ko pathway ratio_in_study ratio_in_pop p_value ko04621 NOD-like receptor signaling pathway 27/135 157/7206 3.64377538516e-19 ko05164 Influenza A 22/135 167/7206 3.05375915437e-13 ko04380 Osteoclast differentiation 20/135 134/7206 3.66975120994e-13 ko04217 Necroptosis 22/135 178/7206 1.15160018873e-12 ko04064 NF-kappa B signaling pathway 17/135 96/7206 1.38833089929e-12 ko04620 Toll-like receptor signaling pathway 17/135 100/7206 2.78190818858e-12 ko05167 Kaposi's sarcoma-associated herpesvirus infection 22/135 191/7206 4.89114111329e-12 ko05162 Measles 18/135 120/7206 5.57777242751e-12 ko05161 Hepatitis B 21/135 173/7206 5.6456741209e-12 ko04060 Cytokine-cytokine receptor interaction 21/135 191/7206 3.86384606346e-11 ko04668 TNF signaling pathway 17/135 120/7206 5.79922968446e-11 ko04630 Jak-STAT signaling pathway 17/135 132/7206 2.71654681798e-10 ko05160 Hepatitis C 18/135 153/7206 3.56128846106e-10 ko05168 Herpes simplex infection 19/135 182/7206 8.81195918505e-10 ko05145 Toxoplasmosis 16/135 126/7206 1.17042907929e-09 ko04623 Cytosolic DNA-sensing pathway 10/135 41/7206 2.60734943153e-09 ko04622 RIG-I-like receptor signaling pathway 11/135 62/7206 1.49257314261e-08 ko04210 Apoptosis 17/135 180/7206 3.33751318851e-08 ko05321 Inflammatory bowel disease (IBD) 10/135 56/7206 6.52305284262e-08 ko05152 Tuberculosis 16/135 187/7206 3.44280017643e-07 ko05140 Leishmaniasis 10/135 75/7206 1.1225635836e-06 ko04659 Th17 cell differentiation 11/135 106/7206 4.05024260462e-06 ko04657 IL-17 signaling pathway 10/135 87/7206 4.47710349922e-06 ko05142 Chagas disease (American trypanosomiasis) 12/135 130/7206 5.01564124777e-06 ko04658 Th1 and Th2 cell differentiation 10/135 96/7206 1.09410417736e-05 ko05320 Autoimmune thyroid disease 6/135 29/7206 1.28914868615e-05 ko04660 T cell receptor signaling pathway 11/135 124/7206 1.84986476356e-05 ko05133 Pertussis 9/135 87/7206 3.24081207435e-05 ko04933 AGE-RAGE signaling pathway in diabetic complications 11/135 135/7206 4.10892068267e-05 ko04672 Intestinal immune network for IgA production 6/135 37/7206 5.57849850665e-05 ko05134 Legionellosis 8/135 74/7206 6.56711014826e-05 ko05330 Allograft rejection 5/135 24/7206 6.83888687574e-05 ko05169 Epstein-Barr virus infection 13/135 206/7206 0.000118326884935 ko04917 Prolactin signaling pathway 8/135 87/7206 0.000207619366863 ko04662 B cell receptor signaling pathway 8/135 88/7206 0.000224827921896 ko05166 HTLV-I infection 15/135 292/7206 0.000346225678522 ko04062 Chemokine signaling pathway 12/135 201/7206 0.000364546659065 ko04650 Natural killer cell mediated cytotoxicity 8/135 97/7206 0.000439007665476 ko05132 Salmonella infection 8/135 98/7206 0.000470602885394 ko05203 Viral carcinogenesis 14/135 277/7206 0.000646470275071 ko05144 Malaria 5/135 45/7206 0.00143440565767 ko04010 MAPK signaling pathway 14/135 321/7206 0.00264228081189 ko05332 Graft-versus-host disease 3/135 18/7206 0.00427022582149 ko05323 Rheumatoid arthritis 6/135 89/7206 0.00630446165207 ko05120 Epithelial cell signaling in Helicobacter pylori infection 6/135 92/7206 0.00739254108824 ko05202 Transcriptional misregulation in cancer 9/135 188/7206 0.00858345583044 ko05200 Pathways in cancer 17/135 492/7206 0.0141156223716 ko04931 Insulin resistance 7/135 137/7206 0.0142022385087 ko05215 Prostate cancer 6/135 111/7206 0.0176232979961 ko05340 Primary immunodeficiency 3/135 30/7206 0.0180480360919 ko05131 Shigellosis 5/135 82/7206 0.0185037214343 ko05212 Pancreatic cancer 5/135 83/7206 0.0194023571513 ko04320 Dorso-ventral axis formation 3/135 31/7206 0.0197135136823 ko04940 Type I diabetes mellitus 3/135 32/7206 0.0214610985376 ko05143 African trypanosomiasis 3/135 32/7206 0.0214610985376 ko04920 Adipocytokine signaling pathway 5/135 89/7206 0.0253983123922 ko05222 Small cell lung cancer 5/135 89/7206 0.0253983123922 ko04066 HIF-1 signaling pathway 6/135 123/7206 0.0276240250883 ko04722 Neurotrophin signaling pathway 7/135 160/7206 0.030319853272 ko04611 Platelet activation 7/135 163/7206 0.0330742469185 ko04068 FoxO signaling pathway 7/135 167/7206 0.0370008527074 ko05146 Amoebiasis 5/135 99/7206 0.0378091208395 ko05310 Asthma 2/135 17/7206 0.0394284632303 ko04024 cAMP signaling pathway 10/135 279/7206 0.0407822434157 ko05418 Fluid shear stress and atherosclerosis 7/135 173/7206 0.0434499383007 ko04218 Cellular senescence 7/135 177/7206 0.0481312265976 ko04115 p53 signaling pathway 4/135 74/7206 0.0495827733176