ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	200/1126	423/7206	3.74895908602e-57
ko04724	Glutamatergic synapse	89/1126	152/7206	1.84783614269e-34
ko05033	Nicotine addiction	49/1126	56/7206	9.75775011896e-33
ko05032	Morphine addiction	66/1126	110/7206	1.23558371111e-26
ko04713	Circadian entrainment	74/1126	136/7206	5.48022486022e-26
ko04727	GABAergic synapse	65/1126	110/7206	1.0362131014e-25
ko04728	Dopaminergic synapse	84/1126	185/7206	2.20520611926e-22
ko04721	Synaptic vesicle cycle	50/1126	80/7206	1.42766426144e-21
ko04725	Cholinergic synapse	74/1126	160/7206	2.04066252004e-20
ko04723	Retrograde endocannabinoid signaling	77/1126	175/7206	1.39689365477e-19
ko04024	cAMP signaling pathway	102/1126	279/7206	3.43976794704e-18
ko04020	Calcium signaling pathway	98/1126	265/7206	4.57209283102e-18
ko04921	Oxytocin signaling pathway	78/1126	209/7206	7.23750016953e-15
ko04911	Insulin secretion	53/1126	117/7206	1.75549381711e-14
ko04742	Taste transduction	35/1126	61/7206	7.36296344823e-14
ko04726	Serotonergic synapse	57/1126	137/7206	1.6473580157e-13
ko04261	Adrenergic signaling in cardiomyocytes	72/1126	205/7206	2.96665677292e-12
ko04744	Phototransduction	24/1126	36/7206	6.75339970424e-12
ko05031	Amphetamine addiction	41/1126	91/7206	2.11266627718e-11
ko04720	Long-term potentiation	43/1126	99/7206	3.03354386714e-11
ko04970	Salivary secretion	41/1126	95/7206	1.12107674304e-10
ko03040	Spliceosome	1/1126	145/7206	8.4445078717e-10
ko05203	Viral carcinogenesis	12/1126	277/7206	3.06421821244e-09
ko04360	Axon guidance	69/1126	233/7206	3.82390882757e-08
ko04022	cGMP-PKG signaling pathway	65/1126	216/7206	5.51154947714e-08
ko05030	Cocaine addiction	30/1126	73/7206	1.36864411253e-07
ko04060	Cytokine-cytokine receptor interaction	7/1126	191/7206	1.55656736633e-07
ko04925	Aldosterone synthesis and secretion	38/1126	105/7206	1.86064619002e-07
ko04740	Olfactory transduction	31/1126	80/7206	4.1053328088e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1126	74/7206	7.3410145655e-07
ko04971	Gastric acid secretion	35/1126	98/7206	8.04373989663e-07
ko05322	Systemic lupus erythematosus	5/1126	151/7206	2.05721863762e-06
ko05168	Herpes simplex infection	8/1126	182/7206	2.32821762481e-06
ko04070	Phosphatidylinositol signaling system	37/1126	112/7206	4.32640288343e-06
ko03013	RNA transport	7/1126	166/7206	6.28675427194e-06
ko04966	Collecting duct acid secretion	14/1126	26/7206	7.24443173596e-06
ko04141	Protein processing in endoplasmic reticulum	9/1126	184/7206	7.31822360862e-06
ko04010	MAPK signaling pathway	80/1126	321/7206	9.30854829462e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1126	79/7206	1.26438961925e-05
ko04621	NOD-like receptor signaling pathway	7/1126	157/7206	1.75981914856e-05
ko05164	Influenza A	8/1126	167/7206	1.94086033514e-05
ko04514	Cell adhesion molecules (CAMs)	39/1126	130/7206	2.66918628455e-05
ko04972	Pancreatic secretion	34/1126	111/7206	5.72471850643e-05
ko04260	Cardiac muscle contraction	31/1126	98/7206	6.13246362752e-05
ko05414	Dilated cardiomyopathy	34/1126	112/7206	6.66999492724e-05
ko04110	Cell cycle	7/1126	145/7206	6.97318860325e-05
ko04924	Renin secretion	28/1126	86/7206	7.35528262004e-05
ko04745	Phototransduction - fly	16/1126	38/7206	8.28753062228e-05
ko04072	Phospholipase D signaling pathway	52/1126	197/7206	8.70040884044e-05
ko04540	Gap junction	37/1126	128/7206	0.000112757418261
ko05110	Vibrio cholerae infection	22/1126	63/7206	0.000146125255111
ko05169	Epstein-Barr virus infection	14/1126	206/7206	0.000186547119098
ko04730	Long-term depression	25/1126	78/7206	0.000238559425384
ko04610	Complement and coagulation cascades	2/1126	79/7206	0.000267805383004
ko03008	Ribosome biogenesis in eukaryotes	2/1126	79/7206	0.000267805383004
ko04612	Antigen processing and presentation	2/1126	77/7206	0.000397568739523
ko04120	Ubiquitin mediated proteolysis	8/1126	138/7206	0.000537600183259
ko05140	Leishmaniasis	2/1126	75/7206	0.000597199984512
ko05205	Proteoglycans in cancer	23/1126	271/7206	0.000601693224948
ko04064	NF-kappa B signaling pathway	4/1126	96/7206	0.000606156208202
ko05161	Hepatitis B	12/1126	173/7206	0.000908254097156
ko04750	Inflammatory mediator regulation of TRP channels	33/1126	122/7206	0.000990401896129
ko04371	Apelin signaling pathway	44/1126	177/7206	0.00151426782232
ko04146	Peroxisome	4/1126	89/7206	0.00177022259225
ko04014	Ras signaling pathway	63/1126	279/7206	0.00178776131252
ko04915	Estrogen signaling pathway	34/1126	131/7206	0.00215848676776
ko04976	Bile secretion	23/1126	80/7206	0.0027685166141
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1126	14/7206	0.00278451462816
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1126	100/7206	0.0032261447627
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1126	59/7206	0.00344612878101
ko04626	Plant-pathogen interaction	8/1126	18/7206	0.00349748232136
ko04923	Regulation of lipolysis in adipocytes	22/1126	77/7206	0.00385778035986
ko00330	Arginine and proline metabolism	2/1126	61/7206	0.00403484752148
ko04330	Notch signaling pathway	2/1126	62/7206	0.00414093104317
ko05162	Measles	8/1126	120/7206	0.00486612991772
ko00240	Pyrimidine metabolism	7/1126	110/7206	0.00503912910399
ko05144	Malaria	1/1126	45/7206	0.00685274606078
ko00071	Fatty acid degradation	1/1126	45/7206	0.00685274606078
ko03420	Nucleotide excision repair	1/1126	46/7206	0.00691607211977
ko04657	IL-17 signaling pathway	5/1126	87/7206	0.00715484359012
ko04630	Jak-STAT signaling pathway	10/1126	132/7206	0.00754612646054
ko05166	HTLV-I infection	30/1126	292/7206	0.00840886725562
ko00480	Glutathione metabolism	2/1126	55/7206	0.00856801968263
ko05321	Inflammatory bowel disease (IBD)	2/1126	56/7206	0.00863886193334
ko04964	Proximal tubule bicarbonate reclamation	10/1126	29/7206	0.00974898446074
ko03018	RNA degradation	5/1126	84/7206	0.00991109859267
ko03022	Basal transcription factors	1/1126	44/7206	0.0105723063103
ko00562	Inositol phosphate metabolism	23/1126	89/7206	0.0117840275404
ko00590	Arachidonic acid metabolism	2/1126	52/7206	0.0124793498982
ko04622	RIG-I-like receptor signaling pathway	3/1126	62/7206	0.0135321234935
ko05131	Shigellosis	5/1126	82/7206	0.0136904482232
ko04214	Apoptosis - fly	4/1126	72/7206	0.0138454005341
ko00310	Lysine degradation	4/1126	73/7206	0.0139982359839
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1126	182/7206	0.0169932035272
ko00380	Tryptophan metabolism	2/1126	50/7206	0.0180386925395
ko04922	Glucagon signaling pathway	30/1126	128/7206	0.0190180992647
ko05418	Fluid shear stress and atherosclerosis	16/1126	173/7206	0.019177442294
ko04930	Type II diabetes mellitus	15/1126	54/7206	0.0219184632859
ko00630	Glyoxylate and dicarboxylate metabolism	1/1126	38/7206	0.0229380449342
ko05133	Pertussis	6/1126	87/7206	0.0245571784351
ko05215	Prostate cancer	9/1126	111/7206	0.0249080778793
ko01524	Platinum drug resistance	5/1126	76/7206	0.025669321087
ko00260	Glycine, serine and threonine metabolism	2/1126	48/7206	0.0262936680792
ko05219	Bladder cancer	2/1126	48/7206	0.0262936680792
ko05206	MicroRNAs in cancer	17/1126	177/7206	0.0270691402083
ko04350	TGF-beta signaling pathway	8/1126	103/7206	0.02767522022
ko04973	Carbohydrate digestion and absorption	12/1126	42/7206	0.030479844925
ko04912	GnRH signaling pathway	28/1126	122/7206	0.0317040889453
ko04114	Oocyte meiosis	31/1126	139/7206	0.0334806454585
ko00500	Starch and sucrose metabolism	1/1126	35/7206	0.0338887740881
ko05145	Toxoplasmosis	11/1126	126/7206	0.0343351470426
ko04918	Thyroid hormone synthesis	21/1126	86/7206	0.0348064751505
ko04115	p53 signaling pathway	5/1126	74/7206	0.0351412465714
ko04640	Hematopoietic cell lineage	4/1126	64/7206	0.0369780515931
ko04210	Apoptosis	18/1126	180/7206	0.0370182079798
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1126	92/7206	0.0413370506658
ko04015	Rap1 signaling pathway	56/1126	278/7206	0.0426909557169
ko04217	Necroptosis	18/1126	178/7206	0.0461970020725
ko04658	Th1 and Th2 cell differentiation	8/1126	96/7206	0.0472975016299
ko04113	Meiosis - yeast	5/1126	70/7206	0.0473571750194