ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	209/1312	423/7206	7.86995504216e-52
ko04724	Glutamatergic synapse	93/1312	152/7206	1.39690246754e-32
ko05033	Nicotine addiction	50/1312	56/7206	4.92068234729e-31
ko04727	GABAergic synapse	73/1312	110/7206	4.52605114584e-29
ko05032	Morphine addiction	73/1312	110/7206	4.52605114584e-29
ko04713	Circadian entrainment	81/1312	136/7206	2.4715546197e-27
ko04721	Synaptic vesicle cycle	52/1312	80/7206	2.10296168843e-20
ko04728	Dopaminergic synapse	87/1312	185/7206	8.62161702929e-20
ko04725	Cholinergic synapse	79/1312	160/7206	1.10498577308e-19
ko04024	cAMP signaling pathway	113/1312	279/7206	6.51719995277e-19
ko04723	Retrograde endocannabinoid signaling	82/1312	175/7206	1.36490221277e-18
ko04020	Calcium signaling pathway	106/1312	265/7206	2.29033017518e-17
ko04911	Insulin secretion	61/1312	117/7206	6.34980009757e-17
ko04744	Phototransduction	28/1312	36/7206	1.01379226141e-14
ko04726	Serotonergic synapse	64/1312	137/7206	1.09784340825e-14
ko04742	Taste transduction	37/1312	61/7206	1.73448253621e-13
ko04921	Oxytocin signaling pathway	81/1312	209/7206	1.80329785912e-12
ko05031	Amphetamine addiction	46/1312	91/7206	1.92087818097e-12
ko04970	Salivary secretion	45/1312	95/7206	5.79586671672e-11
ko03040	Spliceosome	2/1312	145/7206	1.37307424139e-10
ko03010	Ribosome	1/1312	129/7206	2.03675669692e-10
ko04720	Long-term potentiation	45/1312	99/7206	3.22452695614e-10
ko04261	Adrenergic signaling in cardiomyocytes	74/1312	205/7206	6.2177322077e-10
ko04022	cGMP-PKG signaling pathway	74/1312	216/7206	9.6048930007e-09
ko05030	Cocaine addiction	34/1312	73/7206	2.2401435692e-08
ko04925	Aldosterone synthesis and secretion	43/1312	105/7206	5.21635311204e-08
ko04740	Olfactory transduction	35/1312	80/7206	9.95750429272e-08
ko03013	RNA transport	7/1312	166/7206	1.11451704869e-07
ko04966	Collecting duct acid secretion	17/1312	26/7206	1.4277939855e-07
ko04971	Gastric acid secretion	40/1312	98/7206	1.81755265434e-07
ko05322	Systemic lupus erythematosus	6/1312	151/7206	1.82802172649e-07
ko05203	Viral carcinogenesis	21/1312	277/7206	4.31080097813e-07
ko04060	Cytokine-cytokine receptor interaction	11/1312	191/7206	5.4732738312e-07
ko05168	Herpes simplex infection	10/1312	182/7206	7.41967631338e-07
ko04070	Phosphatidylinositol signaling system	41/1312	112/7206	3.08855530806e-06
ko04110	Cell cycle	8/1312	145/7206	1.02542728149e-05
ko04924	Renin secretion	33/1312	86/7206	1.36146429562e-05
ko05164	Influenza A	11/1312	167/7206	1.69099196761e-05
ko04972	Pancreatic secretion	39/1312	111/7206	1.75630178702e-05
ko04730	Long-term depression	30/1312	78/7206	2.17726075185e-05
ko04120	Ubiquitin mediated proteolysis	8/1312	138/7206	2.94875961996e-05
ko04514	Cell adhesion molecules (CAMs)	43/1312	130/7206	4.43546044472e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1312	79/7206	4.5846040069e-05
ko04072	Phospholipase D signaling pathway	59/1312	197/7206	4.79766087844e-05
ko05110	Vibrio cholerae infection	25/1312	63/7206	5.38222007565e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1312	74/7206	5.6597112807e-05
ko04141	Protein processing in endoplasmic reticulum	14/1312	184/7206	6.02926257135e-05
ko04360	Axon guidance	67/1312	233/7206	6.28270429995e-05
ko04621	NOD-like receptor signaling pathway	11/1312	157/7206	8.93196354532e-05
ko04750	Inflammatory mediator regulation of TRP channels	40/1312	122/7206	0.000118392177037
ko04745	Phototransduction - fly	17/1312	38/7206	0.000143384194849
ko04923	Regulation of lipolysis in adipocytes	28/1312	77/7206	0.000144276832043
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1312	59/7206	0.000234659376543
ko04612	Antigen processing and presentation	3/1312	77/7206	0.000289499190737
ko04540	Gap junction	40/1312	128/7206	0.000295327489591
ko05414	Dilated cardiomyopathy	36/1312	112/7206	0.000303331829665
ko05169	Epstein-Barr virus infection	19/1312	206/7206	0.00033460772165
ko04976	Bile secretion	28/1312	80/7206	0.000350109886908
ko04626	Plant-pathogen interaction	10/1312	18/7206	0.000408052715323
ko04915	Estrogen signaling pathway	40/1312	131/7206	0.000534465193051
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1312	79/7206	0.00060962610842
ko04964	Proximal tubule bicarbonate reclamation	13/1312	29/7206	0.000848995396461
ko04371	Apelin signaling pathway	50/1312	177/7206	0.00103449710435
ko04658	Th1 and Th2 cell differentiation	6/1312	96/7206	0.00120348618295
ko05166	HTLV-I infection	33/1312	292/7206	0.00143413180157
ko04014	Ras signaling pathway	72/1312	279/7206	0.001473083256
ko04922	Glucagon signaling pathway	38/1312	128/7206	0.00161189131108
ko03420	Nucleotide excision repair	1/1312	46/7206	0.00174655531815
ko05140	Leishmaniasis	4/1312	75/7206	0.0022255881989
ko04010	MAPK signaling pathway	80/1312	321/7206	0.00232766931427
ko00520	Amino sugar and nucleotide sugar metabolism	2/1312	55/7206	0.0023938947356
ko05321	Inflammatory bowel disease (IBD)	2/1312	56/7206	0.00249844099504
ko03022	Basal transcription factors	1/1312	44/7206	0.00266239368741
ko05161	Hepatitis B	17/1312	173/7206	0.00266737574179
ko04270	Vascular smooth muscle contraction	43/1312	154/7206	0.00290617323607
ko04064	NF-kappa B signaling pathway	7/1312	96/7206	0.00320505881011
ko05145	Toxoplasmosis	11/1312	126/7206	0.00350110595646
ko04930	Type II diabetes mellitus	19/1312	54/7206	0.00376731369202
ko05162	Measles	10/1312	120/7206	0.00385173133377
ko04330	Notch signaling pathway	3/1312	62/7206	0.00422842755598
ko04622	RIG-I-like receptor signaling pathway	3/1312	62/7206	0.00422842755598
ko04710	Circadian rhythm	16/1312	43/7206	0.00432285058324
ko04657	IL-17 signaling pathway	6/1312	87/7206	0.00464812179512
ko05205	Proteoglycans in cancer	32/1312	271/7206	0.00483052133992
ko04260	Cardiac muscle contraction	29/1312	98/7206	0.0053175316965
ko04210	Apoptosis	19/1312	180/7206	0.00594496414597
ko03018	RNA degradation	6/1312	84/7206	0.00632733456405
ko05231	Choline metabolism in cancer	37/1312	134/7206	0.00645013090244
ko04217	Necroptosis	19/1312	178/7206	0.00762057813256
ko05219	Bladder cancer	2/1312	48/7206	0.00767232144828
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1312	100/7206	0.00842244569879
ko05131	Shigellosis	6/1312	82/7206	0.00881463845087
ko03410	Base excision repair	1/1312	38/7206	0.00955077189827
ko04350	TGF-beta signaling pathway	9/1312	103/7206	0.00975322965594
ko05133	Pertussis	7/1312	87/7206	0.0112862775703
ko04978	Mineral absorption	14/1312	40/7206	0.0116295379429
ko04630	Jak-STAT signaling pathway	13/1312	132/7206	0.0117187665254
ko00562	Inositol phosphate metabolism	26/1312	89/7206	0.0119539696416
ko00280	Valine, leucine and isoleucine degradation	3/1312	54/7206	0.0122483314522
ko00480	Glutathione metabolism	3/1312	55/7206	0.0126109678339
ko04960	Aldosterone-regulated sodium reabsorption	14/1312	41/7206	0.0134064541516
ko04142	Lysosome	16/1312	151/7206	0.0137778555166
ko00010	Glycolysis / Gluconeogenesis	22/1312	74/7206	0.0145944322755
ko05150	Staphylococcus aureus infection	1/1312	36/7206	0.0146571686023
ko05132	Salmonella infection	9/1312	98/7206	0.0172988932964
ko04711	Circadian rhythm - fly	6/1312	13/7206	0.0192650390103
ko00290	Valine, leucine and isoleucine biosynthesis	3/1312	4/7206	0.0208127805767
ko04115	p53 signaling pathway	6/1312	74/7206	0.0222459771082
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1312	40/7206	0.0239501182238
ko00140	Steroid hormone biosynthesis	2/1312	41/7206	0.0239910596717
ko04213	Longevity regulating pathway - multiple species	24/1312	86/7206	0.0240644793155
ko04918	Thyroid hormone synthesis	24/1312	86/7206	0.0240644793155
ko00240	Pyrimidine metabolism	11/1312	110/7206	0.0243478846142
ko04912	GnRH signaling pathway	32/1312	122/7206	0.024438925724
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1312	14/7206	0.0286232884224
ko03015	mRNA surveillance pathway	9/1312	93/7206	0.0301505366114
ko04214	Apoptosis - fly	6/1312	72/7206	0.0303564489803
ko05016	Huntington's disease	27/1312	215/7206	0.0308724472219
ko00630	Glyoxylate and dicarboxylate metabolism	2/1312	38/7206	0.0346693543516
ko05217	Basal cell carcinoma	6/1312	68/7206	0.040654324661
ko04659	Th17 cell differentiation	11/1312	106/7206	0.0413006482437
ko04113	Meiosis - yeast	6/1312	70/7206	0.0413158298337
ko04973	Carbohydrate digestion and absorption	13/1312	42/7206	0.0427883516276
ko00680	Methane metabolism	11/1312	34/7206	0.042842484886
ko01230	Biosynthesis of amino acids	23/1312	85/7206	0.0462096483223
ko04218	Cellular senescence	22/1312	177/7206	0.0479799860946
ko04152	AMPK signaling pathway	39/1312	161/7206	0.0496830092707