ko pathway ratio_in_study ratio_in_pop p_value ko04966 Collecting duct acid secretion 12/453 26/7206 1.41999944849e-08 ko04724 Glutamatergic synapse 29/453 152/7206 5.19275575339e-08 ko04713 Circadian entrainment 26/453 136/7206 2.48071870915e-07 ko04911 Insulin secretion 23/453 117/7206 7.39481603695e-07 ko04728 Dopaminergic synapse 30/453 185/7206 1.23526679284e-06 ko04721 Synaptic vesicle cycle 18/453 80/7206 1.5690005661e-06 ko04720 Long-term potentiation 20/453 99/7206 2.52149935927e-06 ko04727 GABAergic synapse 21/453 110/7206 3.68765668685e-06 ko05110 Vibrio cholerae infection 15/453 63/7206 5.56874520002e-06 ko05031 Amphetamine addiction 18/453 91/7206 1.09372329217e-05 ko05032 Morphine addiction 19/453 110/7206 4.67078834693e-05 ko04070 Phosphatidylinositol signaling system 19/453 112/7206 6.03520652869e-05 ko04725 Cholinergic synapse 24/453 160/7206 8.1776946736e-05 ko04726 Serotonergic synapse 21/453 137/7206 0.000115539027459 ko04921 Oxytocin signaling pathway 28/453 209/7206 0.000121309486451 ko04960 Aldosterone-regulated sodium reabsorption 10/453 41/7206 0.000166922262925 ko05120 Epithelial cell signaling in Helicobacter pylori infection 16/453 92/7206 0.000169362279152 ko04745 Phototransduction - fly 9/453 38/7206 0.000447967678052 ko04626 Plant-pathogen interaction 6/453 18/7206 0.000578552768626 ko04922 Glucagon signaling pathway 19/453 128/7206 0.00059752005174 ko00010 Glycolysis / Gluconeogenesis 13/453 74/7206 0.000616833559492 ko04925 Aldosterone synthesis and secretion 16/453 105/7206 0.000789692708602 ko00680 Methane metabolism 8/453 34/7206 0.000973145298972 ko05322 Systemic lupus erythematosus 1/453 151/7206 0.00102221919491 ko04971 Gastric acid secretion 15/453 98/7206 0.00108965688237 ko00190 Oxidative phosphorylation 18/453 127/7206 0.00116155727794 ko04261 Adrenergic signaling in cardiomyocytes 25/453 205/7206 0.00117577984055 ko05323 Rheumatoid arthritis 14/453 89/7206 0.00120602008644 ko04744 Phototransduction 8/453 36/7206 0.00145168400636 ko04145 Phagosome 21/453 162/7206 0.00145828617942 ko04138 Autophagy - yeast 13/453 81/7206 0.00147999697391 ko04964 Proximal tubule bicarbonate reclamation 7/453 29/7206 0.00172030760538 ko05014 Amyotrophic lateral sclerosis (ALS) 12/453 74/7206 0.00203412680426 ko04723 Retrograde endocannabinoid signaling 22/453 175/7206 0.00220997634712 ko05033 Nicotine addiction 10/453 56/7206 0.00226974014611 ko04970 Salivary secretion 14/453 95/7206 0.00228651091431 ko04919 Thyroid hormone signaling pathway 19/453 143/7206 0.00238568920093 ko04022 cGMP-PKG signaling pathway 25/453 216/7206 0.00257674092463 ko04136 Autophagy - other 7/453 31/7206 0.00259862731768 ko04730 Long-term depression 12/453 78/7206 0.00320555629922 ko04024 cAMP signaling pathway 30/453 279/7206 0.00349946839479 ko04371 Apelin signaling pathway 21/453 177/7206 0.00428177849088 ko05168 Herpes simplex infection 3/453 182/7206 0.00485710140151 ko03010 Ribosome 1/453 129/7206 0.00490293929868 ko04514 Cell adhesion molecules (CAMs) 17/453 130/7206 0.00502345380817 ko04360 Axon guidance 25/453 233/7206 0.00838999436244 ko03040 Spliceosome 2/453 145/7206 0.00854914523049 ko04110 Cell cycle 2/453 145/7206 0.00854914523049 ko04961 Endocrine and other factor-regulated calcium reabsorption 9/453 59/7206 0.0107052865823 ko04020 Calcium signaling pathway 27/453 265/7206 0.0133607048397 ko05167 Kaposi's sarcoma-associated herpesvirus infection 21/453 191/7206 0.0142490151944 ko00051 Fructose and mannose metabolism 7/453 42/7206 0.0146905319199 ko04972 Pancreatic secretion 14/453 111/7206 0.0154001236665 ko05230 Central carbon metabolism in cancer 11/453 81/7206 0.0170189089443 ko04137 Mitophagy - animal 11/453 82/7206 0.0177987308206 ko05169 Epstein-Barr virus infection 5/453 206/7206 0.0185383646323 ko00562 Inositol phosphate metabolism 11/453 89/7206 0.0260302606266 ko05214 Glioma 10/453 79/7206 0.0311742221125 ko04152 AMPK signaling pathway 17/453 161/7206 0.0315530432223 ko00120 Primary bile acid biosynthesis 4/453 20/7206 0.0334190686096 ko03013 RNA transport 4/453 166/7206 0.0342951410043 ko05162 Measles 2/453 120/7206 0.03431344976 ko04072 Phospholipase D signaling pathway 20/453 197/7206 0.0351833455362 ko05010 Alzheimer's disease 20/453 202/7206 0.0387355743953 ko04014 Ras signaling pathway 26/453 279/7206 0.0428576330681 ko04973 Carbohydrate digestion and absorption 6/453 42/7206 0.0457424544456