ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 35/289 152/7206 8.48999683953e-18 ko04080 Neuroactive ligand-receptor interaction 57/289 423/7206 1.01838828899e-16 ko04720 Long-term potentiation 26/289 99/7206 5.91158273566e-15 ko04713 Circadian entrainment 30/289 136/7206 7.59806770671e-15 ko05033 Nicotine addiction 18/289 56/7206 2.28393719102e-12 ko05031 Amphetamine addiction 22/289 91/7206 4.87928720582e-12 ko04024 cAMP signaling pathway 38/289 279/7206 1.7543063836e-11 ko04728 Dopaminergic synapse 30/289 185/7206 3.5142092755e-11 ko04020 Calcium signaling pathway 35/289 265/7206 2.83184781148e-10 ko04970 Salivary secretion 20/289 95/7206 6.79922978848e-10 ko04911 Insulin secretion 22/289 117/7206 9.22219466811e-10 ko04723 Retrograde endocannabinoid signaling 26/289 175/7206 5.33177248256e-09 ko04261 Adrenergic signaling in cardiomyocytes 28/289 205/7206 9.19111598658e-09 ko04727 GABAergic synapse 20/289 110/7206 1.0110461117e-08 ko05030 Cocaine addiction 16/289 73/7206 1.97783086624e-08 ko04925 Aldosterone synthesis and secretion 18/289 105/7206 1.4480380374e-07 ko04745 Phototransduction - fly 11/289 38/7206 1.63384511168e-07 ko04971 Gastric acid secretion 17/289 98/7206 2.71738937679e-07 ko04921 Oxytocin signaling pathway 25/289 209/7206 8.00689290006e-07 ko05014 Amyotrophic lateral sclerosis (ALS) 14/289 74/7206 1.0589836236e-06 ko04725 Cholinergic synapse 21/289 160/7206 1.3919920352e-06 ko05032 Morphine addiction 17/289 110/7206 1.48296455675e-06 ko04730 Long-term depression 14/289 78/7206 2.05692922943e-06 ko04022 cGMP-PKG signaling pathway 23/289 216/7206 1.60837854248e-05 ko04726 Serotonergic synapse 17/289 137/7206 3.03425170527e-05 ko04114 Oocyte meiosis 17/289 139/7206 3.666582456e-05 ko04721 Synaptic vesicle cycle 12/289 80/7206 7.20081077357e-05 ko04924 Renin secretion 12/289 86/7206 0.000147393707372 ko04540 Gap junction 15/289 128/7206 0.000171473121477 ko05034 Alcoholism 22/289 238/7206 0.00025671612557 ko04740 Olfactory transduction 11/289 80/7206 0.000316702022304 ko04014 Ras signaling pathway 24/289 279/7206 0.000433715067281 ko04972 Pancreatic secretion 13/289 111/7206 0.000465650687464 ko04626 Plant-pathogen interaction 5/289 18/7206 0.000558127856762 ko04742 Taste transduction 9/289 61/7206 0.00065523281488 ko04514 Cell adhesion molecules (CAMs) 14/289 130/7206 0.00067265681366 ko05010 Alzheimer's disease 19/289 202/7206 0.000678109633599 ko04750 Inflammatory mediator regulation of TRP channels 13/289 122/7206 0.00114822632927 ko04070 Phosphatidylinositol signaling system 12/289 112/7206 0.00168224457866 ko04260 Cardiac muscle contraction 11/289 98/7206 0.00178706617146 ko04072 Phospholipase D signaling pathway 17/289 197/7206 0.0025758272996 ko04966 Collecting duct acid secretion 5/289 26/7206 0.00329318303565 ko04912 GnRH signaling pathway 12/289 122/7206 0.00346426694113 ko04270 Vascular smooth muscle contraction 14/289 154/7206 0.00513147142555 ko00680 Methane metabolism 5/289 34/7206 0.0107295526577 ko05110 Vibrio cholerae infection 7/289 63/7206 0.0125551780282 ko04722 Neurotrophin signaling pathway 13/289 160/7206 0.0131588116477 ko05214 Glioma 8/289 79/7206 0.0134203966383 ko04744 Phototransduction 5/289 36/7206 0.0136231673377 ko04360 Axon guidance 17/289 233/7206 0.015950127941 ko04371 Apelin signaling pathway 14/289 177/7206 0.0170609338163 ko04922 Glucagon signaling pathway 11/289 128/7206 0.0185354152424 ko04978 Mineral absorption 5/289 40/7206 0.0208923748236 ko04918 Thyroid hormone synthesis 8/289 86/7206 0.0214946274246 ko04621 NOD-like receptor signaling pathway 1/289 157/7206 0.0218000517676 ko04960 Aldosterone-regulated sodium reabsorption 5/289 41/7206 0.0230389532934 ko00513 Various types of N-glycan biosynthesis 5/289 42/7206 0.0253233118096 ko05203 Viral carcinogenesis 4/289 277/7206 0.026826959453 ko04964 Proximal tubule bicarbonate reclamation 4/289 29/7206 0.0273010018397 ko04916 Melanogenesis 11/289 142/7206 0.0298763157762 ko04961 Endocrine and other factor-regulated calcium reabsorption 6/289 59/7206 0.0299889719357 ko05120 Epithelial cell signaling in Helicobacter pylori infection 8/289 92/7206 0.0307509701715 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/289 1/7206 0.0401054676659 ko04012 ErbB signaling pathway 9/289 109/7206 0.0416015158468 ko04016 MAPK signaling pathway - plant 3/289 20/7206 0.0439155392003 ko04120 Ubiquitin mediated proteolysis 1/289 138/7206 0.0453858406273 ko05166 HTLV-I infection 5/289 292/7206 0.0455671054736 ko05224 Breast cancer 2/289 174/7206 0.0489377483037