ko pathway ratio_in_study ratio_in_pop p_value ko04744 Phototransduction 25/470 36/7206 3.81261188162e-22 ko04724 Glutamatergic synapse 45/470 152/7206 8.29237187341e-19 ko05033 Nicotine addiction 26/470 56/7206 8.13545280484e-17 ko05032 Morphine addiction 36/470 110/7206 8.1838069001e-17 ko04727 GABAergic synapse 34/470 110/7206 4.29024934743e-15 ko04080 Neuroactive ligand-receptor interaction 71/470 423/7206 3.27910154585e-14 ko04723 Retrograde endocannabinoid signaling 42/470 175/7206 4.69407576156e-14 ko04713 Circadian entrainment 35/470 136/7206 7.47529821663e-13 ko04728 Dopaminergic synapse 36/470 185/7206 1.86595823339e-09 ko04024 cAMP signaling pathway 46/470 279/7206 2.95957873945e-09 ko04721 Synaptic vesicle cycle 22/470 80/7206 3.95957232551e-09 ko04911 Insulin secretion 27/470 117/7206 4.64443653884e-09 ko04921 Oxytocin signaling pathway 37/470 209/7206 1.64069964119e-08 ko04725 Cholinergic synapse 30/470 160/7206 1.04842224384e-07 ko04726 Serotonergic synapse 27/470 137/7206 1.60213325309e-07 ko04020 Calcium signaling pathway 40/470 265/7206 6.43044249097e-07 ko04742 Taste transduction 16/470 61/7206 1.09223031661e-06 ko04720 Long-term potentiation 21/470 99/7206 1.10682112029e-06 ko04070 Phosphatidylinositol signaling system 22/470 112/7206 2.42054157832e-06 ko04010 MAPK signaling pathway 42/470 321/7206 1.26959885188e-05 ko05203 Viral carcinogenesis 3/470 277/7206 1.65119963859e-05 ko05031 Amphetamine addiction 18/470 91/7206 1.8104061198e-05 ko04261 Adrenergic signaling in cardiomyocytes 30/470 205/7206 3.44481768859e-05 ko04260 Cardiac muscle contraction 18/470 98/7206 5.14558992012e-05 ko05030 Cocaine addiction 15/470 73/7206 5.67087658747e-05 ko04072 Phospholipase D signaling pathway 28/470 197/7206 9.09633456676e-05 ko04970 Salivary secretion 17/470 95/7206 0.000116136710306 ko04925 Aldosterone synthesis and secretion 18/470 105/7206 0.000130876521686 ko04972 Pancreatic secretion 18/470 111/7206 0.000269917436913 ko05164 Influenza A 1/470 167/7206 0.000337167788363 ko04730 Long-term depression 14/470 78/7206 0.000444655632806 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 14/470 79/7206 0.000508922181397 ko00562 Inositol phosphate metabolism 15/470 89/7206 0.000566367337457 ko04740 Olfactory transduction 14/470 80/7206 0.000580925467041 ko05205 Proteoglycans in cancer 5/470 271/7206 0.000585819049519 ko05169 Epstein-Barr virus infection 3/470 206/7206 0.000858408394731 ko05014 Amyotrophic lateral sclerosis (ALS) 13/470 74/7206 0.000872014337529 ko03040 Spliceosome 1/470 145/7206 0.00100878486151 ko04710 Circadian rhythm 9/470 43/7206 0.00151759592809 ko05034 Alcoholism 28/470 238/7206 0.00197122396293 ko05166 HTLV-I infection 7/470 292/7206 0.00221134799258 ko04060 Cytokine-cytokine receptor interaction 3/470 191/7206 0.00251760384264 ko05414 Dilated cardiomyopathy 16/470 112/7206 0.00282664977506 ko05168 Herpes simplex infection 3/470 182/7206 0.00343981445113 ko05322 Systemic lupus erythematosus 2/470 151/7206 0.00415509882712 ko04966 Collecting duct acid secretion 6/470 26/7206 0.00559411679784 ko05410 Hypertrophic cardiomyopathy (HCM) 14/470 100/7206 0.00626796554929 ko04062 Chemokine signaling pathway 23/470 201/7206 0.0082395203135 ko04120 Ubiquitin mediated proteolysis 2/470 138/7206 0.00841858703823 ko04550 Signaling pathways regulating pluripotency of stem cells 3/470 165/7206 0.00961978064382 ko05215 Prostate cancer 1/470 111/7206 0.010073565315 ko04022 cGMP-PKG signaling pathway 24/470 216/7206 0.0107887055517 ko04371 Apelin signaling pathway 20/470 177/7206 0.013401258102 ko04350 TGF-beta signaling pathway 1/470 103/7206 0.0142816835335 ko04750 Inflammatory mediator regulation of TRP channels 15/470 122/7206 0.0150657623462 ko04510 Focal adhesion 7/470 240/7206 0.0164663791786 ko05161 Hepatitis B 4/470 173/7206 0.0185014842755 ko05224 Breast cancer 4/470 174/7206 0.0185937981325 ko04218 Cellular senescence 4/470 177/7206 0.0191601477936 ko05110 Vibrio cholerae infection 9/470 63/7206 0.0201008217125 ko04668 TNF signaling pathway 2/470 120/7206 0.0239097916431 ko04014 Ras signaling pathway 28/470 279/7206 0.0248661455345 ko04660 T cell receptor signaling pathway 2/470 124/7206 0.0250115675263 ko03013 RNA transport 4/470 166/7206 0.0251481678794 ko00230 Purine metabolism 21/470 194/7206 0.0253272912901 ko04110 Cell cycle 3/470 145/7206 0.0254356802348 ko05222 Small cell lung cancer 1/470 89/7206 0.0297108734349 ko05231 Choline metabolism in cancer 15/470 134/7206 0.0336524892404 ko04745 Phototransduction - fly 6/470 38/7206 0.0347080114311 ko04971 Gastric acid secretion 12/470 98/7206 0.0351933387038 ko04810 Regulation of actin cytoskeleton 9/470 264/7206 0.0407604153771 ko05218 Melanoma 1/470 85/7206 0.043450304312 ko04210 Apoptosis 5/470 180/7206 0.0446492329055 ko04657 IL-17 signaling pathway 1/470 87/7206 0.0446831933993 ko05160 Hepatitis C 4/470 153/7206 0.0460347304233 ko04621 NOD-like receptor signaling pathway 4/470 157/7206 0.0472614437683 ko04630 Jak-STAT signaling pathway 3/470 132/7206 0.0479807205096