ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	187/1170	423/7206	4.31900647156e-45
ko04724	Glutamatergic synapse	90/1170	152/7206	5.1563151203e-34
ko05033	Nicotine addiction	47/1170	56/7206	6.01430315075e-29
ko04721	Synaptic vesicle cycle	55/1170	80/7206	7.25605077296e-26
ko05032	Morphine addiction	66/1170	110/7206	1.22019425077e-25
ko04713	Circadian entrainment	74/1170	136/7206	6.58700330819e-25
ko04727	GABAergic synapse	64/1170	110/7206	7.50965953142e-24
ko04728	Dopaminergic synapse	86/1170	185/7206	1.37633176776e-22
ko04725	Cholinergic synapse	78/1170	160/7206	3.42389124167e-22
ko04024	cAMP signaling pathway	106/1170	279/7206	4.79674987041e-19
ko04723	Retrograde endocannabinoid signaling	76/1170	175/7206	6.22975837035e-18
ko04921	Oxytocin signaling pathway	81/1170	209/7206	1.63910090008e-15
ko04020	Calcium signaling pathway	95/1170	265/7206	2.46876081669e-15
ko04911	Insulin secretion	55/1170	117/7206	4.14837439484e-15
ko04726	Serotonergic synapse	58/1170	137/7206	2.2342219288e-13
ko04742	Taste transduction	35/1170	61/7206	2.3954990662e-13
ko04720	Long-term potentiation	47/1170	99/7206	2.70137656752e-13
ko04261	Adrenergic signaling in cardiomyocytes	74/1170	205/7206	3.0792035741e-12
ko05031	Amphetamine addiction	43/1170	91/7206	3.46272170667e-12
ko04744	Phototransduction	24/1170	36/7206	1.57456564926e-11
ko04360	Axon guidance	77/1170	233/7206	1.61979871951e-10
ko03040	Spliceosome	1/1170	145/7206	3.21788272972e-10
ko04970	Salivary secretion	40/1170	95/7206	1.51923049559e-09
ko04971	Gastric acid secretion	39/1170	98/7206	1.65134915683e-08
ko04966	Collecting duct acid secretion	17/1170	26/7206	2.45390147621e-08
ko04022	cGMP-PKG signaling pathway	66/1170	216/7206	9.59034911438e-08
ko04925	Aldosterone synthesis and secretion	39/1170	105/7206	1.57279382013e-07
ko03013	RNA transport	6/1170	166/7206	3.55433160975e-07
ko05168	Herpes simplex infection	8/1170	182/7206	1.09337630554e-06
ko05203	Viral carcinogenesis	18/1170	277/7206	1.11809270988e-06
ko05030	Cocaine addiction	29/1170	73/7206	1.18982117474e-06
ko04060	Cytokine-cytokine receptor interaction	9/1170	191/7206	1.21116693641e-06
ko04540	Gap junction	43/1170	128/7206	1.23950287171e-06
ko04740	Olfactory transduction	31/1170	80/7206	1.61595913734e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1170	74/7206	1.65765130195e-06
ko04924	Renin secretion	32/1170	86/7206	2.08758833515e-06
ko04120	Ubiquitin mediated proteolysis	5/1170	138/7206	6.00530597384e-06
ko05110	Vibrio cholerae infection	25/1170	63/7206	6.60595575273e-06
ko04621	NOD-like receptor signaling pathway	7/1170	157/7206	8.3100549012e-06
ko04010	MAPK signaling pathway	82/1170	321/7206	1.25706737541e-05
ko04730	Long-term depression	28/1170	78/7206	1.88358493698e-05
ko04610	Complement and coagulation cascades	1/1170	79/7206	2.0374610661e-05
ko04972	Pancreatic secretion	36/1170	111/7206	2.16231950581e-05
ko04070	Phosphatidylinositol signaling system	36/1170	112/7206	2.51178011554e-05
ko05164	Influenza A	9/1170	167/7206	2.70244301261e-05
ko04014	Ras signaling pathway	72/1170	279/7206	3.03839901349e-05
ko04745	Phototransduction - fly	17/1170	38/7206	3.19806154257e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1170	79/7206	3.62005136781e-05
ko04915	Estrogen signaling pathway	40/1170	131/7206	3.6227658434e-05
ko05322	Systemic lupus erythematosus	8/1170	151/7206	5.03342134499e-05
ko04072	Phospholipase D signaling pathway	54/1170	197/7206	5.14204750618e-05
ko04064	NF-kappa B signaling pathway	3/1170	96/7206	7.30655763343e-05
ko05414	Dilated cardiomyopathy	35/1170	112/7206	7.61277460985e-05
ko04514	Cell adhesion molecules (CAMs)	39/1170	130/7206	9.26604044098e-05
ko04141	Protein processing in endoplasmic reticulum	12/1170	184/7206	0.000101705075499
ko04260	Cardiac muscle contraction	31/1170	98/7206	0.000142913120915
ko04626	Plant-pathogen interaction	10/1170	18/7206	0.000152845173718
ko05169	Epstein-Barr virus infection	15/1170	206/7206	0.000165065597862
ko03008	Ribosome biogenesis in eukaryotes	2/1170	79/7206	0.000171913381108
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1170	59/7206	0.000253408862496
ko05140	Leishmaniasis	2/1170	75/7206	0.000389770905347
ko04371	Apelin signaling pathway	47/1170	177/7206	0.000400832556169
ko04750	Inflammatory mediator regulation of TRP channels	35/1170	122/7206	0.000453651296757
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1170	14/7206	0.000564116310178
ko04976	Bile secretion	25/1170	80/7206	0.000689168755991
ko00240	Pyrimidine metabolism	6/1170	110/7206	0.00097017789056
ko04146	Peroxisome	4/1170	89/7206	0.00121691704079
ko04110	Cell cycle	10/1170	145/7206	0.00129161214164
ko00480	Glutathione metabolism	1/1170	55/7206	0.00134432174412
ko05205	Proteoglycans in cancer	26/1170	271/7206	0.00181453032051
ko00590	Arachidonic acid metabolism	1/1170	52/7206	0.00198660943566
ko03018	RNA degradation	4/1170	84/7206	0.00249163804133
ko05162	Measles	8/1170	120/7206	0.00252798371608
ko04916	Melanogenesis	37/1170	142/7206	0.00258290700761
ko04923	Regulation of lipolysis in adipocytes	23/1170	77/7206	0.00267270118028
ko04964	Proximal tubule bicarbonate reclamation	11/1170	29/7206	0.00400564766215
ko04912	GnRH signaling pathway	32/1170	122/7206	0.00417969484472
ko03420	Nucleotide excision repair	1/1170	46/7206	0.00443813615181
ko04612	Antigen processing and presentation	4/1170	77/7206	0.00486682392689
ko05321	Inflammatory bowel disease (IBD)	2/1170	56/7206	0.00571782425096
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1170	100/7206	0.00582128293255
ko05120	Epithelial cell signaling in Helicobacter pylori infection	25/1170	92/7206	0.00658507900431
ko03022	Basal transcription factors	1/1170	44/7206	0.00668315358572
ko00071	Fatty acid degradation	1/1170	45/7206	0.00691293122307
ko05214	Glioma	22/1170	79/7206	0.0083825190472
ko05161	Hepatitis B	16/1170	173/7206	0.0090396971797
ko04622	RIG-I-like receptor signaling pathway	3/1170	62/7206	0.0093013874789
ko04640	Hematopoietic cell lineage	3/1170	64/7206	0.00950134363367
ko04214	Apoptosis - fly	4/1170	72/7206	0.00965485511926
ko05145	Toxoplasmosis	10/1170	126/7206	0.00989945750865
ko00140	Steroid hormone biosynthesis	1/1170	41/7206	0.00997804047122
ko04062	Chemokine signaling pathway	46/1170	201/7206	0.0116482449138
ko05034	Alcoholism	53/1170	238/7206	0.0123099749334
ko05231	Choline metabolism in cancer	33/1170	134/7206	0.012389335601
ko04015	Rap1 signaling pathway	61/1170	278/7206	0.012536117284
ko00330	Arginine and proline metabolism	3/1170	61/7206	0.0133867390374
ko00630	Glyoxylate and dicarboxylate metabolism	1/1170	38/7206	0.0149700689063
ko03410	Base excision repair	1/1170	38/7206	0.0149700689063
ko04350	TGF-beta signaling pathway	8/1170	103/7206	0.0152488692982
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1170	40/7206	0.0155441904317
ko00260	Glycine, serine and threonine metabolism	2/1170	48/7206	0.0176352585192
ko04973	Carbohydrate digestion and absorption	13/1170	42/7206	0.0181986560531
ko01524	Platinum drug resistance	5/1170	76/7206	0.0183766373832
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1170	182/7206	0.0187072492948
ko00562	Inositol phosphate metabolism	23/1170	89/7206	0.0196441741843
ko04114	Oocyte meiosis	33/1170	139/7206	0.0197838338947
ko04270	Vascular smooth muscle contraction	36/1170	154/7206	0.0198760390341
ko04722	Neurotrophin signaling pathway	37/1170	160/7206	0.0222482909652
ko00982	Drug metabolism - cytochrome P450	1/1170	37/7206	0.02274471346
ko05213	Endometrial cancer	17/1170	62/7206	0.0233484146965
ko05131	Shigellosis	6/1170	82/7206	0.0237078377759
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1170	15/7206	0.0241753247172
ko00310	Lysine degradation	5/1170	73/7206	0.025167916515
ko04115	p53 signaling pathway	5/1170	74/7206	0.0253421871895
ko05144	Malaria	2/1170	45/7206	0.0255432709613
ko00620	Pyruvate metabolism	2/1170	46/7206	0.0256711633515
ko04213	Longevity regulating pathway - multiple species	22/1170	86/7206	0.0260666002481
ko04930	Type II diabetes mellitus	15/1170	54/7206	0.0264082853763
ko00270	Cysteine and methionine metabolism	2/1170	47/7206	0.0264271628306
ko04962	Vasopressin-regulated water reabsorption	16/1170	58/7206	0.0296318830874
ko04668	TNF signaling pathway	11/1170	120/7206	0.0333824434632
ko04658	Th1 and Th2 cell differentiation	8/1170	96/7206	0.0356375019553
ko00600	Sphingolipid metabolism	4/1170	63/7206	0.0372787199364
ko01200	Carbon metabolism	12/1170	128/7206	0.0387104213717
ko00280	Valine, leucine and isoleucine degradation	3/1170	54/7206	0.0388577342377
ko04657	IL-17 signaling pathway	7/1170	87/7206	0.0393805459545
ko05133	Pertussis	7/1170	87/7206	0.0393805459545
ko00512	Mucin type O-glycan biosynthesis	9/1170	29/7206	0.0410956451474
ko04391	Hippo signaling pathway - fly	22/1170	90/7206	0.042833795667
ko03320	PPAR signaling pathway	5/1170	69/7206	0.0471815100838
ko05206	MicroRNAs in cancer	19/1170	177/7206	0.049200269825
ko04136	Autophagy - other	1/1170	31/7206	0.0493679829615