ko pathway ratio_in_study ratio_in_pop p_value ko04360 Axon guidance 33/351 233/7206 2.21137182129e-08 ko04010 MAPK signaling pathway 38/351 321/7206 3.1873997025e-07 ko05032 Morphine addiction 18/351 110/7206 5.03099518094e-06 ko04072 Phospholipase D signaling pathway 24/351 197/7206 2.75520725638e-05 ko04725 Cholinergic synapse 21/351 160/7206 2.88540017899e-05 ko04724 Glutamatergic synapse 19/351 152/7206 0.000134731504141 ko04144 Endocytosis 33/351 342/7206 0.000145520525341 ko04930 Type II diabetes mellitus 10/351 54/7206 0.000231985942743 ko04024 cAMP signaling pathway 28/351 279/7206 0.000283903287332 ko04914 Progesterone-mediated oocyte maturation 14/351 104/7206 0.000478156447297 ko04668 TNF signaling pathway 15/351 120/7206 0.000677181535963 ko04727 GABAergic synapse 14/351 110/7206 0.000847749664631 ko04070 Phosphatidylinositol signaling system 14/351 112/7206 0.00101511857144 ko04071 Sphingolipid signaling pathway 18/351 162/7206 0.00113517134982 ko05033 Nicotine addiction 9/351 56/7206 0.0013835061362 ko04911 Insulin secretion 14/351 117/7206 0.00155881391159 ko04723 Retrograde endocannabinoid signaling 18/351 175/7206 0.00222088029629 ko04211 Longevity regulating pathway 14/351 123/7206 0.00251228245116 ko05210 Colorectal cancer 11/351 86/7206 0.00287014512404 ko04550 Signaling pathways regulating pluripotency of stem cells 17/351 165/7206 0.002930235682 ko05231 Choline metabolism in cancer 15/351 134/7206 0.00327260296226 ko04931 Insulin resistance 15/351 137/7206 0.00362194859254 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/351 14/7206 0.00375266222082 ko04920 Adipocytokine signaling pathway 11/351 89/7206 0.00376242896225 ko04923 Regulation of lipolysis in adipocytes 10/351 77/7206 0.0039356093977 ko04730 Long-term depression 10/351 78/7206 0.00432445259189 ko04710 Circadian rhythm 7/351 43/7206 0.00432951085277 ko04925 Aldosterone synthesis and secretion 12/351 105/7206 0.00483129765472 ko03013 RNA transport 1/351 166/7206 0.00507708180405 ko04915 Estrogen signaling pathway 14/351 131/7206 0.0058417669502 ko00515 Mannose type O-glycan biosynthesis 5/351 25/7206 0.00631765147387 ko05212 Pancreatic cancer 10/351 83/7206 0.00674484535322 ko05322 Systemic lupus erythematosus 1/351 151/7206 0.00703841354402 ko04261 Adrenergic signaling in cardiomyocytes 19/351 205/7206 0.00725392593347 ko04713 Circadian entrainment 14/351 136/7206 0.00730738431256 ko04722 Neurotrophin signaling pathway 16/351 160/7206 0.00767121170763 ko04666 Fc gamma R-mediated phagocytosis 13/351 122/7206 0.00836628044633 ko04213 Longevity regulating pathway - multiple species 10/351 86/7206 0.00863499348354 ko04664 Fc epsilon RI signaling pathway 9/351 77/7206 0.0120410571502 ko04728 Dopaminergic synapse 17/351 185/7206 0.0135084757258 ko04011 MAPK signaling pathway - yeast 7/351 53/7206 0.0136775831002 ko04140 Autophagy - animal 15/351 164/7206 0.0160346624421 ko04520 Adherens junction 11/351 103/7206 0.0168531525406 ko04912 GnRH signaling pathway 12/351 122/7206 0.0175292562021 ko01522 Endocrine resistance 12/351 124/7206 0.0192515047348 ko04921 Oxytocin signaling pathway 18/351 209/7206 0.0203955726425 ko04012 ErbB signaling pathway 11/351 109/7206 0.0208457523482 ko04014 Ras signaling pathway 22/351 279/7206 0.0226385343774 ko04022 cGMP-PKG signaling pathway 18/351 216/7206 0.0234260166609 ko04068 FoxO signaling pathway 15/351 167/7206 0.0262011450453 ko04910 Insulin signaling pathway 15/351 172/7206 0.028683853964 ko05213 Endometrial cancer 7/351 62/7206 0.0301383151408 ko04371 Apelin signaling pathway 15/351 177/7206 0.0323621572603 ko05221 Acute myeloid leukemia 7/351 63/7206 0.0325459743306 ko00510 N-Glycan biosynthesis 6/351 50/7206 0.0333621003823 ko05142 Chagas disease (American trypanosomiasis) 12/351 130/7206 0.0353104509793 ko05166 HTLV-I infection 22/351 292/7206 0.0368692209452 ko00562 Inositol phosphate metabolism 9/351 89/7206 0.0400241035873 ko04960 Aldosterone-regulated sodium reabsorption 5/351 41/7206 0.0473963264554