ko pathway ratio_in_study ratio_in_pop p_value ko04550 Signaling pathways regulating pluripotency of stem cells 46/635 165/7206 4.96739575098e-13 ko05217 Basal cell carcinoma 28/635 68/7206 5.50988971093e-13 ko03030 DNA replication 20/635 38/7206 4.40178951272e-12 ko03040 Spliceosome 35/635 145/7206 2.1105590542e-08 ko04110 Cell cycle 35/635 145/7206 2.1105590542e-08 ko04340 Hedgehog signaling pathway 20/635 58/7206 4.4422427943e-08 ko05224 Breast cancer 38/635 174/7206 9.33317155829e-08 ko04111 Cell cycle - yeast 25/635 90/7206 1.25423639596e-07 ko04310 Wnt signaling pathway 39/635 181/7206 1.37347909579e-07 ko04330 Notch signaling pathway 20/635 62/7206 1.57800854429e-07 ko04390 Hippo signaling pathway 39/635 188/7206 2.90173328606e-07 ko04932 Non-alcoholic fatty liver disease (NAFLD) 1/635 182/7206 1.69747057971e-06 ko03410 Base excision repair 14/635 38/7206 1.93476780446e-06 ko04080 Neuroactive ligand-receptor interaction 13/635 423/7206 2.14916871433e-06 ko04950 Maturity onset diabetes of the young 12/635 29/7206 2.52169188436e-06 ko04144 Endocytosis 9/635 342/7206 3.43325237614e-06 ko04360 Axon guidance 41/635 233/7206 1.58368363408e-05 ko04724 Glutamatergic synapse 1/635 152/7206 1.77657141812e-05 ko05012 Parkinson's disease 1/635 155/7206 1.86109187958e-05 ko05010 Alzheimer's disease 3/635 202/7206 2.15017313877e-05 ko04072 Phospholipase D signaling pathway 3/635 197/7206 3.08007575971e-05 ko05202 Transcriptional misregulation in cancer 33/635 188/7206 0.000114314655795 ko03010 Ribosome 1/635 129/7206 0.000128403454037 ko04723 Retrograde endocannabinoid signaling 3/635 175/7206 0.000129098767322 ko05200 Pathways in cancer 68/635 492/7206 0.000136210826332 ko04921 Oxytocin signaling pathway 5/635 209/7206 0.000265792295482 ko04113 Meiosis - yeast 16/635 70/7206 0.000296046170263 ko04062 Chemokine signaling pathway 5/635 201/7206 0.000364845864553 ko04725 Cholinergic synapse 3/635 160/7206 0.000562632836912 ko03015 mRNA surveillance pathway 19/635 93/7206 0.000569004434442 ko04020 Calcium signaling pathway 9/635 265/7206 0.000578605754421 ko04726 Serotonergic synapse 2/635 137/7206 0.000628878299208 ko05166 HTLV-I infection 43/635 292/7206 0.000675986564397 ko04727 GABAergic synapse 1/635 110/7206 0.000946166081313 ko05032 Morphine addiction 1/635 110/7206 0.000946166081313 ko05205 Proteoglycans in cancer 40/635 271/7206 0.000970749811971 ko00190 Oxidative phosphorylation 2/635 127/7206 0.00129506063592 ko04141 Protein processing in endoplasmic reticulum 5/635 184/7206 0.00138241681955 ko03420 Nucleotide excision repair 11/635 46/7206 0.00173772458253 ko04971 Gastric acid secretion 1/635 98/7206 0.00195594035612 ko04022 cGMP-PKG signaling pathway 7/635 216/7206 0.00205109946762 ko04060 Cytokine-cytokine receptor interaction 6/635 191/7206 0.00269711879969 ko04650 Natural killer cell mediated cytotoxicity 1/635 97/7206 0.00306876382325 ko04915 Estrogen signaling pathway 3/635 131/7206 0.00450365623614 ko04391 Hippo signaling pathway - fly 16/635 90/7206 0.00719162519687 ko04925 Aldosterone synthesis and secretion 2/635 105/7206 0.00806816688061 ko04610 Complement and coagulation cascades 1/635 79/7206 0.00905357723903 ko04211 Longevity regulating pathway 3/635 123/7206 0.00910596379614 ko04138 Autophagy - yeast 1/635 81/7206 0.00912301114381 ko04713 Circadian entrainment 4/635 136/7206 0.00922390233868 ko04270 Vascular smooth muscle contraction 5/635 154/7206 0.00930304230348 ko04621 NOD-like receptor signaling pathway 5/635 157/7206 0.00952918273884 ko05206 MicroRNAs in cancer 26/635 177/7206 0.00990070153123 ko04916 Melanogenesis 22/635 142/7206 0.00991849245712 ko03430 Mismatch repair 6/635 22/7206 0.0100047319534 ko05100 Bacterial invasion of epithelial cells 2/635 99/7206 0.0112460985986 ko04350 TGF-beta signaling pathway 17/635 103/7206 0.0124376458822 ko05231 Choline metabolism in cancer 4/635 134/7206 0.0128326310628 ko05222 Small cell lung cancer 15/635 89/7206 0.012875120856 ko04139 Mitophagy - yeast 8/635 37/7206 0.0135078339987 ko04341 Hedgehog signaling pathway - fly 8/635 38/7206 0.0158296161027 ko04972 Pancreatic secretion 3/635 111/7206 0.0171372828165 ko04070 Phosphatidylinositol signaling system 3/635 112/7206 0.0172908932889 ko04712 Circadian rhythm - plant 3/635 7/7206 0.0181983466243 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 6/635 26/7206 0.0228433737391 ko05130 Pathogenic Escherichia coli infection 13/635 77/7206 0.0229023182428 ko04612 Antigen processing and presentation 13/635 77/7206 0.0229023182428 ko00240 Pyrimidine metabolism 17/635 110/7206 0.0252535186036 ko04512 ECM-receptor interaction 13/635 79/7206 0.0254736203104 ko04910 Insulin signaling pathway 7/635 172/7206 0.0279766077311 ko04013 MAPK signaling pathway - fly 17/635 115/7206 0.0300511451754 ko04213 Longevity regulating pathway - multiple species 2/635 86/7206 0.0325452522105 ko05034 Alcoholism 12/635 238/7206 0.035819998615 ko04611 Platelet activation 7/635 163/7206 0.0358437445536 ko04024 cAMP signaling pathway 15/635 279/7206 0.0400164746828 ko04913 Ovarian steroidogenesis 1/635 63/7206 0.0412836985536 ko00600 Sphingolipid metabolism 1/635 63/7206 0.0412836985536 ko04371 Apelin signaling pathway 8/635 177/7206 0.0428686273211 ko04217 Necroptosis 8/635 178/7206 0.0431640095425 ko00514 Other types of O-glycan biosynthesis 6/635 30/7206 0.0437137362869 ko04721 Synaptic vesicle cycle 2/635 80/7206 0.0450638288395 ko04740 Olfactory transduction 2/635 80/7206 0.0450638288395 ko04970 Salivary secretion 3/635 95/7206 0.0452916590423