ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	179/1003	423/7206	5.02130536808e-50
ko04724	Glutamatergic synapse	88/1003	152/7206	1.29867576999e-37
ko05033	Nicotine addiction	49/1003	56/7206	3.38695302964e-35
ko05032	Morphine addiction	66/1003	110/7206	1.11430670271e-29
ko04713	Circadian entrainment	73/1003	136/7206	2.047095927e-28
ko04727	GABAergic synapse	64/1003	110/7206	1.00328684501e-27
ko04728	Dopaminergic synapse	81/1003	185/7206	1.02112566941e-23
ko04725	Cholinergic synapse	72/1003	160/7206	4.85541601937e-22
ko04723	Retrograde endocannabinoid signaling	75/1003	175/7206	2.44371862833e-21
ko04024	cAMP signaling pathway	100/1003	279/7206	4.22472170652e-21
ko04911	Insulin secretion	56/1003	117/7206	6.21825722221e-19
ko04020	Calcium signaling pathway	91/1003	265/7206	9.97953929313e-18
ko04921	Oxytocin signaling pathway	75/1003	209/7206	4.50271166842e-16
ko04721	Synaptic vesicle cycle	41/1003	80/7206	1.64661679948e-15
ko04261	Adrenergic signaling in cardiomyocytes	73/1003	205/7206	1.82012602723e-15
ko05031	Amphetamine addiction	44/1003	91/7206	2.43089911112e-15
ko04726	Serotonergic synapse	56/1003	137/7206	4.15909138462e-15
ko04720	Long-term potentiation	44/1003	99/7206	1.10914914573e-13
ko05030	Cocaine addiction	35/1003	73/7206	2.49483472797e-12
ko04742	Taste transduction	31/1003	61/7206	6.47275957213e-12
ko04970	Salivary secretion	40/1003	95/7206	1.22422844593e-11
ko04744	Phototransduction	22/1003	36/7206	6.33646962153e-11
ko04971	Gastric acid secretion	39/1003	98/7206	1.7307191714e-10
ko04925	Aldosterone synthesis and secretion	40/1003	105/7206	4.82956893352e-10
ko04022	cGMP-PKG signaling pathway	62/1003	216/7206	9.84546973297e-09
ko04010	MAPK signaling pathway	82/1003	321/7206	1.33315847382e-08
ko03040	Spliceosome	1/1003	145/7206	1.47167508128e-08
ko04972	Pancreatic secretion	38/1003	111/7206	4.05814060488e-08
ko05203	Viral carcinogenesis	11/1003	277/7206	4.15285652954e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1003	74/7206	5.78677585409e-08
ko04060	Cytokine-cytokine receptor interaction	5/1003	191/7206	1.18678682954e-07
ko04360	Axon guidance	62/1003	233/7206	2.07130577147e-07
ko04072	Phospholipase D signaling pathway	53/1003	197/7206	1.04606729328e-06
ko05168	Herpes simplex infection	6/1003	182/7206	2.07646907778e-06
ko04730	Long-term depression	27/1003	78/7206	2.93305458046e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1003	79/7206	3.87547746769e-06
ko04740	Olfactory transduction	27/1003	80/7206	5.08784979394e-06
ko04915	Estrogen signaling pathway	37/1003	131/7206	1.65005613135e-05
ko04745	Phototransduction - fly	16/1003	38/7206	1.92596849638e-05
ko04260	Cardiac muscle contraction	30/1003	98/7206	2.07372426841e-05
ko04070	Phosphatidylinositol signaling system	33/1003	112/7206	2.16700150537e-05
ko05322	Systemic lupus erythematosus	5/1003	151/7206	2.24816782295e-05
ko04540	Gap junction	36/1003	128/7206	2.40552765368e-05
ko05414	Dilated cardiomyopathy	32/1003	112/7206	4.3847195836e-05
ko03013	RNA transport	7/1003	166/7206	5.7297677741e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1003	59/7206	7.87140383498e-05
ko04514	Cell adhesion molecules (CAMs)	35/1003	130/7206	9.02993064802e-05
ko04612	Antigen processing and presentation	1/1003	77/7206	0.000197571189563
ko04610	Complement and coagulation cascades	1/1003	79/7206	0.000209611852288
ko04924	Renin secretion	25/1003	86/7206	0.000219201069209
ko04350	TGF-beta signaling pathway	3/1003	103/7206	0.000274112770266
ko04750	Inflammatory mediator regulation of TRP channels	32/1003	122/7206	0.000288950902683
ko04141	Protein processing in endoplasmic reticulum	10/1003	184/7206	0.000320324906566
ko04110	Cell cycle	7/1003	145/7206	0.000596081148445
ko05164	Influenza A	9/1003	167/7206	0.000604285694514
ko00240	Pyrimidine metabolism	4/1003	110/7206	0.000698795887311
ko04120	Ubiquitin mediated proteolysis	7/1003	138/7206	0.00112973077801
ko04015	Rap1 signaling pathway	58/1003	278/7206	0.001369658121
ko03008	Ribosome biogenesis in eukaryotes	2/1003	79/7206	0.00148947440696
ko04621	NOD-like receptor signaling pathway	9/1003	157/7206	0.00150457916393
ko04976	Bile secretion	22/1003	80/7206	0.00158156401892
ko04146	Peroxisome	3/1003	89/7206	0.00173989988556
ko05169	Epstein-Barr virus infection	14/1003	206/7206	0.00201529159668
ko04932	Non-alcoholic fatty liver disease (NAFLD)	12/1003	182/7206	0.00228767532378
ko04960	Aldosterone-regulated sodium reabsorption	13/1003	41/7206	0.00274791198267
ko04916	Melanogenesis	33/1003	142/7206	0.0029643344655
ko05162	Measles	6/1003	120/7206	0.00304100967031
ko04912	GnRH signaling pathway	29/1003	122/7206	0.0033089959638
ko04014	Ras signaling pathway	56/1003	279/7206	0.00353567027163
ko04918	Thyroid hormone synthesis	22/1003	86/7206	0.00408981029334
ko04964	Proximal tubule bicarbonate reclamation	10/1003	29/7206	0.00424448924368
ko04923	Regulation of lipolysis in adipocytes	20/1003	77/7206	0.00435196666835
ko00480	Glutathione metabolism	1/1003	55/7206	0.00508823744138
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1003	100/7206	0.00552051232676
ko04371	Apelin signaling pathway	38/1003	177/7206	0.00564005837022
ko04114	Oocyte meiosis	31/1003	139/7206	0.00620301775348
ko04270	Vascular smooth muscle contraction	34/1003	154/7206	0.00632538772822
ko05034	Alcoholism	48/1003	238/7206	0.00735670860252
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1003	14/7206	0.00792959896307
ko04930	Type II diabetes mellitus	15/1003	54/7206	0.00845199718949
ko04640	Hematopoietic cell lineage	2/1003	64/7206	0.00962313648503
ko03018	RNA degradation	4/1003	84/7206	0.010608129724
ko04064	NF-kappa B signaling pathway	5/1003	96/7206	0.0107496632893
ko00260	Glycine, serine and threonine metabolism	1/1003	48/7206	0.0109786224845
ko04973	Carbohydrate digestion and absorption	12/1003	42/7206	0.0117049842942
ko05205	Proteoglycans in cancer	24/1003	271/7206	0.0121312889514
ko00562	Inositol phosphate metabolism	21/1003	89/7206	0.0127682208515
ko00330	Arginine and proline metabolism	2/1003	61/7206	0.013883013556
ko04630	Jak-STAT signaling pathway	9/1003	132/7206	0.0153031623088
ko05110	Vibrio cholerae infection	16/1003	63/7206	0.0155179446236
ko00071	Fatty acid degradation	1/1003	45/7206	0.0162740730779
ko00620	Pyruvate metabolism	1/1003	46/7206	0.016569972475
ko03420	Nucleotide excision repair	1/1003	46/7206	0.016569972475
ko04142	Lysosome	11/1003	151/7206	0.016774831117
ko04062	Chemokine signaling pathway	40/1003	201/7206	0.0170583786116
ko05321	Inflammatory bowel disease (IBD)	2/1003	56/7206	0.0191432134664
ko04722	Neurotrophin signaling pathway	33/1003	160/7206	0.0200767352963
ko04966	Collecting duct acid secretion	8/1003	26/7206	0.021112156549
ko04071	Sphingolipid signaling pathway	33/1003	162/7206	0.0212038384697
ko05161	Hepatitis B	14/1003	173/7206	0.0254845684755
ko05016	Huntington's disease	19/1003	215/7206	0.0275037698805
ko04115	p53 signaling pathway	4/1003	74/7206	0.0282169267783
ko05140	Leishmaniasis	4/1003	75/7206	0.0282483965021
ko04210	Apoptosis	15/1003	180/7206	0.0285763866351
ko04626	Plant-pathogen interaction	6/1003	18/7206	0.0300294813952
ko05214	Glioma	18/1003	79/7206	0.0318166743652
ko04012	ErbB signaling pathway	23/1003	109/7206	0.035776572088
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1003	40/7206	0.0361202957906
ko04217	Necroptosis	15/1003	178/7206	0.0363231964585
ko04137	Mitophagy - animal	5/1003	82/7206	0.0366690823894
ko04214	Apoptosis - fly	4/1003	72/7206	0.0388333192156
ko04922	Glucagon signaling pathway	26/1003	128/7206	0.0393463616535
ko00310	Lysine degradation	4/1003	73/7206	0.0393692320202
ko04550	Signaling pathways regulating pluripotency of stem cells	14/1003	165/7206	0.0403471709344
ko04622	RIG-I-like receptor signaling pathway	3/1003	62/7206	0.040433259007
ko05231	Choline metabolism in cancer	27/1003	134/7206	0.0430350179626
ko05222	Small cell lung cancer	6/1003	89/7206	0.0456231501268
ko04666	Fc gamma R-mediated phagocytosis	25/1003	122/7206	0.0463983366056
ko05010	Alzheimer's disease	38/1003	202/7206	0.0494542653408