ko pathway ratio_in_study ratio_in_pop p_value ko04621 NOD-like receptor signaling pathway 27/217 157/7206 9.27946756037e-14 ko05164 Influenza A 25/217 167/7206 2.00478769796e-11 ko04380 Osteoclast differentiation 22/217 134/7206 5.45062969265e-11 ko04060 Cytokine-cytokine receptor interaction 24/217 191/7206 2.09552145548e-09 ko04620 Toll-like receptor signaling pathway 17/217 100/7206 5.36144063692e-09 ko05162 Measles 18/217 120/7206 1.47233100343e-08 ko04660 T cell receptor signaling pathway 18/217 124/7206 2.49875086492e-08 ko05168 Herpes simplex infection 21/217 182/7206 1.02191334539e-07 ko05340 Primary immunodeficiency 9/217 30/7206 1.42433016245e-07 ko04622 RIG-I-like receptor signaling pathway 12/217 62/7206 2.34932411635e-07 ko04064 NF-kappa B signaling pathway 14/217 96/7206 8.92231280855e-07 ko05161 Hepatitis B 19/217 173/7206 9.23709171964e-07 ko05167 Kaposi's sarcoma-associated herpesvirus infection 20/217 191/7206 1.01489891167e-06 ko04650 Natural killer cell mediated cytotoxicity 14/217 97/7206 1.01528016607e-06 ko04217 Necroptosis 19/217 178/7206 1.43083998752e-06 ko04658 Th1 and Th2 cell differentiation 13/217 96/7206 5.18084683933e-06 ko05131 Shigellosis 12/217 82/7206 5.29586431327e-06 ko05133 Pertussis 12/217 87/7206 9.92841359608e-06 ko05160 Hepatitis C 16/217 153/7206 1.30085599071e-05 ko04668 TNF signaling pathway 14/217 120/7206 1.31616267883e-05 ko04623 Cytosolic DNA-sensing pathway 8/217 41/7206 2.40959692428e-05 ko04062 Chemokine signaling pathway 18/217 201/7206 3.17896740173e-05 ko05152 Tuberculosis 17/217 187/7206 4.37914919126e-05 ko04612 Antigen processing and presentation 10/217 77/7206 9.35802355829e-05 ko04210 Apoptosis 16/217 180/7206 9.65858281965e-05 ko05321 Inflammatory bowel disease (IBD) 8/217 56/7206 0.000242927107094 ko04662 B cell receptor signaling pathway 10/217 88/7206 0.00028851387904 ko05323 Rheumatoid arthritis 10/217 89/7206 0.000316626700123 ko04659 Th17 cell differentiation 11/217 106/7206 0.000322958319782 ko05140 Leishmaniasis 9/217 75/7206 0.000385371801978 ko05145 Toxoplasmosis 12/217 126/7206 0.000387905558894 ko04630 Jak-STAT signaling pathway 12/217 132/7206 0.000593365298434 ko05150 Staphylococcus aureus infection 6/217 36/7206 0.000636016888198 ko04672 Intestinal immune network for IgA production 6/217 37/7206 0.000740311452464 ko04666 Fc gamma R-mediated phagocytosis 11/217 122/7206 0.00107027100508 ko05134 Legionellosis 8/217 74/7206 0.00162095678574 ko05142 Chagas disease (American trypanosomiasis) 11/217 130/7206 0.00179673862201 ko05132 Salmonella infection 9/217 98/7206 0.00265836651291 ko05330 Allograft rejection 4/217 24/7206 0.00529176011978 ko05120 Epithelial cell signaling in Helicobacter pylori infection 8/217 92/7206 0.00631366587334 ko05166 HTLV-I infection 17/217 292/7206 0.00797781608346 ko05320 Autoimmune thyroid disease 4/217 29/7206 0.0105202275494 ko05034 Alcoholism 1/217 238/7206 0.0106141409182 ko05144 Malaria 5/217 45/7206 0.0108472218038 ko04215 Apoptosis - multiple species 5/217 47/7206 0.0129768959843 ko04657 IL-17 signaling pathway 7/217 87/7206 0.0155314544965 ko05332 Graft-versus-host disease 3/217 18/7206 0.0157341744921 ko04080 Neuroactive ligand-receptor interaction 5/217 423/7206 0.0183586010174 ko05016 Huntington's disease 1/217 215/7206 0.0227562112789 ko04664 Fc epsilon RI signaling pathway 6/217 77/7206 0.0280066006815 ko05100 Bacterial invasion of epithelial cells 7/217 99/7206 0.0293244467838 ko04145 Phagosome 10/217 162/7206 0.0308095162613 ko04610 Complement and coagulation cascades 6/217 79/7206 0.0312663029355 ko00140 Steroid hormone biosynthesis 4/217 41/7206 0.0339488531568 ko05169 Epstein-Barr virus infection 12/217 206/7206 0.0341545409329 ko00051 Fructose and mannose metabolism 4/217 42/7206 0.0366675708561 ko04917 Prolactin signaling pathway 6/217 87/7206 0.0467373128364 ko04390 Hippo signaling pathway 1/217 188/7206 0.0469393269578 ko04670 Leukocyte transendothelial migration 9/217 151/7206 0.0476776948829