ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	207/1254	423/7206	6.16249149233e-54
ko04724	Glutamatergic synapse	92/1254	152/7206	2.48803533651e-33
ko05032	Morphine addiction	74/1254	110/7206	2.15118588061e-31
ko05033	Nicotine addiction	48/1254	56/7206	5.58501864504e-29
ko04727	GABAergic synapse	69/1254	110/7206	1.47894836611e-26
ko04713	Circadian entrainment	78/1254	136/7206	3.39973351842e-26
ko04721	Synaptic vesicle cycle	53/1254	80/7206	2.65772408717e-22
ko04725	Cholinergic synapse	79/1254	160/7206	6.06986928096e-21
ko04728	Dopaminergic synapse	86/1254	185/7206	1.685601196e-20
ko04723	Retrograde endocannabinoid signaling	81/1254	175/7206	3.20014189074e-19
ko04020	Calcium signaling pathway	105/1254	265/7206	3.48435798374e-18
ko04024	cAMP signaling pathway	108/1254	279/7206	6.89065659717e-18
ko04911	Insulin secretion	59/1254	117/7206	1.76776026394e-16
ko04726	Serotonergic synapse	65/1254	137/7206	2.56852246777e-16
ko04921	Oxytocin signaling pathway	82/1254	209/7206	3.05483961684e-14
ko04742	Taste transduction	37/1254	61/7206	3.98854926201e-14
ko04744	Phototransduction	27/1254	36/7206	4.62684242974e-14
ko04261	Adrenergic signaling in cardiomyocytes	76/1254	205/7206	8.35401438416e-12
ko04970	Salivary secretion	45/1254	95/7206	1.17595243642e-11
ko03040	Spliceosome	1/1254	145/7206	4.38000001877e-11
ko04720	Long-term potentiation	45/1254	99/7206	6.79447566324e-11
ko05031	Amphetamine addiction	42/1254	91/7206	1.62295351773e-10
ko03010	Ribosome	1/1254	129/7206	9.59987128669e-10
ko04925	Aldosterone synthesis and secretion	43/1254	105/7206	1.10622608252e-08
ko04971	Gastric acid secretion	40/1254	98/7206	4.10354076729e-08
ko05168	Herpes simplex infection	8/1254	182/7206	1.48972720087e-07
ko05203	Viral carcinogenesis	19/1254	277/7206	2.66400515151e-07
ko03013	RNA transport	7/1254	166/7206	3.84127216744e-07
ko05322	Systemic lupus erythematosus	6/1254	151/7206	6.43723923161e-07
ko04360	Axon guidance	70/1254	233/7206	1.54168829333e-06
ko04022	cGMP-PKG signaling pathway	66/1254	216/7206	1.55206534291e-06
ko04740	Olfactory transduction	32/1254	80/7206	1.59303657016e-06
ko04060	Cytokine-cytokine receptor interaction	11/1254	191/7206	2.45283360312e-06
ko04972	Pancreatic secretion	40/1254	111/7206	2.98604035775e-06
ko04070	Phosphatidylinositol signaling system	40/1254	112/7206	3.30548577897e-06
ko04966	Collecting duct acid secretion	15/1254	26/7206	4.24920723e-06
ko04621	NOD-like receptor signaling pathway	8/1254	157/7206	5.54669918083e-06
ko05030	Cocaine addiction	29/1254	73/7206	5.86869802577e-06
ko05164	Influenza A	9/1254	167/7206	6.32044525355e-06
ko04540	Gap junction	43/1254	128/7206	8.66523225046e-06
ko04010	MAPK signaling pathway	87/1254	321/7206	1.06747984697e-05
ko04745	Phototransduction - fly	18/1254	38/7206	1.88816711238e-05
ko04120	Ubiquitin mediated proteolysis	7/1254	138/7206	2.06618693565e-05
ko04072	Phospholipase D signaling pathway	58/1254	197/7206	2.28551445357e-05
ko04730	Long-term depression	29/1254	78/7206	2.83294921599e-05
ko04514	Cell adhesion molecules (CAMs)	42/1254	130/7206	3.17842386598e-05
ko04110	Cell cycle	8/1254	145/7206	3.22997869375e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1254	74/7206	3.28072170175e-05
ko04924	Renin secretion	31/1254	86/7206	3.68204690188e-05
ko04976	Bile secretion	29/1254	80/7206	4.35242620411e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1254	79/7206	7.01355025717e-05
ko05110	Vibrio cholerae infection	24/1254	63/7206	7.85763035986e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1254	59/7206	7.96091488954e-05
ko04964	Proximal tubule bicarbonate reclamation	14/1254	29/7206	0.000124767097708
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1254	79/7206	0.000125132029376
ko05414	Dilated cardiomyopathy	36/1254	112/7206	0.000127508109985
ko04141	Protein processing in endoplasmic reticulum	14/1254	184/7206	0.000159212693143
ko04014	Ras signaling pathway	73/1254	279/7206	0.000192751459012
ko04260	Cardiac muscle contraction	32/1254	98/7206	0.000224564046301
ko05162	Measles	7/1254	120/7206	0.00023814054427
ko05169	Epstein-Barr virus infection	17/1254	206/7206	0.000243819013381
ko04750	Inflammatory mediator regulation of TRP channels	37/1254	122/7206	0.000404368227306
ko04923	Regulation of lipolysis in adipocytes	26/1254	77/7206	0.000423241412795
ko00520	Amino sugar and nucleotide sugar metabolism	1/1254	55/7206	0.00052579736248
ko05205	Proteoglycans in cancer	27/1254	271/7206	0.000578907686155
ko04064	NF-kappa B signaling pathway	5/1254	96/7206	0.00059561990351
ko05140	Leishmaniasis	3/1254	75/7206	0.000663353050921
ko04915	Estrogen signaling pathway	38/1254	131/7206	0.000989544088569
ko05161	Hepatitis B	15/1254	173/7206	0.00152042806136
ko04626	Plant-pathogen interaction	9/1254	18/7206	0.00153392356856
ko04610	Complement and coagulation cascades	4/1254	79/7206	0.00159065154738
ko04146	Peroxisome	5/1254	89/7206	0.00171209231901
ko04922	Glucagon signaling pathway	36/1254	128/7206	0.0021263531392
ko04612	Antigen processing and presentation	4/1254	77/7206	0.0022672363571
ko04371	Apelin signaling pathway	47/1254	177/7206	0.00241825444364
ko05144	Malaria	1/1254	45/7206	0.00278377606753
ko00071	Fatty acid degradation	1/1254	45/7206	0.00278377606753
ko03420	Nucleotide excision repair	1/1254	46/7206	0.00278689311979
ko04115	p53 signaling pathway	4/1254	74/7206	0.0032443423576
ko00240	Pyrimidine metabolism	8/1254	110/7206	0.00325897032517
ko00480	Glutathione metabolism	2/1254	55/7206	0.00368934580732
ko05321	Inflammatory bowel disease (IBD)	2/1254	56/7206	0.00382381180768
ko03022	Basal transcription factors	1/1254	44/7206	0.00425865911544
ko00310	Lysine degradation	4/1254	73/7206	0.00464584915094
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1254	14/7206	0.00523281744596
ko00590	Arachidonic acid metabolism	2/1254	52/7206	0.00540047460175
ko05231	Choline metabolism in cancer	36/1254	134/7206	0.00550428311029
ko00330	Arginine and proline metabolism	3/1254	61/7206	0.00614037066109
ko04622	RIG-I-like receptor signaling pathway	3/1254	62/7206	0.00625233324945
ko04658	Th1 and Th2 cell differentiation	7/1254	96/7206	0.00630023741279
ko04918	Thyroid hormone synthesis	25/1254	86/7206	0.00632378983479
ko04657	IL-17 signaling pathway	6/1254	87/7206	0.00650891633487
ko05133	Pertussis	6/1254	87/7206	0.00650891633487
ko04210	Apoptosis	18/1254	180/7206	0.0069142389167
ko05166	HTLV-I infection	34/1254	292/7206	0.007230834323
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1254	100/7206	0.00751510519981
ko04912	GnRH signaling pathway	33/1254	122/7206	0.00757723711012
ko05145	Toxoplasmosis	11/1254	126/7206	0.0086086306225
ko03018	RNA degradation	6/1254	84/7206	0.00896783401569
ko04630	Jak-STAT signaling pathway	12/1254	132/7206	0.0102762942403
ko00562	Inositol phosphate metabolism	25/1254	89/7206	0.0108769970578
ko05131	Shigellosis	6/1254	82/7206	0.0122838699128
ko04510	Focal adhesion	28/1254	240/7206	0.0152646851335
ko04217	Necroptosis	19/1254	178/7206	0.0158888596626
ko05222	Small cell lung cancer	7/1254	89/7206	0.0158906394171
ko04214	Apoptosis - fly	5/1254	72/7206	0.0178899092727
ko00280	Valine, leucine and isoleucine degradation	3/1254	54/7206	0.0180434407065
ko04330	Notch signaling pathway	4/1254	62/7206	0.0180970658659
ko04916	Melanogenesis	36/1254	142/7206	0.0181984383086
ko00860	Porphyrin and chlorophyll metabolism	1/1254	34/7206	0.0214945390595
ko04620	Toll-like receptor signaling pathway	9/1254	100/7206	0.0235235169432
ko04015	Rap1 signaling pathway	63/1254	278/7206	0.023528342634
ko04930	Type II diabetes mellitus	16/1254	54/7206	0.0283227332538
ko04062	Chemokine signaling pathway	47/1254	201/7206	0.0294824767778
ko05132	Salmonella infection	9/1254	98/7206	0.0310217608411
ko01524	Platinum drug resistance	6/1254	76/7206	0.0316067557191
ko04270	Vascular smooth muscle contraction	37/1254	154/7206	0.0317414705816
ko00230	Purine metabolism	45/1254	194/7206	0.0346293881174
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1254	40/7206	0.0355442980558
ko04932	Non-alcoholic fatty liver disease (NAFLD)	21/1254	182/7206	0.0370027286907
ko00380	Tryptophan metabolism	3/1254	50/7206	0.0370182366791
ko04973	Carbohydrate digestion and absorption	13/1254	42/7206	0.0378158390844
ko05202	Transcriptional misregulation in cancer	22/1254	188/7206	0.0400661180497
ko04710	Circadian rhythm	13/1254	43/7206	0.0404127493461
ko05418	Fluid shear stress and atherosclerosis	20/1254	173/7206	0.041908850461
ko05215	Prostate cancer	11/1254	111/7206	0.0423078199682
ko04640	Hematopoietic cell lineage	5/1254	64/7206	0.0454218573175
ko05320	Autoimmune thyroid disease	1/1254	29/7206	0.0478673092215
ko05340	Primary immunodeficiency	1/1254	30/7206	0.0492582628613