ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	197/1167	423/7206	3.17063486387e-52
ko05033	Nicotine addiction	51/1167	56/7206	3.12762564011e-35
ko04724	Glutamatergic synapse	91/1167	152/7206	5.11141980923e-35
ko05032	Morphine addiction	70/1167	110/7206	1.71734936569e-29
ko04727	GABAergic synapse	68/1167	110/7206	1.44999772254e-27
ko04713	Circadian entrainment	77/1167	136/7206	1.73101553406e-27
ko04728	Dopaminergic synapse	85/1167	185/7206	5.4571772375e-22
ko04725	Cholinergic synapse	76/1167	160/7206	7.53994771295e-21
ko04723	Retrograde endocannabinoid signaling	79/1167	175/7206	6.40928897312e-20
ko04024	cAMP signaling pathway	103/1167	279/7206	1.29012757394e-17
ko04721	Synaptic vesicle cycle	46/1167	80/7206	3.08639294871e-17
ko04020	Calcium signaling pathway	94/1167	265/7206	5.56146049355e-15
ko04744	Phototransduction	27/1167	36/7206	7.36514771401e-15
ko04911	Insulin secretion	54/1167	117/7206	1.75043175405e-14
ko04742	Taste transduction	36/1167	61/7206	2.97988306717e-14
ko04726	Serotonergic synapse	59/1167	137/7206	4.91708980503e-14
ko04921	Oxytocin signaling pathway	76/1167	209/7206	5.82945875584e-13
ko04261	Adrenergic signaling in cardiomyocytes	73/1167	205/7206	6.41534804957e-12
ko05031	Amphetamine addiction	41/1167	91/7206	6.77185487504e-11
ko03040	Spliceosome	1/1167	145/7206	3.17197686327e-10
ko04720	Long-term potentiation	42/1167	99/7206	4.09033930331e-10
ko05203	Viral carcinogenesis	13/1167	277/7206	3.13463081364e-09
ko05030	Cocaine addiction	33/1167	73/7206	4.48757095375e-09
ko04360	Axon guidance	72/1167	233/7206	1.2092795892e-08
ko04740	Olfactory transduction	34/1167	80/7206	1.82298653741e-08
ko04970	Salivary secretion	38/1167	95/7206	1.98996118504e-08
ko05168	Herpes simplex infection	6/1167	182/7206	3.6394778391e-08
ko04971	Gastric acid secretion	38/1167	98/7206	8.02815358053e-08
ko04925	Aldosterone synthesis and secretion	39/1167	105/7206	1.47494123005e-07
ko03013	RNA transport	6/1167	166/7206	5.4056363133e-07
ko05322	Systemic lupus erythematosus	5/1167	151/7206	8.99745014761e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1167	74/7206	1.57035149035e-06
ko04010	MAPK signaling pathway	85/1167	321/7206	1.79741336221e-06
ko04060	Cytokine-cytokine receptor interaction	10/1167	191/7206	5.39098597737e-06
ko04972	Pancreatic secretion	37/1167	111/7206	6.63472069206e-06
ko05164	Influenza A	8/1167	167/7206	9.33827034452e-06
ko04022	cGMP-PKG signaling pathway	60/1167	216/7206	1.27122323234e-05
ko04730	Long-term depression	28/1167	78/7206	1.80119154861e-05
ko04610	Complement and coagulation cascades	1/1167	79/7206	2.04587846093e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1167	79/7206	3.55537956775e-05
ko04141	Protein processing in endoplasmic reticulum	11/1167	184/7206	4.02209495387e-05
ko05205	Proteoglycans in cancer	21/1167	271/7206	4.75090871477e-05
ko04540	Gap junction	39/1167	128/7206	4.78589481639e-05
ko04072	Phospholipase D signaling pathway	53/1167	197/7206	0.000111648568473
ko04745	Phototransduction - fly	16/1167	38/7206	0.000128640923988
ko04070	Phosphatidylinositol signaling system	34/1167	112/7206	0.000145832364919
ko04514	Cell adhesion molecules (CAMs)	38/1167	130/7206	0.000159801303216
ko05169	Epstein-Barr virus infection	15/1167	206/7206	0.000165507600894
ko03008	Ribosome biogenesis in eukaryotes	2/1167	79/7206	0.00017243001153
ko04621	NOD-like receptor signaling pathway	10/1167	157/7206	0.000270370562514
ko05140	Leishmaniasis	2/1167	75/7206	0.000387956661895
ko05414	Dilated cardiomyopathy	33/1167	112/7206	0.00039204971376
ko04260	Cardiac muscle contraction	30/1167	98/7206	0.000432506893052
ko04915	Estrogen signaling pathway	37/1167	131/7206	0.000441336794376
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1167	59/7206	0.000989863474241
ko05162	Measles	7/1167	120/7206	0.00100229328025
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1167	182/7206	0.00100973210595
ko04750	Inflammatory mediator regulation of TRP channels	34/1167	122/7206	0.00109485558599
ko04146	Peroxisome	4/1167	89/7206	0.0012118139924
ko00480	Glutathione metabolism	1/1167	55/7206	0.0013388907965
ko04966	Collecting duct acid secretion	11/1167	26/7206	0.0013980734545
ko04612	Antigen processing and presentation	3/1167	77/7206	0.00153978901626
ko04014	Ras signaling pathway	65/1167	279/7206	0.00158681246974
ko05110	Vibrio cholerae infection	20/1167	63/7206	0.00178974091487
ko04640	Hematopoietic cell lineage	2/1167	64/7206	0.00181585402461
ko04064	NF-kappa B signaling pathway	5/1167	96/7206	0.00185800953873
ko04976	Bile secretion	24/1167	80/7206	0.00190192409164
ko00590	Arachidonic acid metabolism	1/1167	52/7206	0.00198386713011
ko00310	Lysine degradation	3/1167	73/7206	0.00218455356071
ko05161	Hepatitis B	14/1167	173/7206	0.00230505951363
ko04120	Ubiquitin mediated proteolysis	10/1167	138/7206	0.00231233633491
ko03018	RNA degradation	4/1167	84/7206	0.00247923697742
ko04110	Cell cycle	11/1167	145/7206	0.00290622678711
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1167	14/7206	0.00343956666975
ko03420	Nucleotide excision repair	1/1167	46/7206	0.00445042948444
ko00260	Glycine, serine and threonine metabolism	1/1167	48/7206	0.00471098519577
ko04658	Th1 and Th2 cell differentiation	6/1167	96/7206	0.00499561996798
ko04371	Apelin signaling pathway	43/1167	177/7206	0.00501604210114
ko05321	Inflammatory bowel disease (IBD)	2/1167	56/7206	0.00572446609788
ko03022	Basal transcription factors	1/1167	44/7206	0.00668557271501
ko05144	Malaria	1/1167	45/7206	0.00688747142316
ko00071	Fatty acid degradation	1/1167	45/7206	0.00688747142316
ko04923	Regulation of lipolysis in adipocytes	22/1167	77/7206	0.00726440339973
ko00240	Pyrimidine metabolism	8/1167	110/7206	0.00856660693067
ko04214	Apoptosis - fly	4/1167	72/7206	0.00967000092127
ko04015	Rap1 signaling pathway	61/1167	278/7206	0.00995833030005
ko04115	p53 signaling pathway	4/1167	74/7206	0.0100460283312
ko04924	Renin secretion	23/1167	86/7206	0.0116196539707
ko05166	HTLV-I infection	32/1167	292/7206	0.0118110421807
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1167	100/7206	0.0129424062656
ko00515	Mannose type O-glycan biosynthesis	9/1167	25/7206	0.0129513268645
ko04140	Autophagy - animal	15/1167	164/7206	0.0131301162046
ko00330	Arginine and proline metabolism	3/1167	61/7206	0.0133615441937
ko03320	PPAR signaling pathway	4/1167	69/7206	0.0135634607013
ko04622	RIG-I-like receptor signaling pathway	3/1167	62/7206	0.0137905904862
ko01200	Carbon metabolism	11/1167	128/7206	0.0153384807117
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1167	40/7206	0.0154905795734
ko04626	Plant-pathogen interaction	7/1167	18/7206	0.0176371170684
ko04657	IL-17 signaling pathway	6/1167	87/7206	0.0179554402851
ko04964	Proximal tubule bicarbonate reclamation	10/1167	29/7206	0.0183844299741
ko00982	Drug metabolism - cytochrome P450	1/1167	37/7206	0.022703072661
ko04630	Jak-STAT signaling pathway	12/1167	132/7206	0.0231821210399
ko04210	Apoptosis	18/1167	180/7206	0.0235831042201
ko05131	Shigellosis	6/1167	82/7206	0.0237635249631
ko00630	Glyoxylate and dicarboxylate metabolism	1/1167	38/7206	0.0238173880781
ko03410	Base excision repair	1/1167	38/7206	0.0238173880781
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1167	15/7206	0.0238909529707
ko05016	Huntington's disease	23/1167	215/7206	0.024087293198
ko04912	GnRH signaling pathway	29/1167	122/7206	0.0257224206561
ko04918	Thyroid hormone synthesis	22/1167	86/7206	0.0258308387933
ko04620	Toll-like receptor signaling pathway	8/1167	100/7206	0.0274972280129
ko04218	Cellular senescence	18/1167	177/7206	0.0294120988885
ko04142	Lysosome	15/1167	151/7206	0.0336740211122
ko05418	Fluid shear stress and atherosclerosis	18/1167	173/7206	0.0363576327991
ko05145	Toxoplasmosis	12/1167	126/7206	0.0381422085033
ko00280	Valine, leucine and isoleucine degradation	3/1167	54/7206	0.0387089442798
ko05133	Pertussis	7/1167	87/7206	0.0393296905998
ko00230	Purine metabolism	42/1167	194/7206	0.0474068914218
ko05034	Alcoholism	50/1167	238/7206	0.0484693832752
ko04136	Autophagy - other	1/1167	31/7206	0.0493909373858
ko04916	Melanogenesis	32/1167	142/7206	0.0494477011789