ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	194/1026	423/7206	1.05271336029e-59
ko04724	Glutamatergic synapse	87/1026	152/7206	7.31212225966e-36
ko05033	Nicotine addiction	49/1026	56/7206	1.03048835447e-34
ko04713	Circadian entrainment	74/1026	136/7206	1.19400432614e-28
ko04727	GABAergic synapse	65/1026	110/7206	4.18985495747e-28
ko05032	Morphine addiction	64/1026	110/7206	3.79327971954e-27
ko04728	Dopaminergic synapse	81/1026	185/7206	4.71632551198e-23
ko04725	Cholinergic synapse	72/1026	160/7206	1.90981516358e-21
ko04721	Synaptic vesicle cycle	48/1026	80/7206	1.95149158834e-21
ko04723	Retrograde endocannabinoid signaling	76/1026	175/7206	2.02322941853e-21
ko04024	cAMP signaling pathway	101/1026	279/7206	6.42142934172e-21
ko04020	Calcium signaling pathway	94/1026	265/7206	8.05671539469e-19
ko04911	Insulin secretion	56/1026	117/7206	1.83686058531e-18
ko04726	Serotonergic synapse	59/1026	137/7206	1.17151465218e-16
ko04921	Oxytocin signaling pathway	74/1026	209/7206	5.72068488637e-15
ko04742	Taste transduction	34/1026	61/7206	3.29329902058e-14
ko05031	Amphetamine addiction	42/1026	91/7206	1.81107217355e-13
ko04720	Long-term potentiation	44/1026	99/7206	2.51974198981e-13
ko04740	Olfactory transduction	38/1026	80/7206	8.49378367198e-13
ko04970	Salivary secretion	40/1026	95/7206	2.53220477234e-11
ko04261	Adrenergic signaling in cardiomyocytes	65/1026	205/7206	8.51058412575e-11
ko04925	Aldosterone synthesis and secretion	41/1026	105/7206	2.43125210334e-10
ko04744	Phototransduction	21/1026	36/7206	9.10401774529e-10
ko05030	Cocaine addiction	31/1026	73/7206	3.50528768134e-09
ko04971	Gastric acid secretion	37/1026	98/7206	5.50209645285e-09
ko03040	Spliceosome	1/1026	145/7206	9.36617219404e-09
ko05203	Viral carcinogenesis	12/1026	277/7206	9.0240592849e-08
ko05168	Herpes simplex infection	5/1026	182/7206	2.45506810206e-07
ko04972	Pancreatic secretion	36/1026	111/7206	7.85591562874e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1026	74/7206	1.41505968537e-06
ko04060	Cytokine-cytokine receptor interaction	7/1026	191/7206	1.66444317908e-06
ko04010	MAPK signaling pathway	77/1026	321/7206	1.738522381e-06
ko04540	Gap junction	39/1026	128/7206	2.17927353862e-06
ko05322	Systemic lupus erythematosus	4/1026	151/7206	2.654476409e-06
ko04730	Long-term depression	27/1026	78/7206	4.55639639032e-06
ko04745	Phototransduction - fly	17/1026	38/7206	5.32919651293e-06
ko04022	cGMP-PKG signaling pathway	55/1026	216/7206	1.02355784447e-05
ko04750	Inflammatory mediator regulation of TRP channels	36/1026	122/7206	1.02810243182e-05
ko04120	Ubiquitin mediated proteolysis	4/1026	138/7206	1.17845442754e-05
ko04360	Axon guidance	58/1026	233/7206	1.39274107776e-05
ko04966	Collecting duct acid secretion	13/1026	26/7206	1.56959802481e-05
ko04514	Cell adhesion molecules (CAMs)	37/1026	130/7206	2.00073784155e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1026	79/7206	2.41844045482e-05
ko04621	NOD-like receptor signaling pathway	6/1026	157/7206	2.48876664249e-05
ko05110	Vibrio cholerae infection	22/1026	63/7206	2.95224734672e-05
ko03013	RNA transport	7/1026	166/7206	4.00218928454e-05
ko05164	Influenza A	7/1026	167/7206	4.12894917792e-05
ko05169	Epstein-Barr virus infection	11/1026	206/7206	6.54126644773e-05
ko04260	Cardiac muscle contraction	29/1026	98/7206	0.000101093893709
ko04072	Phospholipase D signaling pathway	48/1026	197/7206	0.000114490930095
ko04924	Renin secretion	26/1026	86/7206	0.000124439288349
ko04612	Antigen processing and presentation	1/1026	77/7206	0.000201455600272
ko04141	Protein processing in endoplasmic reticulum	10/1026	184/7206	0.000235555306829
ko04976	Bile secretion	24/1026	80/7206	0.000267653283541
ko04110	Cell cycle	7/1026	145/7206	0.000422356495523
ko04014	Ras signaling pathway	61/1026	279/7206	0.000437248903961
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1026	59/7206	0.000453713178009
ko05414	Dilated cardiomyopathy	30/1026	112/7206	0.000516938815273
ko04070	Phosphatidylinositol signaling system	30/1026	112/7206	0.000516938815273
ko05162	Measles	5/1026	120/7206	0.00052114093124
ko04915	Estrogen signaling pathway	33/1026	131/7206	0.000874671425423
ko04912	GnRH signaling pathway	31/1026	122/7206	0.000944016001565
ko04350	TGF-beta signaling pathway	4/1026	103/7206	0.000944740082431
ko03008	Ribosome biogenesis in eukaryotes	2/1026	79/7206	0.00095523093497
ko04330	Notch signaling pathway	1/1026	62/7206	0.00148624942646
ko04626	Plant-pathogen interaction	8/1026	18/7206	0.00190568418779
ko04214	Apoptosis - fly	2/1026	72/7206	0.00202597912866
ko00310	Lysine degradation	2/1026	73/7206	0.00204008762945
ko00520	Amino sugar and nucleotide sugar metabolism	1/1026	55/7206	0.00328193557646
ko00480	Glutathione metabolism	1/1026	55/7206	0.00328193557646
ko05166	HTLV-I infection	25/1026	292/7206	0.00353848258292
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1026	182/7206	0.003617233586
ko05205	Proteoglycans in cancer	23/1026	271/7206	0.00445054148977
ko00590	Arachidonic acid metabolism	1/1026	52/7206	0.00490113549261
ko04964	Proximal tubule bicarbonate reclamation	10/1026	29/7206	0.00501245290598
ko04610	Complement and coagulation cascades	3/1026	79/7206	0.00513182531258
ko04146	Peroxisome	4/1026	89/7206	0.00540161216438
ko00240	Pyrimidine metabolism	6/1026	110/7206	0.00550147645045
ko05140	Leishmaniasis	3/1026	75/7206	0.00712856446788
ko04064	NF-kappa B signaling pathway	5/1026	96/7206	0.00761083195085
ko04630	Jak-STAT signaling pathway	9/1026	132/7206	0.0114483505338
ko04973	Carbohydrate digestion and absorption	12/1026	42/7206	0.0133424727647
ko04015	Rap1 signaling pathway	54/1026	278/7206	0.0141424299537
ko04916	Melanogenesis	31/1026	142/7206	0.0145029982267
ko04371	Apelin signaling pathway	37/1026	177/7206	0.0159330255975
ko05144	Malaria	1/1026	45/7206	0.0163918088238
ko00071	Fatty acid degradation	1/1026	45/7206	0.0163918088238
ko03420	Nucleotide excision repair	1/1026	46/7206	0.0170996508145
ko04930	Type II diabetes mellitus	14/1026	54/7206	0.0189361640581
ko05321	Inflammatory bowel disease (IBD)	2/1026	56/7206	0.0192998916013
ko04657	IL-17 signaling pathway	5/1026	87/7206	0.019731892368
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1026	100/7206	0.0198026108965
ko05418	Fluid shear stress and atherosclerosis	14/1026	173/7206	0.020033796478
ko05161	Hepatitis B	14/1026	173/7206	0.020033796478
ko01524	Platinum drug resistance	4/1026	76/7206	0.020220438642
ko04217	Necroptosis	15/1026	178/7206	0.0223450822315
ko04978	Mineral absorption	11/1026	40/7206	0.0228740770226
ko05120	Epithelial cell signaling in Helicobacter pylori infection	21/1026	92/7206	0.0235637638274
ko04658	Th1 and Th2 cell differentiation	6/1026	96/7206	0.0259380961637
ko04270	Vascular smooth muscle contraction	32/1026	154/7206	0.0259420510956
ko03018	RNA degradation	5/1026	84/7206	0.0268901362502
ko04918	Thyroid hormone synthesis	20/1026	86/7206	0.0279610903604
ko04622	RIG-I-like receptor signaling pathway	3/1026	62/7206	0.0282530474186
ko00600	Sphingolipid metabolism	3/1026	63/7206	0.0283754836776
ko05215	Prostate cancer	8/1026	111/7206	0.0285908581116
ko04923	Regulation of lipolysis in adipocytes	18/1026	77/7206	0.0311615397333
ko05231	Choline metabolism in cancer	28/1026	134/7206	0.0330782017848
ko04668	TNF signaling pathway	9/1026	120/7206	0.0340832553875
ko05214	Glioma	18/1026	79/7206	0.0349709509539
ko00630	Glyoxylate and dicarboxylate metabolism	1/1026	38/7206	0.0352107298711
ko05016	Huntington's disease	20/1026	215/7206	0.0369287354916
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1026	40/7206	0.0369637673588
ko05131	Shigellosis	5/1026	82/7206	0.0369980633385
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/1026	14/7206	0.038185341377
ko04960	Aldosterone-regulated sodium reabsorption	11/1026	41/7206	0.0390275498978
ko05145	Toxoplasmosis	10/1026	126/7206	0.0394185569946
ko04210	Apoptosis	16/1026	180/7206	0.0394687439784
ko00330	Arginine and proline metabolism	3/1026	61/7206	0.0404298878146
ko05133	Pertussis	6/1026	87/7206	0.0452566933927
ko04114	Oocyte meiosis	28/1026	139/7206	0.0496356933702