ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04724	Glutamatergic synapse	79/778	152/7206	2.0249977177e-37
ko04080	Neuroactive ligand-receptor interaction	137/778	423/7206	8.71625658296e-36
ko05033	Nicotine addiction	45/778	56/7206	4.60019600416e-34
ko04727	GABAergic synapse	59/778	110/7206	4.38432116101e-29
ko05032	Morphine addiction	59/778	110/7206	4.38432116101e-29
ko04713	Circadian entrainment	60/778	136/7206	1.02013219592e-23
ko04723	Retrograde endocannabinoid signaling	68/778	175/7206	6.82951629206e-23
ko04728	Dopaminergic synapse	68/778	185/7206	2.72010608541e-21
ko04744	Phototransduction	27/778	36/7206	1.90492985812e-19
ko04725	Cholinergic synapse	58/778	160/7206	5.74634601913e-18
ko04024	cAMP signaling pathway	77/778	279/7206	1.23197305655e-15
ko04721	Synaptic vesicle cycle	35/778	80/7206	3.54369780988e-14
ko04726	Serotonergic synapse	47/778	137/7206	9.91644470489e-14
ko04911	Insulin secretion	42/778	117/7206	3.66178610873e-13
ko04742	Taste transduction	28/778	61/7206	3.16337515773e-12
ko04020	Calcium signaling pathway	67/778	265/7206	9.94805351053e-12
ko04921	Oxytocin signaling pathway	57/778	209/7206	1.29953372039e-11
ko04740	Olfactory transduction	30/778	80/7206	2.61651941075e-10
ko05031	Amphetamine addiction	32/778	91/7206	4.55280921019e-10
ko04261	Adrenergic signaling in cardiomyocytes	53/778	205/7206	6.49238373782e-10
ko04720	Long-term potentiation	33/778	99/7206	1.19888542964e-09
ko04970	Salivary secretion	32/778	95/7206	1.5902530985e-09
ko05030	Cocaine addiction	26/778	73/7206	1.4647763826e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	26/778	74/7206	2.03102341298e-08
ko05203	Viral carcinogenesis	7/778	277/7206	2.87869406004e-07
ko04971	Gastric acid secretion	28/778	98/7206	8.38290804419e-07
ko04010	MAPK signaling pathway	63/778	321/7206	1.93215124549e-06
ko03040	Spliceosome	1/778	145/7206	2.06546906712e-06
ko04972	Pancreatic secretion	29/778	111/7206	3.97478017178e-06
ko04060	Cytokine-cytokine receptor interaction	4/778	191/7206	8.00055098564e-06
ko04022	cGMP-PKG signaling pathway	45/778	216/7206	1.05595103818e-05
ko05164	Influenza A	3/778	167/7206	1.2099055659e-05
ko04730	Long-term depression	22/778	78/7206	1.57129570453e-05
ko04925	Aldosterone synthesis and secretion	27/778	105/7206	1.73475588611e-05
ko04072	Phospholipase D signaling pathway	41/778	197/7206	3.31374565395e-05
ko04260	Cardiac muscle contraction	25/778	98/7206	4.1121846221e-05
ko04110	Cell cycle	3/778	145/7206	0.000114280053126
ko04350	TGF-beta signaling pathway	1/778	103/7206	0.000166562800996
ko05322	Systemic lupus erythematosus	4/778	151/7206	0.000286250879454
ko04514	Cell adhesion molecules (CAMs)	28/778	130/7206	0.000287314702411
ko05168	Herpes simplex infection	6/778	182/7206	0.00036986219189
ko05169	Epstein-Barr virus infection	8/778	206/7206	0.000542046953248
ko04621	NOD-like receptor signaling pathway	5/778	157/7206	0.000641663958248
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	19/778	79/7206	0.000684902614883
ko04924	Renin secretion	20/778	86/7206	0.000707635907182
ko04070	Phosphatidylinositol signaling system	24/778	112/7206	0.000985734496223
ko05034	Alcoholism	42/778	238/7206	0.00129882864586
ko05205	Proteoglycans in cancer	14/778	271/7206	0.00132093866156
ko04540	Gap junction	26/778	128/7206	0.00132354972383
ko03013	RNA transport	6/778	166/7206	0.00134988208497
ko05162	Measles	3/778	120/7206	0.00150179196568
ko04014	Ras signaling pathway	47/778	279/7206	0.0015842049536
ko04750	Inflammatory mediator regulation of TRP channels	25/778	122/7206	0.00164010834446
ko04745	Phototransduction - fly	11/778	38/7206	0.00168006225718
ko05414	Dilated cardiomyopathy	23/778	112/7206	0.00194726507679
ko04915	Estrogen signaling pathway	26/778	131/7206	0.00242339058955
ko04062	Chemokine signaling pathway	36/778	201/7206	0.00246073917903
ko04964	Proximal tubule bicarbonate reclamation	9/778	29/7206	0.0025901757131
ko04612	Antigen processing and presentation	1/778	77/7206	0.00262885867037
ko03008	Ribosome biogenesis in eukaryotes	1/778	79/7206	0.00276366100438
ko04371	Apelin signaling pathway	32/778	177/7206	0.00301905385133
ko04120	Ubiquitin mediated proteolysis	5/778	138/7206	0.00334617068688
ko04550	Signaling pathways regulating pluripotency of stem cells	7/778	165/7206	0.00336746323022
ko04146	Peroxisome	2/778	89/7206	0.0051339602658
ko04976	Bile secretion	17/778	80/7206	0.00557881523894
ko05161	Hepatitis B	8/778	173/7206	0.00594179190731
ko03018	RNA degradation	2/778	84/7206	0.00725773275024
ko04932	Non-alcoholic fatty liver disease (NAFLD)	9/778	182/7206	0.00741105702419
ko04141	Protein processing in endoplasmic reticulum	9/778	184/7206	0.00756823717015
ko04961	Endocrine and other factor-regulated calcium reabsorption	13/778	59/7206	0.0100876904256
ko04510	Focal adhesion	14/778	240/7206	0.0106530350482
ko05231	Choline metabolism in cancer	24/778	134/7206	0.0110325833191
ko04064	NF-kappa B signaling pathway	3/778	96/7206	0.0117427971534
ko05202	Transcriptional misregulation in cancer	10/778	188/7206	0.0118976003391
ko05215	Prostate cancer	4/778	111/7206	0.0124037053472
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/778	14/7206	0.0126166620353
ko04630	Jak-STAT signaling pathway	6/778	132/7206	0.0155794773182
ko05166	HTLV-I infection	19/778	292/7206	0.0156307068643
ko00562	Inositol phosphate metabolism	17/778	89/7206	0.0158507792653
ko04217	Necroptosis	10/778	178/7206	0.0200633445978
ko05140	Leishmaniasis	2/778	75/7206	0.0222843724808
ko00280	Valine, leucine and isoleucine degradation	1/778	54/7206	0.0265055561007
ko00480	Glutathione metabolism	1/778	55/7206	0.026774806817
ko04140	Autophagy - animal	9/778	164/7206	0.0292583335023
ko00240	Pyrimidine metabolism	5/778	110/7206	0.029592907039
ko05217	Basal cell carcinoma	2/778	68/7206	0.0301077769446
ko03320	PPAR signaling pathway	2/778	69/7206	0.0302768897177
ko04626	Plant-pathogen interaction	5/778	18/7206	0.0375730155714
ko04210	Apoptosis	11/778	180/7206	0.0383787753976
ko04071	Sphingolipid signaling pathway	26/778	162/7206	0.0392062027154
ko04360	Axon guidance	35/778	233/7206	0.0409179690317
ko04640	Hematopoietic cell lineage	2/778	64/7206	0.0426482814396
ko04930	Type II diabetes mellitus	11/778	54/7206	0.0426505045226
ko04610	Complement and coagulation cascades	3/778	79/7206	0.0433857569984
ko04710	Circadian rhythm	9/778	43/7206	0.0443914192502
ko05206	MicroRNAs in cancer	11/778	177/7206	0.0489137042031
ko04218	Cellular senescence	11/778	177/7206	0.0489137042031