ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	195/1193	423/7206	3.4394019766e-49
ko04724	Glutamatergic synapse	89/1193	152/7206	1.94964829188e-32
ko05032	Morphine addiction	70/1193	110/7206	7.10096179286e-29
ko05033	Nicotine addiction	47/1193	56/7206	1.47891572878e-28
ko04713	Circadian entrainment	77/1193	136/7206	7.7772668259e-27
ko04727	GABAergic synapse	66/1193	110/7206	3.87814659414e-25
ko04725	Cholinergic synapse	79/1193	160/7206	2.34269535409e-22
ko04728	Dopaminergic synapse	85/1193	185/7206	2.48400507412e-21
ko04723	Retrograde endocannabinoid signaling	79/1193	175/7206	2.57673225127e-19
ko04721	Synaptic vesicle cycle	48/1193	80/7206	1.35326852591e-18
ko04024	cAMP signaling pathway	105/1193	279/7206	5.5627342866e-18
ko04020	Calcium signaling pathway	101/1193	265/7206	7.71464895551e-18
ko04921	Oxytocin signaling pathway	81/1193	209/7206	5.91686346331e-15
ko04742	Taste transduction	37/1193	61/7206	7.76573370474e-15
ko04911	Insulin secretion	55/1193	117/7206	9.84580342687e-15
ko04726	Serotonergic synapse	60/1193	137/7206	3.29792469619e-14
ko04261	Adrenergic signaling in cardiomyocytes	76/1193	205/7206	5.8668371869e-13
ko04744	Phototransduction	25/1193	36/7206	2.23217215674e-12
ko04360	Axon guidance	78/1193	233/7206	1.29313280639e-10
ko04970	Salivary secretion	42/1193	95/7206	1.71768278818e-10
ko03040	Spliceosome	1/1193	145/7206	1.99199284331e-10
ko05031	Amphetamine addiction	40/1193	91/7206	5.80495862713e-10
ko04720	Long-term potentiation	42/1193	99/7206	8.26770197515e-10
ko05203	Viral carcinogenesis	15/1193	277/7206	2.0245829823e-08
ko04925	Aldosterone synthesis and secretion	41/1193	105/7206	2.90011865432e-08
ko04022	cGMP-PKG signaling pathway	68/1193	216/7206	3.90152317643e-08
ko04971	Gastric acid secretion	37/1193	98/7206	3.37426873815e-07
ko05322	Systemic lupus erythematosus	5/1193	151/7206	3.84820208862e-07
ko04070	Phosphatidylinositol signaling system	40/1193	112/7206	9.64000263436e-07
ko03013	RNA transport	7/1193	166/7206	1.27373536488e-06
ko05030	Cocaine addiction	29/1193	73/7206	1.79579980345e-06
ko04740	Olfactory transduction	31/1193	80/7206	1.97407933618e-06
ko05168	Herpes simplex infection	9/1193	182/7206	2.34423819155e-06
ko04060	Cytokine-cytokine receptor interaction	10/1193	191/7206	2.53224753708e-06
ko04621	NOD-like receptor signaling pathway	7/1193	157/7206	3.77108603283e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1193	74/7206	3.90822123724e-06
ko05164	Influenza A	8/1193	167/7206	4.2587320021e-06
ko04010	MAPK signaling pathway	85/1193	321/7206	4.80209088719e-06
ko04514	Cell adhesion molecules (CAMs)	42/1193	130/7206	7.39592778785e-06
ko04072	Phospholipase D signaling pathway	57/1193	197/7206	9.79602693265e-06
ko04972	Pancreatic secretion	37/1193	111/7206	1.3390214645e-05
ko04141	Protein processing in endoplasmic reticulum	11/1193	184/7206	1.98983124668e-05
ko04924	Renin secretion	30/1193	86/7206	2.84847842244e-05
ko04540	Gap junction	40/1193	128/7206	3.29224273968e-05
ko04730	Long-term depression	28/1193	78/7206	3.73076001432e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1193	79/7206	4.3530796004e-05
ko04923	Regulation of lipolysis in adipocytes	27/1193	77/7206	7.14259198951e-05
ko05414	Dilated cardiomyopathy	35/1193	112/7206	9.6291918471e-05
ko04612	Antigen processing and presentation	2/1193	77/7206	0.00016787241961
ko04745	Phototransduction - fly	16/1193	38/7206	0.000168176990062
ko04610	Complement and coagulation cascades	2/1193	79/7206	0.00017618485123
ko03008	Ribosome biogenesis in eukaryotes	2/1193	79/7206	0.00017618485123
ko04750	Inflammatory mediator regulation of TRP channels	37/1193	122/7206	0.000177885421689
ko04014	Ras signaling pathway	70/1193	279/7206	0.000201294247577
ko04110	Cell cycle	9/1193	145/7206	0.000264815138687
ko05169	Epstein-Barr virus infection	16/1193	206/7206	0.00027131578491
ko04371	Apelin signaling pathway	48/1193	177/7206	0.000305921223409
ko04260	Cardiac muscle contraction	30/1193	98/7206	0.000505178658904
ko05205	Proteoglycans in cancer	25/1193	271/7206	0.000594033518927
ko04120	Ubiquitin mediated proteolysis	9/1193	138/7206	0.000698108969097
ko04915	Estrogen signaling pathway	37/1193	131/7206	0.000768692996937
ko04064	NF-kappa B signaling pathway	5/1193	96/7206	0.00127385562871
ko05140	Leishmaniasis	3/1193	75/7206	0.00149164375185
ko04966	Collecting duct acid secretion	11/1193	26/7206	0.00168444256091
ko04976	Bile secretion	24/1193	80/7206	0.00228936054529
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1193	59/7206	0.00252725740227
ko00240	Pyrimidine metabolism	7/1193	110/7206	0.00261849820289
ko00330	Arginine and proline metabolism	2/1193	61/7206	0.0026792741067
ko04657	IL-17 signaling pathway	5/1193	87/7206	0.0035296294253
ko05161	Hepatitis B	15/1193	173/7206	0.00354852950929
ko04146	Peroxisome	5/1193	89/7206	0.00361639605353
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1193	14/7206	0.00391447996889
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1193	100/7206	0.00397701656202
ko05144	Malaria	1/1193	45/7206	0.0043715967338
ko00071	Fatty acid degradation	1/1193	45/7206	0.0043715967338
ko03420	Nucleotide excision repair	1/1193	46/7206	0.00441629863002
ko04626	Plant-pathogen interaction	8/1193	18/7206	0.00506143950048
ko00480	Glutathione metabolism	2/1193	55/7206	0.00563472566574
ko05321	Inflammatory bowel disease (IBD)	2/1193	56/7206	0.0057779848668
ko00562	Inositol phosphate metabolism	25/1193	89/7206	0.00584270037688
ko05162	Measles	9/1193	120/7206	0.00596272713866
ko05110	Vibrio cholerae infection	19/1193	63/7206	0.00607592073861
ko04640	Hematopoietic cell lineage	3/1193	64/7206	0.00638826561381
ko03022	Basal transcription factors	1/1193	44/7206	0.00676254421858
ko00310	Lysine degradation	4/1193	73/7206	0.00676683270456
ko04115	p53 signaling pathway	4/1193	74/7206	0.00682757394602
ko05131	Shigellosis	5/1193	82/7206	0.00686665949042
ko00590	Arachidonic acid metabolism	2/1193	52/7206	0.00822677973464
ko04622	RIG-I-like receptor signaling pathway	3/1193	62/7206	0.00919081884619
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1193	40/7206	0.00985322839851
ko04217	Necroptosis	17/1193	178/7206	0.0102868818544
ko04015	Rap1 signaling pathway	62/1193	278/7206	0.0106292481014
ko04710	Circadian rhythm	14/1193	43/7206	0.0112682214457
ko00380	Tryptophan metabolism	2/1193	50/7206	0.0120222032155
ko04658	Th1 and Th2 cell differentiation	7/1193	96/7206	0.0121221316321
ko03410	Base excision repair	1/1193	38/7206	0.0147649462839
ko04930	Type II diabetes mellitus	16/1193	54/7206	0.0154495508576
ko04270	Vascular smooth muscle contraction	37/1193	154/7206	0.0155202346403
ko03018	RNA degradation	6/1193	84/7206	0.0173565148283
ko04722	Neurotrophin signaling pathway	38/1193	160/7206	0.0175295313915
ko00260	Glycine, serine and threonine metabolism	2/1193	48/7206	0.0176621322999
ko05231	Choline metabolism in cancer	33/1193	134/7206	0.0181778977797
ko04918	Thyroid hormone synthesis	23/1193	86/7206	0.0182617716858
ko04912	GnRH signaling pathway	30/1193	122/7206	0.019528049777
ko04973	Carbohydrate digestion and absorption	13/1193	42/7206	0.0197052613813
ko04964	Proximal tubule bicarbonate reclamation	10/1193	29/7206	0.0197211766263
ko00500	Starch and sucrose metabolism	1/1193	35/7206	0.0220443069166
ko00982	Drug metabolism - cytochrome P450	1/1193	37/7206	0.023272630064
ko04214	Apoptosis - fly	5/1193	72/7206	0.0249309903642
ko00280	Valine, leucine and isoleucine degradation	3/1193	54/7206	0.0263043829043
ko04062	Chemokine signaling pathway	45/1193	201/7206	0.0269148987825
ko05215	Prostate cancer	10/1193	111/7206	0.0285242894575
ko05133	Pertussis	7/1193	87/7206	0.029138444773
ko05166	HTLV-I infection	35/1193	292/7206	0.030079357307
ko04630	Jak-STAT signaling pathway	13/1193	132/7206	0.0335441335471
ko03320	PPAR signaling pathway	5/1193	69/7206	0.0340017829788
ko04113	Meiosis - yeast	5/1193	70/7206	0.0342639108071
ko00983	Drug metabolism - other enzymes	2/1193	42/7206	0.0364523852497
ko04916	Melanogenesis	33/1193	142/7206	0.0392310165538
ko00230	Purine metabolism	43/1193	194/7206	0.0392854694442
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1193	182/7206	0.0428607935681
ko04142	Lysosome	16/1193	151/7206	0.0462851057889
ko05340	Primary immunodeficiency	1/1193	30/7206	0.0488799969946
ko04114	Oocyte meiosis	32/1193	139/7206	0.0491045297878
ko04711	Circadian rhythm - fly	5/1193	13/7206	0.0497240941261