ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	203/1266	423/7206	2.27909816957e-50
ko04724	Glutamatergic synapse	92/1266	152/7206	5.47968682876e-33
ko05032	Morphine addiction	70/1266	110/7206	3.16699512043e-27
ko04713	Circadian entrainment	79/1266	136/7206	9.61424108368e-27
ko05033	Nicotine addiction	46/1266	56/7206	5.25023476682e-26
ko04727	GABAergic synapse	67/1266	110/7206	1.70448148337e-24
ko04721	Synaptic vesicle cycle	53/1266	80/7206	4.21934883976e-22
ko04725	Cholinergic synapse	79/1266	160/7206	1.12292549776e-20
ko04728	Dopaminergic synapse	86/1266	185/7206	3.22919177609e-20
ko04020	Calcium signaling pathway	106/1266	265/7206	2.13374877839e-18
ko04723	Retrograde endocannabinoid signaling	79/1266	175/7206	1.03010709238e-17
ko04024	cAMP signaling pathway	107/1266	279/7206	4.60943955788e-17
ko04911	Insulin secretion	60/1266	117/7206	5.51081346299e-17
ko04726	Serotonergic synapse	65/1266	137/7206	4.20324348432e-16
ko04742	Taste transduction	39/1266	61/7206	8.57005337077e-16
ko04921	Oxytocin signaling pathway	84/1266	209/7206	6.22316861146e-15
ko04970	Salivary secretion	48/1266	95/7206	1.60462641038e-13
ko04720	Long-term potentiation	46/1266	99/7206	2.2735293491e-11
ko04261	Adrenergic signaling in cardiomyocytes	75/1266	205/7206	4.06701155652e-11
ko05031	Amphetamine addiction	43/1266	91/7206	5.17522866979e-11
ko03040	Spliceosome	2/1266	145/7206	6.21412922371e-10
ko04744	Phototransduction	23/1266	36/7206	7.91692075752e-10
ko04925	Aldosterone synthesis and secretion	44/1266	105/7206	4.97399518654e-09
ko05168	Herpes simplex infection	7/1266	182/7206	1.75289791539e-08
ko05203	Viral carcinogenesis	17/1266	277/7206	1.8252483377e-08
ko04971	Gastric acid secretion	41/1266	98/7206	1.84267928366e-08
ko04022	cGMP-PKG signaling pathway	71/1266	216/7206	3.02055366036e-08
ko04740	Olfactory transduction	35/1266	80/7206	3.92765690855e-08
ko04540	Gap junction	47/1266	128/7206	2.07279195454e-07
ko03013	RNA transport	7/1266	166/7206	2.50673939952e-07
ko04972	Pancreatic secretion	42/1266	111/7206	3.93588703114e-07
ko05322	Systemic lupus erythematosus	6/1266	151/7206	6.58707150057e-07
ko04966	Collecting duct acid secretion	16/1266	26/7206	6.81114130208e-07
ko04924	Renin secretion	34/1266	86/7206	1.18428559695e-06
ko04360	Axon guidance	70/1266	233/7206	1.84225318926e-06
ko04976	Bile secretion	32/1266	80/7206	1.89624539204e-06
ko04730	Long-term depression	31/1266	78/7206	3.19046889048e-06
ko04010	MAPK signaling pathway	89/1266	321/7206	3.94994323654e-06
ko04120	Ubiquitin mediated proteolysis	6/1266	138/7206	4.13870978749e-06
ko05164	Influenza A	9/1266	167/7206	4.22016406128e-06
ko04070	Phosphatidylinositol signaling system	39/1266	112/7206	1.31175975165e-05
ko04621	NOD-like receptor signaling pathway	9/1266	157/7206	1.68510464248e-05
ko04110	Cell cycle	8/1266	145/7206	2.21734916364e-05
ko04014	Ras signaling pathway	77/1266	279/7206	2.58343135408e-05
ko04964	Proximal tubule bicarbonate reclamation	15/1266	29/7206	2.84301105142e-05
ko05030	Cocaine addiction	28/1266	73/7206	3.09745562869e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1266	74/7206	3.56850943931e-05
ko04514	Cell adhesion molecules (CAMs)	42/1266	130/7206	3.60703214317e-05
ko04072	Phospholipase D signaling pathway	58/1266	197/7206	3.63432634056e-05
ko05169	Epstein-Barr virus infection	16/1266	206/7206	5.75137880037e-05
ko04060	Cytokine-cytokine receptor interaction	14/1266	191/7206	6.45970389685e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1266	79/7206	7.1093966632e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1266	59/7206	8.94387562896e-05
ko05110	Vibrio cholerae infection	24/1266	63/7206	9.03234618809e-05
ko04745	Phototransduction - fly	17/1266	38/7206	9.04544960081e-05
ko04923	Regulation of lipolysis in adipocytes	27/1266	77/7206	0.000213728422964
ko04260	Cardiac muscle contraction	32/1266	98/7206	0.000249234490097
ko04750	Inflammatory mediator regulation of TRP channels	38/1266	122/7206	0.000256607480778
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1266	79/7206	0.000302239305329
ko04141	Protein processing in endoplasmic reticulum	15/1266	184/7206	0.000364734440892
ko05414	Dilated cardiomyopathy	35/1266	112/7206	0.000377419658406
ko04371	Apelin signaling pathway	50/1266	177/7206	0.000409764338837
ko04610	Complement and coagulation cascades	3/1266	79/7206	0.000472595878926
ko00520	Amino sugar and nucleotide sugar metabolism	1/1266	55/7206	0.0005232111994
ko04064	NF-kappa B signaling pathway	5/1266	96/7206	0.000601578690297
ko05140	Leishmaniasis	3/1266	75/7206	0.000653095800261
ko04915	Estrogen signaling pathway	38/1266	131/7206	0.00106910442339
ko05205	Proteoglycans in cancer	28/1266	271/7206	0.00107029043718
ko05161	Hepatitis B	15/1266	173/7206	0.00112663002854
ko04330	Notch signaling pathway	2/1266	62/7206	0.0011430123075
ko04626	Plant-pathogen interaction	9/1266	18/7206	0.00164560827216
ko05162	Measles	9/1266	120/7206	0.00227158478305
ko05321	Inflammatory bowel disease (IBD)	2/1266	56/7206	0.0024749175333
ko04270	Vascular smooth muscle contraction	42/1266	154/7206	0.00253254559789
ko00071	Fatty acid degradation	1/1266	45/7206	0.00274445703324
ko03420	Nucleotide excision repair	1/1266	46/7206	0.00280080940541
ko00480	Glutathione metabolism	2/1266	55/7206	0.00370903468084
ko03022	Basal transcription factors	1/1266	44/7206	0.00430748303916
ko04146	Peroxisome	6/1266	89/7206	0.00468237047336
ko00310	Lysine degradation	4/1266	73/7206	0.00471357408319
ko05166	HTLV-I infection	34/1266	292/7206	0.0058617644244
ko04622	RIG-I-like receptor signaling pathway	3/1266	62/7206	0.00635214465811
ko04657	IL-17 signaling pathway	6/1266	87/7206	0.00651710840589
ko05133	Pertussis	6/1266	87/7206	0.00651710840589
ko04922	Glucagon signaling pathway	35/1266	128/7206	0.00656982258727
ko04612	Antigen processing and presentation	5/1266	77/7206	0.00657100605659
ko04217	Necroptosis	18/1266	178/7206	0.00684834161472
ko00562	Inositol phosphate metabolism	26/1266	89/7206	0.00704455761657
ko04710	Circadian rhythm	15/1266	43/7206	0.00726628228822
ko00240	Pyrimidine metabolism	9/1266	110/7206	0.00754246997171
ko04630	Jak-STAT signaling pathway	12/1266	132/7206	0.00768788661561
ko05231	Choline metabolism in cancer	36/1266	134/7206	0.00791529295773
ko04912	GnRH signaling pathway	33/1266	122/7206	0.00800629085525
ko03018	RNA degradation	6/1266	84/7206	0.0089097814003
ko04916	Melanogenesis	37/1266	142/7206	0.0101094371411
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1266	100/7206	0.0111433860909
ko04930	Type II diabetes mellitus	17/1266	54/7206	0.0111756769069
ko05131	Shigellosis	6/1266	82/7206	0.0123001056881
ko04015	Rap1 signaling pathway	65/1266	278/7206	0.0124697480055
ko04214	Apoptosis - fly	5/1266	72/7206	0.0127035217403
ko04115	p53 signaling pathway	5/1266	74/7206	0.0129435828272
ko04658	Th1 and Th2 cell differentiation	8/1266	96/7206	0.0145265451804
ko05144	Malaria	2/1266	45/7206	0.0168997941239
ko05145	Toxoplasmosis	12/1266	126/7206	0.0174326153742
ko00280	Valine, leucine and isoleucine degradation	3/1266	54/7206	0.0181160866802
ko04978	Mineral absorption	13/1266	40/7206	0.0200693450013
ko04210	Apoptosis	20/1266	180/7206	0.0220091781145
ko01524	Platinum drug resistance	6/1266	76/7206	0.0226633410783
ko04620	Toll-like receptor signaling pathway	9/1266	100/7206	0.023581888465
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1266	14/7206	0.0242795433308
ko00380	Tryptophan metabolism	3/1266	50/7206	0.0254616788489
ko00590	Arachidonic acid metabolism	3/1266	52/7206	0.0260831997393
ko04932	Non-alcoholic fatty liver disease (NAFLD)	21/1266	182/7206	0.02972594948
ko04213	Longevity regulating pathway - multiple species	23/1266	86/7206	0.0316017867105
ko04918	Thyroid hormone synthesis	23/1266	86/7206	0.0316017867105
ko05222	Small cell lung cancer	8/1266	89/7206	0.0343899717056
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1266	40/7206	0.0354977711742
ko05219	Bladder cancer	3/1266	48/7206	0.0359073384176
ko04973	Carbohydrate digestion and absorption	13/1266	42/7206	0.0385502391749
ko05340	Primary immunodeficiency	1/1266	30/7206	0.0497273921835