ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	209/1219	423/7206	1.19118502291e-57
ko04724	Glutamatergic synapse	96/1219	152/7206	4.42400863777e-38
ko05033	Nicotine addiction	50/1219	56/7206	1.26935478623e-32
ko05032	Morphine addiction	73/1219	110/7206	3.18863841497e-31
ko04713	Circadian entrainment	80/1219	136/7206	9.32175470165e-29
ko04727	GABAergic synapse	70/1219	110/7206	2.8322724209e-28
ko04728	Dopaminergic synapse	91/1219	185/7206	9.37085779412e-25
ko04725	Cholinergic synapse	81/1219	160/7206	3.54141754717e-23
ko04721	Synaptic vesicle cycle	52/1219	80/7206	6.51689771116e-22
ko04723	Retrograde endocannabinoid signaling	81/1219	175/7206	5.15722950251e-20
ko04024	cAMP signaling pathway	108/1219	279/7206	1.03317856812e-18
ko04911	Insulin secretion	61/1219	117/7206	1.51637837976e-18
ko04020	Calcium signaling pathway	102/1219	265/7206	1.53442398002e-17
ko04742	Taste transduction	39/1219	61/7206	2.26533090049e-16
ko04726	Serotonergic synapse	64/1219	137/7206	2.7031093538e-16
ko04921	Oxytocin signaling pathway	83/1219	209/7206	1.92712991732e-15
ko04744	Phototransduction	27/1219	36/7206	2.24755154116e-14
ko04720	Long-term potentiation	48/1219	99/7206	2.70390430659e-13
ko05031	Amphetamine addiction	45/1219	91/7206	6.22574361662e-13
ko04261	Adrenergic signaling in cardiomyocytes	75/1219	205/7206	7.84626972941e-12
ko03040	Spliceosome	1/1219	145/7206	7.23770504011e-11
ko04970	Salivary secretion	43/1219	95/7206	8.33506882326e-11
ko04740	Olfactory transduction	38/1219	80/7206	1.82984242038e-10
ko04925	Aldosterone synthesis and secretion	43/1219	105/7206	3.88794106921e-09
ko05030	Cocaine addiction	33/1219	73/7206	1.38432135252e-08
ko04971	Gastric acid secretion	40/1219	98/7206	1.5245560159e-08
ko04360	Axon guidance	74/1219	233/7206	2.00190932314e-08
ko05203	Viral carcinogenesis	17/1219	277/7206	7.71920201754e-08
ko04010	MAPK signaling pathway	91/1219	321/7206	1.66493251104e-07
ko05322	Systemic lupus erythematosus	5/1219	151/7206	2.48368343599e-07
ko04060	Cytokine-cytokine receptor interaction	9/1219	191/7206	3.80507541615e-07
ko03013	RNA transport	7/1219	166/7206	8.76270817054e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1219	74/7206	1.14593561118e-06
ko04022	cGMP-PKG signaling pathway	65/1219	216/7206	1.17129684512e-06
ko04730	Long-term depression	30/1219	78/7206	4.67900152752e-06
ko05168	Herpes simplex infection	10/1219	182/7206	4.84111246769e-06
ko04070	Phosphatidylinositol signaling system	39/1219	112/7206	4.85905902023e-06
ko04972	Pancreatic secretion	38/1219	111/7206	8.53218365364e-06
ko04745	Phototransduction - fly	18/1219	38/7206	1.2599172282e-05
ko04610	Complement and coagulation cascades	1/1219	79/7206	1.26288451077e-05
ko04141	Protein processing in endoplasmic reticulum	11/1219	184/7206	1.40830690317e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1219	79/7206	2.43837609233e-05
ko05164	Influenza A	10/1219	167/7206	3.68245128387e-05
ko04072	Phospholipase D signaling pathway	56/1219	197/7206	4.33231299902e-05
ko04540	Gap junction	40/1219	128/7206	6.41578003829e-05
ko04014	Ras signaling pathway	73/1219	279/7206	8.17127940199e-05
ko04966	Collecting duct acid secretion	13/1219	26/7206	0.000102813786266
ko03008	Ribosome biogenesis in eukaryotes	2/1219	79/7206	0.000110282736754
ko04924	Renin secretion	29/1219	86/7206	0.000124451056667
ko04621	NOD-like receptor signaling pathway	10/1219	157/7206	0.000137013320715
ko05110	Vibrio cholerae infection	23/1219	63/7206	0.000148123585923
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1219	59/7206	0.000152929091544
ko04612	Antigen processing and presentation	2/1219	77/7206	0.000167594189789
ko05414	Dilated cardiomyopathy	35/1219	112/7206	0.000177354892329
ko04110	Cell cycle	9/1219	145/7206	0.000186960810541
ko04514	Cell adhesion molecules (CAMs)	39/1219	130/7206	0.000204312786226
ko04260	Cardiac muscle contraction	31/1219	98/7206	0.000326583539785
ko04371	Apelin signaling pathway	49/1219	177/7206	0.000330794191129
ko04750	Inflammatory mediator regulation of TRP channels	36/1219	122/7206	0.000543443174893
ko04146	Peroxisome	4/1219	89/7206	0.000553486800519
ko00480	Glutathione metabolism	1/1219	55/7206	0.000840941810997
ko05169	Epstein-Barr virus infection	18/1219	206/7206	0.00090188596022
ko04120	Ubiquitin mediated proteolysis	10/1219	138/7206	0.00121647660542
ko05162	Measles	8/1219	120/7206	0.00129489069265
ko04915	Estrogen signaling pathway	37/1219	131/7206	0.00131682422631
ko04976	Bile secretion	25/1219	80/7206	0.00140336878142
ko00240	Pyrimidine metabolism	7/1219	110/7206	0.00184773459653
ko04912	GnRH signaling pathway	34/1219	122/7206	0.00214568873034
ko04711	Circadian rhythm - fly	7/1219	13/7206	0.00259577153046
ko04064	NF-kappa B signaling pathway	6/1219	96/7206	0.00356690488136
ko05321	Inflammatory bowel disease (IBD)	2/1219	56/7206	0.00376715345997
ko03022	Basal transcription factors	1/1219	44/7206	0.00429553494176
ko05144	Malaria	1/1219	45/7206	0.00433138327646
ko00071	Fatty acid degradation	1/1219	45/7206	0.00433138327646
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1219	14/7206	0.00443975646616
ko03420	Nucleotide excision repair	1/1219	46/7206	0.00454754377721
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1219	100/7206	0.00462603662153
ko05140	Leishmaniasis	4/1219	75/7206	0.00475213163838
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1219	182/7206	0.00480315915808
ko05205	Proteoglycans in cancer	29/1219	271/7206	0.00481679633493
ko03018	RNA degradation	5/1219	84/7206	0.00488921277823
ko04923	Regulation of lipolysis in adipocytes	23/1219	77/7206	0.00519805079961
ko04062	Chemokine signaling pathway	49/1219	201/7206	0.0056037121905
ko04916	Melanogenesis	37/1219	142/7206	0.00624168755795
ko04640	Hematopoietic cell lineage	3/1219	64/7206	0.00645062794609
ko00310	Lysine degradation	4/1219	73/7206	0.00681800636576
ko04015	Rap1 signaling pathway	64/1219	278/7206	0.00704683654433
ko04622	RIG-I-like receptor signaling pathway	3/1219	62/7206	0.009444559362
ko00562	Inositol phosphate metabolism	25/1219	89/7206	0.00956565316298
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1219	40/7206	0.00976538133398
ko04710	Circadian rhythm	14/1219	43/7206	0.0122357141336
ko05016	Huntington's disease	23/1219	215/7206	0.0123933327366
ko00982	Drug metabolism - cytochrome P450	1/1219	37/7206	0.0145398538375
ko05214	Glioma	22/1219	79/7206	0.0146970784048
ko04922	Glucagon signaling pathway	32/1219	128/7206	0.0172101131272
ko04930	Type II diabetes mellitus	16/1219	54/7206	0.0173808885602
ko05161	Hepatitis B	18/1219	173/7206	0.0181812341476
ko04115	p53 signaling pathway	5/1219	74/7206	0.0181855638989
ko04960	Aldosterone-regulated sodium reabsorption	13/1219	41/7206	0.0191955796212
ko05231	Choline metabolism in cancer	33/1219	134/7206	0.0198481365954
ko04658	Th1 and Th2 cell differentiation	8/1219	96/7206	0.0198565215659
ko04918	Thyroid hormone synthesis	23/1219	86/7206	0.0198599411634
ko05166	HTLV-I infection	35/1219	292/7206	0.020707374476
ko00512	Mucin type O-glycan biosynthesis	10/1219	29/7206	0.0213838109333
ko04964	Proximal tubule bicarbonate reclamation	10/1219	29/7206	0.0213838109333
ko04973	Carbohydrate digestion and absorption	13/1219	42/7206	0.021854147642
ko04975	Fat digestion and absorption	1/1219	35/7206	0.0218801238675
ko00500	Starch and sucrose metabolism	1/1219	35/7206	0.0218801238675
ko04626	Plant-pathogen interaction	7/1219	18/7206	0.0221430015258
ko04350	TGF-beta signaling pathway	9/1219	103/7206	0.0239141020042
ko04722	Neurotrophin signaling pathway	38/1219	160/7206	0.0246804608096
ko04214	Apoptosis - fly	5/1219	72/7206	0.0253420089814
ko04217	Necroptosis	19/1219	178/7206	0.0253906259939
ko00330	Arginine and proline metabolism	4/1219	61/7206	0.0256696474455
ko04330	Notch signaling pathway	4/1219	62/7206	0.0257689241695
ko04657	IL-17 signaling pathway	7/1219	87/7206	0.0294998813557
ko05133	Pertussis	7/1219	87/7206	0.0294998813557
ko04620	Toll-like receptor signaling pathway	9/1219	100/7206	0.0313704844679
ko04071	Sphingolipid signaling pathway	38/1219	162/7206	0.0332399455041
ko03320	PPAR signaling pathway	5/1219	69/7206	0.0342179518307
ko00140	Steroid hormone biosynthesis	2/1219	41/7206	0.036053612729
ko05230	Central carbon metabolism in cancer	21/1219	81/7206	0.0362849945025
ko00983	Drug metabolism - other enzymes	2/1219	42/7206	0.0365485174913
ko04012	ErbB signaling pathway	27/1219	109/7206	0.0381844392708
ko05131	Shigellosis	7/1219	82/7206	0.0384280371348
ko05418	Fluid shear stress and atherosclerosis	19/1219	173/7206	0.0393386325559
ko05034	Alcoholism	52/1219	238/7206	0.0430413185811
ko05320	Autoimmune thyroid disease	1/1219	29/7206	0.0485586342599