ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	188/1133	423/7206	5.36821136182e-48
ko05033	Nicotine addiction	49/1133	56/7206	1.32038189988e-32
ko04724	Glutamatergic synapse	86/1133	152/7206	1.45429816502e-31
ko04727	GABAergic synapse	67/1133	110/7206	2.0713201829e-27
ko05032	Morphine addiction	66/1133	110/7206	1.79132534022e-26
ko04713	Circadian entrainment	69/1133	136/7206	8.16302539891e-22
ko04728	Dopaminergic synapse	81/1133	185/7206	3.29852174226e-20
ko04721	Synaptic vesicle cycle	48/1133	80/7206	1.47198822416e-19
ko04723	Retrograde endocannabinoid signaling	76/1133	175/7206	9.06453167832e-19
ko04725	Cholinergic synapse	71/1133	160/7206	3.11099971385e-18
ko04744	Phototransduction	27/1133	36/7206	3.44732618773e-15
ko04024	cAMP signaling pathway	96/1133	279/7206	3.48945652326e-15
ko04742	Taste transduction	35/1133	61/7206	8.91560567549e-14
ko04726	Serotonergic synapse	56/1133	137/7206	8.55316816009e-13
ko04911	Insulin secretion	49/1133	117/7206	8.12447760895e-12
ko04020	Calcium signaling pathway	85/1133	265/7206	1.23710994607e-11
ko04261	Adrenergic signaling in cardiomyocytes	71/1133	205/7206	1.45581826608e-11
ko04921	Oxytocin signaling pathway	69/1133	209/7206	4.08534894426e-10
ko03040	Spliceosome	1/1133	145/7206	5.26220932809e-10
ko05203	Viral carcinogenesis	11/1133	277/7206	6.26294429948e-10
ko05031	Amphetamine addiction	37/1133	91/7206	8.01568250732e-09
ko04740	Olfactory transduction	34/1133	80/7206	8.4238898066e-09
ko04970	Salivary secretion	38/1133	95/7206	8.64718214307e-09
ko04720	Long-term potentiation	38/1133	99/7206	3.27616516881e-08
ko05030	Cocaine addiction	29/1133	73/7206	5.9822840384e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1133	74/7206	8.38238603432e-07
ko05322	Systemic lupus erythematosus	5/1133	151/7206	1.3461401037e-06
ko05168	Herpes simplex infection	8/1133	182/7206	2.34009331077e-06
ko04971	Gastric acid secretion	34/1133	98/7206	3.57709460397e-06
ko03013	RNA transport	7/1133	166/7206	4.13618378391e-06
ko05164	Influenza A	7/1133	167/7206	4.22566956524e-06
ko05205	Proteoglycans in cancer	18/1133	271/7206	5.57466379164e-06
ko04514	Cell adhesion molecules (CAMs)	41/1133	130/7206	7.39155914365e-06
ko04925	Aldosterone synthesis and secretion	35/1133	105/7206	8.38372622733e-06
ko04022	cGMP-PKG signaling pathway	59/1133	216/7206	9.96448954921e-06
ko04060	Cytokine-cytokine receptor interaction	10/1133	191/7206	1.10553993569e-05
ko04360	Axon guidance	61/1133	233/7206	3.18810770685e-05
ko04610	Complement and coagulation cascades	1/1133	79/7206	3.25894206862e-05
ko04010	MAPK signaling pathway	78/1133	321/7206	4.12660792671e-05
ko04621	NOD-like receptor signaling pathway	8/1133	157/7206	5.26876122295e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1133	79/7206	0.00012884825673
ko04972	Pancreatic secretion	33/1133	111/7206	0.000178767224043
ko04966	Collecting duct acid secretion	12/1133	26/7206	0.000242141030643
ko03008	Ribosome biogenesis in eukaryotes	2/1133	79/7206	0.000266002765665
ko05161	Hepatitis B	11/1133	173/7206	0.00027917130099
ko04260	Cardiac muscle contraction	29/1133	98/7206	0.00041936307527
ko05162	Measles	6/1133	120/7206	0.000526010039855
ko04120	Ubiquitin mediated proteolysis	8/1133	138/7206	0.000536682484701
ko05414	Dilated cardiomyopathy	32/1133	112/7206	0.000545036203024
ko05140	Leishmaniasis	2/1133	75/7206	0.000604736608091
ko04072	Phospholipase D signaling pathway	49/1133	197/7206	0.000692269707434
ko04110	Cell cycle	9/1133	145/7206	0.000733926780461
ko04730	Long-term depression	24/1133	78/7206	0.000794048680554
ko04924	Renin secretion	26/1133	86/7206	0.00081098781408
ko05169	Epstein-Barr virus infection	16/1133	206/7206	0.000883568941098
ko04976	Bile secretion	24/1133	80/7206	0.00105094017087
ko04745	Phototransduction - fly	14/1133	38/7206	0.0012222998581
ko04540	Gap junction	34/1133	128/7206	0.00134699857976
ko00480	Glutathione metabolism	1/1133	55/7206	0.00134756074757
ko04141	Protein processing in endoplasmic reticulum	14/1133	184/7206	0.00136275661092
ko04070	Phosphatidylinositol signaling system	31/1133	112/7206	0.00144872606863
ko04146	Peroxisome	4/1133	89/7206	0.00178055984292
ko04915	Estrogen signaling pathway	34/1133	131/7206	0.00225946731375
ko04612	Antigen processing and presentation	3/1133	77/7206	0.00231848559817
ko04064	NF-kappa B signaling pathway	5/1133	96/7206	0.00266865841802
ko04640	Hematopoietic cell lineage	2/1133	64/7206	0.00278632701189
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1133	14/7206	0.00288868145871
ko04964	Proximal tubule bicarbonate reclamation	11/1133	29/7206	0.00309337538856
ko00590	Arachidonic acid metabolism	1/1133	52/7206	0.00321174938422
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1133	59/7206	0.00362652046546
ko03018	RNA degradation	4/1133	84/7206	0.00362926443031
ko05110	Vibrio cholerae infection	19/1133	63/7206	0.00446158129869
ko00240	Pyrimidine metabolism	7/1133	110/7206	0.00508349326906
ko05166	HTLV-I infection	29/1133	292/7206	0.0050845354935
ko04750	Inflammatory mediator regulation of TRP channels	31/1133	122/7206	0.00536757252288
ko05144	Malaria	1/1133	45/7206	0.00681761530723
ko00071	Fatty acid degradation	1/1133	45/7206	0.00681761530723
ko03420	Nucleotide excision repair	1/1133	46/7206	0.0069444192702
ko04658	Th1 and Th2 cell differentiation	6/1133	96/7206	0.00702085225541
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1133	182/7206	0.00718289280842
ko05321	Inflammatory bowel disease (IBD)	2/1133	56/7206	0.00867849161079
ko04140	Autophagy - animal	14/1133	164/7206	0.00888292022363
ko04014	Ras signaling pathway	60/1133	279/7206	0.00912057239307
ko04115	p53 signaling pathway	4/1133	74/7206	0.00986441467055
ko04923	Regulation of lipolysis in adipocytes	21/1133	77/7206	0.0106077456234
ko03022	Basal transcription factors	1/1133	44/7206	0.0106698873454
ko05145	Toxoplasmosis	10/1133	126/7206	0.0131151214992
ko04622	RIG-I-like receptor signaling pathway	3/1133	62/7206	0.0134784774868
ko05131	Shigellosis	5/1133	82/7206	0.0137238765083
ko04214	Apoptosis - fly	4/1133	72/7206	0.0138317565861
ko00310	Lysine degradation	4/1133	73/7206	0.0140960666978
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1133	40/7206	0.01524357765
ko04630	Jak-STAT signaling pathway	11/1133	132/7206	0.0155924729448
ko04371	Apelin signaling pathway	40/1133	177/7206	0.0156650138571
ko03320	PPAR signaling pathway	4/1133	69/7206	0.0192319431216
ko00330	Arginine and proline metabolism	3/1133	61/7206	0.0197756860243
ko04218	Cellular senescence	17/1133	177/7206	0.02129956868
ko00982	Drug metabolism - cytochrome P450	1/1133	37/7206	0.0226697073074
ko03410	Base excision repair	1/1133	38/7206	0.0230000789116
ko04657	IL-17 signaling pathway	6/1133	87/7206	0.0247876788423
ko05133	Pertussis	6/1133	87/7206	0.0247876788423
ko00260	Glycine, serine and threonine metabolism	2/1133	48/7206	0.0264015221723
ko05219	Bladder cancer	2/1133	48/7206	0.0264015221723
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1133	100/7206	0.0267092980138
ko04137	Mitophagy - animal	6/1133	82/7206	0.0324506335765
ko04620	Toll-like receptor signaling pathway	8/1133	100/7206	0.0366021822972
ko00280	Valine, leucine and isoleucine degradation	3/1133	54/7206	0.0379554931194
ko05215	Prostate cancer	10/1133	111/7206	0.0488594679295