ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 148/864 423/7206 1.30132839986e-37 ko04724 Glutamatergic synapse 73/864 152/7206 1.18940673266e-28 ko05033 Nicotine addiction 42/864 56/7206 9.18889531295e-28 ko04727 GABAergic synapse 53/864 110/7206 3.86899820072e-21 ko04721 Synaptic vesicle cycle 44/864 80/7206 1.10265840969e-20 ko05032 Morphine addiction 52/864 110/7206 2.75285154651e-20 ko04728 Dopaminergic synapse 66/864 185/7206 1.95027613908e-17 ko04744 Phototransduction 26/864 36/7206 6.18594229061e-17 ko04713 Circadian entrainment 54/864 136/7206 8.25940509286e-17 ko04723 Retrograde endocannabinoid signaling 62/864 175/7206 2.82955991249e-16 ko04725 Cholinergic synapse 55/864 160/7206 6.31264058834e-14 ko04024 cAMP signaling pathway 78/864 279/7206 1.35683166449e-13 ko04726 Serotonergic synapse 49/864 137/7206 2.75275500318e-13 ko04742 Taste transduction 29/864 61/7206 6.09748852663e-12 ko04911 Insulin secretion 39/864 117/7206 8.63444792278e-10 ko04740 Olfactory transduction 30/864 80/7206 3.37204493845e-09 ko05031 Amphetamine addiction 31/864 91/7206 2.64728042996e-08 ko04921 Oxytocin signaling pathway 54/864 209/7206 2.67495892488e-08 ko05014 Amyotrophic lateral sclerosis (ALS) 27/864 74/7206 4.0706023879e-08 ko04720 Long-term potentiation 32/864 99/7206 6.5582173428e-08 ko05030 Cocaine addiction 26/864 73/7206 1.27758837298e-07 ko05203 Viral carcinogenesis 9/864 277/7206 2.3762348152e-07 ko04261 Adrenergic signaling in cardiomyocytes 51/864 205/7206 2.6789646768e-07 ko04020 Calcium signaling pathway 60/864 265/7206 6.24154713444e-07 ko05164 Influenza A 3/864 167/7206 1.59724951901e-06 ko03040 Spliceosome 2/864 145/7206 3.37543160774e-06 ko04120 Ubiquitin mediated proteolysis 2/864 138/7206 7.36000964581e-06 ko04970 Salivary secretion 27/864 95/7206 1.59002779876e-05 ko04060 Cytokine-cytokine receptor interaction 6/864 191/7206 2.16848474199e-05 ko05168 Herpes simplex infection 6/864 182/7206 4.28447249527e-05 ko05162 Measles 2/864 120/7206 5.08255982531e-05 ko05322 Systemic lupus erythematosus 4/864 151/7206 6.39064366337e-05 ko04730 Long-term depression 22/864 78/7206 0.000124682054713 ko04932 Non-alcoholic fatty liver disease (NAFLD) 7/864 182/7206 0.000181542011457 ko05169 Epstein-Barr virus infection 9/864 206/7206 0.000192918446509 ko05166 HTLV-I infection 16/864 292/7206 0.000208507304741 ko04260 Cardiac muscle contraction 25/864 98/7206 0.000209823338926 ko04514 Cell adhesion molecules (CAMs) 30/864 130/7206 0.000320915373275 ko05205 Proteoglycans in cancer 15/864 271/7206 0.000386139342737 ko04010 MAPK signaling pathway 60/864 321/7206 0.000397747682075 ko04971 Gastric acid secretion 24/864 98/7206 0.000467582610223 ko04966 Collecting duct acid secretion 10/864 26/7206 0.000508451885727 ko04621 NOD-like receptor signaling pathway 6/864 157/7206 0.000667605369749 ko04925 Aldosterone synthesis and secretion 25/864 105/7206 0.000668438728793 ko03013 RNA transport 7/864 166/7206 0.000946988714055 ko04745 Phototransduction - fly 12/864 38/7206 0.00113237310807 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 20/864 79/7206 0.00125440730233 ko04964 Proximal tubule bicarbonate reclamation 10/864 29/7206 0.00137001246825 ko00310 Lysine degradation 1/864 73/7206 0.00167372478508 ko04141 Protein processing in endoplasmic reticulum 9/864 184/7206 0.00170828690429 ko04350 TGF-beta signaling pathway 3/864 103/7206 0.00192587731801 ko03018 RNA degradation 2/864 84/7206 0.00340290709161 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/864 14/7206 0.00373880217236 ko04961 Endocrine and other factor-regulated calcium reabsorption 15/864 59/7206 0.0038196379241 ko04110 Cell cycle 7/864 145/7206 0.00433858597319 ko04972 Pancreatic secretion 24/864 111/7206 0.00448584307981 ko04610 Complement and coagulation cascades 2/864 79/7206 0.00478696396427 ko03008 Ribosome biogenesis in eukaryotes 2/864 79/7206 0.00478696396427 ko04540 Gap junction 26/864 128/7206 0.00575769619251 ko04974 Protein digestion and absorption 21/864 96/7206 0.00623440805947 ko05140 Leishmaniasis 2/864 75/7206 0.00690057282703 ko04612 Antigen processing and presentation 2/864 77/7206 0.00707155322481 ko04022 cGMP-PKG signaling pathway 39/864 216/7206 0.00764340647827 ko04146 Peroxisome 3/864 89/7206 0.00783437053082 ko04976 Bile secretion 18/864 80/7206 0.00811695077489 ko00330 Arginine and proline metabolism 1/864 61/7206 0.00839618042381 ko05161 Hepatitis B 10/864 173/7206 0.00873157677204 ko04360 Axon guidance 41/864 233/7206 0.0101449827525 ko05034 Alcoholism 42/864 238/7206 0.0107276820563 ko00520 Amino sugar and nucleotide sugar metabolism 1/864 55/7206 0.0118146496915 ko05321 Inflammatory bowel disease (IBD) 1/864 56/7206 0.0118643067574 ko04064 NF-kappa B signaling pathway 4/864 96/7206 0.0162464948418 ko00590 Arachidonic acid metabolism 1/864 52/7206 0.0173940397988 ko00280 Valine, leucine and isoleucine degradation 1/864 54/7206 0.0180760973052 ko05110 Vibrio cholerae infection 14/864 63/7206 0.0182909712423 ko05016 Huntington's disease 15/864 215/7206 0.0188403083534 ko04611 Platelet activation 10/864 163/7206 0.0196476707338 ko04014 Ras signaling pathway 46/864 279/7206 0.0236086927237 ko05204 Chemical carcinogenesis 1/864 48/7206 0.0255927150973 ko00260 Glycine, serine and threonine metabolism 1/864 48/7206 0.0255927150973 ko04072 Phospholipase D signaling pathway 34/864 197/7206 0.0257658591424 ko04915 Estrogen signaling pathway 24/864 131/7206 0.0295732145992 ko00561 Glycerolipid metabolism 2/864 63/7206 0.0296834426684 ko04657 IL-17 signaling pathway 4/864 87/7206 0.0298765754759 ko04668 TNF signaling pathway 7/864 120/7206 0.0332111175091 ko00240 Pyrimidine metabolism 6/864 110/7206 0.0366983354849 ko05144 Malaria 1/864 45/7206 0.0374951336087 ko00071 Fatty acid degradation 1/864 45/7206 0.0374951336087 ko04140 Autophagy - animal 11/864 164/7206 0.0376823968424 ko00620 Pyruvate metabolism 1/864 46/7206 0.0378160715002 ko05414 Dilated cardiomyopathy 21/864 112/7206 0.038326390427 ko01200 Carbon metabolism 8/864 128/7206 0.0397550736924 ko04924 Renin secretion 17/864 86/7206 0.0425273789303 ko04214 Apoptosis - fly 3/864 72/7206 0.0425646976066 ko05200 Pathways in cancer 45/864 492/7206 0.0440615622583 ko04750 Inflammatory mediator regulation of TRP channels 22/864 122/7206 0.0477777424916 ko04978 Mineral absorption 9/864 40/7206 0.0496014347441