ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 38/342 191/7206 1.71725267877e-14 ko04380 Osteoclast differentiation 31/342 134/7206 7.02231386954e-14 ko04650 Natural killer cell mediated cytotoxicity 24/342 97/7206 1.12206077965e-11 ko05340 Primary immunodeficiency 13/342 30/7206 2.85036803199e-10 ko04621 NOD-like receptor signaling pathway 28/342 157/7206 8.42625946433e-10 ko05152 Tuberculosis 30/342 187/7206 2.88894719613e-09 ko05140 Leishmaniasis 18/342 75/7206 7.68784845449e-09 ko04064 NF-kappa B signaling pathway 20/342 96/7206 1.53577722614e-08 ko05164 Influenza A 27/342 167/7206 1.56364981783e-08 ko05150 Staphylococcus aureus infection 12/342 36/7206 4.81398465297e-08 ko05145 Toxoplasmosis 22/342 126/7206 8.60537848044e-08 ko04660 T cell receptor signaling pathway 21/342 124/7206 2.9176618788e-07 ko04610 Complement and coagulation cascades 16/342 79/7206 6.54511492265e-07 ko05162 Measles 20/342 120/7206 7.34183134059e-07 ko04620 Toll-like receptor signaling pathway 18/342 100/7206 8.29011547355e-07 ko04630 Jak-STAT signaling pathway 21/342 132/7206 8.58088593624e-07 ko05321 Inflammatory bowel disease (IBD) 13/342 56/7206 1.46128780062e-06 ko05144 Malaria 11/342 45/7206 5.5572084776e-06 ko04672 Intestinal immune network for IgA production 10/342 37/7206 5.61881320657e-06 ko04659 Th17 cell differentiation 17/342 106/7206 8.63775292073e-06 ko04658 Th1 and Th2 cell differentiation 16/342 96/7206 9.60439390819e-06 ko05133 Pertussis 15/342 87/7206 1.19516917914e-05 ko05168 Herpes simplex infection 23/342 182/7206 1.47511772208e-05 ko05323 Rheumatoid arthritis 15/342 89/7206 1.58904527591e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 23/342 191/7206 3.24504185675e-05 ko04640 Hematopoietic cell lineage 12/342 64/7206 3.79059535868e-05 ko04662 B cell receptor signaling pathway 14/342 88/7206 5.92289948047e-05 ko04145 Phagosome 20/342 162/7206 7.48517662839e-05 ko04611 Platelet activation 20/342 163/7206 8.16837971592e-05 ko05330 Allograft rejection 7/342 24/7206 8.75988546133e-05 ko04217 Necroptosis 21/342 178/7206 9.66348453386e-05 ko05034 Alcoholism 1/342 238/7206 0.000246949982415 ko04062 Chemokine signaling pathway 22/342 201/7206 0.000250277059303 ko05320 Autoimmune thyroid disease 7/342 29/7206 0.000321676097426 ko04670 Leukocyte transendothelial migration 17/342 151/7206 0.000764864435065 ko05310 Asthma 5/342 17/7206 0.000901556943797 ko04612 Antigen processing and presentation 11/342 77/7206 0.000936732572785 ko04664 Fc epsilon RI signaling pathway 11/342 77/7206 0.000936732572785 ko05142 Chagas disease (American trypanosomiasis) 15/342 130/7206 0.00119968524244 ko05332 Graft-versus-host disease 5/342 18/7206 0.00120026784661 ko04666 Fc gamma R-mediated phagocytosis 14/342 122/7206 0.00182646381661 ko05132 Salmonella infection 12/342 98/7206 0.00219819128695 ko04310 Wnt signaling pathway 1/342 181/7206 0.00228710119775 ko04728 Dopaminergic synapse 1/342 185/7206 0.00233515796927 ko04623 Cytosolic DNA-sensing pathway 7/342 41/7206 0.00283847726327 ko05224 Breast cancer 1/342 174/7206 0.00334204191359 ko04723 Retrograde endocannabinoid signaling 1/342 175/7206 0.00335827164852 ko05418 Fluid shear stress and atherosclerosis 17/342 173/7206 0.00534792442477 ko05161 Hepatitis B 17/342 173/7206 0.00534792442477 ko04142 Lysosome 15/342 151/7206 0.0057952808574 ko00982 Drug metabolism - cytochrome P450 6/342 37/7206 0.00730193852199 ko04622 RIG-I-like receptor signaling pathway 8/342 62/7206 0.0085285271404 ko04146 Peroxisome 10/342 89/7206 0.00917851268584 ko04514 Cell adhesion molecules (CAMs) 13/342 130/7206 0.0102067183351 ko05020 Prion diseases 6/342 40/7206 0.0107034463277 ko00590 Arachidonic acid metabolism 7/342 52/7206 0.0108220528779 ko00592 alpha-Linolenic acid metabolism 4/342 19/7206 0.0109630683578 ko00120 Primary bile acid biosynthesis 4/342 20/7206 0.013201774991 ko05016 Huntington's disease 3/342 215/7206 0.0136209531931 ko05416 Viral myocarditis 7/342 55/7206 0.0145487649342 ko04114 Oocyte meiosis 1/342 139/7206 0.0148090946384 ko05131 Shigellosis 9/342 82/7206 0.0151783661338 ko04110 Cell cycle 1/342 145/7206 0.0154727329166 ko04940 Type I diabetes mellitus 5/342 32/7206 0.0163694312281 ko04915 Estrogen signaling pathway 1/342 131/7206 0.0214056493062 ko04713 Circadian entrainment 1/342 136/7206 0.0221741909333 ko05134 Legionellosis 8/342 74/7206 0.0233238368656 ko04550 Signaling pathways regulating pluripotency of stem cells 2/342 165/7206 0.0247945570582 ko04144 Endocytosis 25/342 342/7206 0.0267328628208 ko04210 Apoptosis 15/342 180/7206 0.0310946178276 ko04540 Gap junction 1/342 128/7206 0.032132417117 ko00511 Other glycan degradation 4/342 26/7206 0.032609639269 ko04080 Neuroactive ligand-receptor interaction 11/342 423/7206 0.0329449309909 ko04512 ECM-receptor interaction 8/342 79/7206 0.0329818626471 ko05160 Hepatitis C 13/342 153/7206 0.0342690293213 ko05012 Parkinson's disease 2/342 155/7206 0.0346649866399 ko04390 Hippo signaling pathway 3/342 188/7206 0.0357067162072 ko04152 AMPK signaling pathway 2/342 161/7206 0.035968340131 ko00980 Metabolism of xenobiotics by cytochrome P450 5/342 40/7206 0.0393734090146 ko00480 Glutathione metabolism 6/342 55/7206 0.0448523151239 ko00051 Fructose and mannose metabolism 5/342 42/7206 0.0471752259513 ko00966 Glucosinolate biosynthesis 1/342 1/7206 0.0474604496254 ko05206 MicroRNAs in cancer 3/342 177/7206 0.0487620857381 ko05166 HTLV-I infection 21/342 292/7206 0.0492643353095