362 ko04142 Lysosome 1/369 151/7206 0.00744143179294 ko04723 Retrograde endocannabinoid signaling 2/369 175/7206 0.00872410300042 ko04914 Progesterone-mediated oocyte maturation 12/369 104/7206 0.010682550639 ko05203 Viral carcinogenesis 24/369 277/7206 0.0113939176048 ko04910 Insulin signaling pathway 2/369 172/7206 0.0126773591093 ko05418 Fluid shear stress and atherosclerosis 2/369 173/7206 0.0128274317133 ko05322 Systemic lupus erythematosus 15/369 151/7206 0.013280995039 ko04530 Tight junction 4/369 228/7206 0.0138871069657 ko05169 Epstein-Barr virus infection 19/369 206/7206 0.0144951241486 ko01200 Carbon metabolism 1/369 128/7206 0.014699103432 ko05142 Chagas disease (American trypanosomiasis) 1/369 130/7206 0.0147210724872 ko04514 Cell adhesion molecules (CAMs) 1/369 130/7206 0.0147210724872 ko04630 Jak-STAT signaling pathway 1/369 132/7206 0.0149072423759 ko05231 Choline metabolism in cancer 1/369 134/7206 0.0152589233449 ko04933 AGE-RAGE signaling pathway in diabetic complications 1/369 135/7206 0.0154974251712 ko04120 Ubiquitin mediated proteolysis 14/369 138/7206 0.0164673507057 ko04071 Sphingolipid signaling pathway 2/369 162/7206 0.0175945962351 ko04611 Platelet activation 2/369 163/7206 0.0177218974147 ko04912 GnRH signaling pathway 1/369 122/7206 0.0212706657917 ko04660 T cell receptor signaling pathway 1/369 124/7206 0.0215167874552 ko00190 Oxidative phosphorylation 1/369 127/7206 0.0223152158462 ko04218 Cellular senescence 16/369 177/7206 0.023627029716 ko04724 Glutamatergic synapse 2/369 152/7206 0.0245709786489 ko04013 MAPK signaling pathway - fly 1/369 115/7206 0.0307978254641 ko04062 Chemokine signaling pathway 4/369 201/7206 0.0348557058821 ko04371 Apelin signaling pathway 3/369 177/7206 0.0360119231843 ko03450 Non-homologous end-joining 3/369 15/7206 0.0382934737177 ko04659 Th17 cell differentiation 1/369 106/7206 0.0441383002693 ko04972 Pancreatic secretion 1/369 111/7206 0.0460272616849 ko04712 Circadian rhythm - plant 2/369 7/7206 0.0462801683639 ko04070 Phosphatidylinositol signaling system 1/369 112/7206 0.0467229428114 ko04713 Circadian entrainment 2/369 136/7206 0.0482065806937 ko04140 Autophagy - animal 3/369 164/7206 0.0485293568696