ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	204/1237	423/7206	7.70541045791e-53
ko04724	Glutamatergic synapse	85/1237	152/7206	7.88221704304e-28
ko05033	Nicotine addiction	46/1237	56/7206	1.85913231717e-26
ko04713	Circadian entrainment	75/1237	136/7206	3.77952309323e-24
ko05032	Morphine addiction	65/1237	110/7206	2.45574171581e-23
ko04020	Calcium signaling pathway	110/1237	265/7206	1.53079327962e-21
ko04727	GABAergic synapse	61/1237	110/7206	5.20488860123e-20
ko04728	Dopaminergic synapse	83/1237	185/7206	5.30141065942e-19
ko04721	Synaptic vesicle cycle	49/1237	80/7206	8.22367952935e-19
ko04725	Cholinergic synapse	72/1237	160/7206	1.027314019e-16
ko04911	Insulin secretion	58/1237	117/7206	4.60750297222e-16
ko04921	Oxytocin signaling pathway	85/1237	209/7206	5.14496295787e-16
ko04723	Retrograde endocannabinoid signaling	75/1237	175/7206	6.39719751957e-16
ko04024	cAMP signaling pathway	103/1237	279/7206	9.36960056332e-16
ko04726	Serotonergic synapse	60/1237	137/7206	1.75724299582e-13
ko04742	Taste transduction	35/1237	61/7206	1.30768343771e-12
ko05031	Amphetamine addiction	43/1237	91/7206	2.356009396e-11
ko04970	Salivary secretion	44/1237	95/7206	3.20189605606e-11
ko04261	Adrenergic signaling in cardiomyocytes	73/1237	205/7206	1.03769760652e-10
ko04720	Long-term potentiation	43/1237	99/7206	6.84231722735e-10
ko03010	Ribosome	1/1237	129/7206	9.3875717244e-10
ko03040	Spliceosome	2/1237	145/7206	9.65543421449e-10
ko04022	cGMP-PKG signaling pathway	73/1237	216/7206	1.96914475698e-09
ko05322	Systemic lupus erythematosus	4/1237	151/7206	2.33053343252e-08
ko04744	Phototransduction	21/1237	36/7206	2.9320806713e-08
ko05203	Viral carcinogenesis	18/1237	277/7206	1.45014177376e-07
ko04925	Aldosterone synthesis and secretion	40/1237	105/7206	2.71385526576e-07
ko04360	Axon guidance	71/1237	233/7206	3.45359729783e-07
ko04971	Gastric acid secretion	38/1237	98/7206	4.41240948485e-07
ko04070	Phosphatidylinositol signaling system	41/1237	112/7206	7.20652373279e-07
ko05168	Herpes simplex infection	9/1237	182/7206	7.45007194346e-07
ko03013	RNA transport	8/1237	166/7206	1.93900019706e-06
ko04730	Long-term depression	31/1237	78/7206	2.14307895712e-06
ko04060	Cytokine-cytokine receptor interaction	11/1237	191/7206	3.53994543357e-06
ko04740	Olfactory transduction	31/1237	80/7206	3.58470392603e-06
ko05164	Influenza A	9/1237	167/7206	6.19715993464e-06
ko04972	Pancreatic secretion	38/1237	111/7206	1.06731698621e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	30/1237	79/7206	1.32688974651e-05
ko05030	Cocaine addiction	28/1237	73/7206	1.33572849101e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1237	74/7206	1.75041437962e-05
ko04514	Cell adhesion molecules (CAMs)	42/1237	130/7206	1.86334641557e-05
ko04010	MAPK signaling pathway	85/1237	321/7206	1.94073041149e-05
ko04621	NOD-like receptor signaling pathway	9/1237	157/7206	2.45658910216e-05
ko04072	Phospholipase D signaling pathway	57/1237	197/7206	3.1689177292e-05
ko05414	Dilated cardiomyopathy	37/1237	112/7206	3.76248509326e-05
ko04110	Cell cycle	8/1237	145/7206	4.74507812791e-05
ko04745	Phototransduction - fly	17/1237	38/7206	6.68438721369e-05
ko04924	Renin secretion	30/1237	86/7206	6.70832984596e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1237	79/7206	7.16801000959e-05
ko04966	Collecting duct acid secretion	13/1237	26/7206	0.000120193533103
ko04540	Gap junction	39/1237	128/7206	0.000198120941435
ko04260	Cardiac muscle contraction	32/1237	98/7206	0.000200558335479
ko04141	Protein processing in endoplasmic reticulum	14/1237	184/7206	0.000218994493132
ko05161	Hepatitis B	13/1237	173/7206	0.000312115252384
ko05169	Epstein-Barr virus infection	17/1237	206/7206	0.000327327384335
ko04120	Ubiquitin mediated proteolysis	9/1237	138/7206	0.000351999268371
ko04750	Inflammatory mediator regulation of TRP channels	37/1237	122/7206	0.000364058907954
ko04930	Type II diabetes mellitus	20/1237	54/7206	0.000405133351493
ko04710	Circadian rhythm	17/1237	43/7206	0.000413859655895
ko04964	Proximal tubule bicarbonate reclamation	13/1237	29/7206	0.000471805910686
ko05110	Vibrio cholerae infection	22/1237	63/7206	0.000592396701658
ko04014	Ras signaling pathway	70/1237	279/7206	0.000633519686843
ko04612	Antigen processing and presentation	3/1237	77/7206	0.000673737151871
ko05140	Leishmaniasis	3/1237	75/7206	0.000992526548448
ko05410	Hypertrophic cardiomyopathy (HCM)	30/1237	100/7206	0.00125225935777
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1237	59/7206	0.00154086869999
ko04371	Apelin signaling pathway	47/1237	177/7206	0.00161697778481
ko04610	Complement and coagulation cascades	4/1237	79/7206	0.00232667484968
ko04976	Bile secretion	25/1237	80/7206	0.00241931101458
ko04657	IL-17 signaling pathway	5/1237	87/7206	0.00242809795228
ko04064	NF-kappa B signaling pathway	6/1237	96/7206	0.00247831897675
ko03420	Nucleotide excision repair	1/1237	46/7206	0.00280667267176
ko05162	Measles	9/1237	120/7206	0.00313820067889
ko04270	Vascular smooth muscle contraction	41/1237	154/7206	0.00327860219026
ko05321	Inflammatory bowel disease (IBD)	2/1237	56/7206	0.00375702760191
ko03022	Basal transcription factors	1/1237	44/7206	0.00424342117517
ko05144	Malaria	1/1237	45/7206	0.00439485567162
ko00071	Fatty acid degradation	1/1237	45/7206	0.00439485567162
ko00310	Lysine degradation	4/1237	73/7206	0.00464791336824
ko04630	Jak-STAT signaling pathway	11/1237	132/7206	0.0049114525174
ko00280	Valine, leucine and isoleucine degradation	2/1237	54/7206	0.00560223726162
ko04923	Regulation of lipolysis in adipocytes	23/1237	77/7206	0.00560350102943
ko04622	RIG-I-like receptor signaling pathway	3/1237	62/7206	0.00621598404922
ko04626	Plant-pathogen interaction	8/1237	18/7206	0.00635973089056
ko04922	Glucagon signaling pathway	34/1237	128/7206	0.00637558304855
ko04916	Melanogenesis	37/1237	142/7206	0.00672527208854
ko05145	Toxoplasmosis	11/1237	126/7206	0.00858693948302
ko05166	HTLV-I infection	34/1237	292/7206	0.00891503542463
ko05133	Pertussis	6/1237	87/7206	0.00923914928922
ko04915	Estrogen signaling pathway	34/1237	131/7206	0.00983078671011
ko00240	Pyrimidine metabolism	9/1237	110/7206	0.0102591042883
ko04960	Aldosterone-regulated sodium reabsorption	14/1237	41/7206	0.0105154363282
ko05205	Proteoglycans in cancer	31/1237	271/7206	0.0106563882198
ko04217	Necroptosis	18/1237	178/7206	0.0114336286062
ko05219	Bladder cancer	2/1237	48/7206	0.0117012044064
ko04115	p53 signaling pathway	5/1237	74/7206	0.0128763709592
ko03410	Base excision repair	1/1237	38/7206	0.0151212835151
ko04146	Peroxisome	7/1237	89/7206	0.0158659707009
ko05222	Small cell lung cancer	7/1237	89/7206	0.0158659707009
ko04210	Apoptosis	19/1237	180/7206	0.01598017998
ko04142	Lysosome	15/1237	151/7206	0.0160076740793
ko05131	Shigellosis	6/1237	82/7206	0.0172904700392
ko04214	Apoptosis - fly	5/1237	72/7206	0.0177796560409
ko04658	Th1 and Th2 cell differentiation	8/1237	96/7206	0.0197497417156
ko00860	Porphyrin and chlorophyll metabolism	1/1237	34/7206	0.0215697725694
ko05215	Prostate cancer	10/1237	111/7206	0.0216057997895
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1237	14/7206	0.021795458971
ko04973	Carbohydrate digestion and absorption	13/1237	42/7206	0.0236281414515
ko00590	Arachidonic acid metabolism	3/1237	52/7206	0.0257603873156
ko04330	Notch signaling pathway	4/1237	62/7206	0.0260733524521
ko03018	RNA degradation	7/1237	84/7206	0.0285906417371
ko05200	Pathways in cancer	67/1237	492/7206	0.0301432797524
ko04620	Toll-like receptor signaling pathway	9/1237	100/7206	0.0315081000157
ko00562	Inositol phosphate metabolism	23/1237	89/7206	0.0338199384979
ko04015	Rap1 signaling pathway	61/1237	278/7206	0.0348406845572
ko04140	Autophagy - animal	18/1237	164/7206	0.0355508828625
ko04912	GnRH signaling pathway	30/1237	122/7206	0.0384657313066
ko00230	Purine metabolism	44/1237	194/7206	0.0426700468729
ko05231	Choline metabolism in cancer	32/1237	134/7206	0.0482993635271
ko05340	Primary immunodeficiency	1/1237	30/7206	0.0488146411174