ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	204/1284	423/7206	5.35753915176e-50
ko04724	Glutamatergic synapse	90/1284	152/7206	9.48329552568e-31
ko05033	Nicotine addiction	47/1284	56/7206	4.37418274319e-27
ko05032	Morphine addiction	70/1284	110/7206	7.76254120231e-27
ko04713	Circadian entrainment	78/1284	136/7206	1.70615607808e-25
ko04727	GABAergic synapse	66/1284	110/7206	2.92765842117e-23
ko04721	Synaptic vesicle cycle	52/1284	80/7206	7.62282233435e-21
ko04725	Cholinergic synapse	78/1284	160/7206	1.30806173521e-19
ko04728	Dopaminergic synapse	84/1284	185/7206	1.4569958849e-18
ko04024	cAMP signaling pathway	110/1284	279/7206	3.72445843534e-18
ko04020	Calcium signaling pathway	105/1284	265/7206	1.86143292301e-17
ko04723	Retrograde endocannabinoid signaling	79/1284	175/7206	2.44159327804e-17
ko04911	Insulin secretion	56/1284	117/7206	5.60302540537e-14
ko04921	Oxytocin signaling pathway	82/1284	209/7206	1.24468051301e-13
ko04742	Taste transduction	35/1284	61/7206	4.02829174438e-12
ko04726	Serotonergic synapse	59/1284	137/7206	5.13791213216e-12
ko04744	Phototransduction	24/1284	36/7206	1.20550518405e-10
ko03010	Ribosome	1/1284	129/7206	3.43787224518e-10
ko05031	Amphetamine addiction	42/1284	91/7206	3.5039553262e-10
ko04970	Salivary secretion	42/1284	95/7206	1.81422579702e-09
ko04261	Adrenergic signaling in cardiomyocytes	72/1284	205/7206	2.32846728479e-09
ko03040	Spliceosome	3/1284	145/7206	3.84497939414e-09
ko05322	Systemic lupus erythematosus	4/1284	151/7206	9.25513329367e-09
ko04022	cGMP-PKG signaling pathway	73/1284	216/7206	1.11962443534e-08
ko04720	Long-term potentiation	42/1284	99/7206	1.13874688344e-08
ko04925	Aldosterone synthesis and secretion	42/1284	105/7206	8.71907852852e-08
ko04070	Phosphatidylinositol signaling system	43/1284	112/7206	2.57306562728e-07
ko04971	Gastric acid secretion	38/1284	98/7206	7.79678744276e-07
ko04966	Collecting duct acid secretion	16/1284	26/7206	8.31266281116e-07
ko05203	Viral carcinogenesis	21/1284	277/7206	8.47798487463e-07
ko03013	RNA transport	8/1284	166/7206	8.86415057729e-07
ko05030	Cocaine addiction	30/1284	73/7206	3.06440314529e-06
ko05168	Herpes simplex infection	12/1284	182/7206	1.27793797882e-05
ko04072	Phospholipase D signaling pathway	59/1284	197/7206	2.6372939189e-05
ko04972	Pancreatic secretion	38/1284	111/7206	2.67091378706e-05
ko04141	Protein processing in endoplasmic reticulum	13/1284	184/7206	3.38936735552e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1284	74/7206	4.1837640998e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1284	79/7206	4.46876629766e-05
ko04010	MAPK signaling pathway	86/1284	321/7206	4.9912210054e-05
ko04110	Cell cycle	9/1284	145/7206	6.39640720276e-05
ko04745	Phototransduction - fly	17/1284	38/7206	0.000108618491627
ko04060	Cytokine-cytokine receptor interaction	15/1284	191/7206	0.000108895871182
ko04514	Cell adhesion molecules (CAMs)	41/1284	130/7206	0.000114509668542
ko04014	Ras signaling pathway	75/1284	279/7206	0.000118701549091
ko04730	Long-term depression	28/1284	78/7206	0.000134736484498
ko04924	Renin secretion	30/1284	86/7206	0.000160006763133
ko04750	Inflammatory mediator regulation of TRP channels	39/1284	122/7206	0.000171003692117
ko04740	Olfactory transduction	28/1284	80/7206	0.000191032816028
ko04710	Circadian rhythm	18/1284	43/7206	0.00019432642242
ko04360	Axon guidance	64/1284	233/7206	0.000230471481981
ko04923	Regulation of lipolysis in adipocytes	27/1284	77/7206	0.000250029183571
ko04371	Apelin signaling pathway	51/1284	177/7206	0.000299453757197
ko04621	NOD-like receptor signaling pathway	12/1284	157/7206	0.000309796232871
ko04915	Estrogen signaling pathway	40/1284	131/7206	0.000311984884159
ko05110	Vibrio cholerae infection	23/1284	63/7206	0.00037086776219
ko04540	Gap junction	39/1284	128/7206	0.000409092873487
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1284	59/7206	0.00041941729266
ko04612	Antigen processing and presentation	3/1284	77/7206	0.000443745560783
ko00520	Amino sugar and nucleotide sugar metabolism	1/1284	55/7206	0.000531986984621
ko04976	Bile secretion	27/1284	80/7206	0.000570308990457
ko05164	Influenza A	14/1284	167/7206	0.000676198904123
ko04964	Proximal tubule bicarbonate reclamation	13/1284	29/7206	0.000685549553835
ko05161	Hepatitis B	15/1284	173/7206	0.000836594882085
ko04270	Vascular smooth muscle contraction	44/1284	154/7206	0.000879835371453
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1284	79/7206	0.00100373847039
ko05414	Dilated cardiomyopathy	34/1284	112/7206	0.00106957597466
ko04120	Ubiquitin mediated proteolysis	11/1284	138/7206	0.0014999095542
ko04930	Type II diabetes mellitus	19/1284	54/7206	0.00199318575262
ko04922	Glucagon signaling pathway	37/1284	128/7206	0.0022025814062
ko03022	Basal transcription factors	1/1284	44/7206	0.00271868436522
ko03420	Nucleotide excision repair	1/1284	46/7206	0.00286560252113
ko05169	Epstein-Barr virus infection	21/1284	206/7206	0.00296506095696
ko05131	Shigellosis	5/1284	82/7206	0.00331557685817
ko04622	RIG-I-like receptor signaling pathway	3/1284	62/7206	0.00417299411695
ko05205	Proteoglycans in cancer	31/1284	271/7206	0.0044851104724
ko04064	NF-kappa B signaling pathway	7/1284	96/7206	0.00450191674766
ko05133	Pertussis	6/1284	87/7206	0.00461896854244
ko04260	Cardiac muscle contraction	29/1284	98/7206	0.00473850232244
ko04973	Carbohydrate digestion and absorption	15/1284	42/7206	0.00689181292999
ko00562	Inositol phosphate metabolism	26/1284	89/7206	0.00758411412288
ko04626	Plant-pathogen interaction	8/1284	18/7206	0.00802300728968
ko04115	p53 signaling pathway	5/1284	74/7206	0.00902796815376
ko05140	Leishmaniasis	5/1284	75/7206	0.00913135581843
ko03410	Base excision repair	1/1284	38/7206	0.00938806086886
ko04146	Peroxisome	7/1284	89/7206	0.0114835946965
ko05166	HTLV-I infection	36/1284	292/7206	0.0122470569406
ko04214	Apoptosis - fly	5/1284	72/7206	0.012566620447
ko04962	Vasopressin-regulated water reabsorption	18/1284	58/7206	0.0143928726637
ko04657	IL-17 signaling pathway	7/1284	87/7206	0.0156640156295
ko05231	Choline metabolism in cancer	35/1284	134/7206	0.0161089452338
ko00240	Pyrimidine metabolism	10/1284	110/7206	0.0162456305127
ko04510	Focal adhesion	29/1284	240/7206	0.0162669936959
ko05144	Malaria	2/1284	45/7206	0.0170664840885
ko04711	Circadian rhythm - fly	6/1284	13/7206	0.0173812657484
ko00280	Valine, leucine and isoleucine degradation	3/1284	54/7206	0.018446952437
ko03018	RNA degradation	7/1284	84/7206	0.0209442598614
ko00860	Porphyrin and chlorophyll metabolism	1/1284	34/7206	0.021768272172
ko04217	Necroptosis	20/1284	178/7206	0.0219752832908
ko05162	Measles	12/1284	120/7206	0.0219798253626
ko04213	Longevity regulating pathway - multiple species	24/1284	86/7206	0.0220719744389
ko04912	GnRH signaling pathway	32/1284	122/7206	0.0225121209141
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1284	100/7206	0.0241728767514
ko05217	Basal cell carcinoma	5/1284	68/7206	0.0243235827589
ko05145	Toxoplasmosis	13/1284	126/7206	0.0252484852785
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1284	14/7206	0.025919127136
ko04630	Jak-STAT signaling pathway	14/1284	132/7206	0.0286712297403
ko04658	Th1 and Th2 cell differentiation	9/1284	96/7206	0.0307242376381
ko05340	Primary immunodeficiency	1/1284	30/7206	0.0316609557384
ko05219	Bladder cancer	3/1284	48/7206	0.0358115866087
ko05206	MicroRNAs in cancer	21/1284	177/7206	0.0364467316804
ko04960	Aldosterone-regulated sodium reabsorption	13/1284	41/7206	0.0373029864
ko04932	Non-alcoholic fatty liver disease (NAFLD)	22/1284	182/7206	0.0394290938412
ko04113	Meiosis - yeast	6/1284	70/7206	0.0410289659538
ko04330	Notch signaling pathway	5/1284	62/7206	0.0446675718234
ko00480	Glutathione metabolism	4/1284	55/7206	0.0491931865537
ko05416	Viral myocarditis	4/1284	55/7206	0.0491931865537