ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	201/1299	423/7206	4.37994661847e-47
ko04724	Glutamatergic synapse	92/1299	152/7206	4.58644583547e-32
ko05033	Nicotine addiction	48/1299	56/7206	2.95218814182e-28
ko04727	GABAergic synapse	70/1299	110/7206	1.62001636971e-26
ko05032	Morphine addiction	69/1299	110/7206	1.32644341637e-25
ko04713	Circadian entrainment	74/1299	136/7206	5.12952238183e-22
ko04728	Dopaminergic synapse	87/1299	185/7206	4.3575240568e-20
ko04721	Synaptic vesicle cycle	51/1299	80/7206	1.12040053168e-19
ko04723	Retrograde endocannabinoid signaling	81/1299	175/7206	3.01758130448e-18
ko04725	Cholinergic synapse	76/1299	160/7206	5.37886528282e-18
ko04024	cAMP signaling pathway	107/1299	279/7206	2.71982320902e-16
ko04020	Calcium signaling pathway	101/1299	265/7206	3.25244908664e-15
ko04726	Serotonergic synapse	62/1299	137/7206	1.10260979776e-13
ko04911	Insulin secretion	55/1299	117/7206	4.01478715251e-13
ko04742	Taste transduction	36/1299	61/7206	8.75553612781e-13
ko04744	Phototransduction	26/1299	36/7206	1.43474228135e-12
ko04921	Oxytocin signaling pathway	78/1299	209/7206	2.46467237111e-11
ko03010	Ribosome	1/1299	129/7206	3.44146253833e-10
ko05031	Amphetamine addiction	42/1299	91/7206	5.10054076394e-10
ko04720	Long-term potentiation	44/1299	99/7206	8.87522125957e-10
ko04261	Adrenergic signaling in cardiomyocytes	70/1299	205/7206	1.84490626769e-08
ko03040	Spliceosome	4/1299	145/7206	2.02420436481e-08
ko04925	Aldosterone synthesis and secretion	43/1299	105/7206	4.58121762985e-08
ko04970	Salivary secretion	39/1299	95/7206	1.19785642048e-07
ko05322	Systemic lupus erythematosus	6/1299	151/7206	2.77048456994e-07
ko03013	RNA transport	8/1299	166/7206	5.8807817863e-07
ko05168	Herpes simplex infection	10/1299	182/7206	7.35785698796e-07
ko04966	Collecting duct acid secretion	16/1299	26/7206	9.78945393731e-07
ko04971	Gastric acid secretion	38/1299	98/7206	1.00519816562e-06
ko05203	Viral carcinogenesis	22/1299	277/7206	2.0177290096e-06
ko04070	Phosphatidylinositol signaling system	41/1299	112/7206	2.56653336311e-06
ko05030	Cocaine addiction	30/1299	73/7206	3.67898678869e-06
ko04022	cGMP-PKG signaling pathway	66/1299	216/7206	5.47662760195e-06
ko04110	Cell cycle	8/1299	145/7206	1.51545731149e-05
ko04745	Phototransduction - fly	18/1299	38/7206	3.10866224908e-05
ko04072	Phospholipase D signaling pathway	59/1299	197/7206	3.11403374661e-05
ko04621	NOD-like receptor signaling pathway	10/1299	157/7206	3.32292167356e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1299	79/7206	4.45505470131e-05
ko04740	Olfactory transduction	30/1299	80/7206	4.75963763046e-05
ko04972	Pancreatic secretion	38/1299	111/7206	4.80406773158e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1299	74/7206	4.88771632714e-05
ko04010	MAPK signaling pathway	86/1299	321/7206	7.465644546e-05
ko04915	Estrogen signaling pathway	42/1299	131/7206	8.07191277699e-05
ko04730	Long-term depression	28/1299	78/7206	0.000152989428217
ko04014	Ras signaling pathway	75/1299	279/7206	0.000176711745168
ko04750	Inflammatory mediator regulation of TRP channels	39/1299	122/7206	0.00018519249888
ko00520	Amino sugar and nucleotide sugar metabolism	1/1299	55/7206	0.00033143960734
ko04360	Axon guidance	64/1299	233/7206	0.000346602612166
ko04064	NF-kappa B signaling pathway	5/1299	96/7206	0.000407980531529
ko05110	Vibrio cholerae infection	23/1299	63/7206	0.000422218297092
ko05140	Leishmaniasis	3/1299	75/7206	0.000431958588049
ko04141	Protein processing in endoplasmic reticulum	16/1299	184/7206	0.000432093695528
ko04120	Ubiquitin mediated proteolysis	10/1299	138/7206	0.000454165993781
ko04060	Cytokine-cytokine receptor interaction	17/1299	191/7206	0.000536628076213
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1299	79/7206	0.000555136363344
ko05161	Hepatitis B	15/1299	173/7206	0.00062013507457
ko04976	Bile secretion	27/1299	80/7206	0.000638194804185
ko04514	Cell adhesion molecules (CAMs)	39/1299	130/7206	0.000750887014437
ko04964	Proximal tubule bicarbonate reclamation	13/1299	29/7206	0.000769363329893
ko04710	Circadian rhythm	17/1299	43/7206	0.000934345958846
ko04610	Complement and coagulation cascades	4/1299	79/7206	0.0010625923485
ko04540	Gap junction	38/1299	128/7206	0.00106541098607
ko05169	Epstein-Barr virus infection	20/1299	206/7206	0.0011955806209
ko05414	Dilated cardiomyopathy	34/1299	112/7206	0.00119930668107
ko04371	Apelin signaling pathway	49/1299	177/7206	0.00141537794748
ko05164	Influenza A	15/1299	167/7206	0.0014644291413
ko03420	Nucleotide excision repair	1/1299	46/7206	0.00176683390951
ko04626	Plant-pathogen interaction	9/1299	18/7206	0.0019879646964
ko04270	Vascular smooth muscle contraction	43/1299	154/7206	0.00203246923416
ko04930	Type II diabetes mellitus	19/1299	54/7206	0.00221259085944
ko04922	Glucagon signaling pathway	37/1299	128/7206	0.00234593700651
ko04924	Renin secretion	27/1299	86/7206	0.00264663971264
ko03022	Basal transcription factors	1/1299	44/7206	0.00267474341562
ko05144	Malaria	1/1299	45/7206	0.0027481280826
ko05205	Proteoglycans in cancer	31/1299	271/7206	0.00359775469769
ko04622	RIG-I-like receptor signaling pathway	3/1299	62/7206	0.00417348073567
ko04923	Regulation of lipolysis in adipocytes	24/1299	77/7206	0.00436078984781
ko05133	Pertussis	6/1299	87/7206	0.00458991014903
ko04260	Cardiac muscle contraction	29/1299	98/7206	0.00499377226895
ko05166	HTLV-I infection	35/1299	292/7206	0.00506676723514
ko04217	Necroptosis	19/1299	178/7206	0.00763464009227
ko05219	Bladder cancer	2/1299	48/7206	0.00769828730533
ko00562	Inositol phosphate metabolism	26/1299	89/7206	0.00820940317809
ko05321	Inflammatory bowel disease (IBD)	3/1299	56/7206	0.00859537075354
ko05131	Shigellosis	6/1299	82/7206	0.00874324417674
ko00630	Glyoxylate and dicarboxylate metabolism	1/1299	38/7206	0.00944170471879
ko05145	Toxoplasmosis	12/1299	126/7206	0.0098876902006
ko04658	Th1 and Th2 cell differentiation	8/1299	96/7206	0.0106201637455
ko04213	Longevity regulating pathway - multiple species	25/1299	86/7206	0.010660788128
ko04657	IL-17 signaling pathway	7/1299	87/7206	0.0113461847368
ko05016	Huntington's disease	25/1299	215/7206	0.0115483164384
ko00240	Pyrimidine metabolism	10/1299	110/7206	0.0120003308341
ko04214	Apoptosis - fly	5/1299	72/7206	0.0126577021961
ko04960	Aldosterone-regulated sodium reabsorption	14/1299	41/7206	0.0127216988591
ko04973	Carbohydrate digestion and absorption	14/1299	42/7206	0.0148011728044
ko04962	Vasopressin-regulated water reabsorption	18/1299	58/7206	0.0151749804056
ko05206	MicroRNAs in cancer	20/1299	177/7206	0.0172180977034
ko05217	Basal cell carcinoma	5/1299	68/7206	0.0172212291886
ko03018	RNA degradation	7/1299	84/7206	0.0211711795684
ko00860	Porphyrin and chlorophyll metabolism	1/1299	34/7206	0.0220999103612
ko04630	Jak-STAT signaling pathway	14/1299	132/7206	0.0223009480266
ko04210	Apoptosis	21/1299	180/7206	0.0236535122429
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1299	100/7206	0.0251293065497
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1299	14/7206	0.0273441952016
ko04350	TGF-beta signaling pathway	10/1299	103/7206	0.02737485309
ko05231	Choline metabolism in cancer	34/1299	134/7206	0.0307401231313
ko04015	Rap1 signaling pathway	64/1299	278/7206	0.0314507059199
ko03410	Base excision repair	2/1299	38/7206	0.034969352287
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1299	59/7206	0.0398250545535
ko04510	Focal adhesion	31/1299	240/7206	0.0399283737111
ko05230	Central carbon metabolism in cancer	22/1299	81/7206	0.0406476678284
ko04113	Meiosis - yeast	6/1299	70/7206	0.0410028567052
ko05162	Measles	13/1299	120/7206	0.0410532919444
ko04912	GnRH signaling pathway	31/1299	122/7206	0.042444963824
ko04330	Notch signaling pathway	5/1299	62/7206	0.0447989212903
ko00280	Valine, leucine and isoleucine degradation	4/1299	54/7206	0.0484052008278