ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	200/1225	423/7206	9.68775805734e-51
ko04724	Glutamatergic synapse	91/1225	152/7206	2.80741641596e-33
ko05033	Nicotine addiction	48/1225	56/7206	1.84610656951e-29
ko05032	Morphine addiction	68/1225	110/7206	2.89933215666e-26
ko04713	Circadian entrainment	77/1225	136/7206	4.67833070554e-26
ko04727	GABAergic synapse	66/1225	110/7206	1.85453549001e-24
ko04721	Synaptic vesicle cycle	51/1225	80/7206	7.53179172157e-21
ko04728	Dopaminergic synapse	85/1225	185/7206	1.50782928226e-20
ko04725	Cholinergic synapse	75/1225	160/7206	7.03793694015e-19
ko04020	Calcium signaling pathway	103/1225	265/7206	4.57969633942e-18
ko04723	Retrograde endocannabinoid signaling	78/1225	175/7206	5.67680728545e-18
ko04024	cAMP signaling pathway	106/1225	279/7206	1.4410794772e-17
ko04742	Taste transduction	39/1225	61/7206	2.69361758111e-16
ko04911	Insulin secretion	56/1225	117/7206	6.84723643035e-15
ko04921	Oxytocin signaling pathway	81/1225	209/7206	3.01563295167e-14
ko04726	Serotonergic synapse	59/1225	137/7206	4.41814950615e-13
ko04744	Phototransduction	25/1225	36/7206	4.11861536681e-12
ko04970	Salivary secretion	45/1225	95/7206	5.09713224156e-12
ko04261	Adrenergic signaling in cardiomyocytes	74/1225	205/7206	2.17833064897e-11
ko03040	Spliceosome	1/1225	145/7206	7.10929870572e-11
ko05031	Amphetamine addiction	42/1225	91/7206	7.52463988436e-11
ko04720	Long-term potentiation	44/1225	99/7206	1.24776811979e-10
ko04740	Olfactory transduction	37/1225	80/7206	9.51176248911e-10
ko04022	cGMP-PKG signaling pathway	73/1225	216/7206	1.0222384583e-09
ko05203	Viral carcinogenesis	16/1225	277/7206	1.92561482454e-08
ko04360	Axon guidance	74/1225	233/7206	2.15492648369e-08
ko04925	Aldosterone synthesis and secretion	41/1225	105/7206	5.52027791319e-08
ko04971	Gastric acid secretion	38/1225	98/7206	2.10213656115e-07
ko05168	Herpes simplex infection	8/1225	182/7206	2.24210013713e-07
ko05030	Cocaine addiction	31/1225	73/7206	2.4709546609e-07
ko04060	Cytokine-cytokine receptor interaction	9/1225	191/7206	2.59935179111e-07
ko03013	RNA transport	7/1225	166/7206	5.69599636472e-07
ko05164	Influenza A	7/1225	167/7206	5.80217897133e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1225	74/7206	1.27545055846e-06
ko05322	Systemic lupus erythematosus	6/1225	151/7206	1.50817412106e-06
ko04540	Gap junction	43/1225	128/7206	4.00146002459e-06
ko04924	Renin secretion	32/1225	86/7206	7.03883582417e-06
ko04621	NOD-like receptor signaling pathway	8/1225	157/7206	8.24095827055e-06
ko04120	Ubiquitin mediated proteolysis	6/1225	138/7206	9.35626496857e-06
ko04010	MAPK signaling pathway	85/1225	321/7206	1.26857382429e-05
ko04514	Cell adhesion molecules (CAMs)	42/1225	130/7206	1.57710791228e-05
ko05169	Epstein-Barr virus infection	14/1225	206/7206	1.89655356805e-05
ko04966	Collecting duct acid secretion	14/1225	26/7206	1.98252576497e-05
ko04972	Pancreatic secretion	37/1225	111/7206	3.04937092516e-05
ko04976	Bile secretion	29/1225	80/7206	3.07207221812e-05
ko05110	Vibrio cholerae infection	24/1225	63/7206	5.70323170934e-05
ko04260	Cardiac muscle contraction	33/1225	98/7206	5.76411000253e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1225	79/7206	6.20282017095e-05
ko04141	Protein processing in endoplasmic reticulum	13/1225	184/7206	9.27364855602e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1225	79/7206	0.000111156902781
ko05140	Leishmaniasis	2/1225	75/7206	0.00016196466991
ko04064	NF-kappa B signaling pathway	4/1225	96/7206	0.000182411373791
ko04730	Long-term depression	27/1225	78/7206	0.000184887056861
ko05414	Dilated cardiomyopathy	35/1225	112/7206	0.000186308102341
ko04070	Phosphatidylinositol signaling system	35/1225	112/7206	0.000186308102341
ko04750	Inflammatory mediator regulation of TRP channels	37/1225	122/7206	0.000226143300936
ko04745	Phototransduction - fly	16/1225	38/7206	0.000231347331612
ko05205	Proteoglycans in cancer	25/1225	271/7206	0.00026804611868
ko04371	Apelin signaling pathway	49/1225	177/7206	0.000342006364633
ko05161	Hepatitis B	13/1225	173/7206	0.000434550177511
ko04110	Cell cycle	10/1225	145/7206	0.000478763449848
ko05162	Measles	7/1225	120/7206	0.000499460894322
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1225	59/7206	0.000644144133846
ko04612	Antigen processing and presentation	3/1225	77/7206	0.000679752340389
ko04610	Complement and coagulation cascades	3/1225	79/7206	0.000713485160401
ko04630	Jak-STAT signaling pathway	9/1225	132/7206	0.000931759739327
ko04923	Regulation of lipolysis in adipocytes	25/1225	77/7206	0.00106982125651
ko04626	Plant-pathogen interaction	9/1225	18/7206	0.00128972564978
ko04072	Phospholipase D signaling pathway	51/1225	197/7206	0.00140621961132
ko04014	Ras signaling pathway	68/1225	279/7206	0.00144659971157
ko04915	Estrogen signaling pathway	36/1225	131/7206	0.00217271044629
ko04146	Peroxisome	5/1225	89/7206	0.00249839876955
ko03420	Nucleotide excision repair	1/1225	46/7206	0.00284833802519
ko05321	Inflammatory bowel disease (IBD)	2/1225	56/7206	0.00375460473273
ko03022	Basal transcription factors	1/1225	44/7206	0.00427038825767
ko05144	Malaria	1/1225	45/7206	0.00434417527943
ko00071	Fatty acid degradation	1/1225	45/7206	0.00434417527943
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1225	14/7206	0.00456850818037
ko05145	Toxoplasmosis	10/1225	126/7206	0.00548977035442
ko04964	Proximal tubule bicarbonate reclamation	11/1225	29/7206	0.00575943891826
ko00480	Glutathione metabolism	2/1225	55/7206	0.00577832526523
ko04330	Notch signaling pathway	3/1225	62/7206	0.00626391694121
ko04622	RIG-I-like receptor signaling pathway	3/1225	62/7206	0.00626391694121
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1225	100/7206	0.00669888569075
ko00310	Lysine degradation	4/1225	73/7206	0.00688272875823
ko00590	Arachidonic acid metabolism	2/1225	52/7206	0.00825144848584
ko00330	Arginine and proline metabolism	3/1225	61/7206	0.00914794895202
ko04657	IL-17 signaling pathway	6/1225	87/7206	0.00915074075261
ko05133	Pertussis	6/1225	87/7206	0.00915074075261
ko00562	Inositol phosphate metabolism	25/1225	89/7206	0.00971176106894
ko00240	Pyrimidine metabolism	9/1225	110/7206	0.0102535280982
ko05215	Prostate cancer	9/1225	111/7206	0.0103191136166
ko05219	Bladder cancer	2/1225	48/7206	0.0117919538913
ko04922	Glucagon signaling pathway	33/1225	128/7206	0.0120316517894
ko03018	RNA degradation	6/1225	84/7206	0.0124860743533
ko04918	Thyroid hormone synthesis	24/1225	86/7206	0.0130319928095
ko05166	HTLV-I infection	34/1225	292/7206	0.0134011619731
ko00630	Glyoxylate and dicarboxylate metabolism	1/1225	38/7206	0.0149263140066
ko04620	Toll-like receptor signaling pathway	8/1225	100/7206	0.0149984717107
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1225	182/7206	0.0160917431255
ko00290	Valine, leucine and isoleucine biosynthesis	3/1225	4/7206	0.017115812211
ko05131	Shigellosis	6/1225	82/7206	0.0171168231593
ko04916	Melanogenesis	35/1225	142/7206	0.0176403392345
ko04214	Apoptosis - fly	5/1225	72/7206	0.0178934084109
ko04930	Type II diabetes mellitus	16/1225	54/7206	0.0179026125496
ko04115	p53 signaling pathway	5/1225	74/7206	0.0183009012092
ko04640	Hematopoietic cell lineage	4/1225	64/7206	0.0183976324676
ko04658	Th1 and Th2 cell differentiation	8/1225	96/7206	0.0197631702548
ko04933	AGE-RAGE signaling pathway in diabetic complications	13/1225	135/7206	0.0202237499425
ko04210	Apoptosis	19/1225	180/7206	0.0203010598563
ko05222	Small cell lung cancer	7/1225	89/7206	0.0219061647149
ko04270	Vascular smooth muscle contraction	37/1225	154/7206	0.0226155283303
ko04510	Focal adhesion	28/1225	240/7206	0.0231016164816
ko00280	Valine, leucine and isoleucine degradation	3/1225	54/7206	0.0268450447885
ko04912	GnRH signaling pathway	30/1225	122/7206	0.0285637030182
ko01524	Platinum drug resistance	6/1225	76/7206	0.0312244484609
ko05418	Fluid shear stress and atherosclerosis	19/1225	173/7206	0.0313580052273
ko03320	PPAR signaling pathway	5/1225	69/7206	0.0344307864973
ko04140	Autophagy - animal	18/1225	164/7206	0.0355757733734
ko00380	Tryptophan metabolism	3/1225	50/7206	0.0365788467972
ko04668	TNF signaling pathway	12/1225	120/7206	0.0373061791356
ko04137	Mitophagy - animal	7/1225	82/7206	0.0382843646619
ko04710	Circadian rhythm	13/1225	43/7206	0.0382851469848
ko04114	Oocyte meiosis	33/1225	139/7206	0.0395103184956
ko04015	Rap1 signaling pathway	60/1225	278/7206	0.0416980049621
ko04217	Necroptosis	20/1225	178/7206	0.0426047444141
ko05320	Autoimmune thyroid disease	1/1225	29/7206	0.0483656276912
ko05340	Primary immunodeficiency	1/1225	30/7206	0.0486581755667
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1225	92/7206	0.0493662714913