ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	211/1348	423/7206	4.08679815307e-51
ko04724	Glutamatergic synapse	94/1348	152/7206	1.79372069445e-32
ko05032	Morphine addiction	76/1348	110/7206	3.15017839988e-31
ko05033	Nicotine addiction	49/1348	56/7206	6.09722895593e-29
ko04713	Circadian entrainment	81/1348	136/7206	1.70047774339e-26
ko04727	GABAergic synapse	71/1348	110/7206	2.05732092078e-26
ko04725	Cholinergic synapse	82/1348	160/7206	6.11261025779e-21
ko04728	Dopaminergic synapse	89/1348	185/7206	3.11079838006e-20
ko04721	Synaptic vesicle cycle	52/1348	80/7206	7.47174876568e-20
ko04723	Retrograde endocannabinoid signaling	85/1348	175/7206	1.04130376322e-19
ko04024	cAMP signaling pathway	110/1348	279/7206	1.72307131166e-16
ko04911	Insulin secretion	60/1348	117/7206	1.19504860617e-15
ko04020	Calcium signaling pathway	104/1348	265/7206	1.88710299062e-15
ko04726	Serotonergic synapse	64/1348	137/7206	4.17510408644e-14
ko04921	Oxytocin signaling pathway	84/1348	209/7206	2.10406531431e-13
ko04742	Taste transduction	37/1348	61/7206	4.15426710619e-13
ko04744	Phototransduction	26/1348	36/7206	3.50276598446e-12
ko03040	Spliceosome	2/1348	145/7206	8.40251921978e-11
ko03010	Ribosome	1/1348	129/7206	1.2390326113e-10
ko05031	Amphetamine addiction	43/1348	91/7206	4.21199879536e-10
ko04970	Salivary secretion	44/1348	95/7206	5.92056027108e-10
ko04720	Long-term potentiation	45/1348	99/7206	8.07456476858e-10
ko04261	Adrenergic signaling in cardiomyocytes	75/1348	205/7206	9.01672434638e-10
ko04925	Aldosterone synthesis and secretion	45/1348	105/7206	8.30916874722e-09
ko04971	Gastric acid secretion	41/1348	98/7206	1.1551508128e-07
ko05322	Systemic lupus erythematosus	6/1348	151/7206	1.19794967581e-07
ko03013	RNA transport	8/1348	166/7206	1.74214760571e-07
ko04360	Axon guidance	76/1348	233/7206	2.19949802462e-07
ko04740	Olfactory transduction	35/1348	80/7206	2.57183392828e-07
ko05168	Herpes simplex infection	10/1348	182/7206	3.41818641304e-07
ko04022	cGMP-PKG signaling pathway	71/1348	216/7206	4.80357538254e-07
ko04070	Phosphatidylinositol signaling system	43/1348	112/7206	9.5819721375e-07
ko05203	Viral carcinogenesis	23/1348	277/7206	1.28696628886e-06
ko04966	Collecting duct acid secretion	16/1348	26/7206	1.64502534718e-06
ko05030	Cocaine addiction	31/1348	73/7206	2.41259393961e-06
ko04972	Pancreatic secretion	41/1348	111/7206	5.99540142248e-06
ko04110	Cell cycle	8/1348	145/7206	7.09140469144e-06
ko04010	MAPK signaling pathway	92/1348	321/7206	9.62236480461e-06
ko04621	NOD-like receptor signaling pathway	10/1348	157/7206	1.1064185793e-05
ko04072	Phospholipase D signaling pathway	62/1348	197/7206	1.13535370079e-05
ko04745	Phototransduction - fly	19/1348	38/7206	1.21479323276e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1348	79/7206	2.85373758524e-05
ko04060	Cytokine-cytokine receptor interaction	15/1348	191/7206	2.92968061167e-05
ko04141	Protein processing in endoplasmic reticulum	14/1348	184/7206	3.08924360722e-05
ko05164	Influenza A	12/1348	167/7206	3.12793937873e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1348	74/7206	3.31079251644e-05
ko04014	Ras signaling pathway	80/1348	279/7206	4.0894086491e-05
ko04730	Long-term depression	30/1348	78/7206	4.88856301347e-05
ko04976	Bile secretion	30/1348	80/7206	6.86670085288e-05
ko04540	Gap junction	42/1348	128/7206	0.000128365495279
ko04750	Inflammatory mediator regulation of TRP channels	40/1348	122/7206	0.000157340064509
ko04514	Cell adhesion molecules (CAMs)	42/1348	130/7206	0.000159140425012
ko04612	Antigen processing and presentation	3/1348	77/7206	0.00018862808135
ko05110	Vibrio cholerae infection	24/1348	63/7206	0.000266936628125
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1348	59/7206	0.000280512615373
ko00520	Amino sugar and nucleotide sugar metabolism	1/1348	55/7206	0.000334974130691
ko04710	Circadian rhythm	18/1348	43/7206	0.000497253523163
ko04120	Ubiquitin mediated proteolysis	11/1348	138/7206	0.000562278602945
ko04371	Apelin signaling pathway	52/1348	177/7206	0.000569787095605
ko05162	Measles	9/1348	120/7206	0.000831011942966
ko05169	Epstein-Barr virus infection	21/1348	206/7206	0.00102560671948
ko04964	Proximal tubule bicarbonate reclamation	13/1348	29/7206	0.00110751849471
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1348	79/7206	0.00115057710851
ko05414	Dilated cardiomyopathy	35/1348	112/7206	0.00132418197401
ko05140	Leishmaniasis	4/1348	75/7206	0.00148693505582
ko00071	Fatty acid degradation	1/1348	45/7206	0.0016987834487
ko03420	Nucleotide excision repair	1/1348	46/7206	0.00178246625602
ko04924	Renin secretion	28/1348	86/7206	0.00194633027141
ko04915	Estrogen signaling pathway	39/1348	131/7206	0.00206737781142
ko04064	NF-kappa B signaling pathway	7/1348	96/7206	0.00225445648098
ko04146	Peroxisome	6/1348	89/7206	0.00230499741226
ko03022	Basal transcription factors	1/1348	44/7206	0.00275461391434
ko04622	RIG-I-like receptor signaling pathway	3/1348	62/7206	0.0027699324343
ko04610	Complement and coagulation cascades	5/1348	79/7206	0.00324095284805
ko04657	IL-17 signaling pathway	6/1348	87/7206	0.00325347325497
ko05133	Pertussis	6/1348	87/7206	0.00325347325497
ko04260	Cardiac muscle contraction	30/1348	98/7206	0.00387879913878
ko05205	Proteoglycans in cancer	33/1348	271/7206	0.00415257083252
ko04922	Glucagon signaling pathway	37/1348	128/7206	0.00415348340933
ko04015	Rap1 signaling pathway	71/1348	278/7206	0.00459462153524
ko04270	Vascular smooth muscle contraction	43/1348	154/7206	0.0046017914626
ko04923	Regulation of lipolysis in adipocytes	25/1348	77/7206	0.00462571520756
ko04918	Thyroid hormone synthesis	27/1348	86/7206	0.00484456706119
ko00630	Glyoxylate and dicarboxylate metabolism	1/1348	38/7206	0.00592228780209
ko03410	Base excision repair	1/1348	38/7206	0.00592228780209
ko00310	Lysine degradation	5/1348	73/7206	0.00620888569581
ko05131	Shigellosis	6/1348	82/7206	0.00621102311616
ko00240	Pyrimidine metabolism	10/1348	110/7206	0.0065906790043
ko04912	GnRH signaling pathway	35/1348	122/7206	0.00672852701795
ko05231	Choline metabolism in cancer	38/1348	134/7206	0.00685740284006
ko05161	Hepatitis B	19/1348	173/7206	0.0074353216653
ko04658	Th1 and Th2 cell differentiation	8/1348	96/7206	0.00779216819481
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1348	14/7206	0.00791944911391
ko00280	Valine, leucine and isoleucine degradation	3/1348	54/7206	0.0083354605801
ko04217	Necroptosis	20/1348	178/7206	0.00837183401528
ko05321	Inflammatory bowel disease (IBD)	3/1348	56/7206	0.00866967091581
ko04916	Melanogenesis	39/1348	142/7206	0.00898323975748
ko04626	Plant-pathogen interaction	8/1348	18/7206	0.0108147193904
ko03018	RNA degradation	7/1348	84/7206	0.0110229370174
ko05144	Malaria	2/1348	45/7206	0.0111904317146
ko04932	Non-alcoholic fatty liver disease (NAFLD)	21/1348	182/7206	0.0119306896813
ko00590	Arachidonic acid metabolism	3/1348	52/7206	0.0119540304145
ko00330	Arginine and proline metabolism	4/1348	61/7206	0.0123682115368
ko04930	Type II diabetes mellitus	18/1348	54/7206	0.0126456553406
ko00860	Porphyrin and chlorophyll metabolism	1/1348	34/7206	0.0136346496145
ko00562	Inositol phosphate metabolism	26/1348	89/7206	0.0137026869653
ko05145	Toxoplasmosis	13/1348	126/7206	0.0148921039317
ko04960	Aldosterone-regulated sodium reabsorption	14/1348	41/7206	0.0157328838185
ko04115	p53 signaling pathway	6/1348	74/7206	0.0159667951036
ko05166	HTLV-I infection	39/1348	292/7206	0.0172877054124
ko04214	Apoptosis - fly	6/1348	72/7206	0.0218506817531
ko04711	Circadian rhythm - fly	6/1348	13/7206	0.0218993425872
ko00260	Glycine, serine and threonine metabolism	3/1348	48/7206	0.0245214195464
ko05219	Bladder cancer	3/1348	48/7206	0.0245214195464
ko04210	Apoptosis	22/1348	180/7206	0.0254748441897
ko04973	Carbohydrate digestion and absorption	14/1348	42/7206	0.0262616730712
ko04620	Toll-like receptor signaling pathway	10/1348	100/7206	0.0271037702501
ko04113	Meiosis - yeast	6/1348	70/7206	0.029830051504
ko05320	Autoimmune thyroid disease	1/1348	29/7206	0.030699458484
ko04630	Jak-STAT signaling pathway	15/1348	132/7206	0.0315621186486
ko00230	Purine metabolism	48/1348	194/7206	0.0318723508023
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1348	100/7206	0.0383458194817
ko01212	Fatty acid metabolism	5/1348	60/7206	0.044183173523
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1348	15/7206	0.0456507772859