ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 23/256 80/7206 1.93432778159e-15 ko04080 Neuroactive ligand-receptor interaction 44/256 423/7206 5.72237038187e-11 ko04728 Dopaminergic synapse 27/256 185/7206 2.63036661624e-10 ko04724 Glutamatergic synapse 24/256 152/7206 5.3152662103e-10 ko04727 GABAergic synapse 20/256 110/7206 1.22856750793e-09 ko05033 Nicotine addiction 14/256 56/7206 5.4700408261e-09 ko04966 Collecting duct acid secretion 9/256 26/7206 1.44162852519e-07 ko04145 Phagosome 21/256 162/7206 2.29658949505e-07 ko05014 Amyotrophic lateral sclerosis (ALS) 14/256 74/7206 2.42173603786e-07 ko04713 Circadian entrainment 19/256 136/7206 2.70220301715e-07 ko04723 Retrograde endocannabinoid signaling 21/256 175/7206 8.51624171413e-07 ko05110 Vibrio cholerae infection 12/256 63/7206 1.65950903442e-06 ko05120 Epithelial cell signaling in Helicobacter pylori infection 14/256 92/7206 3.77319386051e-06 ko05032 Morphine addiction 15/256 110/7206 6.87078092333e-06 ko04911 Insulin secretion 15/256 117/7206 1.47651001688e-05 ko04261 Adrenergic signaling in cardiomyocytes 20/256 205/7206 3.64144981252e-05 ko04725 Cholinergic synapse 17/256 160/7206 4.84387630209e-05 ko05323 Rheumatoid arthritis 12/256 89/7206 6.4891105384e-05 ko05031 Amphetamine addiction 12/256 91/7206 8.09730596799e-05 ko04024 cAMP signaling pathway 23/256 279/7206 0.000168078642256 ko04962 Vasopressin-regulated water reabsorption 9/256 58/7206 0.000181389448523 ko04961 Endocrine and other factor-regulated calcium reabsorption 9/256 59/7206 0.000207506474148 ko04726 Serotonergic synapse 14/256 137/7206 0.000339768246837 ko00190 Oxidative phosphorylation 13/256 127/7206 0.00054279565034 ko04514 Cell adhesion molecules (CAMs) 13/256 130/7206 0.000679098968731 ko05030 Cocaine addiction 9/256 73/7206 0.00103980511011 ko04972 Pancreatic secretion 11/256 111/7206 0.00187125203266 ko04970 Salivary secretion 10/256 95/7206 0.00190118069751 ko04260 Cardiac muscle contraction 10/256 98/7206 0.00240107649098 ko04720 Long-term potentiation 10/256 99/7206 0.00258938869547 ko04742 Taste transduction 7/256 61/7206 0.00557798557829 ko05010 Alzheimer's disease 15/256 202/7206 0.00599204258311 ko04730 Long-term depression 8/256 78/7206 0.00621404777955 ko04971 Gastric acid secretion 9/256 98/7206 0.00782019855342 ko04921 Oxytocin signaling pathway 15/256 209/7206 0.0114914434275 ko00230 Purine metabolism 1/256 194/7206 0.0158084903769 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 7/256 79/7206 0.0216740551428 ko05206 MicroRNAs in cancer 1/256 177/7206 0.0219032488609 ko04217 Necroptosis 1/256 178/7206 0.0219950977976 ko05168 Herpes simplex infection 1/256 182/7206 0.022639704787 ko04540 Gap junction 10/256 128/7206 0.0247740401937 ko04010 MAPK signaling pathway 19/256 321/7206 0.0289059462526 ko05034 Alcoholism 15/256 238/7206 0.0300842810727 ko04550 Signaling pathways regulating pluripotency of stem cells 1/256 165/7206 0.0314878236189 ko04068 FoxO signaling pathway 1/256 167/7206 0.0317328965016 ko05166 HTLV-I infection 4/256 292/7206 0.0351659998505 ko04745 Phototransduction - fly 4/256 38/7206 0.0446131662163 ko05322 Systemic lupus erythematosus 1/256 151/7206 0.0451122063575 ko04621 NOD-like receptor signaling pathway 1/256 157/7206 0.0459413601315 ko04360 Axon guidance 14/256 233/7206 0.0468897841309