ko pathway ratio_in_study ratio_in_pop p_value ko03010 Ribosome 90/802 129/7206 4.14187002194e-57 ko03040 Spliceosome 85/802 145/7206 9.02885478114e-45 ko03013 RNA transport 84/802 166/7206 1.43999783537e-37 ko03008 Ribosome biogenesis in eukaryotes 52/802 79/7206 3.13863567957e-31 ko03050 Proteasome 35/802 54/7206 4.93618490894e-21 ko03030 DNA replication 28/802 38/7206 2.06231246848e-19 ko03020 RNA polymerase 23/802 29/7206 2.17178100339e-17 ko00240 Pyrimidine metabolism 45/802 110/7206 5.278429012e-16 ko04110 Cell cycle 48/802 145/7206 7.90586657246e-13 ko04020 Calcium signaling pathway 1/802 265/7206 9.1698390996e-13 ko04111 Cell cycle - yeast 33/802 90/7206 1.51281984781e-10 ko03430 Mismatch repair 15/802 22/7206 3.54325677657e-10 ko04024 cAMP signaling pathway 5/802 279/7206 2.54936430027e-09 ko05169 Epstein-Barr virus infection 53/802 206/7206 2.72779590488e-09 ko03420 Nucleotide excision repair 21/802 46/7206 3.37424212205e-09 ko04060 Cytokine-cytokine receptor interaction 1/802 191/7206 6.40957338261e-09 ko03015 mRNA surveillance pathway 31/802 93/7206 8.0196740064e-09 ko00230 Purine metabolism 50/802 194/7206 8.10752400387e-09 ko04010 MAPK signaling pathway 8/802 321/7206 9.23677095592e-09 ko04810 Regulation of actin cytoskeleton 6/802 264/7206 7.22057461182e-08 ko03060 Protein export 13/802 23/7206 1.44362250475e-07 ko04725 Cholinergic synapse 1/802 160/7206 1.66332022632e-07 ko04144 Endocytosis 12/802 342/7206 3.5028089008e-07 ko04360 Axon guidance 5/802 233/7206 3.65297952038e-07 ko04015 Rap1 signaling pathway 8/802 278/7206 4.59608994298e-07 ko04723 Retrograde endocannabinoid signaling 2/802 175/7206 5.31915819655e-07 ko04724 Glutamatergic synapse 1/802 152/7206 6.01203511419e-07 ko04261 Adrenergic signaling in cardiomyocytes 4/802 205/7206 8.01783597353e-07 ko04113 Meiosis - yeast 23/802 70/7206 9.22056664449e-07 ko03410 Base excision repair 16/802 38/7206 9.97123133748e-07 ko05010 Alzheimer's disease 4/802 202/7206 1.16790699068e-06 ko04014 Ras signaling pathway 9/802 279/7206 1.46468884394e-06 ko04022 cGMP-PKG signaling pathway 5/802 216/7206 1.54660337388e-06 ko03018 RNA degradation 25/802 84/7206 2.48253191931e-06 ko04713 Circadian entrainment 1/802 136/7206 2.90797130661e-06 ko04726 Serotonergic synapse 1/802 137/7206 2.97748802245e-06 ko04510 Focal adhesion 7/802 240/7206 3.24690057926e-06 ko05012 Parkinson's disease 2/802 155/7206 3.59517003723e-06 ko04380 Osteoclast differentiation 1/802 134/7206 4.57151825311e-06 ko04062 Chemokine signaling pathway 5/802 201/7206 6.63874688755e-06 ko04514 Cell adhesion molecules (CAMs) 1/802 130/7206 6.73608582702e-06 ko03440 Homologous recombination 15/802 41/7206 1.70678631772e-05 ko04668 TNF signaling pathway 1/802 120/7206 2.33545898451e-05 ko05200 Pathways in cancer 28/802 492/7206 2.82318324591e-05 ko04151 PI3K-Akt signaling pathway 20/802 390/7206 3.10411792688e-05 ko04630 Jak-STAT signaling pathway 2/802 132/7206 3.70387146984e-05 ko04728 Dopaminergic synapse 5/802 185/7206 4.12119584139e-05 ko04072 Phospholipase D signaling pathway 6/802 197/7206 4.57962181345e-05 ko04727 GABAergic synapse 1/802 110/7206 4.89159228529e-05 ko05032 Morphine addiction 1/802 110/7206 4.89159228529e-05 ko04915 Estrogen signaling pathway 2/802 131/7206 5.67677459e-05 ko04921 Oxytocin signaling pathway 7/802 209/7206 7.32404407789e-05 ko04371 Apelin signaling pathway 5/802 177/7206 8.20011440128e-05 ko04540 Gap junction 2/802 128/7206 8.56170742871e-05 ko04925 Aldosterone synthesis and secretion 1/802 105/7206 0.000112843024646 ko04916 Melanogenesis 3/802 142/7206 0.000115515240053 ko04912 GnRH signaling pathway 2/802 122/7206 0.000117520127068 ko04620 Toll-like receptor signaling pathway 1/802 100/7206 0.000162718566747 ko00970 Aminoacyl-tRNA biosynthesis 14/802 44/7206 0.000186777490874 ko04670 Leukocyte transendothelial migration 4/802 151/7206 0.00019818604539 ko05231 Choline metabolism in cancer 3/802 134/7206 0.000236117084191 ko04650 Natural killer cell mediated cytotoxicity 1/802 97/7206 0.000244604353798 ko04611 Platelet activation 5/802 163/7206 0.000335718705697 ko05142 Chagas disease (American trypanosomiasis) 3/802 130/7206 0.000337547895591 ko04070 Phosphatidylinositol signaling system 2/802 112/7206 0.000373701917943 ko04530 Tight junction 10/802 228/7206 0.000375824282746 ko04621 NOD-like receptor signaling pathway 5/802 157/7206 0.000450505262448 ko04920 Adipocytokine signaling pathway 1/802 89/7206 0.000534912064145 ko04270 Vascular smooth muscle contraction 5/802 154/7206 0.000638018100712 ko04750 Inflammatory mediator regulation of TRP channels 3/802 122/7206 0.000689063118808 ko04918 Thyroid hormone synthesis 1/802 86/7206 0.000800126231539 ko04659 Th17 cell differentiation 2/802 106/7206 0.000828146479084 ko03460 Fanconi anemia pathway 14/802 51/7206 0.00100028559136 ko05230 Central carbon metabolism in cancer 1/802 81/7206 0.00117771716401 ko04623 Cytosolic DNA-sensing pathway 12/802 41/7206 0.0012303203126 ko05211 Renal cell carcinoma 2/802 96/7206 0.0016451938629 ko04512 ECM-receptor interaction 1/802 79/7206 0.0017658173659 ko04932 Non-alcoholic fatty liver disease (NAFLD) 8/802 182/7206 0.00177372331867 ko04721 Synaptic vesicle cycle 1/802 80/7206 0.00181842662243 ko04972 Pancreatic secretion 3/802 111/7206 0.00201532389757 ko04660 T cell receptor signaling pathway 4/802 124/7206 0.00223872731671 ko05145 Toxoplasmosis 4/802 126/7206 0.00230674396203 ko04931 Insulin resistance 5/802 137/7206 0.00237922349511 ko05120 Epithelial cell signaling in Helicobacter pylori infection 2/802 92/7206 0.00238182675709 ko04068 FoxO signaling pathway 7/802 167/7206 0.00250931017662 ko05140 Leishmaniasis 1/802 75/7206 0.00259523523789 ko04664 Fc epsilon RI signaling pathway 1/802 77/7206 0.00275981315999 ko04666 Fc gamma R-mediated phagocytosis 4/802 122/7206 0.00321435981818 ko04933 AGE-RAGE signaling pathway in diabetic complications 5/802 135/7206 0.00333142063642 ko00562 Inositol phosphate metabolism 2/802 89/7206 0.00345270767825 ko00670 One carbon pool by folate 7/802 20/7206 0.00433562472498 ko04917 Prolactin signaling pathway 2/802 87/7206 0.00514616206583 ko05133 Pertussis 2/802 87/7206 0.00514616206583 ko04720 Long-term potentiation 3/802 99/7206 0.00571288858659 ko00564 Glycerophospholipid metabolism 3/802 99/7206 0.00571288858659 ko03320 PPAR signaling pathway 1/802 69/7206 0.00583478299759 ko04141 Protein processing in endoplasmic reticulum 33/802 184/7206 0.00583954221836 ko04922 Glucagon signaling pathway 5/802 128/7206 0.00639240270939 ko05167 Kaposi's sarcoma-associated herpesvirus infection 10/802 191/7206 0.00689166395455 ko03022 Basal transcription factors 11/802 44/7206 0.0073713378841 ko04658 Th1 and Th2 cell differentiation 3/802 96/7206 0.00812058054998 ko04913 Ovarian steroidogenesis 1/802 63/7206 0.00828543728089 ko04012 ErbB signaling pathway 4/802 109/7206 0.00850408756261 ko04976 Bile secretion 2/802 80/7206 0.0107498015973 ko05031 Amphetamine addiction 3/802 91/7206 0.0113280971366 ko01212 Fatty acid metabolism 1/802 60/7206 0.0122107370047 ko04622 RIG-I-like receptor signaling pathway 1/802 62/7206 0.0127588803477 ko05205 Proteoglycans in cancer 18/802 271/7206 0.0137584397424 ko04919 Thyroid hormone signaling pathway 7/802 143/7206 0.0147793981319 ko04217 Necroptosis 10/802 178/7206 0.0153208160097 ko01200 Carbon metabolism 6/802 128/7206 0.0154144084254 ko04657 IL-17 signaling pathway 3/802 87/7206 0.0158877919452 ko04391 Hippo signaling pathway - fly 3/802 90/7206 0.0165118815266 ko05152 Tuberculosis 11/802 187/7206 0.0180661259344 ko04390 Hippo signaling pathway 11/802 188/7206 0.018146583498 ko05160 Hepatitis C 8/802 153/7206 0.0183815820514 ko04962 Vasopressin-regulated water reabsorption 1/802 58/7206 0.0185120899789 ko04722 Neurotrophin signaling pathway 9/802 160/7206 0.0217818473981 ko05132 Salmonella infection 4/802 98/7206 0.0224183343502 ko00280 Valine, leucine and isoleucine degradation 1/802 54/7206 0.0268716135115 ko05034 Alcoholism 16/802 238/7206 0.0272339102913 ko04066 HIF-1 signaling pathway 6/802 123/7206 0.0284872181272 ko04064 NF-kappa B signaling pathway 4/802 96/7206 0.0315629004252 ko04550 Signaling pathways regulating pluripotency of stem cells 10/802 165/7206 0.0331294874681 ko04712 Circadian rhythm - plant 3/802 7/7206 0.034087457331 ko04520 Adherens junction 5/802 103/7206 0.0394724431013 ko04146 Peroxisome 4/802 89/7206 0.0416284122082 ko05323 Rheumatoid arthritis 4/802 89/7206 0.0416284122082 ko05168 Herpes simplex infection 29/802 182/7206 0.0421255554202 ko04071 Sphingolipid signaling pathway 10/802 162/7206 0.0425581720964 ko04145 Phagosome 10/802 162/7206 0.0425581720964 ko04370 VEGF signaling pathway 3/802 77/7206 0.043177718298 ko04142 Lysosome 9/802 151/7206 0.0482747711956 ko04013 MAPK signaling pathway - fly 6/802 115/7206 0.0499418364136