ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	215/1325	423/7206	2.52346272215e-55
ko04724	Glutamatergic synapse	94/1325	152/7206	4.2003547654e-33
ko05033	Nicotine addiction	50/1325	56/7206	8.02771104954e-31
ko05032	Morphine addiction	71/1325	110/7206	6.81651749614e-27
ko04713	Circadian entrainment	80/1325	136/7206	3.40010260769e-26
ko04727	GABAergic synapse	69/1325	110/7206	4.52096503556e-25
ko04721	Synaptic vesicle cycle	53/1325	80/7206	3.8100685833e-21
ko04728	Dopaminergic synapse	87/1325	185/7206	1.68954876219e-19
ko04725	Cholinergic synapse	78/1325	160/7206	9.32905161989e-19
ko04024	cAMP signaling pathway	112/1325	279/7206	4.67059054981e-18
ko04020	Calcium signaling pathway	107/1325	265/7206	1.49424234724e-17
ko04723	Retrograde endocannabinoid signaling	80/1325	175/7206	4.19151391057e-17
ko04911	Insulin secretion	59/1325	117/7206	2.48410435645e-15
ko04742	Taste transduction	39/1325	61/7206	4.20450146561e-15
ko04726	Serotonergic synapse	64/1325	137/7206	1.78908041794e-14
ko04921	Oxytocin signaling pathway	84/1325	209/7206	1.13912254289e-13
ko04744	Phototransduction	27/1325	36/7206	1.87450166258e-13
ko03040	Spliceosome	1/1325	145/7206	5.69398516468e-12
ko04970	Salivary secretion	46/1325	95/7206	1.9262437485e-11
ko04740	Olfactory transduction	41/1325	80/7206	2.43865382582e-11
ko04720	Long-term potentiation	47/1325	99/7206	2.80317852833e-11
ko05031	Amphetamine addiction	44/1325	91/7206	5.63677420652e-11
ko04261	Adrenergic signaling in cardiomyocytes	76/1325	205/7206	1.69951109615e-10
ko05203	Viral carcinogenesis	17/1325	277/7206	2.85128051747e-09
ko04360	Axon guidance	80/1325	233/7206	4.3096456479e-09
ko04022	cGMP-PKG signaling pathway	74/1325	216/7206	1.75972424637e-08
ko04060	Cytokine-cytokine receptor interaction	9/1325	191/7206	2.30559201792e-08
ko04925	Aldosterone synthesis and secretion	44/1325	105/7206	2.70319212743e-08
ko05168	Herpes simplex infection	8/1325	182/7206	2.89256988123e-08
ko03013	RNA transport	7/1325	166/7206	7.16297416261e-08
ko04540	Gap junction	49/1325	128/7206	9.68607812607e-08
ko04971	Gastric acid secretion	40/1325	98/7206	2.11519053845e-07
ko05030	Cocaine addiction	32/1325	73/7206	4.20086218674e-07
ko05322	Systemic lupus erythematosus	7/1325	151/7206	6.86966200126e-07
ko04924	Renin secretion	34/1325	86/7206	3.77688178539e-06
ko05164	Influenza A	10/1325	167/7206	4.06418058526e-06
ko04966	Collecting duct acid secretion	15/1325	26/7206	8.64013315952e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1325	74/7206	1.16639230136e-05
ko04976	Bile secretion	31/1325	80/7206	1.58856946984e-05
ko04141	Protein processing in endoplasmic reticulum	13/1325	184/7206	1.73094338542e-05
ko04621	NOD-like receptor signaling pathway	10/1325	157/7206	2.34805647335e-05
ko04730	Long-term depression	30/1325	78/7206	2.55842550048e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1325	79/7206	2.80510252894e-05
ko04514	Cell adhesion molecules (CAMs)	44/1325	130/7206	2.81713632913e-05
ko04972	Pancreatic secretion	39/1325	111/7206	3.15605758744e-05
ko05169	Epstein-Barr virus infection	17/1325	206/7206	5.08399958841e-05
ko04064	NF-kappa B signaling pathway	4/1325	96/7206	5.20261124015e-05
ko05140	Leishmaniasis	2/1325	75/7206	6.41513052833e-05
ko04010	MAPK signaling pathway	87/1325	321/7206	8.56691608184e-05
ko04260	Cardiac muscle contraction	34/1325	98/7206	0.000106019263446
ko05162	Measles	7/1325	120/7206	0.000112019407477
ko04146	Peroxisome	4/1325	89/7206	0.000162432238574
ko04745	Phototransduction - fly	17/1325	38/7206	0.000162658180625
ko04610	Complement and coagulation cascades	3/1325	79/7206	0.000194837100942
ko05110	Vibrio cholerae infection	24/1325	63/7206	0.00021869605772
ko04964	Proximal tubule bicarbonate reclamation	14/1325	29/7206	0.000230084068652
ko04072	Phospholipase D signaling pathway	57/1325	197/7206	0.000247997376228
ko04110	Cell cycle	11/1325	145/7206	0.000307957148163
ko04120	Ubiquitin mediated proteolysis	10/1325	138/7206	0.000325135509942
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1325	79/7206	0.000336167854808
ko05414	Dilated cardiomyopathy	36/1325	112/7206	0.000476684979273
ko04070	Phosphatidylinositol signaling system	36/1325	112/7206	0.000476684979273
ko04923	Regulation of lipolysis in adipocytes	27/1325	77/7206	0.000509409092596
ko04371	Apelin signaling pathway	51/1325	177/7206	0.000550646933756
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1325	59/7206	0.000552545899296
ko05205	Proteoglycans in cancer	29/1325	271/7206	0.000555214844518
ko04750	Inflammatory mediator regulation of TRP channels	38/1325	122/7206	0.000559115723111
ko05161	Hepatitis B	16/1325	173/7206	0.000982518960438
ko00240	Pyrimidine metabolism	8/1325	110/7206	0.0011845566793
ko04612	Antigen processing and presentation	4/1325	77/7206	0.0015663767152
ko04014	Ras signaling pathway	72/1325	279/7206	0.00158826762223
ko05321	Inflammatory bowel disease (IBD)	2/1325	56/7206	0.00158946486429
ko05144	Malaria	1/1325	45/7206	0.00173188783806
ko00071	Fatty acid degradation	1/1325	45/7206	0.00173188783806
ko03420	Nucleotide excision repair	1/1325	46/7206	0.00174380065375
ko00310	Lysine degradation	4/1325	73/7206	0.00214124660594
ko05131	Shigellosis	5/1325	82/7206	0.00228522894162
ko04626	Plant-pathogen interaction	9/1325	18/7206	0.00229736561064
ko00480	Glutathione metabolism	2/1325	55/7206	0.00241151766524
ko03022	Basal transcription factors	1/1325	44/7206	0.00267408763888
ko04622	RIG-I-like receptor signaling pathway	3/1325	62/7206	0.00279827679358
ko04915	Estrogen signaling pathway	38/1325	131/7206	0.00284519819421
ko04214	Apoptosis - fly	4/1325	72/7206	0.0031557876656
ko04657	IL-17 signaling pathway	6/1325	87/7206	0.00322324761032
ko05133	Pertussis	6/1325	87/7206	0.00322324761032
ko05145	Toxoplasmosis	11/1325	126/7206	0.00347799975756
ko00590	Arachidonic acid metabolism	2/1325	52/7206	0.00349324196742
ko04630	Jak-STAT signaling pathway	12/1325	132/7206	0.00428853161379
ko01524	Platinum drug resistance	5/1325	76/7206	0.00450887693148
ko04115	p53 signaling pathway	5/1325	74/7206	0.00630389634462
ko03018	RNA degradation	6/1325	84/7206	0.00642947235833
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1325	14/7206	0.00718058960592
ko04922	Glucagon signaling pathway	36/1325	128/7206	0.00762276448848
ko04658	Th1 and Th2 cell differentiation	8/1325	96/7206	0.00773379692832
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1325	182/7206	0.00855524296334
ko04640	Hematopoietic cell lineage	4/1325	64/7206	0.00881958500704
ko00630	Glyoxylate and dicarboxylate metabolism	1/1325	38/7206	0.00971844218982
ko04916	Melanogenesis	38/1325	142/7206	0.0117516376488
ko04620	Toll-like receptor signaling pathway	9/1325	100/7206	0.0129624453593
ko05166	HTLV-I infection	38/1325	292/7206	0.0165316853261
ko04668	TNF signaling pathway	12/1325	120/7206	0.0167932756246
ko05418	Fluid shear stress and atherosclerosis	20/1325	173/7206	0.0169921393957
ko05132	Salmonella infection	9/1325	98/7206	0.0173324702723
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1325	100/7206	0.0184250091613
ko05215	Prostate cancer	11/1325	111/7206	0.0185157405645
ko05222	Small cell lung cancer	8/1325	89/7206	0.0188147789154
ko04142	Lysosome	17/1325	151/7206	0.0195374375607
ko00290	Valine, leucine and isoleucine biosynthesis	3/1325	4/7206	0.021404487148
ko04217	Necroptosis	21/1325	178/7206	0.023674888365
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1325	40/7206	0.0237253386867
ko05219	Bladder cancer	3/1325	48/7206	0.0247142112411
ko00380	Tryptophan metabolism	3/1325	50/7206	0.0256945949544
ko05320	Autoimmune thyroid disease	1/1325	29/7206	0.0311328887303
ko04210	Apoptosis	22/1325	180/7206	0.0316218257313
ko04912	GnRH signaling pathway	32/1325	122/7206	0.0329332793522
ko00280	Valine, leucine and isoleucine degradation	4/1325	54/7206	0.034001116275
ko04918	Thyroid hormone synthesis	24/1325	86/7206	0.0342557459323
ko03410	Base excision repair	2/1325	38/7206	0.0345159690791
ko04270	Vascular smooth muscle contraction	39/1325	154/7206	0.0347018680402
ko03320	PPAR signaling pathway	6/1325	69/7206	0.0408227627144
ko05231	Choline metabolism in cancer	34/1325	134/7206	0.0421422895579
ko04137	Mitophagy - animal	8/1325	82/7206	0.0439921081257
ko00330	Arginine and proline metabolism	5/1325	61/7206	0.044543767997
ko04930	Type II diabetes mellitus	16/1325	54/7206	0.0497857141527
ko00500	Starch and sucrose metabolism	2/1325	35/7206	0.0499765567649