ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	166/1015	423/7206	2.81218135607e-40
ko04724	Glutamatergic synapse	83/1015	152/7206	1.50966513497e-32
ko05033	Nicotine addiction	43/1015	56/7206	3.41003194069e-26
ko05032	Morphine addiction	60/1015	110/7206	9.78533341312e-24
ko04713	Circadian entrainment	67/1015	136/7206	4.83481033244e-23
ko04727	GABAergic synapse	59/1015	110/7206	7.43605552831e-23
ko04728	Dopaminergic synapse	78/1015	185/7206	2.74345706102e-21
ko04721	Synaptic vesicle cycle	47/1015	80/7206	1.13101847846e-20
ko04725	Cholinergic synapse	69/1015	160/7206	1.34285613553e-19
ko04723	Retrograde endocannabinoid signaling	71/1015	175/7206	2.4095403372e-18
ko04024	cAMP signaling pathway	91/1015	279/7206	8.79558377374e-16
ko04911	Insulin secretion	52/1015	117/7206	1.01390352514e-15
ko04726	Serotonergic synapse	55/1015	137/7206	3.10201156161e-14
ko04921	Oxytocin signaling pathway	72/1015	209/7206	4.86233612227e-14
ko04020	Calcium signaling pathway	83/1015	265/7206	2.06631686503e-13
ko04742	Taste transduction	32/1015	61/7206	1.31799003352e-12
ko04261	Adrenergic signaling in cardiomyocytes	66/1015	205/7206	1.63205024324e-11
ko05031	Amphetamine addiction	38/1015	91/7206	7.78290243122e-11
ko04744	Phototransduction	22/1015	36/7206	8.04517753912e-11
ko04970	Salivary secretion	39/1015	95/7206	8.15072143411e-11
ko04720	Long-term potentiation	39/1015	99/7206	3.55715341688e-10
ko03040	Spliceosome	1/1015	145/7206	9.02734583562e-09
ko04971	Gastric acid secretion	35/1015	98/7206	5.60727718125e-08
ko04925	Aldosterone synthesis and secretion	36/1015	105/7206	1.20218993635e-07
ko05203	Viral carcinogenesis	13/1015	277/7206	3.71911016893e-07
ko04060	Cytokine-cytokine receptor interaction	6/1015	191/7206	4.68170307565e-07
ko05168	Herpes simplex infection	6/1015	182/7206	1.41532397973e-06
ko04740	Olfactory transduction	28/1015	80/7206	1.9047987734e-06
ko04966	Collecting duct acid secretion	14/1015	26/7206	2.0480104283e-06
ko05164	Influenza A	5/1015	167/7206	2.44034394264e-06
ko05322	Systemic lupus erythematosus	4/1015	151/7206	2.64253754107e-06
ko05030	Cocaine addiction	26/1015	73/7206	3.0421249966e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1015	74/7206	4.07202603981e-06
ko04514	Cell adhesion molecules (CAMs)	38/1015	130/7206	5.51645290231e-06
ko04022	cGMP-PKG signaling pathway	55/1015	216/7206	6.1818218517e-06
ko04360	Axon guidance	58/1015	233/7206	8.2074161083e-06
ko04010	MAPK signaling pathway	74/1015	321/7206	1.12284183159e-05
ko03013	RNA transport	6/1015	166/7206	1.26338510486e-05
ko04120	Ubiquitin mediated proteolysis	4/1015	138/7206	1.78309077399e-05
ko04730	Long-term depression	26/1015	78/7206	1.89158811183e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1015	79/7206	2.15501978765e-05
ko04972	Pancreatic secretion	33/1015	111/7206	2.18382284755e-05
ko04745	Phototransduction - fly	16/1015	38/7206	2.24329783678e-05
ko04924	Renin secretion	27/1015	86/7206	3.05429249597e-05
ko04621	NOD-like receptor signaling pathway	6/1015	157/7206	3.65594889932e-05
ko04964	Proximal tubule bicarbonate reclamation	13/1015	29/7206	6.02242167972e-05
ko04976	Bile secretion	25/1015	80/7206	6.60504856593e-05
ko05110	Vibrio cholerae infection	21/1015	63/7206	8.28515908948e-05
ko04540	Gap junction	35/1015	128/7206	8.5956444881e-05
ko05414	Dilated cardiomyopathy	31/1015	112/7206	0.000158274898739
ko04260	Cardiac muscle contraction	28/1015	98/7206	0.000178959042814
ko04612	Antigen processing and presentation	1/1015	77/7206	0.000197340953818
ko04141	Protein processing in endoplasmic reticulum	10/1015	184/7206	0.000229755046784
ko04070	Phosphatidylinositol signaling system	30/1015	112/7206	0.0003189717276
ko05169	Epstein-Barr virus infection	13/1015	206/7206	0.0005119523576
ko05162	Measles	5/1015	120/7206	0.000774225353316
ko05161	Hepatitis B	10/1015	173/7206	0.000799379326892
ko04750	Inflammatory mediator regulation of TRP channels	31/1015	122/7206	0.000862223093182
ko03008	Ribosome biogenesis in eukaryotes	2/1015	79/7206	0.000953307342395
ko04014	Ras signaling pathway	59/1015	279/7206	0.00108645021533
ko05166	HTLV-I infection	23/1015	292/7206	0.00139441252248
ko04110	Cell cycle	8/1015	145/7206	0.00153882850109
ko04072	Phospholipase D signaling pathway	44/1015	197/7206	0.00167733281746
ko04626	Plant-pathogen interaction	8/1015	18/7206	0.00177452660613
ko04630	Jak-STAT signaling pathway	7/1015	132/7206	0.00216507455089
ko05205	Proteoglycans in cancer	22/1015	271/7206	0.00316104788174
ko04915	Estrogen signaling pathway	31/1015	131/7206	0.00319135358102
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1015	100/7206	0.00336009625247
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1015	59/7206	0.00375375496741
ko04371	Apelin signaling pathway	39/1015	177/7206	0.00413495882606
ko04146	Peroxisome	4/1015	89/7206	0.00538370509753
ko04640	Hematopoietic cell lineage	2/1015	64/7206	0.00630557064619
ko05140	Leishmaniasis	3/1015	75/7206	0.00713422986127
ko04064	NF-kappa B signaling pathway	5/1015	96/7206	0.00765450580439
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1015	14/7206	0.00841038615049
ko00330	Arginine and proline metabolism	2/1015	61/7206	0.00913845330135
ko00260	Glycine, serine and threonine metabolism	1/1015	48/7206	0.0109951846504
ko05215	Prostate cancer	7/1015	111/7206	0.0132275161515
ko04270	Vascular smooth muscle contraction	33/1015	154/7206	0.0132474629937
ko03022	Basal transcription factors	1/1015	44/7206	0.0161708373293
ko05144	Malaria	1/1015	45/7206	0.0162862494226
ko00071	Fatty acid degradation	1/1015	45/7206	0.0162862494226
ko03420	Nucleotide excision repair	1/1015	46/7206	0.0167941921827
ko04912	GnRH signaling pathway	27/1015	122/7206	0.0171320117555
ko00240	Pyrimidine metabolism	7/1015	110/7206	0.0179133988029
ko00480	Glutathione metabolism	2/1015	55/7206	0.0190318721222
ko05321	Inflammatory bowel disease (IBD)	2/1015	56/7206	0.0191553203198
ko04657	IL-17 signaling pathway	5/1015	87/7206	0.0197823089359
ko04916	Melanogenesis	30/1015	142/7206	0.0200062354423
ko04658	Th1 and Th2 cell differentiation	6/1015	96/7206	0.0255829440048
ko03018	RNA degradation	5/1015	84/7206	0.0269311853318
ko00590	Arachidonic acid metabolism	2/1015	52/7206	0.0273343552994
ko04115	p53 signaling pathway	4/1015	74/7206	0.0280853632788
ko00310	Lysine degradation	4/1015	73/7206	0.0280968619453
ko00280	Valine, leucine and isoleucine degradation	2/1015	54/7206	0.0281579604372
ko04217	Necroptosis	15/1015	178/7206	0.0284711371852
ko04923	Regulation of lipolysis in adipocytes	18/1015	77/7206	0.0301576541806
ko04350	TGF-beta signaling pathway	7/1015	103/7206	0.031458954875
ko00380	Tryptophan metabolism	2/1015	50/7206	0.0393592305167
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1015	182/7206	0.0396286928895
ko04550	Signaling pathways regulating pluripotency of stem cells	14/1015	165/7206	0.0406192364982
ko04973	Carbohydrate digestion and absorption	11/1015	42/7206	0.0406715149996
ko04330	Notch signaling pathway	3/1015	62/7206	0.0409667858558
ko04622	RIG-I-like receptor signaling pathway	3/1015	62/7206	0.0409667858558
ko04930	Type II diabetes mellitus	13/1015	54/7206	0.0468075064345
ko04114	Oocyte meiosis	28/1015	139/7206	0.0477760110638
ko05120	Epithelial cell signaling in Helicobacter pylori infection	20/1015	92/7206	0.0478905347715
ko04218	Cellular senescence	16/1015	177/7206	0.0491257463285
ko04210	Apoptosis	16/1015	180/7206	0.0498169264024