ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	203/1224	423/7206	6.20898088357e-53
ko04724	Glutamatergic synapse	90/1224	152/7206	2.02021088907e-32
ko05033	Nicotine addiction	48/1224	56/7206	1.7760852078e-29
ko05032	Morphine addiction	68/1224	110/7206	2.75737343045e-26
ko04713	Circadian entrainment	75/1224	136/7206	1.90276250785e-24
ko04727	GABAergic synapse	65/1224	110/7206	1.33565989212e-23
ko04728	Dopaminergic synapse	86/1224	185/7206	3.19129194605e-21
ko04721	Synaptic vesicle cycle	51/1224	80/7206	7.25248612934e-21
ko04020	Calcium signaling pathway	104/1224	265/7206	1.44821218362e-18
ko04725	Cholinergic synapse	74/1224	160/7206	3.01809470972e-18
ko04024	cAMP signaling pathway	107/1224	279/7206	3.13154056926e-18
ko04723	Retrograde endocannabinoid signaling	77/1224	175/7206	2.22233623939e-17
ko04742	Taste transduction	39/1224	61/7206	2.6171688094e-16
ko04911	Insulin secretion	55/1224	117/7206	3.04766124522e-14
ko04921	Oxytocin signaling pathway	80/1224	209/7206	7.95647879588e-14
ko04726	Serotonergic synapse	60/1224	137/7206	1.08155668059e-13
ko04744	Phototransduction	25/1224	36/7206	4.04162790698e-12
ko04261	Adrenergic signaling in cardiomyocytes	74/1224	205/7206	2.10731206962e-11
ko03040	Spliceosome	1/1224	145/7206	7.11706050037e-11
ko05031	Amphetamine addiction	42/1224	91/7206	7.32455076894e-11
ko04720	Long-term potentiation	44/1224	99/7206	1.21372907483e-10
ko04970	Salivary secretion	42/1224	95/7206	3.94235358924e-10
ko04022	cGMP-PKG signaling pathway	70/1224	216/7206	1.82864718188e-08
ko05203	Viral carcinogenesis	16/1224	277/7206	1.93384372544e-08
ko04360	Axon guidance	74/1224	233/7206	2.12366918755e-08
ko05030	Cocaine addiction	31/1224	73/7206	2.42462096869e-07
ko04060	Cytokine-cytokine receptor interaction	9/1224	191/7206	3.88774290233e-07
ko04925	Aldosterone synthesis and secretion	39/1224	105/7206	5.70279742314e-07
ko03013	RNA transport	7/1224	166/7206	5.70654164483e-07
ko05164	Influenza A	7/1224	167/7206	5.78770346498e-07
ko04971	Gastric acid secretion	37/1224	98/7206	8.42392904773e-07
ko05168	Herpes simplex infection	9/1224	182/7206	1.08878550928e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1224	74/7206	1.25295782996e-06
ko05322	Systemic lupus erythematosus	6/1224	151/7206	1.50101564476e-06
ko04924	Renin secretion	33/1224	86/7206	1.73549651784e-06
ko04740	Olfactory transduction	31/1224	80/7206	2.95166983269e-06
ko04966	Collecting duct acid secretion	15/1224	26/7206	3.10242445093e-06
ko04610	Complement and coagulation cascades	1/1224	79/7206	1.27196186502e-05
ko04514	Cell adhesion molecules (CAMs)	42/1224	130/7206	1.55728716305e-05
ko05169	Epstein-Barr virus infection	14/1224	206/7206	1.89847075205e-05
ko04010	MAPK signaling pathway	84/1224	321/7206	2.5156462656e-05
ko04070	Phosphatidylinositol signaling system	37/1224	112/7206	3.32417474566e-05
ko04621	NOD-like receptor signaling pathway	9/1224	157/7206	3.51706002092e-05
ko04972	Pancreatic secretion	36/1224	111/7206	5.80231756112e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1224	79/7206	6.12770321103e-05
ko04540	Gap junction	40/1224	128/7206	6.67022919762e-05
ko04141	Protein processing in endoplasmic reticulum	13/1224	184/7206	9.28886250349e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1224	79/7206	0.000110965105412
ko04976	Bile secretion	28/1224	80/7206	0.000118508675743
ko04120	Ubiquitin mediated proteolysis	8/1224	138/7206	0.000130456890355
ko05205	Proteoglycans in cancer	24/1224	271/7206	0.000135106098623
ko05140	Leishmaniasis	2/1224	75/7206	0.000162319619569
ko04064	NF-kappa B signaling pathway	4/1224	96/7206	0.000182765516965
ko05414	Dilated cardiomyopathy	35/1224	112/7206	0.000184706573991
ko04110	Cell cycle	9/1224	145/7206	0.000188264095393
ko04745	Phototransduction - fly	16/1224	38/7206	0.000229093805644
ko05110	Vibrio cholerae infection	23/1224	63/7206	0.000256283920355
ko04260	Cardiac muscle contraction	31/1224	98/7206	0.00033925646971
ko05161	Hepatitis B	13/1224	173/7206	0.000433236070764
ko05162	Measles	7/1224	120/7206	0.00049803065506
ko04612	Antigen processing and presentation	3/1224	77/7206	0.000680798342204
ko04371	Apelin signaling pathway	47/1224	177/7206	0.00110918665157
ko04730	Long-term depression	25/1224	78/7206	0.00115662445508
ko04626	Plant-pathogen interaction	9/1224	18/7206	0.00128191954356
ko04750	Inflammatory mediator regulation of TRP channels	35/1224	122/7206	0.00136997074611
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1224	59/7206	0.00139398631056
ko04014	Ras signaling pathway	68/1224	279/7206	0.00143903013229
ko04964	Proximal tubule bicarbonate reclamation	12/1224	29/7206	0.00166252393783
ko00330	Arginine and proline metabolism	2/1224	61/7206	0.00173141679938
ko00240	Pyrimidine metabolism	7/1224	110/7206	0.00186838049356
ko04923	Regulation of lipolysis in adipocytes	24/1224	77/7206	0.00196475265059
ko04630	Jak-STAT signaling pathway	10/1224	132/7206	0.00221314158117
ko04146	Peroxisome	5/1224	89/7206	0.00249507919324
ko04072	Phospholipase D signaling pathway	50/1224	197/7206	0.00268721635535
ko05321	Inflammatory bowel disease (IBD)	2/1224	56/7206	0.00375606035401
ko03022	Basal transcription factors	1/1224	44/7206	0.00427403964296
ko00071	Fatty acid degradation	1/1224	45/7206	0.00434146473578
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1224	14/7206	0.0045468479509
ko04915	Estrogen signaling pathway	35/1224	131/7206	0.00455404163348
ko03420	Nucleotide excision repair	1/1224	46/7206	0.00459211317432
ko05145	Toxoplasmosis	10/1224	126/7206	0.00547799429422
ko00480	Glutathione metabolism	2/1224	55/7206	0.00576826241874
ko04622	RIG-I-like receptor signaling pathway	3/1224	62/7206	0.00627065565022
ko04640	Hematopoietic cell lineage	3/1224	64/7206	0.00649832943045
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1224	100/7206	0.00668229178262
ko00310	Lysine degradation	4/1224	73/7206	0.00687055104039
ko00590	Arachidonic acid metabolism	2/1224	52/7206	0.0082437427506
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1224	182/7206	0.0089965850901
ko04657	IL-17 signaling pathway	6/1224	87/7206	0.00914872982864
ko05133	Pertussis	6/1224	87/7206	0.00914872982864
ko05215	Prostate cancer	9/1224	111/7206	0.0103131707656
ko05219	Bladder cancer	2/1224	48/7206	0.0118029471534
ko00380	Tryptophan metabolism	2/1224	50/7206	0.0122795943785
ko03018	RNA degradation	6/1224	84/7206	0.0124897326408
ko01524	Platinum drug resistance	5/1224	76/7206	0.0130834187267
ko00630	Glyoxylate and dicarboxylate metabolism	1/1224	38/7206	0.0149133886616
ko04620	Toll-like receptor signaling pathway	8/1224	100/7206	0.0149844018849
ko00562	Inositol phosphate metabolism	24/1224	89/7206	0.0154728920833
ko04270	Vascular smooth muscle contraction	38/1224	154/7206	0.0163938764861
ko05131	Shigellosis	6/1224	82/7206	0.0171104122741
ko04930	Type II diabetes mellitus	16/1224	54/7206	0.0178136370298
ko04214	Apoptosis - fly	5/1224	72/7206	0.0179100563485
ko04115	p53 signaling pathway	5/1224	74/7206	0.0182787422233
ko04658	Th1 and Th2 cell differentiation	8/1224	96/7206	0.0197747132527
ko04933	AGE-RAGE signaling pathway in diabetic complications	13/1224	135/7206	0.020220990508
ko04210	Apoptosis	19/1224	180/7206	0.0202804531775
ko05166	HTLV-I infection	35/1224	292/7206	0.0207430145827
ko05222	Small cell lung cancer	7/1224	89/7206	0.0218795853419
ko05144	Malaria	2/1224	45/7206	0.0258522149393
ko00280	Valine, leucine and isoleucine degradation	3/1224	54/7206	0.0268108760867
ko04510	Focal adhesion	28/1224	240/7206	0.0283600314335
ko04916	Melanogenesis	34/1224	142/7206	0.0314829412772
ko03320	PPAR signaling pathway	5/1224	69/7206	0.0343910752877
ko04140	Autophagy - animal	18/1224	164/7206	0.0356049976606
ko04668	TNF signaling pathway	12/1224	120/7206	0.0373325139765
ko04710	Circadian rhythm	13/1224	43/7206	0.0382285645248
ko04918	Thyroid hormone synthesis	22/1224	86/7206	0.0419165239118
ko05206	MicroRNAs in cancer	20/1224	177/7206	0.0423299447636
ko04217	Necroptosis	20/1224	178/7206	0.0425653678673
ko05320	Autoimmune thyroid disease	1/1224	29/7206	0.0483956431555
ko05340	Primary immunodeficiency	1/1224	30/7206	0.048651011129
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1224	92/7206	0.0492391613504