ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	196/1195	423/7206	9.12570586098e-50
ko04724	Glutamatergic synapse	88/1195	152/7206	1.67288234132e-31
ko05033	Nicotine addiction	48/1195	56/7206	5.70208236501e-30
ko05032	Morphine addiction	68/1195	110/7206	6.29215206654e-27
ko04713	Circadian entrainment	76/1195	136/7206	5.97985094851e-26
ko04727	GABAergic synapse	63/1195	110/7206	1.80489606526e-22
ko04721	Synaptic vesicle cycle	52/1195	80/7206	2.52791426886e-22
ko04728	Dopaminergic synapse	86/1195	185/7206	6.04474828444e-22
ko04725	Cholinergic synapse	76/1195	160/7206	3.29960491835e-20
ko04024	cAMP signaling pathway	107/1195	279/7206	5.00253104229e-19
ko04020	Calcium signaling pathway	102/1195	265/7206	3.1016049161e-18
ko04723	Retrograde endocannabinoid signaling	77/1195	175/7206	5.27277598225e-18
ko04742	Taste transduction	38/1195	61/7206	9.93217883386e-16
ko04921	Oxytocin signaling pathway	82/1195	209/7206	2.45602220442e-15
ko04911	Insulin secretion	55/1195	117/7206	1.06030410106e-14
ko04261	Adrenergic signaling in cardiomyocytes	77/1195	205/7206	2.25772012154e-13
ko04726	Serotonergic synapse	58/1195	137/7206	5.69402957256e-13
ko04744	Phototransduction	24/1195	36/7206	2.50704581153e-11
ko05031	Amphetamine addiction	42/1195	91/7206	3.30787716211e-11
ko04970	Salivary secretion	43/1195	95/7206	4.27134133179e-11
ko04720	Long-term potentiation	44/1195	99/7206	5.36627398578e-11
ko04360	Axon guidance	78/1195	233/7206	1.36439679401e-10
ko03040	Spliceosome	1/1195	145/7206	2.02520361289e-10
ko04022	cGMP-PKG signaling pathway	71/1195	216/7206	2.29235626027e-09
ko05203	Viral carcinogenesis	15/1195	277/7206	1.38991840388e-08
ko04925	Aldosterone synthesis and secretion	40/1195	105/7206	8.86132699398e-08
ko05168	Herpes simplex infection	7/1195	182/7206	1.43368530415e-07
ko04971	Gastric acid secretion	37/1195	98/7206	3.5107107377e-07
ko04740	Olfactory transduction	32/1195	80/7206	4.5663325322e-07
ko05030	Cocaine addiction	30/1195	73/7206	5.22106927298e-07
ko04060	Cytokine-cytokine receptor interaction	9/1195	191/7206	5.6152460767e-07
ko04010	MAPK signaling pathway	88/1195	321/7206	6.86047063842e-07
ko03013	RNA transport	7/1195	166/7206	1.27936826279e-06
ko05322	Systemic lupus erythematosus	6/1195	151/7206	2.21040967305e-06
ko04924	Renin secretion	32/1195	86/7206	3.14815123055e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1195	74/7206	3.9622220217e-06
ko04966	Collecting duct acid secretion	14/1195	26/7206	1.47707064611e-05
ko05164	Influenza A	9/1195	167/7206	1.9065256583e-05
ko04141	Protein processing in endoplasmic reticulum	11/1195	184/7206	1.98692807161e-05
ko04610	Complement and coagulation cascades	1/1195	79/7206	2.10941402732e-05
ko04540	Gap junction	40/1195	128/7206	3.37018337382e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1195	79/7206	4.43823479074e-05
ko04070	Phosphatidylinositol signaling system	36/1195	112/7206	4.96480237573e-05
ko04120	Ubiquitin mediated proteolysis	7/1195	138/7206	6.55399388918e-05
ko04730	Long-term depression	27/1195	78/7206	8.82447331578e-05
ko05414	Dilated cardiomyopathy	35/1195	112/7206	9.86538510214e-05
ko05110	Vibrio cholerae infection	23/1195	63/7206	0.000112888029454
ko04514	Cell adhesion molecules (CAMs)	39/1195	130/7206	0.000114909146657
ko04745	Phototransduction - fly	16/1195	38/7206	0.000171622361404
ko03008	Ribosome biogenesis in eukaryotes	2/1195	79/7206	0.000177262650493
ko04260	Cardiac muscle contraction	31/1195	98/7206	0.000186383062635
ko04621	NOD-like receptor signaling pathway	10/1195	157/7206	0.000192056868245
ko04371	Apelin signaling pathway	49/1195	177/7206	0.000194930269334
ko04014	Ras signaling pathway	70/1195	279/7206	0.000205511925811
ko04972	Pancreatic secretion	34/1195	111/7206	0.000245668688257
ko05140	Leishmaniasis	2/1195	75/7206	0.000248922790813
ko04110	Cell cycle	9/1195	145/7206	0.000264691373006
ko05169	Epstein-Barr virus infection	16/1195	206/7206	0.000271756294386
ko04072	Phospholipase D signaling pathway	52/1195	197/7206	0.000421363337443
ko05205	Proteoglycans in cancer	25/1195	271/7206	0.00059629889977
ko00480	Glutathione metabolism	1/1195	55/7206	0.000843244334021
ko04612	Antigen processing and presentation	3/1195	77/7206	0.00101849823409
ko04626	Plant-pathogen interaction	9/1195	18/7206	0.00107203629016
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1195	59/7206	0.00114296681038
ko04976	Bile secretion	25/1195	80/7206	0.00120161862601
ko04064	NF-kappa B signaling pathway	5/1195	96/7206	0.00127574269243
ko04923	Regulation of lipolysis in adipocytes	24/1195	77/7206	0.00166860719105
ko05161	Hepatitis B	14/1195	173/7206	0.00175054310218
ko05162	Measles	8/1195	120/7206	0.00181318084419
ko04915	Estrogen signaling pathway	36/1195	131/7206	0.00182887967949
ko00590	Arachidonic acid metabolism	1/1195	52/7206	0.00206138762358
ko00240	Pyrimidine metabolism	7/1195	110/7206	0.00263083903628
ko00330	Arginine and proline metabolism	2/1195	61/7206	0.00268651797586
ko00260	Glycine, serine and threonine metabolism	1/1195	48/7206	0.00290400609356
ko04750	Inflammatory mediator regulation of TRP channels	33/1195	122/7206	0.00301415064695
ko04146	Peroxisome	5/1195	89/7206	0.00362978761875
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1195	14/7206	0.00395305216069
ko05144	Malaria	1/1195	45/7206	0.00436300806441
ko00071	Fatty acid degradation	1/1195	45/7206	0.00436300806441
ko03420	Nucleotide excision repair	1/1195	46/7206	0.00442047873453
ko04964	Proximal tubule bicarbonate reclamation	11/1195	29/7206	0.0047387791675
ko05321	Inflammatory bowel disease (IBD)	2/1195	56/7206	0.00579256316245
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1195	182/7206	0.00622362490674
ko04640	Hematopoietic cell lineage	3/1195	64/7206	0.00638207318163
ko00310	Lysine degradation	4/1195	73/7206	0.00675761879843
ko03022	Basal transcription factors	1/1195	44/7206	0.00677768609084
ko05131	Shigellosis	5/1195	82/7206	0.00685562994827
ko03018	RNA degradation	5/1195	84/7206	0.00711212121757
ko04622	RIG-I-like receptor signaling pathway	3/1195	62/7206	0.00919602341629
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1195	100/7206	0.00931722583149
ko04214	Apoptosis - fly	4/1195	72/7206	0.00978282924833
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1195	40/7206	0.00983719781688
ko00140	Steroid hormone biosynthesis	1/1195	41/7206	0.00996148141564
ko00380	Tryptophan metabolism	2/1195	50/7206	0.0120219269591
ko04657	IL-17 signaling pathway	6/1195	87/7206	0.0128269520039
ko05133	Pertussis	6/1195	87/7206	0.0128269520039
ko03410	Base excision repair	1/1195	38/7206	0.0147598031306
ko04930	Type II diabetes mellitus	16/1195	54/7206	0.0155794762686
ko04270	Vascular smooth muscle contraction	37/1195	154/7206	0.0156595882743
ko04015	Rap1 signaling pathway	61/1195	278/7206	0.0169618720397
ko04630	Jak-STAT signaling pathway	12/1195	132/7206	0.0177377060693
ko04115	p53 signaling pathway	5/1195	74/7206	0.0181461650028
ko00500	Starch and sucrose metabolism	1/1195	35/7206	0.0220168570464
ko04916	Melanogenesis	34/1195	142/7206	0.0221637860977
ko04922	Glucagon signaling pathway	31/1195	128/7206	0.0226872121298
ko00982	Drug metabolism - cytochrome P450	1/1195	37/7206	0.0233360176356
ko00280	Valine, leucine and isoleucine degradation	3/1195	54/7206	0.0263047464439
ko04658	Th1 and Th2 cell differentiation	8/1195	96/7206	0.0266038374695
ko04114	Oocyte meiosis	33/1195	139/7206	0.0280415194222
ko04918	Thyroid hormone synthesis	22/1195	86/7206	0.0286694636418
ko05145	Toxoplasmosis	12/1195	126/7206	0.0294543640972
ko04140	Autophagy - animal	17/1195	164/7206	0.0329485947459
ko00640	Propanoate metabolism	1/1195	34/7206	0.0338838339026
ko03320	PPAR signaling pathway	5/1195	69/7206	0.0339775882779
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1195	92/7206	0.0341454284582
ko00983	Drug metabolism - other enzymes	2/1195	42/7206	0.0364340799237
ko04912	GnRH signaling pathway	29/1195	122/7206	0.0365918234909
ko04620	Toll-like receptor signaling pathway	9/1195	100/7206	0.0414625073412
ko04510	Focal adhesion	28/1195	240/7206	0.0417919960808
ko01524	Platinum drug resistance	6/1195	76/7206	0.0426620350789
ko00562	Inositol phosphate metabolism	22/1195	89/7206	0.0442545303627
ko05166	HTLV-I infection	36/1195	292/7206	0.044781788968
ko05340	Primary immunodeficiency	1/1195	30/7206	0.0488387246476
ko04136	Autophagy - other	1/1195	31/7206	0.0495172848608