ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 128/921 423/7206 1.13480626566e-22 ko04020 Calcium signaling pathway 82/921 265/7206 2.11283065625e-15 ko04724 Glutamatergic synapse 56/921 152/7206 1.94894217387e-14 ko04713 Circadian entrainment 51/921 136/7206 1.31247752915e-13 ko05033 Nicotine addiction 29/921 56/7206 1.94775570792e-12 ko05032 Morphine addiction 41/921 110/7206 4.32494256256e-11 ko04921 Oxytocin signaling pathway 62/921 209/7206 5.55399670638e-11 ko04727 GABAergic synapse 40/921 110/7206 1.80885394046e-10 ko04721 Synaptic vesicle cycle 32/921 80/7206 7.51492260036e-10 ko04728 Dopaminergic synapse 55/921 185/7206 7.68243936968e-10 ko04911 Insulin secretion 40/921 117/7206 1.52206169355e-09 ko04970 Salivary secretion 35/921 95/7206 1.68031296821e-09 ko04726 Serotonergic synapse 44/921 137/7206 2.19104041481e-09 ko04024 cAMP signaling pathway 70/921 279/7206 1.25162379828e-08 ko04022 cGMP-PKG signaling pathway 58/921 216/7206 1.78432197417e-08 ko04725 Cholinergic synapse 47/921 160/7206 2.17911789666e-08 ko04723 Retrograde endocannabinoid signaling 49/921 175/7206 5.37730814593e-08 ko04720 Long-term potentiation 32/921 99/7206 2.94121179717e-07 ko04261 Adrenergic signaling in cardiomyocytes 53/921 205/7206 3.31707585377e-07 ko05031 Amphetamine addiction 30/921 91/7206 4.2690920612e-07 ko03010 Ribosome 1/921 129/7206 7.23835941706e-07 ko03040 Spliceosome 2/921 145/7206 9.19366484395e-07 ko04072 Phospholipase D signaling pathway 50/921 197/7206 1.16512243123e-06 ko04070 Phosphatidylinositol signaling system 33/921 112/7206 2.24850744254e-06 ko03013 RNA transport 4/921 166/7206 3.04434793038e-06 ko04925 Aldosterone synthesis and secretion 31/921 105/7206 4.50172729425e-06 ko04971 Gastric acid secretion 29/921 98/7206 9.10007604347e-06 ko05322 Systemic lupus erythematosus 4/921 151/7206 1.97525594585e-05 ko05203 Viral carcinogenesis 14/921 277/7206 2.02294872883e-05 ko04014 Ras signaling pathway 61/921 279/7206 2.09281182953e-05 ko04710 Circadian rhythm 16/921 43/7206 4.05982478473e-05 ko05168 Herpes simplex infection 7/921 182/7206 6.44054816775e-05 ko04514 Cell adhesion molecules (CAMs) 33/921 130/7206 8.54109102705e-05 ko04730 Long-term depression 23/921 78/7206 9.26300026751e-05 ko04745 Phototransduction - fly 14/921 38/7206 0.000139010328399 ko04922 Glucagon signaling pathway 32/921 128/7206 0.00013919710023 ko04540 Gap junction 32/921 128/7206 0.00013919710023 ko04750 Inflammatory mediator regulation of TRP channels 31/921 122/7206 0.000159042832909 ko04110 Cell cycle 5/921 145/7206 0.00021031270109 ko04015 Rap1 signaling pathway 56/921 278/7206 0.000450785069155 ko04371 Apelin signaling pathway 39/921 177/7206 0.000541884687972 ko04360 Axon guidance 48/921 233/7206 0.00063512139968 ko04966 Collecting duct acid secretion 10/921 26/7206 0.000850882463026 ko04626 Plant-pathogen interaction 8/921 18/7206 0.000925471973878 ko04010 MAPK signaling pathway 61/921 321/7206 0.00110822413594 ko04744 Phototransduction 12/921 36/7206 0.00117074949869 ko04120 Ubiquitin mediated proteolysis 6/921 138/7206 0.00118071959428 ko04270 Vascular smooth muscle contraction 34/921 154/7206 0.00131570157547 ko05030 Cocaine addiction 19/921 73/7206 0.00211492229134 ko04972 Pancreatic secretion 26/921 111/7206 0.00221785170944 ko04964 Proximal tubule bicarbonate reclamation 10/921 29/7206 0.00224018331332 ko04924 Renin secretion 21/921 86/7206 0.0028943752068 ko05130 Pathogenic Escherichia coli infection 2/921 77/7206 0.00318212230546 ko05161 Hepatitis B 10/921 173/7206 0.00368051924279 ko05222 Small cell lung cancer 3/921 89/7206 0.00373765023196 ko04960 Aldosterone-regulated sodium reabsorption 12/921 41/7206 0.00403245331383 ko04621 NOD-like receptor signaling pathway 9/921 157/7206 0.00516603610308 ko05110 Vibrio cholerae infection 16/921 63/7206 0.00652289173243 ko05164 Influenza A 10/921 167/7206 0.00653692554456 ko04141 Protein processing in endoplasmic reticulum 12/921 184/7206 0.00715340006088 ko05169 Epstein-Barr virus infection 14/921 206/7206 0.00775207395407 ko00562 Inositol phosphate metabolism 20/921 89/7206 0.00983188627384 ko04742 Taste transduction 15/921 61/7206 0.0107053318716 ko03050 Proteasome 1/921 54/7206 0.0119817873161 ko05014 Amyotrophic lateral sclerosis (ALS) 17/921 74/7206 0.0133168258811 ko04260 Cardiac muscle contraction 21/921 98/7206 0.0142584990805 ko05016 Huntington's disease 16/921 215/7206 0.0165706141479 ko04711 Circadian rhythm - fly 5/921 13/7206 0.0179439387876 ko05205 Proteoglycans in cancer 22/921 271/7206 0.0199309244019 ko04930 Type II diabetes mellitus 13/921 54/7206 0.0217033616258 ko04657 IL-17 signaling pathway 4/921 87/7206 0.0219696761981 ko04217 Necroptosis 13/921 178/7206 0.0230243986411 ko04210 Apoptosis 13/921 180/7206 0.0231182734544 ko05323 Rheumatoid arthritis 19/921 89/7206 0.0236128143259 ko03420 Nucleotide excision repair 1/921 46/7206 0.0250227573154 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/921 14/7206 0.0250382148843 ko04550 Signaling pathways regulating pluripotency of stem cells 12/921 165/7206 0.0329273325837 ko00280 Valine, leucine and isoleucine degradation 2/921 54/7206 0.0405247701702 ko04620 Toll-like receptor signaling pathway 6/921 100/7206 0.0479405895425