ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	207/1247	423/7206	2.24574283686e-54
ko04724	Glutamatergic synapse	91/1247	152/7206	1.20792946179e-32
ko04713	Circadian entrainment	80/1247	136/7206	4.70264429535e-28
ko05033	Nicotine addiction	47/1247	56/7206	1.13939235747e-27
ko05032	Morphine addiction	69/1247	110/7206	1.04248299025e-26
ko04727	GABAergic synapse	67/1247	110/7206	6.89055656308e-25
ko04721	Synaptic vesicle cycle	52/1247	80/7206	1.91473886875e-21
ko04728	Dopaminergic synapse	87/1247	185/7206	2.5733318408e-21
ko04020	Calcium signaling pathway	110/1247	265/7206	2.88545495548e-21
ko04725	Cholinergic synapse	78/1247	160/7206	2.05959745518e-20
ko04024	cAMP signaling pathway	108/1247	279/7206	5.42485697355e-18
ko04723	Retrograde endocannabinoid signaling	78/1247	175/7206	1.67213821468e-17
ko04911	Insulin secretion	60/1247	117/7206	2.60106098824e-17
ko04742	Taste transduction	39/1247	61/7206	5.04026069372e-16
ko04921	Oxytocin signaling pathway	85/1247	209/7206	6.66160215789e-16
ko04726	Serotonergic synapse	62/1247	137/7206	1.56761185187e-14
ko04970	Salivary secretion	48/1247	95/7206	8.86288017708e-14
ko04261	Adrenergic signaling in cardiomyocytes	77/1247	205/7206	2.97899242275e-12
ko04720	Long-term potentiation	46/1247	99/7206	1.31975128574e-11
ko03040	Spliceosome	1/1247	145/7206	4.29907578707e-11
ko05031	Amphetamine addiction	42/1247	91/7206	1.35117343552e-10
ko04740	Olfactory transduction	38/1247	80/7206	3.63425494504e-10
ko04744	Phototransduction	23/1247	36/7206	5.79731085955e-10
ko04022	cGMP-PKG signaling pathway	74/1247	216/7206	1.21079236091e-09
ko04971	Gastric acid secretion	42/1247	98/7206	2.29499737449e-09
ko04360	Axon guidance	77/1247	233/7206	3.0761830967e-09
ko04925	Aldosterone synthesis and secretion	43/1247	105/7206	9.76893960007e-09
ko05203	Viral carcinogenesis	17/1247	277/7206	3.76164498608e-08
ko04540	Gap junction	48/1247	128/7206	4.0533734191e-08
ko04060	Cytokine-cytokine receptor interaction	8/1247	191/7206	5.12205844816e-08
ko05030	Cocaine addiction	31/1247	73/7206	3.72664575294e-07
ko03013	RNA transport	7/1247	166/7206	3.78128518179e-07
ko05168	Herpes simplex infection	9/1247	182/7206	7.43745206181e-07
ko04120	Ubiquitin mediated proteolysis	5/1247	138/7206	1.10281429316e-06
ko04972	Pancreatic secretion	40/1247	111/7206	1.66067060603e-06
ko04730	Long-term depression	31/1247	78/7206	2.43811589239e-06
ko05322	Systemic lupus erythematosus	7/1247	151/7206	3.44577437761e-06
ko04966	Collecting duct acid secretion	15/1247	26/7206	3.95171439206e-06
ko04924	Renin secretion	32/1247	86/7206	9.00297856399e-06
ko04010	MAPK signaling pathway	86/1247	321/7206	1.45850707506e-05
ko05164	Influenza A	10/1247	167/7206	1.80158742772e-05
ko04141	Protein processing in endoplasmic reticulum	12/1247	184/7206	2.66663774501e-05
ko04371	Apelin signaling pathway	53/1247	177/7206	2.92708538783e-05
ko04514	Cell adhesion molecules (CAMs)	42/1247	130/7206	3.00045058977e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	24/1247	59/7206	3.14892030346e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1247	74/7206	3.15396098522e-05
ko04976	Bile secretion	29/1247	80/7206	3.98181130235e-05
ko04070	Phosphatidylinositol signaling system	37/1247	112/7206	4.22448734077e-05
ko04621	NOD-like receptor signaling pathway	10/1247	157/7206	6.81461502501e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1247	79/7206	7.03645479575e-05
ko04260	Cardiac muscle contraction	33/1247	98/7206	7.16959607569e-05
ko05110	Vibrio cholerae infection	24/1247	63/7206	7.25424444315e-05
ko04745	Phototransduction - fly	17/1247	38/7206	7.42734844279e-05
ko05169	Epstein-Barr virus infection	16/1247	206/7206	0.000109361767317
ko04964	Proximal tubule bicarbonate reclamation	14/1247	29/7206	0.000117173041806
ko05414	Dilated cardiomyopathy	36/1247	112/7206	0.000120126408701
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1247	79/7206	0.000120214256989
ko04750	Inflammatory mediator regulation of TRP channels	38/1247	122/7206	0.000149820350666
ko05140	Leishmaniasis	2/1247	75/7206	0.000159990041843
ko04072	Phospholipase D signaling pathway	55/1247	197/7206	0.000172242687683
ko04064	NF-kappa B signaling pathway	4/1247	96/7206	0.000183197321185
ko04014	Ras signaling pathway	72/1247	279/7206	0.000261898274958
ko04626	Plant-pathogen interaction	10/1247	18/7206	0.000264711025789
ko04110	Cell cycle	10/1247	145/7206	0.000341869375865
ko04610	Complement and coagulation cascades	3/1247	79/7206	0.000458035812871
ko04146	Peroxisome	4/1247	89/7206	0.0005628343421
ko05205	Proteoglycans in cancer	27/1247	271/7206	0.000745783247702
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1247	14/7206	0.00088053936179
ko05162	Measles	8/1247	120/7206	0.000917523449821
ko04915	Estrogen signaling pathway	38/1247	131/7206	0.000957183117948
ko05161	Hepatitis B	15/1247	173/7206	0.00151062425593
ko04612	Antigen processing and presentation	4/1247	77/7206	0.002285468822
ko03420	Nucleotide excision repair	1/1247	46/7206	0.00278945312178
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1247	182/7206	0.00279650546223
ko00240	Pyrimidine metabolism	8/1247	110/7206	0.00325418647541
ko01524	Platinum drug resistance	4/1247	76/7206	0.00329716844355
ko03018	RNA degradation	5/1247	84/7206	0.00339113339886
ko04270	Vascular smooth muscle contraction	41/1247	154/7206	0.00342574047335
ko04923	Regulation of lipolysis in adipocytes	24/1247	77/7206	0.00343448853144
ko00480	Glutathione metabolism	2/1247	55/7206	0.00369408995105
ko05321	Inflammatory bowel disease (IBD)	2/1247	56/7206	0.0037872511414
ko05145	Toxoplasmosis	10/1247	126/7206	0.00401008458055
ko03022	Basal transcription factors	1/1247	44/7206	0.00424476716016
ko04640	Hematopoietic cell lineage	3/1247	64/7206	0.00429014493222
ko00071	Fatty acid degradation	1/1247	45/7206	0.00446291680891
ko04214	Apoptosis - fly	4/1247	72/7206	0.00462820275651
ko05131	Shigellosis	5/1247	82/7206	0.00478371703081
ko00330	Arginine and proline metabolism	3/1247	61/7206	0.00617104439469
ko04622	RIG-I-like receptor signaling pathway	3/1247	62/7206	0.00622252112495
ko04658	Th1 and Th2 cell differentiation	7/1247	96/7206	0.00631224034777
ko01200	Carbon metabolism	11/1247	128/7206	0.00645860656612
ko05133	Pertussis	6/1247	87/7206	0.00654509038111
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1247	100/7206	0.00725773964669
ko04912	GnRH signaling pathway	33/1247	122/7206	0.00739376763964
ko00380	Tryptophan metabolism	2/1247	50/7206	0.00795575713158
ko04922	Glucagon signaling pathway	34/1247	128/7206	0.00894686715804
ko04916	Melanogenesis	37/1247	142/7206	0.00945900330135
ko00630	Glyoxylate and dicarboxylate metabolism	1/1247	38/7206	0.00958443908451
ko04630	Jak-STAT signaling pathway	12/1247	132/7206	0.0102176619398
ko04620	Toll-like receptor signaling pathway	8/1247	100/7206	0.010942970266
ko00260	Glycine, serine and threonine metabolism	2/1247	48/7206	0.0116835782599
ko04115	p53 signaling pathway	5/1247	74/7206	0.0128155642674
ko04918	Thyroid hormone synthesis	24/1247	86/7206	0.013896593487
ko05418	Fluid shear stress and atherosclerosis	18/1247	173/7206	0.0142504623173
ko04974	Protein digestion and absorption	26/1247	96/7206	0.0142655245021
ko04668	TNF signaling pathway	11/1247	120/7206	0.0147220810906
ko05222	Small cell lung cancer	7/1247	89/7206	0.0158365925977
ko05144	Malaria	2/1247	45/7206	0.0169503533241
ko00280	Valine, leucine and isoleucine degradation	3/1247	54/7206	0.0180556255664
ko04330	Notch signaling pathway	4/1247	62/7206	0.0181991421855
ko00310	Lysine degradation	5/1247	73/7206	0.0182749911645
ko04657	IL-17 signaling pathway	7/1247	87/7206	0.0214796864692
ko05166	HTLV-I infection	36/1247	292/7206	0.0217618147583
ko00500	Starch and sucrose metabolism	1/1247	35/7206	0.0221689063059
ko00590	Arachidonic acid metabolism	3/1247	52/7206	0.0257743193932
ko04930	Type II diabetes mellitus	16/1247	54/7206	0.0278796347594
ko04015	Rap1 signaling pathway	62/1247	278/7206	0.0287978766759
ko05132	Salmonella infection	9/1247	98/7206	0.0310129039917
ko00910	Nitrogen metabolism	7/1247	19/7206	0.0336768320771
ko04217	Necroptosis	20/1247	178/7206	0.0344339077459
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1247	40/7206	0.0356356825554
ko04210	Apoptosis	21/1247	180/7206	0.0454848987872
ko00562	Inositol phosphate metabolism	23/1247	89/7206	0.0467552584349
ko04350	TGF-beta signaling pathway	10/1247	103/7206	0.0477293049617
ko05231	Choline metabolism in cancer	32/1247	134/7206	0.0494553390482
ko04142	Lysosome	17/1247	151/7206	0.0498514579921