ko pathway ratio_in_study ratio_in_pop p_value ko04976 Bile secretion 21/315 80/7206 1.41833583418e-11 ko04610 Complement and coagulation cascades 18/315 79/7206 5.09356058899e-09 ko04974 Protein digestion and absorption 19/315 96/7206 2.2656563869e-08 ko05204 Chemical carcinogenesis 12/315 48/7206 6.66383650367e-07 ko00643 Styrene degradation 4/315 4/7206 3.5852857218e-06 ko00980 Metabolism of xenobiotics by cytochrome P450 10/315 40/7206 5.81024676355e-06 ko00380 Tryptophan metabolism 11/315 50/7206 7.56795670338e-06 ko00350 Tyrosine metabolism 9/315 33/7206 7.91734530691e-06 ko00983 Drug metabolism - other enzymes 10/315 42/7206 9.32911503829e-06 ko04975 Fat digestion and absorption 9/315 35/7206 1.3414806741e-05 ko00140 Steroid hormone biosynthesis 9/315 41/7206 5.27821969803e-05 ko04614 Renin-angiotensin system 6/315 18/7206 7.90510577537e-05 ko04972 Pancreatic secretion 15/315 111/7206 8.77196116892e-05 ko00982 Drug metabolism - cytochrome P450 8/315 37/7206 0.000155022135236 ko00260 Glycine, serine and threonine metabolism 9/315 48/7206 0.000192891205144 ko04977 Vitamin digestion and absorption 6/315 22/7206 0.000273893582396 ko04978 Mineral absorption 8/315 40/7206 0.000275398546309 ko00830 Retinol metabolism 8/315 42/7206 0.000391656289355 ko01200 Carbon metabolism 15/315 128/7206 0.000435246397668 ko04360 Axon guidance 1/315 233/7206 0.000502605973281 ko00360 Phenylalanine metabolism 5/315 17/7206 0.000619472012594 ko00040 Pentose and glucuronate interconversions 6/315 26/7206 0.000728894971142 ko00232 Caffeine metabolism 3/315 5/7206 0.00077486800981 ko02010 ABC transporters 7/315 39/7206 0.00131128735104 ko00120 Primary bile acid biosynthesis 5/315 20/7206 0.00139297729262 ko00100 Steroid biosynthesis 5/315 21/7206 0.00176368344557 ko00591 Linoleic acid metabolism 5/315 22/7206 0.00220185693475 ko00053 Ascorbate and aldarate metabolism 5/315 22/7206 0.00220185693475 ko00480 Glutathione metabolism 8/315 55/7206 0.00246675317558 ko05200 Pathways in cancer 9/315 492/7206 0.0027259398904 ko04080 Neuroactive ligand-receptor interaction 7/315 423/7206 0.00295847293533 ko04151 PI3K-Akt signaling pathway 6/315 390/7206 0.00303698866082 ko05034 Alcoholism 2/315 238/7206 0.00313278895155 ko00620 Pyruvate metabolism 7/315 46/7206 0.00351290142561 ko01230 Biosynthesis of amino acids 10/315 85/7206 0.00375416902901 ko00340 Histidine metabolism 5/315 25/7206 0.0039893499858 ko05150 Staphylococcus aureus infection 6/315 36/7206 0.00426900949513 ko00720 Carbon fixation pathways in prokaryotes 4/315 17/7206 0.00542417921557 ko04723 Retrograde endocannabinoid signaling 1/315 175/7206 0.00737007762386 ko04010 MAPK signaling pathway 5/315 321/7206 0.00751665832292 ko05166 HTLV-I infection 4/315 292/7206 0.00766143508304 ko04740 Olfactory transduction 9/315 80/7206 0.00784547888291 ko04973 Carbohydrate digestion and absorption 6/315 42/7206 0.00923523547029 ko03320 PPAR signaling pathway 8/315 69/7206 0.00999870587974 ko04014 Ras signaling pathway 4/315 279/7206 0.0102879872694 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 3/315 11/7206 0.0105076671685 ko04550 Signaling pathways regulating pluripotency of stem cells 1/315 165/7206 0.0105788370498 ko03013 RNA transport 1/315 166/7206 0.0106984902321 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/315 4/7206 0.0107790280326 ko05133 Pertussis 9/315 87/7206 0.0133119661962 ko04144 Endocytosis 6/315 342/7206 0.0137006297122 ko04724 Glutamatergic synapse 1/315 152/7206 0.0149399001822 ko05134 Legionellosis 8/315 74/7206 0.0149463177259 ko00680 Methane metabolism 5/315 34/7206 0.01516583771 ko04920 Adipocytokine signaling pathway 9/315 89/7206 0.0152963811516 ko00500 Starch and sucrose metabolism 5/315 35/7206 0.017078436964 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/315 5/7206 0.0174484680478 ko03040 Spliceosome 1/315 145/7206 0.0217942744554 ko00630 Glyoxylate and dicarboxylate metabolism 5/315 38/7206 0.0237538060507 ko00590 Arachidonic acid metabolism 6/315 52/7206 0.0249477085024 ko00362 Benzoate degradation 2/315 6/7206 0.0254228991727 ko04141 Protein processing in endoplasmic reticulum 2/315 184/7206 0.0257620233319 ko04922 Glucagon signaling pathway 11/315 128/7206 0.0270967384839 ko00230 Purine metabolism 15/315 194/7206 0.0302768587943 ko00520 Amino sugar and nucleotide sugar metabolism 6/315 55/7206 0.0318886808402 ko05224 Breast cancer 2/315 174/7206 0.0358767377384 ko04964 Proximal tubule bicarbonate reclamation 4/315 29/7206 0.0359214722911 ko00010 Glycolysis / Gluconeogenesis 7/315 74/7206 0.042065242446 ko05160 Hepatitis C 12/315 153/7206 0.0434138428474 ko00401 Novobiocin biosynthesis 1/315 1/7206 0.0437135720234