ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 16/111 80/7206 3.96457985665e-14 ko04713 Circadian entrainment 15/111 136/7206 1.83870763171e-09 ko04728 Dopaminergic synapse 17/111 185/7206 2.42887779156e-09 ko04966 Collecting duct acid secretion 8/111 26/7206 3.050225902e-09 ko04724 Glutamatergic synapse 15/111 152/7206 8.68105743934e-09 ko05014 Amyotrophic lateral sclerosis (ALS) 11/111 74/7206 1.30280648208e-08 ko05031 Amphetamine addiction 11/111 91/7206 1.18560438352e-07 ko05120 Epithelial cell signaling in Helicobacter pylori infection 11/111 92/7206 1.32941479694e-07 ko05033 Nicotine addiction 9/111 56/7206 1.4577969511e-07 ko05110 Vibrio cholerae infection 9/111 63/7206 4.16305889267e-07 ko04911 Insulin secretion 11/111 117/7206 1.55601209009e-06 ko04720 Long-term potentiation 10/111 99/7206 2.47516668737e-06 ko04261 Adrenergic signaling in cardiomyocytes 14/111 205/7206 2.69348697369e-06 ko04080 Neuroactive ligand-receptor interaction 20/111 423/7206 5.59740121598e-06 ko04145 Phagosome 12/111 162/7206 6.38049162713e-06 ko04727 GABAergic synapse 10/111 110/7206 6.46869839569e-06 ko05030 Cocaine addiction 8/111 73/7206 1.43959419699e-05 ko04024 cAMP signaling pathway 15/111 279/7206 2.15722582487e-05 ko05323 Rheumatoid arthritis 8/111 89/7206 6.16762169778e-05 ko04723 Retrograde endocannabinoid signaling 11/111 175/7206 7.28817563435e-05 ko00190 Oxidative phosphorylation 8/111 127/7206 0.000721700967811 ko04725 Cholinergic synapse 9/111 160/7206 0.000764846544356 ko04071 Sphingolipid signaling pathway 9/111 162/7206 0.000836148136742 ko05034 Alcoholism 11/111 238/7206 0.00104006580328 ko04015 Rap1 signaling pathway 12/111 278/7206 0.00111528797528 ko04014 Ras signaling pathway 12/111 279/7206 0.001150501156 ko04730 Long-term depression 6/111 78/7206 0.00121789763397 ko05032 Morphine addiction 7/111 110/7206 0.00147043185092 ko04972 Pancreatic secretion 7/111 111/7206 0.00154979182463 ko04961 Endocrine and other factor-regulated calcium reabsorption 5/111 59/7206 0.00204699558467 ko04745 Phototransduction - fly 4/111 38/7206 0.00262979136153 ko04971 Gastric acid secretion 6/111 98/7206 0.00389506645668 ko04726 Serotonergic synapse 7/111 137/7206 0.0050644222843 ko04151 PI3K-Akt signaling pathway 13/111 390/7206 0.00867713034716 ko04964 Proximal tubule bicarbonate reclamation 3/111 29/7206 0.00971360236434 ko04940 Type I diabetes mellitus 3/111 32/7206 0.0127535249149 ko03015 mRNA surveillance pathway 5/111 93/7206 0.0140824693133 ko04921 Oxytocin signaling pathway 8/111 209/7206 0.0150499451477 ko04970 Salivary secretion 5/111 95/7206 0.0153267719996 ko04010 MAPK signaling pathway 11/111 321/7206 0.0163428753316 ko04260 Cardiac muscle contraction 5/111 98/7206 0.0173280968539 ko00430 Taurine and hypotaurine metabolism 2/111 14/7206 0.0189643529096 ko02024 Quorum sensing 2/111 15/7206 0.021664367901 ko04978 Mineral absorption 3/111 40/7206 0.0232537297578 ko04530 Tight junction 8/111 228/7206 0.0240527006439 ko04960 Aldosterone-regulated sodium reabsorption 3/111 41/7206 0.0248146071061 ko05152 Tuberculosis 7/111 187/7206 0.0250042765729 ko04973 Carbohydrate digestion and absorption 3/111 42/7206 0.026430795376 ko04360 Axon guidance 8/111 233/7206 0.0269451624376 ko04370 VEGF signaling pathway 4/111 77/7206 0.030569320258 ko04626 Plant-pathogen interaction 2/111 18/7206 0.0306380083684 ko05010 Alzheimer's disease 7/111 202/7206 0.0359437501499 ko04722 Neurotrophin signaling pathway 6/111 160/7206 0.0366356603306 ko04912 GnRH signaling pathway 5/111 122/7206 0.0396967166643 ko04924 Renin secretion 4/111 86/7206 0.0432364980761 ko04918 Thyroid hormone synthesis 4/111 86/7206 0.0432364980761 ko04391 Hippo signaling pathway - fly 4/111 90/7206 0.049685603653 ko05142 Chagas disease (American trypanosomiasis) 5/111 130/7206 0.0498459211667