ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	180/1077	423/7206	6.28379099693e-46
ko04724	Glutamatergic synapse	80/1077	152/7206	4.48765755723e-28
ko05033	Nicotine addiction	43/1077	56/7206	4.05081765898e-25
ko04721	Synaptic vesicle cycle	50/1077	80/7206	1.85567915962e-22
ko05032	Morphine addiction	59/1077	110/7206	1.64246893104e-21
ko04713	Circadian entrainment	66/1077	136/7206	8.52577226763e-21
ko04727	GABAergic synapse	56/1077	110/7206	4.64237475071e-19
ko04728	Dopaminergic synapse	77/1077	185/7206	5.04583292367e-19
ko04725	Cholinergic synapse	68/1077	160/7206	1.69065846106e-17
ko04723	Retrograde endocannabinoid signaling	69/1077	175/7206	1.0851450586e-15
ko04020	Calcium signaling pathway	88/1077	265/7206	2.6475711886e-14
ko04911	Insulin secretion	51/1077	117/7206	5.92856656116e-14
ko04024	cAMP signaling pathway	90/1077	279/7206	1.14710125057e-13
ko04921	Oxytocin signaling pathway	72/1077	209/7206	8.67726080779e-13
ko04742	Taste transduction	33/1077	61/7206	1.01688841794e-12
ko04726	Serotonergic synapse	54/1077	137/7206	1.55604492843e-12
ko04261	Adrenergic signaling in cardiomyocytes	67/1077	205/7206	9.86733058065e-11
ko04970	Salivary secretion	39/1077	95/7206	4.98109658942e-10
ko05031	Amphetamine addiction	37/1077	91/7206	1.92041316066e-09
ko04720	Long-term potentiation	39/1077	99/7206	2.09134589334e-09
ko03040	Spliceosome	1/1077	145/7206	2.18407512609e-09
ko04360	Axon guidance	70/1077	233/7206	3.03771297755e-09
ko05203	Viral carcinogenesis	12/1077	277/7206	1.39310503438e-08
ko05168	Herpes simplex infection	5/1077	182/7206	7.08156627575e-08
ko05164	Influenza A	4/1077	167/7206	1.15320511486e-07
ko04060	Cytokine-cytokine receptor interaction	6/1077	191/7206	1.44109305161e-07
ko04010	MAPK signaling pathway	82/1077	321/7206	3.54638788099e-07
ko04925	Aldosterone synthesis and secretion	36/1077	105/7206	5.76777667178e-07
ko03013	RNA transport	5/1077	166/7206	7.17502652941e-07
ko04022	cGMP-PKG signaling pathway	60/1077	216/7206	8.37014176443e-07
ko04924	Renin secretion	31/1077	86/7206	9.64350877017e-07
ko04740	Olfactory transduction	29/1077	80/7206	1.88597569305e-06
ko04540	Gap junction	40/1077	128/7206	2.21426903407e-06
ko05030	Cocaine addiction	27/1077	73/7206	2.72132004228e-06
ko04744	Phototransduction	17/1077	36/7206	4.18751509936e-06
ko05322	Systemic lupus erythematosus	5/1077	151/7206	4.553183899e-06
ko04971	Gastric acid secretion	32/1077	98/7206	9.61475977919e-06
ko04621	NOD-like receptor signaling pathway	6/1077	157/7206	1.17707591877e-05
ko04120	Ubiquitin mediated proteolysis	5/1077	138/7206	2.93981105237e-05
ko04730	Long-term depression	26/1077	78/7206	3.84722313493e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	25/1077	74/7206	4.44967496967e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1077	79/7206	4.80159552376e-05
ko04514	Cell adhesion molecules (CAMs)	37/1077	130/7206	5.72627563678e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1077	59/7206	6.70458450096e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1077	79/7206	8.44124826572e-05
ko04972	Pancreatic secretion	32/1077	111/7206	0.000139496115402
ko04966	Collecting duct acid secretion	12/1077	26/7206	0.000147432633403
ko05169	Epstein-Barr virus infection	13/1077	206/7206	0.000147965733111
ko04260	Cardiac muscle contraction	29/1077	98/7206	0.000168288663275
ko04745	Phototransduction - fly	15/1077	38/7206	0.000196283914215
ko04141	Protein processing in endoplasmic reticulum	11/1077	184/7206	0.000213747638452
ko05414	Dilated cardiomyopathy	31/1077	112/7206	0.000428518384115
ko04014	Ras signaling pathway	63/1077	279/7206	0.000566979887572
ko04612	Antigen processing and presentation	2/1077	77/7206	0.000613733341562
ko04610	Complement and coagulation cascades	2/1077	79/7206	0.000642994328434
ko05140	Leishmaniasis	2/1077	75/7206	0.000907528400576
ko04070	Phosphatidylinositol signaling system	30/1077	112/7206	0.00113295865659
ko04750	Inflammatory mediator regulation of TRP channels	32/1077	122/7206	0.00116647430796
ko04064	NF-kappa B signaling pathway	4/1077	96/7206	0.00129802215744
ko05161	Hepatitis B	12/1077	173/7206	0.00163597318926
ko04371	Apelin signaling pathway	42/1077	177/7206	0.0018087950354
ko05110	Vibrio cholerae infection	19/1077	63/7206	0.00198460472394
ko04110	Cell cycle	9/1077	145/7206	0.00198678300674
ko00480	Glutathione metabolism	1/1077	55/7206	0.00211847649819
ko04146	Peroxisome	4/1077	89/7206	0.00260111241721
ko05162	Measles	7/1077	120/7206	0.00277094741351
ko00240	Pyrimidine metabolism	6/1077	110/7206	0.00279023535727
ko05205	Proteoglycans in cancer	24/1077	271/7206	0.00305760998986
ko04072	Phospholipase D signaling pathway	45/1077	197/7206	0.00308384957741
ko04976	Bile secretion	22/1077	80/7206	0.00385018676746
ko04915	Estrogen signaling pathway	32/1077	131/7206	0.00407955046529
ko04640	Hematopoietic cell lineage	2/1077	64/7206	0.00419032962338
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1077	182/7206	0.00421999792591
ko00590	Arachidonic acid metabolism	1/1077	52/7206	0.00502280055968
ko00330	Arginine and proline metabolism	2/1077	61/7206	0.00608627089734
ko04214	Apoptosis - fly	3/1077	72/7206	0.00698454610484
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1077	100/7206	0.00702427716455
ko04964	Proximal tubule bicarbonate reclamation	10/1077	29/7206	0.00711649291458
ko01200	Carbon metabolism	9/1077	128/7206	0.00837190282949
ko04668	TNF signaling pathway	8/1077	120/7206	0.0091527420087
ko03022	Basal transcription factors	1/1077	44/7206	0.0105577352063
ko00071	Fatty acid degradation	1/1077	45/7206	0.010567210546
ko04217	Necroptosis	15/1077	178/7206	0.0105857070271
ko00620	Pyruvate metabolism	1/1077	46/7206	0.0108811967804
ko03420	Nucleotide excision repair	1/1077	46/7206	0.0108811967804
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1077	14/7206	0.0112498021047
ko04626	Plant-pathogen interaction	7/1077	18/7206	0.0114900776576
ko05166	HTLV-I infection	29/1077	292/7206	0.0119412750654
ko04930	Type II diabetes mellitus	15/1077	54/7206	0.012323482631
ko05321	Inflammatory bowel disease (IBD)	2/1077	56/7206	0.012972643278
ko01524	Platinum drug resistance	4/1077	76/7206	0.0142897964807
ko04657	IL-17 signaling pathway	5/1077	87/7206	0.0143509597054
ko00983	Drug metabolism - other enzymes	1/1077	42/7206	0.0156842680804
ko05131	Shigellosis	5/1077	82/7206	0.0192192647962
ko00280	Valine, leucine and isoleucine degradation	2/1077	54/7206	0.0192525238596
ko03018	RNA degradation	5/1077	84/7206	0.0196094917672
ko04330	Notch signaling pathway	3/1077	62/7206	0.0196268791675
ko04622	RIG-I-like receptor signaling pathway	3/1077	62/7206	0.0196268791675
ko00561	Glycerolipid metabolism	3/1077	63/7206	0.019745036271
ko05145	Toxoplasmosis	10/1077	126/7206	0.0230357553737
ko04620	Toll-like receptor signaling pathway	7/1077	100/7206	0.0230465770148
ko04923	Regulation of lipolysis in adipocytes	19/1077	77/7206	0.0231947615036
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1077	40/7206	0.023633785781
ko00380	Tryptophan metabolism	2/1077	50/7206	0.0267881642812
ko04658	Th1 and Th2 cell differentiation	7/1077	96/7206	0.0306000668232
ko05418	Fluid shear stress and atherosclerosis	16/1077	173/7206	0.0308781764464
ko05133	Pertussis	6/1077	87/7206	0.0332714441016
ko04071	Sphingolipid signaling pathway	34/1077	162/7206	0.033948833494
ko00982	Drug metabolism - cytochrome P450	1/1077	37/7206	0.0348272459644
ko04630	Jak-STAT signaling pathway	11/1077	132/7206	0.0351173574824
ko04391	Hippo signaling pathway - fly	21/1077	90/7206	0.0356031783285
ko03410	Base excision repair	1/1077	38/7206	0.0360291508761
ko00270	Cysteine and methionine metabolism	2/1077	47/7206	0.0383509325678
ko04015	Rap1 signaling pathway	54/1077	278/7206	0.0390651141857
ko04916	Melanogenesis	30/1077	142/7206	0.0428725133821
ko05215	Prostate cancer	9/1077	111/7206	0.0433228977625
ko00310	Lysine degradation	5/1077	73/7206	0.0482302528689
ko04115	p53 signaling pathway	5/1077	74/7206	0.0482633001369