ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 110/872 423/7206 7.16126986952e-16 ko04020 Calcium signaling pathway 76/872 265/7206 1.31432639442e-13 ko04713 Circadian entrainment 43/872 136/7206 1.03887059516e-09 ko04724 Glutamatergic synapse 46/872 152/7206 1.34922448372e-09 ko05033 Nicotine addiction 22/872 56/7206 1.91328364186e-07 ko04921 Oxytocin signaling pathway 51/872 209/7206 7.32398440733e-07 ko04970 Salivary secretion 29/872 95/7206 1.26948550886e-06 ko03010 Ribosome 1/872 129/7206 1.75756840158e-06 ko04022 cGMP-PKG signaling pathway 51/872 216/7206 1.99468560767e-06 ko04911 Insulin secretion 33/872 117/7206 1.99566937956e-06 ko03040 Spliceosome 2/872 145/7206 2.18362566456e-06 ko04024 cAMP signaling pathway 61/872 279/7206 3.25671792165e-06 ko04726 Serotonergic synapse 36/872 137/7206 4.08272943035e-06 ko05031 Amphetamine addiction 27/872 91/7206 5.37231810791e-06 ko03013 RNA transport 4/872 166/7206 1.00067556576e-05 ko04728 Dopaminergic synapse 43/872 185/7206 1.73518276884e-05 ko04710 Circadian rhythm 16/872 43/7206 2.03810875001e-05 ko04730 Long-term depression 23/872 78/7206 2.9557537812e-05 ko04720 Long-term potentiation 27/872 99/7206 3.209501312e-05 ko04725 Cholinergic synapse 38/872 160/7206 3.64280612507e-05 ko04727 GABAergic synapse 29/872 110/7206 4.04087712643e-05 ko04925 Aldosterone synthesis and secretion 28/872 105/7206 5.16222911667e-05 ko05322 Systemic lupus erythematosus 4/872 151/7206 6.62272902698e-05 ko05032 Morphine addiction 28/872 110/7206 9.16520592739e-05 ko04070 Phosphatidylinositol signaling system 28/872 112/7206 0.000179972276924 ko04514 Cell adhesion molecules (CAMs) 31/872 130/7206 0.000182037434733 ko05203 Viral carcinogenesis 15/872 277/7206 0.000220023165023 ko04971 Gastric acid secretion 25/872 98/7206 0.000230042907785 ko04922 Glucagon signaling pathway 30/872 128/7206 0.000294985532514 ko04721 Synaptic vesicle cycle 21/872 80/7206 0.000425069080859 ko04110 Cell cycle 5/872 145/7206 0.000427144623593 ko04072 Phospholipase D signaling pathway 41/872 197/7206 0.000511341955514 ko04261 Adrenergic signaling in cardiomyocytes 41/872 205/7206 0.00100862178503 ko04745 Phototransduction - fly 12/872 38/7206 0.00122916695623 ko04270 Vascular smooth muscle contraction 32/872 154/7206 0.00169638701493 ko04723 Retrograde endocannabinoid signaling 35/872 175/7206 0.00217524352551 ko04750 Inflammatory mediator regulation of TRP channels 26/872 122/7206 0.00311977504617 ko04014 Ras signaling pathway 50/872 279/7206 0.00360036404001 ko04924 Renin secretion 20/872 86/7206 0.00388238570945 ko04964 Proximal tubule bicarbonate reclamation 9/872 29/7206 0.00563271196517 ko00120 Primary bile acid biosynthesis 7/872 20/7206 0.00692319849839 ko05130 Pathogenic Escherichia coli infection 2/872 77/7206 0.00719763113414 ko04972 Pancreatic secretion 23/872 111/7206 0.00796819442285 ko04141 Protein processing in endoplasmic reticulum 11/872 184/7206 0.0080378210029 ko04540 Gap junction 26/872 128/7206 0.00857106606376 ko00010 Glycolysis / Gluconeogenesis 17/872 74/7206 0.0105199188697 ko04960 Aldosterone-regulated sodium reabsorption 11/872 41/7206 0.0127927924625 ko04360 Axon guidance 41/872 233/7206 0.0137339519905 ko04711 Circadian rhythm - fly 5/872 13/7206 0.0143321812038 ko04626 Plant-pathogen interaction 6/872 18/7206 0.0158509275979 ko04120 Ubiquitin mediated proteolysis 8/872 138/7206 0.0175519834925 ko05224 Breast cancer 11/872 174/7206 0.0178330249645 ko05014 Amyotrophic lateral sclerosis (ALS) 16/872 74/7206 0.0183453943752 ko00592 alpha-Linolenic acid metabolism 6/872 19/7206 0.0208521816636 ko05222 Small cell lung cancer 4/872 89/7206 0.0216542464127 ko01040 Biosynthesis of unsaturated fatty acids 7/872 25/7206 0.0250803728549 ko00140 Steroid hormone biosynthesis 10/872 41/7206 0.0264842313402 ko05169 Epstein-Barr virus infection 15/872 206/7206 0.0298451107636 ko04371 Apelin signaling pathway 31/872 177/7206 0.0346568104388 ko04919 Thyroid hormone signaling pathway 26/872 143/7206 0.0368622741472 ko03420 Nucleotide excision repair 1/872 46/7206 0.0380096867008 ko04015 Rap1 signaling pathway 45/872 278/7206 0.0386923593233 ko04260 Cardiac muscle contraction 19/872 98/7206 0.0404512502173 ko05231 Choline metabolism in cancer 24/872 134/7206 0.0442431071687 ko00562 Inositol phosphate metabolism 17/872 89/7206 0.0489798164783